CA2157288A1 - Methods and compositions for inhibition of angiogenesis - Google Patents

Methods and compositions for inhibition of angiogenesis

Info

Publication number
CA2157288A1
CA2157288A1 CA 2157288 CA2157288A CA2157288A1 CA 2157288 A1 CA2157288 A1 CA 2157288A1 CA 2157288 CA2157288 CA 2157288 CA 2157288 A CA2157288 A CA 2157288A CA 2157288 A1 CA2157288 A1 CA 2157288A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
compounds
angiogenesis
thalidomide
inhibit
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2157288
Other languages
French (fr)
Other versions
CA2157288C (en )
Inventor
Robert D'amato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Children s Medical Center Corp
Original Assignee
Children s Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/825Arthritis

Abstract

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis.
Importantly, these compounds can be administered orally.
CA 2157288 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis Expired - Lifetime CA2157288C (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US2504693 true 1993-03-01 1993-03-01
US025,046 1993-03-01
US168,817 1993-12-15
US08168817 US5629327A (en) 1993-03-01 1993-12-15 Methods and compositions for inhibition of angiogenesis
PCT/US1994/001971 WO1994020085A1 (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA 2512926 CA2512926C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA 2342974 CA2342974C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
CA2157288A1 true true CA2157288A1 (en) 1994-09-15
CA2157288C CA2157288C (en) 2005-11-08

Family

ID=26699202

Family Applications (3)

Application Number Title Priority Date Filing Date
CA 2512926 Expired - Lifetime CA2512926C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA 2342974 Expired - Lifetime CA2342974C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA 2157288 Expired - Lifetime CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA 2512926 Expired - Lifetime CA2512926C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA 2342974 Expired - Lifetime CA2342974C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Country Status (10)

Country Link
US (18) US5629327A (en)
EP (4) EP1537870A3 (en)
JP (4) JPH08507767A (en)
CA (3) CA2512926C (en)
DE (5) DE69430796T2 (en)
DK (2) DK1264597T3 (en)
ES (2) ES2245711T3 (en)
LU (1) LU91471I2 (en)
NL (1) NL300358I2 (en)
WO (1) WO1994020085A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546430B2 (en) 2003-09-17 2013-10-01 P2D, Inc. Thalidomide analogs
US8853253B2 (en) 2003-09-17 2014-10-07 P2D, Inc. Thalidomide analogs

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* Cited by examiner, † Cited by third party
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