CA2215825A1 - Oligonucleotides a boucle et tige et circulaires - Google Patents

Oligonucleotides a boucle et tige et circulaires Download PDF

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Publication number
CA2215825A1
CA2215825A1 CA002215825A CA2215825A CA2215825A1 CA 2215825 A1 CA2215825 A1 CA 2215825A1 CA 002215825 A CA002215825 A CA 002215825A CA 2215825 A CA2215825 A CA 2215825A CA 2215825 A1 CA2215825 A1 CA 2215825A1
Authority
CA
Canada
Prior art keywords
domain
oligonucleotide
target
binding
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002215825A
Other languages
English (en)
Inventor
Eric T. Kool
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002215825A priority Critical patent/CA2215825A1/fr
Publication of CA2215825A1 publication Critical patent/CA2215825A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des oligonucléotides à tige/boucle et circulaires comprenant chacun un domaine de liaison de Watson Crick (WC) et au moins un domaine de liaison de Hoogsteen (H) correspondant, ces derniers étant séparés l'un de l'autre par des domaines de liaison. Chaque domaine WC présente une complémentarité suffisante pour se lier à un brin d'acide nucléique cible défini, par appariement de bases de Watson Crick selon une orientation antiparallèle. Chaque domaine H correspondant est capable de se lier au domaine WC par appariement de bases de Hoogsteen selon une configuration antiparallèle. L'invention concerne également des procédés de préparation et d'utilisation de ces oligonucléotides ainsi que des trousses et des compositions pharmaceutiques contenant ces derniers.
CA002215825A 1995-03-21 1995-03-21 Oligonucleotides a boucle et tige et circulaires Abandoned CA2215825A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002215825A CA2215825A1 (fr) 1995-03-21 1995-03-21 Oligonucleotides a boucle et tige et circulaires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002215825A CA2215825A1 (fr) 1995-03-21 1995-03-21 Oligonucleotides a boucle et tige et circulaires

Publications (1)

Publication Number Publication Date
CA2215825A1 true CA2215825A1 (fr) 1996-09-26

Family

ID=4161488

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215825A Abandoned CA2215825A1 (fr) 1995-03-21 1995-03-21 Oligonucleotides a boucle et tige et circulaires

Country Status (1)

Country Link
CA (1) CA2215825A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114062672A (zh) * 2021-11-12 2022-02-18 福州大学 一种检测covid-19抗体的血糖生物传感器

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114062672A (zh) * 2021-11-12 2022-02-18 福州大学 一种检测covid-19抗体的血糖生物传感器

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20020321