CA2113716A1 - Method for detection of mutations - Google Patents
Method for detection of mutationsInfo
- Publication number
- CA2113716A1 CA2113716A1 CA002113716A CA2113716A CA2113716A1 CA 2113716 A1 CA2113716 A1 CA 2113716A1 CA 002113716 A CA002113716 A CA 002113716A CA 2113716 A CA2113716 A CA 2113716A CA 2113716 A1 CA2113716 A1 CA 2113716A1
- Authority
- CA
- Canada
- Prior art keywords
- binding
- protein
- partner
- mismatch
- hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
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- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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- Analysing Materials By The Use Of Radiation (AREA)
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| US73221991A | 1991-07-19 | 1991-07-19 | |
| US732,219 | 1991-07-19 |
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| CA2113716A1 true CA2113716A1 (en) | 1993-02-04 |
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| JP (1) | JPH07500493A (https=) |
| AT (1) | ATE151114T1 (https=) |
| AU (1) | AU664381B2 (https=) |
| CA (1) | CA2113716A1 (https=) |
| DE (1) | DE69218776T2 (https=) |
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| IL (1) | IL102550A (https=) |
| NZ (1) | NZ243615A (https=) |
| TW (1) | TW209248B (https=) |
| WO (1) | WO1993002216A1 (https=) |
| ZA (1) | ZA925427B (https=) |
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| US5556750A (en) * | 1989-05-12 | 1996-09-17 | Duke University | Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems |
| US6008031A (en) * | 1989-05-12 | 1999-12-28 | Duke University | Method of analysis and manipulation of DNA utilizing mismatch repair systems |
| US5750335A (en) * | 1992-04-24 | 1998-05-12 | Massachusetts Institute Of Technology | Screening for genetic variation |
| US5389515A (en) * | 1992-09-15 | 1995-02-14 | Boehringer Mannheim Corporation | Isolated nucleotide sequences for identifying Neisseria gonorrhoeae |
| FR2707010B1 (https=) * | 1993-06-25 | 1995-09-29 | Bio Merieux | |
| FR2709761B1 (fr) * | 1993-09-10 | 1995-11-24 | Pasteur Institut | Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases . |
| US6027877A (en) * | 1993-11-04 | 2000-02-22 | Gene Check, Inc. | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification |
| US6120992A (en) * | 1993-11-04 | 2000-09-19 | Valigene Corporation | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, and allele identification in a diseased human |
| US5851770A (en) * | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| AU693198B2 (en) * | 1994-04-25 | 1998-06-25 | Avitech Diagnostics, Inc. | Detection of mutation by resolvase cleavage |
| GB9408344D0 (en) * | 1994-04-27 | 1994-06-15 | St James S University Hospital | Nucleic acid assays |
| US5919623A (en) * | 1994-04-27 | 1999-07-06 | St. James's And Seacroft University Hospitals Nhs Trust | Nucleic acid mutation assays |
| US5834181A (en) * | 1994-07-28 | 1998-11-10 | Genzyme Corporation | High throughput screening method for sequences or genetic alterations in nucleic acids |
| DE69605803T2 (de) * | 1995-05-11 | 2000-07-20 | Arild Lagerkvist | Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger |
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| SE9602062D0 (sv) * | 1996-05-29 | 1996-05-29 | Pharmacia Biotech Ab | Method for detection of mutations |
| US5869245A (en) * | 1996-06-05 | 1999-02-09 | Fox Chase Cancer Center | Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands |
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| WO1999006591A1 (en) * | 1997-07-31 | 1999-02-11 | The Institute Of Physical And Chemical Research | Methods for detecting mutation in base sequence |
| WO1999013108A1 (en) * | 1997-09-10 | 1999-03-18 | University Of Maryland, Baltimore | Method of amplifying dna and rna mismatch cleavage products |
| GB9724480D0 (en) * | 1997-11-19 | 1998-01-14 | Hexagen Technology Limited | Screening process |
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| US4794075A (en) * | 1985-08-29 | 1988-12-27 | Lifecodes Corporation | Method for locating and purifying DNA containing single base mismatches |
| US4978608A (en) * | 1987-09-04 | 1990-12-18 | Molecular Devices Corporation | DNA detection system |
-
1992
- 1992-07-17 DE DE69218776T patent/DE69218776T2/de not_active Expired - Fee Related
- 1992-07-17 EP EP92917193A patent/EP0596028B1/en not_active Expired - Lifetime
- 1992-07-17 WO PCT/US1992/006045 patent/WO1993002216A1/en not_active Ceased
- 1992-07-17 CA CA002113716A patent/CA2113716A1/en not_active Abandoned
- 1992-07-17 AT AT92917193T patent/ATE151114T1/de not_active IP Right Cessation
- 1992-07-17 JP JP5503014A patent/JPH07500493A/ja active Pending
- 1992-07-17 AU AU24159/92A patent/AU664381B2/en not_active Ceased
- 1992-07-19 IL IL102550A patent/IL102550A/xx not_active IP Right Cessation
- 1992-07-20 NZ NZ243615A patent/NZ243615A/en unknown
- 1992-07-20 IE IE235592A patent/IE922355A1/en not_active Application Discontinuation
- 1992-07-30 TW TW081106024A patent/TW209248B/zh active
- 1992-08-03 ZA ZA925427A patent/ZA925427B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW209248B (https=) | 1993-07-11 |
| DE69218776D1 (de) | 1997-05-07 |
| IL102550A0 (en) | 1993-01-14 |
| ATE151114T1 (de) | 1997-04-15 |
| AU664381B2 (en) | 1995-11-16 |
| EP0596028A1 (en) | 1994-05-11 |
| EP0596028B1 (en) | 1997-04-02 |
| ZA925427B (en) | 1993-04-28 |
| IL102550A (en) | 1997-03-18 |
| WO1993002216A1 (en) | 1993-02-04 |
| AU2415992A (en) | 1993-02-23 |
| NZ243615A (en) | 1993-06-25 |
| DE69218776T2 (de) | 1997-11-27 |
| IE922355A1 (en) | 1993-01-27 |
| JPH07500493A (ja) | 1995-01-19 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |