CA2201592A1 - Reponse immunitaire amelioree par l'introduction par recombinaison du gene de la cytokine et/ou du gene de la proteine co-stimulatrice b7 dans un systeme d'expression virale - Google Patents
Reponse immunitaire amelioree par l'introduction par recombinaison du gene de la cytokine et/ou du gene de la proteine co-stimulatrice b7 dans un systeme d'expression viraleInfo
- Publication number
- CA2201592A1 CA2201592A1 CA002201592A CA2201592A CA2201592A1 CA 2201592 A1 CA2201592 A1 CA 2201592A1 CA 002201592 A CA002201592 A CA 002201592A CA 2201592 A CA2201592 A CA 2201592A CA 2201592 A1 CA2201592 A1 CA 2201592A1
- Authority
- CA
- Canada
- Prior art keywords
- virus
- gal
- cancer
- mice
- recombinant virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne un virus de recombinaison qui comprend dans son génome ou dans une partie de celui-ci un gène codant pour un antigène d'un agent provoquant une maladie, en combinaison avec un gène codant pour une molécule immunostimulatrice permettant de stimuler la réponse immunitaire contre l'agent provoquant la maladie. On décrit des procédés de traitement de maladies telles que le cancer ou des maladies provoquées par des micro-organismes pathogènes, utilisant le virus de recombinaison.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31740294A | 1994-10-03 | 1994-10-03 | |
| US08/317,402 | 1994-10-03 | ||
| US47463995A | 1995-06-07 | 1995-06-07 | |
| US08/474,639 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2201592A1 true CA2201592A1 (fr) | 1996-04-18 |
Family
ID=26980930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002201592A Abandoned CA2201592A1 (fr) | 1994-10-03 | 1995-10-02 | Reponse immunitaire amelioree par l'introduction par recombinaison du gene de la cytokine et/ou du gene de la proteine co-stimulatrice b7 dans un systeme d'expression virale |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0789774A2 (fr) |
| AU (1) | AU712714B2 (fr) |
| CA (1) | CA2201592A1 (fr) |
| WO (1) | WO1996011279A2 (fr) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994024267A1 (fr) * | 1993-04-20 | 1994-10-27 | Robinson, William, S. | Methode et materiel de traitement de patients infectes par des agents infectieux intracellulaires |
| AU5507098A (en) * | 1995-12-19 | 1998-03-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Enhancement of dna immunization through the use of cytokines |
| AU718945B2 (en) * | 1996-07-25 | 2000-05-04 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| AU731860B2 (en) | 1996-07-25 | 2001-04-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Recombinant pox virus for immunization against tumor-associated antigens |
| FR2751879B1 (fr) * | 1996-07-30 | 1998-10-30 | Transgene Sa | Composition pharmaceutique contre les tumeurs et infections a papillomavirus |
| AU729579B2 (en) * | 1996-10-23 | 2001-02-01 | Trustees Of The University Of Pennsylvania, The | Immunotherapy and improved vaccines |
| US6077833A (en) * | 1996-12-31 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US7235653B2 (en) | 1996-12-31 | 2007-06-26 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| US6319906B1 (en) | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| AU5805798A (en) * | 1996-12-31 | 1998-07-31 | Wistar Institute, The | Recombinant adenoviral vector expressing antigens associated with colorectal tumors |
| US6730512B2 (en) | 1997-04-09 | 2004-05-04 | Amdl, Inc. | Combination immunogene therapy |
| CA2284689C (fr) * | 1997-04-09 | 2009-10-06 | Lung-Ji Chang | Modele animal aux fins d'une appreciation de vaccins |
| EP1518927A3 (fr) * | 1998-02-11 | 2005-06-22 | Maxygen, Inc. | Optimisation des propriétés immunomodulatrices de vaccins génétiques |
| CA2320431A1 (fr) * | 1998-02-11 | 1999-08-19 | Maxygen, Inc. | Ciblage de vecteurs de vaccins genetiques |
| JP2002504380A (ja) * | 1998-02-27 | 2002-02-12 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | ワクチン、免疫療法剤およびそれらの使用法 |
| EP1073749B1 (fr) * | 1998-04-22 | 2006-01-11 | Chiron Corporation | Procede pouvant ameliorer des reponses immunitaires a une immunisation genetique |
| US6919318B1 (en) | 1998-04-22 | 2005-07-19 | Chiron Corporation | Enhancing immune responses to genetic immunization by using a chemokine |
| US6734172B2 (en) | 1998-11-18 | 2004-05-11 | Pacific Northwest Research Institute | Surface receptor antigen vaccines |
| US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
| MXPA01011079A (es) | 1999-04-30 | 2002-07-22 | Univ Pennsylvania | Cd80 mutante de humano y composiciones y metodos para hacer y usar las mismas. |
| AU1013701A (en) | 1999-10-22 | 2001-05-08 | Aventis Pasteur Limited | Modified gp100 and uses thereof |
| US7361329B2 (en) | 2000-04-21 | 2008-04-22 | Chemocentryx, Inc. | Compositions for inducing an immune response |
| US7851212B2 (en) | 2000-05-10 | 2010-12-14 | Sanofi Pasteur Limited | Immunogenic polypeptides encoded by MAGE minigenes and uses thereof |
| US6544780B1 (en) | 2000-06-02 | 2003-04-08 | Genphar, Inc. | Adenovirus vector with multiple expression cassettes |
| US7754201B2 (en) | 2000-06-02 | 2010-07-13 | GenPhar, Inc | Method of vaccination through serotype rotation |
| US20020155127A1 (en) * | 2000-06-02 | 2002-10-24 | Danher Wang | Genetic vaccine against human immunodeficiency virus |
| JP2004507231A (ja) * | 2000-06-15 | 2004-03-11 | アメリカ合衆国 | 免疫応答を向上させるための、ｇｍ−ｃｓｆを発現する組換え非−複製性ウィルスおよびその使用 |
| US7092633B2 (en) | 2000-11-14 | 2006-08-15 | University Of Texas System Board Of Regents | System and method for configuring optical circuits |
| WO2003008537A2 (fr) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Sequences d'epitope |
| ES2290449T3 (es) | 2002-04-09 | 2008-02-16 | Sanofi Pasteur Limited | Acido nucleico de cea modificado y vectores de expresion. |
| WO2005035773A2 (fr) | 2003-10-08 | 2005-04-21 | Sanofi Pasteur, Inc. | Vecteur cea/b7 modifie |
| JP2006506072A (ja) | 2002-11-12 | 2006-02-23 | デイッセロース，アルバート，ビー | アデノウイルスベクターワクチン |
| AU2003297155B2 (en) * | 2002-12-16 | 2010-03-18 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant vaccine viruses expressing IL-15 and methods of using the same |
| US7960355B2 (en) | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
| US7897582B2 (en) | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
| EP1526185B1 (fr) * | 2003-10-22 | 2012-09-12 | Genelux Corporation | Utilisation des micro-organismes ou des cellules pour induire l'autoimmunisation contre des tumeurs |
| DE602004018927D1 (de) | 2003-06-18 | 2009-02-26 | Genelux Corp | Modifizierte rekombinante vacciniaviren, verwendungen davon |
| BRPI0413334A (pt) * | 2003-09-05 | 2006-10-10 | Sanofi Pasteur Ltd | vetores de multiantìgenos para melanoma |
| WO2005051991A2 (fr) | 2003-11-24 | 2005-06-09 | Sidney Kimmel Cancer Center | Vaccin d'antigene de mucine |
| US8828957B2 (en) | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
| EP2426142A3 (fr) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Souches de virus de vaccin modifiées pour une utilisation pour le diagnostic et procédé thérapeutique |
| CA2687688C (fr) * | 2007-05-23 | 2017-03-28 | Sangamo Biosciences, Inc. | Methodes et compositions destinees a augmenter l'expression transgenique dans les cellules t |
| JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
| KR20130075732A (ko) | 2010-03-30 | 2013-07-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
| CN108164602A (zh) | 2011-09-20 | 2018-06-15 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| NZ627796A (en) | 2012-12-18 | 2017-07-28 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| WO2014159960A1 (fr) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Anticorps contre l'hémagglutinine du virus de la grippe et utilisations correspondantes |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| WO1994024267A1 (fr) * | 1993-04-20 | 1994-10-27 | Robinson, William, S. | Methode et materiel de traitement de patients infectes par des agents infectieux intracellulaires |
| JP4148635B2 (ja) * | 2000-06-12 | 2008-09-10 | 国立大学法人 奈良先端科学技術大学院大学 | ナノサイズの希土類酸化物、及びその光化学反応を用いた製法 |
-
1995
- 1995-10-02 CA CA002201592A patent/CA2201592A1/fr not_active Abandoned
- 1995-10-02 WO PCT/US1995/012638 patent/WO1996011279A2/fr not_active Application Discontinuation
- 1995-10-02 EP EP95938706A patent/EP0789774A2/fr not_active Ceased
- 1995-10-02 AU AU39982/95A patent/AU712714B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3998295A (en) | 1996-05-02 |
| WO1996011279A3 (fr) | 1996-05-17 |
| AU712714B2 (en) | 1999-11-11 |
| WO1996011279A2 (fr) | 1996-04-18 |
| EP0789774A2 (fr) | 1997-08-20 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |