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CA2208671A1 - Substituted imides as tnf inhibitors - Google Patents

Substituted imides as tnf inhibitors

Info

Publication number
CA2208671A1
CA2208671A1 CA 2208671 CA2208671A CA2208671A1 CA 2208671 A1 CA2208671 A1 CA 2208671A1 CA 2208671 CA2208671 CA 2208671 CA 2208671 A CA2208671 A CA 2208671A CA 2208671 A1 CA2208671 A1 CA 2208671A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
inhibitors
imides
formula
cachexia
tnf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2208671
Other languages
French (fr)
Other versions
CA2208671C (en )
Inventor
George Muller
Mary Shire
David I. Stirling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corporation
George Muller
Mary Shire
David I. Stirling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1

Abstract

Novel imides of the general formula (see above formula) are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-Phthalimido-3-(3',4'-dimethoxyphenyl)propane.
CA 2208671 1994-12-30 1995-11-20 Substituted imides as tnf inhibitors Expired - Fee Related CA2208671C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US08/366,679 1994-12-30
US08366679 US6429221B1 (en) 1994-12-30 1994-12-30 Substituted imides
PCT/US1995/015384 WO1996020926A1 (en) 1994-12-30 1995-11-20 Substituted imides as tnf inhibitors

Publications (2)

Publication Number Publication Date
CA2208671A1 true true CA2208671A1 (en) 1996-07-11
CA2208671C CA2208671C (en) 2009-02-10

Family

ID=23444039

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2208671 Expired - Fee Related CA2208671C (en) 1994-12-30 1995-11-20 Substituted imides as tnf inhibitors

Country Status (11)

Country Link
US (3) US6429221B1 (en)
EP (1) EP0800514B1 (en)
JP (1) JP4118329B2 (en)
KR (1) KR20040007729A (en)
CA (1) CA2208671C (en)
DE (2) DE69535195T2 (en)
DK (1) DK0800514T3 (en)
ES (1) ES2271948T3 (en)
FI (1) FI972709A (en)
RU (1) RU2162078C2 (en)
WO (1) WO1996020926A1 (en)

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EP2395995A1 (en) 2009-02-10 2011-12-21 Celgene Corporation Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis
CA2794096A1 (en) 2010-04-07 2011-10-13 Celgene Corporation Methods for treating respiratory viral infection
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Also Published As

Publication number Publication date Type
KR20040007729A (en) 2004-01-24 application
US20020143027A1 (en) 2002-10-03 application
DE69535195T2 (en) 2007-07-12 grant
US7329761B2 (en) 2008-02-12 grant
US20050090516A1 (en) 2005-04-28 application
ES2271948T3 (en) 2007-04-16 grant
EP0800514A1 (en) 1997-10-15 application
US6429221B1 (en) 2002-08-06 grant
RU2162078C2 (en) 2001-01-20 grant
JPH10511946A (en) 1998-11-17 application
DK0800514T3 (en) 2006-12-27 grant
FI972709D0 (en) grant
WO1996020926A1 (en) 1996-07-11 application
JP4118329B2 (en) 2008-07-16 grant
CA2208671C (en) 2009-02-10 grant
DE69535195D1 (en) 2006-10-05 grant
FI972709A (en) 1997-08-29 application
US6844359B2 (en) 2005-01-18 grant
EP0800514B1 (en) 2006-08-23 grant
FI972709A0 (en) 1997-06-23 application

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