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Indane dimer compounds and their pharmaceutical use

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Publication number
CA2239853A1
CA2239853A1 CA 2239853 CA2239853A CA2239853A1 CA 2239853 A1 CA2239853 A1 CA 2239853A1 CA 2239853 CA2239853 CA 2239853 CA 2239853 A CA2239853 A CA 2239853A CA 2239853 A1 CA2239853 A1 CA 2239853A1
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groups
alkyl
activity
containing
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CA 2239853
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French (fr)
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CA2239853C (en )
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John Walsh
Neil Frankish
Helen Sheridan
William Byrne
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Venantius Ltd
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Venantius Limited
John Walsh
Neil Frankish
Helen Sheridan
William Byrne
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Abstract

Indane dimer compounds of general formula 5, 6 or 9 and their pharma-ceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilising activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R1 and R3 to R15, and in formula 6, R1, R2 and R4 to R15, are selected from one or more of the same or different of H, halo, hy-droxy, alkoxy, aryloxy acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino hydroxylamino, amine oxide groups, azo groups, cyano, hy-drazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, hete-rocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may be saturated or unsaturated, substituted alkyl or cycloalkyl groups which may be saturated or unsaturated. In formulae 5, 6 and 9, X is O, NR (wherein R is acyl, alkyl or sulphonate groups), S, SO or SO2.
In formulae 5, 6 and 9, any one or more of R1, 1R1; R2, 1R2; R3 1R3; R9 1R9; R10, 1R10 and R14, 1R14 may together represent oxo.
CA 2239853 1995-12-06 1996-12-06 Indane dimer compounds and their pharmaceutical use Expired - Fee Related CA2239853C (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IE950922 1995-12-06
IE950922 1995-12-06
IE960762 1996-10-31
IE960762 1996-10-31
PCT/IE1996/000081 WO1997020805A1 (en) 1995-12-06 1996-12-06 Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or antiinflammatory activity

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CA2239853A1 true true CA2239853A1 (en) 1997-06-12
CA2239853C CA2239853C (en) 2006-11-28

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US (3) US6300376B1 (en)
JP (3) JP2000502072A (en)
CA (2) CA2239853C (en)
DE (6) DE69631688D1 (en)
DK (1) DK0865419T3 (en)
EP (3) EP0865419B1 (en)
GB (3) GB9812215D0 (en)
WO (3) WO1997020805A1 (en)

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DE10142659A1 (en) * 2001-08-31 2003-03-20 Aventis Pharma Gmbh Using multi-substituted indan-1-ol. Systems for the production of medicaments for the prophylaxis or treatment of obesity
DE10142668A1 (en) * 2001-08-31 2003-03-20 Aventis Pharma Gmbh Use of C2-substituted indan-1-on systems for the production of medicaments for the prophylaxis or treatment of obesity
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