CA2081703A1 - Thrombine et methode permettant de la produire - Google Patents
Thrombine et methode permettant de la produireInfo
- Publication number
- CA2081703A1 CA2081703A1 CA2081703A CA2081703A CA2081703A1 CA 2081703 A1 CA2081703 A1 CA 2081703A1 CA 2081703 A CA2081703 A CA 2081703A CA 2081703 A CA2081703 A CA 2081703A CA 2081703 A1 CA2081703 A1 CA 2081703A1
- Authority
- CA
- Canada
- Prior art keywords
- thrombin
- producing
- same
- infectious agents
- prothrombin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000190 Thrombin Proteins 0.000 title abstract 2
- 229960004072 thrombin Drugs 0.000 title abstract 2
- 239000012678 infectious agent Substances 0.000 abstract 2
- 108010094028 Prothrombin Proteins 0.000 abstract 1
- 102100027378 Prothrombin Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 229940039716 prothrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Amplifiers (AREA)
- Revetment (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0218391A AT398079B (de) | 1991-11-04 | 1991-11-04 | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
ATA2183/91 | 1991-11-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2081703A1 true CA2081703A1 (fr) | 1993-05-05 |
CA2081703C CA2081703C (fr) | 1999-01-19 |
Family
ID=3529491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002081703A Expired - Lifetime CA2081703C (fr) | 1991-11-04 | 1992-10-29 | Thrombine et methode permettant de la produire |
Country Status (19)
Country | Link |
---|---|
US (1) | US5714370A (fr) |
EP (1) | EP0541507B1 (fr) |
JP (1) | JP2572513B2 (fr) |
AT (2) | AT398079B (fr) |
AU (1) | AU645715B2 (fr) |
CA (1) | CA2081703C (fr) |
CZ (1) | CZ281502B6 (fr) |
DE (1) | DE59209922D1 (fr) |
DK (1) | DK0541507T3 (fr) |
ES (1) | ES2165355T3 (fr) |
FI (1) | FI104378B (fr) |
HR (1) | HRP921171B1 (fr) |
HU (1) | HU213867B (fr) |
MX (1) | MX9206303A (fr) |
NO (1) | NO312125B1 (fr) |
PL (1) | PL170156B1 (fr) |
SI (1) | SI9200299B (fr) |
SK (1) | SK330992A3 (fr) |
YU (1) | YU96192A (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT402891B (de) * | 1991-06-20 | 1997-09-25 | Immuno Ag | Verfahren zur herstellung eines inaktivierten blutproduktes |
DE4137996A1 (de) * | 1991-11-19 | 1993-05-27 | Behringwerke Ag | Verfahren zur herstellung eines virussicheren thrombinkonzentrates |
AT399818B (de) * | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
WO1994013329A1 (fr) * | 1992-12-16 | 1994-06-23 | Immuno Aktiengesellschaft | Procede de preparation de compositions biologiques exemptes de virus |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
JPH07308190A (ja) * | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | トロンビンの製造方法 |
US5506127A (en) * | 1994-09-21 | 1996-04-09 | Proba; Zbigniew | Therapeutic grade thrombin produced by chromatography |
GB9503750D0 (en) * | 1995-02-24 | 1995-04-12 | Common Services Agency | Thrombin preparation |
AT404597B (de) | 1995-11-24 | 1998-12-28 | Immuno Ag | Verfahren zur herstellung von proteinen |
JP3944267B2 (ja) * | 1996-08-09 | 2007-07-11 | 財団法人化学及血清療法研究所 | プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法 |
US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
US6066325A (en) * | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
US8303981B2 (en) | 1996-08-27 | 2012-11-06 | Baxter International Inc. | Fragmented polymeric compositions and methods for their use |
US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
AT405608B (de) * | 1997-04-08 | 1999-10-25 | Immuno Ag | Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material |
AT405485B (de) | 1997-05-28 | 1999-08-25 | Immuno Ag | Eine das vwf-propeptid enthaltende pharmazeutische präparation |
AU5903000A (en) * | 1999-06-29 | 2001-01-31 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Novel anti-thrombin peptide |
US7795218B2 (en) | 2001-04-12 | 2010-09-14 | Bioaxone Therapeutique Inc. | ADP-ribosyl transferase fusion variant proteins |
GB0216002D0 (en) * | 2002-07-10 | 2002-08-21 | Nat Blood Authority | Process and composition |
US8834864B2 (en) * | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
CA2651941C (fr) * | 2006-05-31 | 2015-02-17 | Baxter International Inc. | Procede pour reguler l'invasion cellulaire et la regeneration tissulaire en chirurgie rachidienne |
TWI436793B (zh) | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
JP2011500237A (ja) | 2007-10-30 | 2011-01-06 | バクスター・インターナショナル・インコーポレイテッド | 内臓または体腔壁の欠陥を治療するための再生性の生体機能性コラーゲン生物基質の使用 |
CN102014973A (zh) | 2008-02-29 | 2011-04-13 | 弗罗桑医疗设备公司 | 用于促进止血和/或伤口愈合的装置 |
AR081227A1 (es) | 2008-12-11 | 2012-07-18 | Baxter Int | Preparaciones basadas en fibrinogenos y polisacaridos sulfatados |
KR101105026B1 (ko) * | 2009-04-06 | 2012-01-16 | 김기영 | 다방향 굴절형 핸드 그라인더 |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
PT2442835E (pt) | 2009-06-16 | 2015-03-23 | Baxter Healthcare Sa | Esponja hemostática |
US8771258B2 (en) * | 2009-12-16 | 2014-07-08 | Baxter International Inc. | Hemostatic sponge |
SA111320355B1 (ar) | 2010-04-07 | 2015-01-08 | Baxter Heathcare S A | إسفنجة لايقاف النزف |
CN103037847B (zh) | 2010-06-01 | 2016-01-20 | 巴克斯特国际公司 | 用于制备干燥、稳定的止血组合物的方法 |
KR20130083393A (ko) | 2010-06-01 | 2013-07-22 | 백스터 인터내셔널 인코포레이티드 | 건조 및 안정한 지혈 조성물의 제조 방법 |
WO2011151400A1 (fr) | 2010-06-01 | 2011-12-08 | Baxter International Inc. | Procédé de fabrication de compositions hémostatiques sous forme sèche et stable |
US20130096063A1 (en) | 2011-10-11 | 2013-04-18 | Baxter Healthcare S.A. | Hemostatic compositions |
KR102135484B1 (ko) | 2011-10-11 | 2020-07-20 | 백스터 인터내셔널 인코포레이티드 | 지혈 조성물 |
CN103889447B (zh) | 2011-10-27 | 2015-11-25 | 巴克斯特国际公司 | 止血组合物 |
WO2013091895A1 (fr) * | 2011-12-23 | 2013-06-27 | Merz Pharma Gmbh & Co. Kgaa | Nouveau procédé pour la fabrication de protéines di-chaînes pour utilisation dans les êtres humains |
EP2822474B1 (fr) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Récipient mis sous pression contenant de la pâte hémostatique |
EP2977066A3 (fr) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Composition hémostatique sèche |
RU2700162C2 (ru) | 2013-06-21 | 2019-09-13 | Ферросан Медикал Дивайсиз А/С | Расширенная под вакуумом сухая композиция и шприц для ее сохранения |
US10111980B2 (en) | 2013-12-11 | 2018-10-30 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
JP6726852B2 (ja) | 2014-10-13 | 2020-07-22 | フェッローサン メディカル ディバイス エー/エス | 止血および創傷治癒に使用するための乾燥組成物 |
AU2015371184B2 (en) | 2014-12-24 | 2020-06-25 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
CN107771093B (zh) | 2015-07-03 | 2021-06-15 | 弗罗桑医疗设备公司 | 用于混合两种组分和用于在存储条件下保持真空的注射器 |
MX2019010731A (es) | 2017-03-09 | 2019-11-01 | Baxter Int | Sistema y metodos de deposicion de disolventes. |
EP3790600B1 (fr) | 2018-05-09 | 2023-12-27 | Ferrosan Medical Devices A/S | Procédé de préparation d'une composition hémostatique |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT350726B (de) * | 1976-08-30 | 1979-06-11 | Immuno Ag | Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma |
DE2902158A1 (de) * | 1979-01-20 | 1980-07-31 | Biotest Serum Institut Gmbh | Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen |
US4357321A (en) * | 1980-01-28 | 1982-11-02 | Baxter Travenol Laboratories, Inc. | Method and composition for treating clotting factor inhibitors |
DE3019612A1 (de) * | 1980-05-22 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisiertes thrombinpraeparat |
US4404132A (en) * | 1980-05-27 | 1983-09-13 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
US4364861A (en) * | 1980-05-27 | 1982-12-21 | Cutter Laboratories, Inc. | Blood-coagulation-promoting products and methods of preparing them |
AT368883B (de) * | 1980-07-22 | 1982-11-25 | Immuno Ag | Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen |
US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
US4480029A (en) * | 1981-04-27 | 1984-10-30 | Baxter Travenol Laboratories, Inc. | Biological indicators and their use |
US4764369A (en) * | 1983-07-14 | 1988-08-16 | New York Blood Center Inc. | Undenatured virus-free biologically active protein derivatives |
AT385657B (de) * | 1984-03-09 | 1988-05-10 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
US4613501A (en) * | 1984-12-21 | 1986-09-23 | New York Blood Center, Inc. | Inactivation of viruses in labile blood derivatives |
US4673733A (en) * | 1985-04-11 | 1987-06-16 | Sudhish Chandra | Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents |
JPS63243032A (ja) * | 1987-03-27 | 1988-10-07 | Green Cross Corp:The | トロンビンの加熱処理方法 |
DE3843126C3 (de) * | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
ES2057191T5 (es) * | 1989-01-13 | 2003-05-01 | Mitsubishi Pharma Corp | Metodo de produccion para una composicion que contiene proteinas. |
IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
EP0443724B1 (fr) * | 1990-02-20 | 1999-03-17 | Baxter International Inc. | Thrombine humaine purifiée et exempte de virus |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
DE4137996A1 (de) * | 1991-11-19 | 1993-05-27 | Behringwerke Ag | Verfahren zur herstellung eines virussicheren thrombinkonzentrates |
-
1991
- 1991-11-04 AT AT0218391A patent/AT398079B/de not_active IP Right Cessation
-
1992
- 1992-10-27 AU AU27361/92A patent/AU645715B2/en not_active Ceased
- 1992-10-27 HU HU9203366A patent/HU213867B/hu not_active IP Right Cessation
- 1992-10-29 CA CA002081703A patent/CA2081703C/fr not_active Expired - Lifetime
- 1992-11-02 HR HRA2183/91A patent/HRP921171B1/xx not_active IP Right Cessation
- 1992-11-02 DK DK92890232T patent/DK0541507T3/da active
- 1992-11-02 EP EP92890232A patent/EP0541507B1/fr not_active Revoked
- 1992-11-02 DE DE59209922T patent/DE59209922D1/de not_active Revoked
- 1992-11-02 ES ES92890232T patent/ES2165355T3/es not_active Expired - Lifetime
- 1992-11-02 AT AT92890232T patent/ATE206757T1/de not_active IP Right Cessation
- 1992-11-03 PL PL92296460A patent/PL170156B1/pl not_active IP Right Cessation
- 1992-11-03 NO NO19924229A patent/NO312125B1/no not_active IP Right Cessation
- 1992-11-03 MX MX9206303A patent/MX9206303A/es unknown
- 1992-11-04 CZ CS923309A patent/CZ281502B6/cs not_active IP Right Cessation
- 1992-11-04 YU YU96192A patent/YU96192A/sh unknown
- 1992-11-04 SK SK3309-92A patent/SK330992A3/sk unknown
- 1992-11-04 FI FI924975A patent/FI104378B/fi not_active IP Right Cessation
- 1992-11-04 SI SI9200299A patent/SI9200299B/sl not_active IP Right Cessation
- 1992-11-04 JP JP4294962A patent/JP2572513B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-01 US US08/458,082 patent/US5714370A/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2081703A1 (fr) | Thrombine et methode permettant de la produire | |
CA2131316A1 (fr) | Fraction thrombine du sang pour utilisation dans une procedure medicale | |
CA2104857A1 (fr) | Sterilisation au gaz | |
EP0240307A3 (en) | Bipolar transistor and method of producing the same | |
FR2617488B1 (fr) | Procede de fabrication de structures organisees de collagene, notamment d'origine humaine, et structures organisees de collagene correspondantes | |
DE69600084D1 (de) | Verwendung von hydroxylierte Carbonsäure zur Behandlung von Nägeln | |
RU94020410A (ru) | Способ лечения или профилактики рвоты у млекопитающих и человека с использованием некоторых хинуклидиновых, пиперидиновых, азанорборнановых, этилендиаминовых производных и родственных им соединений | |
DE69110713D1 (de) | 7-Oxabicycloheptan-imidazol-prostaglandin-Analoge, verwendbar bei der Behandlung von thrombotischen und vasospastischen Erkrankungen. | |
GB8906891D0 (en) | Improvements in or relating to the inactivation of infectious agents | |
AU569102B2 (en) | Monohydroxy-benzoyl peroxide | |
DE58901906D1 (de) | Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz. | |
AU647934B2 (en) | A method of preparing activated protein C | |
NO179245C (no) | Arylalkylestere av 4,5-dihydroksy-9,10-dihydro-9,10-diokso-2-antracenkarboksylsyre med terapeutisk aktivitet | |
GB2272572B (en) | Insulated-gate bipolar transistor and process of producing the same | |
NZ226569A (en) | Process for the two-stage inactivation of viruses using both heat and alkalisation | |
DE69131058D1 (de) | Verwendung einer therapeutischen Zusammensetzung zur Behandlung von Bronchitis | |
DE3881377D1 (de) | Mittel zur prophylaxe und behandlung von thrombocytopenie. | |
DE3467341D1 (en) | Cyclohexane carboxylic acids and derivatives thereof as antidysrhythmic agents | |
KR900009960A (ko) | 글루타민산을 생산하는 미생물 및 이를 이용한 글루타민산의 제조방법 | |
KR900009963A (ko) | 글루타민산을 생산하는 미생물 및 이를 이용한 글루타민산의 제조방법 | |
EP0417033A3 (en) | Production of dehydrosine fungin by microorganisms and agricultural use | |
MY101875A (en) | Lankacidin derivatives and production thereof. | |
KR900009964A (ko) | 글루타민산을 생산하는 미생물 및 이를 이용한 글루타민산의 제조방법 | |
KR900009961A (ko) | 글루타민산을 생산하는 미생물 및 이를 이용한 글루타민산의 제조방법 | |
HUT51857A (en) | Process for sterilization of bearers of pollensacks of plants |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |