CA2224439A1 - Improved process for synthesizing carbapenem intermediates - Google Patents

Improved process for synthesizing carbapenem intermediates Download PDF

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Publication number
CA2224439A1
CA2224439A1 CA002224439A CA2224439A CA2224439A1 CA 2224439 A1 CA2224439 A1 CA 2224439A1 CA 002224439 A CA002224439 A CA 002224439A CA 2224439 A CA2224439 A CA 2224439A CA 2224439 A1 CA2224439 A1 CA 2224439A1
Authority
CA
Canada
Prior art keywords
compound
formula
base
substantially non
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002224439A
Other languages
English (en)
French (fr)
Inventor
Chunhua Yang
Nobuyoshi Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602921.0A external-priority patent/GB9602921D0/en
Application filed by Individual filed Critical Individual
Publication of CA2224439A1 publication Critical patent/CA2224439A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002224439A 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates Abandoned CA2224439A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58595P 1995-06-28 1995-06-28
US60/000,585 1995-06-28
GB9602921.0 1996-02-13
GBGB9602921.0A GB9602921D0 (en) 1996-02-13 1996-02-13 Improved process for synthesizing carbapenem intermediates

Publications (1)

Publication Number Publication Date
CA2224439A1 true CA2224439A1 (en) 1997-01-16

Family

ID=26308678

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224439A Abandoned CA2224439A1 (en) 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates

Country Status (13)

Country Link
EP (1) EP0836607A1 (cs)
JP (1) JPH11513979A (cs)
KR (1) KR19990028406A (cs)
CN (1) CN1193322A (cs)
AR (1) AR002507A1 (cs)
AU (1) AU696543B2 (cs)
BR (1) BR9609338A (cs)
CA (1) CA2224439A1 (cs)
CZ (1) CZ419097A3 (cs)
EA (1) EA199800096A1 (cs)
HU (1) HUP9903016A3 (cs)
SK (1) SK176597A3 (cs)
WO (1) WO1997001564A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2732619A1 (en) 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
JP2675625B2 (ja) * 1989-01-12 1997-11-12 鐘淵化学工業株式会社 エノールシリルエーテル化合物の製造方法
NZ234411A (en) * 1989-07-18 1991-05-28 Merck & Co Inc Preparation of 2-diazo-3-silyloxy-3-butenoate esters
DE3934100A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Verfahren zur herstellung von 0-silylierten hydroxylverbindungen und ihre verwendung zur herstellung von estergruppen aufweisenden isocyanaten

Also Published As

Publication number Publication date
AU6392196A (en) 1997-01-30
BR9609338A (pt) 1999-05-11
KR19990028406A (ko) 1999-04-15
HUP9903016A3 (en) 2000-04-28
EP0836607A1 (en) 1998-04-22
AR002507A1 (es) 1998-03-25
EA199800096A1 (ru) 1998-08-27
CN1193322A (zh) 1998-09-16
WO1997001564A1 (en) 1997-01-16
SK176597A3 (en) 1998-07-08
MX9800041A (es) 1998-08-30
JPH11513979A (ja) 1999-11-30
CZ419097A3 (cs) 1998-07-15
AU696543B2 (en) 1998-09-10
HUP9903016A2 (hu) 2000-03-28

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Legal Events

Date Code Title Description
FZDE Discontinued