CA2246754C - Vecteurs d'apport de structures cochleaires - Google Patents
Vecteurs d'apport de structures cochleaires Download PDFInfo
- Publication number
- CA2246754C CA2246754C CA002246754A CA2246754A CA2246754C CA 2246754 C CA2246754 C CA 2246754C CA 002246754 A CA002246754 A CA 002246754A CA 2246754 A CA2246754 A CA 2246754A CA 2246754 C CA2246754 C CA 2246754C
- Authority
- CA
- Canada
- Prior art keywords
- nutrient
- cochleate formulation
- component
- cochleate
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18811—Sendai virus
- C12N2760/18834—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention se rapporte à des structures cochléaires comportant (a) un composant moléculaire biologiquement utile, (b) un composant lipidique négativement chargé et (c) un composant cationique divalent. Ladite structure cochléaire a une durée de conservation prolongée, même sous sa forme déshydratée. Elle peut être avantageusement ingérée. La molécule biologiquement utile peut être un polynucléotide ou un polypeptide.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1996/001704 WO1996025942A1 (fr) | 1995-02-22 | 1996-02-22 | Phospholipides cochleaires utilises dans l'administration de medicaments |
WOPCT/US96/01704 | 1996-02-22 | ||
PCT/US1997/002632 WO1997030725A1 (fr) | 1996-02-22 | 1997-02-21 | Vecteurs d'apport de structures cochleaires |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2246754A1 CA2246754A1 (fr) | 1997-08-28 |
CA2246754C true CA2246754C (fr) | 2002-10-22 |
Family
ID=22254697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002246754A Expired - Fee Related CA2246754C (fr) | 1996-02-22 | 1997-02-21 | Vecteurs d'apport de structures cochleaires |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2246754C (fr) |
WO (1) | WO1997030725A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9810051D0 (en) * | 1998-05-11 | 1998-07-08 | Nycomed Imaging As | Contrast media |
US6340591B1 (en) | 1998-12-14 | 2002-01-22 | University Of Maryland | Integrative protein-DNA cochleate formulations and methods for transforming cells |
AU2007200813B2 (en) * | 1999-01-22 | 2010-06-03 | Biodelivery Sicencies, Inc. | Novel hydrogel isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules |
US6153217A (en) | 1999-01-22 | 2000-11-28 | Biodelivery Sciences, Inc. | Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents |
AU3111401A (en) * | 2000-01-24 | 2001-07-31 | Biodelivery Sciences, Inc. | New cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules |
JP4886297B2 (ja) | 2002-11-01 | 2012-02-29 | バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド | ジオデート送達媒体 |
WO2004064805A1 (fr) * | 2003-01-15 | 2004-08-05 | Biodelivery Sciences International, Inc. | Preparations cochleaires de nutriants fragiles |
WO2004091578A2 (fr) | 2003-04-09 | 2004-10-28 | Biodelivery Sciences International, Inc. | Procedes de formation de structures cochleaires, structures cochleaires, et procedes d'utilisation |
WO2004091572A2 (fr) * | 2003-04-09 | 2004-10-28 | Biodelivery Sciences International, Inc. | Compositions contenant des structures cochleaires, dirigees contre l'expression de proteines |
KR101089534B1 (ko) * | 2003-10-15 | 2011-12-05 | 가부시키가이샤 나노에그 | 다가 금속 무기염 피복 레티노인산 나노입자의 입경의조정방법 및 당해 조정방법에 의해 얻어진 나노입자 |
JP4627727B2 (ja) * | 2003-10-15 | 2011-02-09 | 株式会社ナノエッグ | 多価金属無機塩被覆レチノイン酸ナノ粒子含有組成物 |
WO2011016043A2 (fr) | 2009-08-06 | 2011-02-10 | Technion Research & Development Foundation Ltd. | Libération de médicament antibiotique et potentialisation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4874795A (en) * | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
US4663161A (en) * | 1985-04-22 | 1987-05-05 | Mannino Raphael J | Liposome methods and compositions |
US4871488A (en) * | 1985-04-22 | 1989-10-03 | Albany Medical College Of Union University | Reconstituting viral glycoproteins into large phospholipid vesicles |
US4906476A (en) * | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
US5571517A (en) * | 1990-08-13 | 1996-11-05 | Yesair; David W. | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories |
-
1997
- 1997-02-21 CA CA002246754A patent/CA2246754C/fr not_active Expired - Fee Related
- 1997-02-21 WO PCT/US1997/002632 patent/WO1997030725A1/fr active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
WO1997030725A1 (fr) | 1997-08-28 |
CA2246754A1 (fr) | 1997-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20130221 |