CA2086179A1 - Composes de thiazolidine contenant un groupe quinone, leur preparation et leurs utilisations a des fins therapeutiques - Google Patents
Composes de thiazolidine contenant un groupe quinone, leur preparation et leurs utilisations a des fins therapeutiquesInfo
- Publication number
- CA2086179A1 CA2086179A1 CA2086179A CA2086179A CA2086179A1 CA 2086179 A1 CA2086179 A1 CA 2086179A1 CA 2086179 A CA2086179 A CA 2086179A CA 2086179 A CA2086179 A CA 2086179A CA 2086179 A1 CA2086179 A1 CA 2086179A1
- Authority
- CA
- Canada
- Prior art keywords
- preparation
- compounds containing
- therapeutic uses
- quinone group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 125000004151 quinonyl group Chemical group 0.000 title 1
- 150000003548 thiazolidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34457091 | 1991-12-26 | ||
| JP3-344570 | 1991-12-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2086179A1 true CA2086179A1 (fr) | 1993-06-27 |
| CA2086179C CA2086179C (fr) | 2000-10-17 |
Family
ID=18370296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002086179A Expired - Fee Related CA2086179C (fr) | 1991-12-26 | 1992-12-23 | Composes de thiazolidine contenant un groupe quinone, leur preparation et leurs utilisations a des fins therapeutiques |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5338855A (fr) |
| EP (1) | EP0549366B1 (fr) |
| JP (1) | JP2833948B2 (fr) |
| KR (1) | KR100198183B1 (fr) |
| CN (1) | CN1033639C (fr) |
| AT (1) | ATE165092T1 (fr) |
| AU (1) | AU654222B2 (fr) |
| CA (1) | CA2086179C (fr) |
| CZ (1) | CZ279917B6 (fr) |
| DE (1) | DE69225123T2 (fr) |
| DK (1) | DK0549366T3 (fr) |
| ES (1) | ES2115650T3 (fr) |
| FI (1) | FI925848A (fr) |
| GR (1) | GR3026656T3 (fr) |
| HK (1) | HK1007050A1 (fr) |
| HU (1) | HU215448B (fr) |
| IL (1) | IL104237A (fr) |
| MX (1) | MX9207594A (fr) |
| NO (1) | NO302519B1 (fr) |
| NZ (1) | NZ245611A (fr) |
| RU (1) | RU2103265C1 (fr) |
| TW (1) | TW211008B (fr) |
| ZA (1) | ZA9210020B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO302471B1 (no) * | 1991-12-26 | 1998-03-09 | Sankyo Co | Tiazolidinforbindelser og farmasöytisk preparat |
| RU2151145C1 (ru) * | 1994-04-11 | 2000-06-20 | Санкио Компани Лимитед | Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью |
| IL118474A (en) * | 1995-06-01 | 2001-08-08 | Sankyo Co | Benzimideol derivatives and pharmaceutical preparations containing them |
| JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| US6147101A (en) * | 1995-06-02 | 2000-11-14 | Kyorin Pharmaceutical Co., Ltd. | N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same |
| US6001862A (en) * | 1995-06-02 | 1999-12-14 | Kyorin Pharameuticals Co., Ltd. | N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same |
| EP0783888A1 (fr) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Utilisation de la troglitazone et de thiazolidinediones apparentées dans la fabrication d'un médicament destiné au traitement et la prévention de l'ostéoporose |
| JPH10338679A (ja) * | 1997-04-08 | 1998-12-22 | Mitsubishi Rayon Co Ltd | チアゾリジン誘導体の製造方法 |
| US6414123B1 (en) * | 1997-10-21 | 2002-07-02 | Vitro Diagnostics, Inc. | Method for purifying FSH |
| US6077849A (en) * | 1998-04-02 | 2000-06-20 | Merck & Co., Inc. | Antidiabetic agents |
| US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
| US6127394A (en) * | 1999-03-08 | 2000-10-03 | The University Of Mississippi | 1,2-Dithiolane derivatives |
| US6204288B1 (en) | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| US6818776B2 (en) | 2000-02-01 | 2004-11-16 | Kyorin Pharmaceutical Co., Ltd. | Alkali metal salt of thiazolidine-2,4-dione derivative |
| IL173807A (en) | 2003-08-22 | 2014-02-27 | Antipodean Pharmaceuticals Inc | Antioxidant amphiphilic compounds, histoquinone history and pharmaceutical preparations containing them |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4725010A (en) * | 1986-07-18 | 1988-02-16 | Essex Group, Inc. | Control apparatus and method |
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| US5120754A (en) * | 1988-03-08 | 1992-06-09 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| US5130379A (en) * | 1988-03-08 | 1992-07-14 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
| GB8910639D0 (en) * | 1989-05-09 | 1989-06-21 | Beecham Group Plc | Novel compounds |
| GB8919434D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
| NO302471B1 (no) * | 1991-12-26 | 1998-03-09 | Sankyo Co | Tiazolidinforbindelser og farmasöytisk preparat |
-
1992
- 1992-12-22 NO NO924988A patent/NO302519B1/no not_active IP Right Cessation
- 1992-12-23 NZ NZ245611A patent/NZ245611A/en unknown
- 1992-12-23 ZA ZA9210020A patent/ZA9210020B/xx unknown
- 1992-12-23 HU HUP9204121A patent/HU215448B/hu not_active IP Right Cessation
- 1992-12-23 CA CA002086179A patent/CA2086179C/fr not_active Expired - Fee Related
- 1992-12-23 FI FI925848A patent/FI925848A/fi unknown
- 1992-12-24 TW TW081110380A patent/TW211008B/zh active
- 1992-12-24 ES ES92311814T patent/ES2115650T3/es not_active Expired - Lifetime
- 1992-12-24 DK DK92311814T patent/DK0549366T3/da active
- 1992-12-24 EP EP92311814A patent/EP0549366B1/fr not_active Expired - Lifetime
- 1992-12-24 KR KR1019920025528A patent/KR100198183B1/ko not_active IP Right Cessation
- 1992-12-24 DE DE69225123T patent/DE69225123T2/de not_active Expired - Fee Related
- 1992-12-24 AT AT92311814T patent/ATE165092T1/de not_active IP Right Cessation
- 1992-12-24 AU AU30429/92A patent/AU654222B2/en not_active Ceased
- 1992-12-25 RU RU92016230A patent/RU2103265C1/ru active
- 1992-12-25 IL IL10423792A patent/IL104237A/en not_active IP Right Cessation
- 1992-12-25 JP JP4346121A patent/JP2833948B2/ja not_active Expired - Fee Related
- 1992-12-26 CN CN92113835A patent/CN1033639C/zh not_active Expired - Fee Related
- 1992-12-28 US US07/997,210 patent/US5338855A/en not_active Expired - Fee Related
- 1992-12-28 MX MX9207594A patent/MX9207594A/es not_active IP Right Cessation
- 1992-12-28 CZ CS923896A patent/CZ279917B6/cs not_active IP Right Cessation
-
1998
- 1998-04-15 GR GR980400859T patent/GR3026656T3/el unknown
- 1998-06-23 HK HK98106107A patent/HK1007050A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2115650T3 (es) | 1998-07-01 |
| FI925848A0 (fi) | 1992-12-23 |
| HUT67704A (en) | 1995-04-28 |
| ATE165092T1 (de) | 1998-05-15 |
| RU2103265C1 (ru) | 1998-01-27 |
| CZ389692A3 (en) | 1994-01-19 |
| FI925848A (fi) | 1993-06-27 |
| NO924988D0 (no) | 1992-12-22 |
| HU9204121D0 (en) | 1993-04-28 |
| EP0549366B1 (fr) | 1998-04-15 |
| AU3042992A (en) | 1993-07-01 |
| GR3026656T3 (en) | 1998-07-31 |
| CZ279917B6 (cs) | 1995-08-16 |
| IL104237A (en) | 1996-10-16 |
| JPH05255288A (ja) | 1993-10-05 |
| US5338855A (en) | 1994-08-16 |
| NZ245611A (en) | 1994-06-27 |
| CA2086179C (fr) | 2000-10-17 |
| MX9207594A (es) | 1994-06-30 |
| NO302519B1 (no) | 1998-03-16 |
| HK1007050A1 (en) | 1999-03-26 |
| KR100198183B1 (ko) | 1999-06-15 |
| ZA9210020B (en) | 1993-07-02 |
| HU215448B (hu) | 1999-04-28 |
| CN1033639C (zh) | 1996-12-25 |
| EP0549366A1 (fr) | 1993-06-30 |
| CN1074679A (zh) | 1993-07-28 |
| DE69225123T2 (de) | 1998-12-24 |
| JP2833948B2 (ja) | 1998-12-09 |
| TW211008B (fr) | 1993-08-11 |
| AU654222B2 (en) | 1994-10-27 |
| DK0549366T3 (da) | 1999-03-08 |
| DE69225123D1 (de) | 1998-05-20 |
| NO924988L (no) | 1993-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |