CA2171211A1 - Cellules secretant la cytokine, appariees a des haplotypes; methodes d'utilisation pour activer une reponse immune - Google Patents
Cellules secretant la cytokine, appariees a des haplotypes; methodes d'utilisation pour activer une reponse immuneInfo
- Publication number
- CA2171211A1 CA2171211A1 CA002171211A CA2171211A CA2171211A1 CA 2171211 A1 CA2171211 A1 CA 2171211A1 CA 002171211 A CA002171211 A CA 002171211A CA 2171211 A CA2171211 A CA 2171211A CA 2171211 A1 CA2171211 A1 CA 2171211A1
- Authority
- CA
- Canada
- Prior art keywords
- cytokine
- cells
- interleukin
- patient
- tumor cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
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- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Mycology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne une composition comprenant des cellules tumorales appariées par haplotype, qui ont subi une modification génétique pour leur faire exprimer un gène de cytokine, ainsi qu'une composition comprenant des fibroblastes autologues, qui ont subi une modification génétique pour leur faire exprimer un gène de cytokine, et des cellules tumorales non modifiées. L'invention concerne également des procédés d'utilisation des cellules sécrétrices de cytokines appariées par haplotype en vue de stimuler une réponse immunitaire contre une tumeur du système nerveux central d'un patient cancéreux. L'invention se rapporte en outre à un procédé d'inhibition ou de prévention de la croissance de cellules tumorales dans le système nerveux central par l'immunisation du patient à l'aide des cellules sécrétrices de cytokines appariées par haplotype.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11838393A | 1993-09-07 | 1993-09-07 | |
| US08/118,383 | 1993-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2171211A1 true CA2171211A1 (fr) | 1995-03-16 |
Family
ID=22378237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002171211A Abandoned CA2171211A1 (fr) | 1993-09-07 | 1994-09-06 | Cellules secretant la cytokine, appariees a des haplotypes; methodes d'utilisation pour activer une reponse immune |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0721351A4 (fr) |
| JP (1) | JPH09504786A (fr) |
| CA (1) | CA2171211A1 (fr) |
| WO (1) | WO1995007105A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69433110T2 (de) * | 1993-02-17 | 2004-06-03 | Sloan-Kettering Institute For Cancer Research | Allogenes vakzin und synthesemethode für selbiges |
| US5772995A (en) * | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
| US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
| DE19716098A1 (de) * | 1997-04-17 | 1998-10-22 | Univ Ludwigs Albert | Fibroblasten mit einem Fremdgen enthaltende Zusammensetzung zur Behandlung von Wunden |
| WO1999021887A2 (fr) * | 1997-10-23 | 1999-05-06 | Klehr Nikolaus W | Procede pour la production de cytokines de sang autologue humain |
| US20210171910A1 (en) * | 2018-08-27 | 2021-06-10 | Figene, Llc | Chimeric antigen receptor fibroblast cells for treatment of cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69433110T2 (de) * | 1993-02-17 | 2004-06-03 | Sloan-Kettering Institute For Cancer Research | Allogenes vakzin und synthesemethode für selbiges |
-
1994
- 1994-09-06 JP JP7508816A patent/JPH09504786A/ja active Pending
- 1994-09-06 EP EP94927393A patent/EP0721351A4/fr not_active Withdrawn
- 1994-09-06 CA CA002171211A patent/CA2171211A1/fr not_active Abandoned
- 1994-09-06 WO PCT/US1994/010217 patent/WO1995007105A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0721351A4 (fr) | 1998-08-19 |
| JPH09504786A (ja) | 1997-05-13 |
| EP0721351A1 (fr) | 1996-07-17 |
| WO1995007105A1 (fr) | 1995-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |