CA2072584A1 - Dilatation balloon catheter and method of manufacture - Google Patents
Dilatation balloon catheter and method of manufactureInfo
- Publication number
- CA2072584A1 CA2072584A1 CA002072584A CA2072584A CA2072584A1 CA 2072584 A1 CA2072584 A1 CA 2072584A1 CA 002072584 A CA002072584 A CA 002072584A CA 2072584 A CA2072584 A CA 2072584A CA 2072584 A1 CA2072584 A1 CA 2072584A1
- Authority
- CA
- Canada
- Prior art keywords
- tube
- distal
- section
- balloon
- diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1063—Balloon catheters with special features or adapted for special applications having only one lumen used for guide wire and inflation, e.g. to minimise the diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1093—Balloon catheters with special features or adapted for special applications having particular tip characteristics
Abstract
An angioplasty catheter has a one-piece, flexible elongated tube (12, 12a) in which a hollow proximal section (22, 22a) tapers to form a solid distal core (18, 18a) with a solid cross-section.
The core (18, 18a) further tapers to form a safety wire (42, 42a) at the distal end of the catheter. An inflatable balloon (16, 16a) circumscribes the elongated tube (12, 12a) and the interior of the balloon (16, 16a) is in fluid communication with a lumen (26, 26a) defined by the hollow proximal section (22, 22a) of the tube (12, 12a) through at least one aperture (30, 30a) extending through the tube wall (31, 31a) and into the balloon interior (28, 28a). A coil spring (44, 44a) extends distally from the balloon (16, 16a) about the solid distal core (18, 18a) and safety wire (42, 42a), with the safety wire (42, 42a) secured to an end cap (43, 43a) of the coil spring (44, 44a).
The core (18, 18a) further tapers to form a safety wire (42, 42a) at the distal end of the catheter. An inflatable balloon (16, 16a) circumscribes the elongated tube (12, 12a) and the interior of the balloon (16, 16a) is in fluid communication with a lumen (26, 26a) defined by the hollow proximal section (22, 22a) of the tube (12, 12a) through at least one aperture (30, 30a) extending through the tube wall (31, 31a) and into the balloon interior (28, 28a). A coil spring (44, 44a) extends distally from the balloon (16, 16a) about the solid distal core (18, 18a) and safety wire (42, 42a), with the safety wire (42, 42a) secured to an end cap (43, 43a) of the coil spring (44, 44a).
Description
WO 91tO9640 PC~/IJS90/07597 1- 2~72~
DI~ATATION BA~LOON C~THETER ~ND
MET~IOD OF MANtJF~CTU~E
BACKGROUND OF_THE INVENTION
1. Field of the Invention.
The present invention relates to the fiel~ --angioplasty. In particular, the present in~en'io~
relates to a dilatation balloon catheter.
~. Descri~tion of the Prior Art.
Angioplasty has gained wide acceptance ir recent years as an efficient and effective method ~o-treating types of vascular diseases. In particula , angioplasty is widely used for opening stenoses in ~he - coronary arteries, although it is also used for t~eat~ent of stenoses in other parts of the vascular system.
The most widely used form of angioplasty makes use of a dilatation catheter which has an inflatable balloon at its distal end. Using fluoroscopy, the physician guides the catheter through the vascular syste~
until the balloon is positioned across the stenosis. The balloon is then inflated by supplying fluid under pressure through an inflation lumen to the balloon. The inflation of the balloon causes stretching of the artery and prcssing of the lesion into the artery wall to re-establish acceptable blood ~low through the ar'ery.
Two commonly used types o~ dilatation catheters are referred to as "over-the-wire" and "non-over-the-wire" cath~ters. An over-the-wire catheter is one i-which a separate guide wire lumen is provided so that 2 guide wire can be used to establish a path across the stenosis. The dilatation catheter can then be advance~
W091tO~lJ PCr/US90/07~97 ~2- 2~72~
over the guide wire until the ballosn LS positioned across the stenosis. A non-over-the-wire catheter acts as its own guide wire, and thus there ls no need for a separate guide wire lumen. A non-over-the-wire catheter S can therefore achieve a smaller outer diameter f~r i s main shaft since a guide wire lumen is not required.
There has been a continuing effort to reduce the profile and shaft size of the dilatation catheter t~
allow the catheter to not only reach, but also cross, a very tight stenosis. A successful dilatatiun catheter must also be sufficiently flexible to pass through tight curvatures, especially in the tortuous coronary arteries.
A further requirement of a success~ul dilatation catheter is its "pushability." This involves the transmission of longitudinal forces along the catheter from i~s proximal end to its distal end allowing a physician to push the catheter through the vascular system and across the stenosis.
SU~ Y OF~THE INVENTION
The present invention is a non-over-the-wire dilatation cathetar which has a low profile shaft, is flexible, has good torque response and pushability, and which also is relatively simple to manufacture.
One e~hodiment of the inventive catheter includes a one-piece, flexible elongate tube having a hollow proximal end formed by a tubular wall which defin2s a lumen, and having a distal end. The distal end of the tube has a tapered section, which has a diamete~
which necks down from a first diameter of the tube to a second diameter smaller than the ~irst diameter. At a W09l/~9~0 PCT/US90/07597 -3- 2072~8 ~
distal end of the tapered section, the lumen terminates and a generally solid distal core is formed distally ~' the tapered section. An inflatable balloon segment cir-cumscribes the tube and has a proximal end bonded to ~.e tube adjacent the tapered section and a distal end bon~le~
to the tube adjacent the solid section thereo~. Th.
interior of the balloon segment is in communication ~it~
the lumen via at least one apertur~ extending through the tubular wall.
Preferably, a flexible coil spring tip extends distally from the tube and balloon segment. The distal end of the tube tapers to form a safety wire extending within the coil spring and is attached to an end cap o~
the ccil spring. In a preferred embodiment, the tube is formed from a stainless steel hypotube and coated wi~h a lubricious material in the proximal unnecked segment.
In another embodiment, the tube is formed from semi-rigid plastic tubing. In the distal end, the tube has a tapered section which tapers from a first diameter to a distal section of a smaller second diameter, formed about a metal core wire. The distal ~ection has a gener~lly solid cross-~ection. The metal core wire tapers and extends out of the distal section to define a safety wire, which extends within a coil spring, and attaches to an end cap of the coil spring.
The inventive catheter is relatively simple to manu~acture by a method including the formation of a lumen from an elongated tube having a proximal section and a distal section; the formation of a tapered portion in the distal section of the tube wherein the cross-WOgl/~9~0 PCT/US9~/0759~
DI~ATATION BA~LOON C~THETER ~ND
MET~IOD OF MANtJF~CTU~E
BACKGROUND OF_THE INVENTION
1. Field of the Invention.
The present invention relates to the fiel~ --angioplasty. In particular, the present in~en'io~
relates to a dilatation balloon catheter.
~. Descri~tion of the Prior Art.
Angioplasty has gained wide acceptance ir recent years as an efficient and effective method ~o-treating types of vascular diseases. In particula , angioplasty is widely used for opening stenoses in ~he - coronary arteries, although it is also used for t~eat~ent of stenoses in other parts of the vascular system.
The most widely used form of angioplasty makes use of a dilatation catheter which has an inflatable balloon at its distal end. Using fluoroscopy, the physician guides the catheter through the vascular syste~
until the balloon is positioned across the stenosis. The balloon is then inflated by supplying fluid under pressure through an inflation lumen to the balloon. The inflation of the balloon causes stretching of the artery and prcssing of the lesion into the artery wall to re-establish acceptable blood ~low through the ar'ery.
Two commonly used types o~ dilatation catheters are referred to as "over-the-wire" and "non-over-the-wire" cath~ters. An over-the-wire catheter is one i-which a separate guide wire lumen is provided so that 2 guide wire can be used to establish a path across the stenosis. The dilatation catheter can then be advance~
W091tO~lJ PCr/US90/07~97 ~2- 2~72~
over the guide wire until the ballosn LS positioned across the stenosis. A non-over-the-wire catheter acts as its own guide wire, and thus there ls no need for a separate guide wire lumen. A non-over-the-wire catheter S can therefore achieve a smaller outer diameter f~r i s main shaft since a guide wire lumen is not required.
There has been a continuing effort to reduce the profile and shaft size of the dilatation catheter t~
allow the catheter to not only reach, but also cross, a very tight stenosis. A successful dilatatiun catheter must also be sufficiently flexible to pass through tight curvatures, especially in the tortuous coronary arteries.
A further requirement of a success~ul dilatation catheter is its "pushability." This involves the transmission of longitudinal forces along the catheter from i~s proximal end to its distal end allowing a physician to push the catheter through the vascular system and across the stenosis.
SU~ Y OF~THE INVENTION
The present invention is a non-over-the-wire dilatation cathetar which has a low profile shaft, is flexible, has good torque response and pushability, and which also is relatively simple to manufacture.
One e~hodiment of the inventive catheter includes a one-piece, flexible elongate tube having a hollow proximal end formed by a tubular wall which defin2s a lumen, and having a distal end. The distal end of the tube has a tapered section, which has a diamete~
which necks down from a first diameter of the tube to a second diameter smaller than the ~irst diameter. At a W09l/~9~0 PCT/US90/07597 -3- 2072~8 ~
distal end of the tapered section, the lumen terminates and a generally solid distal core is formed distally ~' the tapered section. An inflatable balloon segment cir-cumscribes the tube and has a proximal end bonded to ~.e tube adjacent the tapered section and a distal end bon~le~
to the tube adjacent the solid section thereo~. Th.
interior of the balloon segment is in communication ~it~
the lumen via at least one apertur~ extending through the tubular wall.
Preferably, a flexible coil spring tip extends distally from the tube and balloon segment. The distal end of the tube tapers to form a safety wire extending within the coil spring and is attached to an end cap o~
the ccil spring. In a preferred embodiment, the tube is formed from a stainless steel hypotube and coated wi~h a lubricious material in the proximal unnecked segment.
In another embodiment, the tube is formed from semi-rigid plastic tubing. In the distal end, the tube has a tapered section which tapers from a first diameter to a distal section of a smaller second diameter, formed about a metal core wire. The distal ~ection has a gener~lly solid cross-~ection. The metal core wire tapers and extends out of the distal section to define a safety wire, which extends within a coil spring, and attaches to an end cap of the coil spring.
The inventive catheter is relatively simple to manu~acture by a method including the formation of a lumen from an elongated tube having a proximal section and a distal section; the formation of a tapered portion in the distal section of the tube wherein the cross-WOgl/~9~0 PCT/US9~/0759~
2~72.~
sectional diameter of the tube tapers distall~ t~
terminate the lumen and form a qenerally solid dis.a' core, either of metal or plastic, of plastic form~d about a metal core wire; and mounting an inflatable balloo~ cn the distal section of the tube, with a proximal end 5~
the balloon se~ment secured to the tube proximally of the aperture and a distal end of the balloon segment secured to the solid distal core.
Preferably, the cross-sectional diameter of th~
distal core wire is further reduced to define a distal safety wire segment of the tube. In the case where tne tube is semi-rigid plastic tubing, the metal core ~ire is reduced in cross-sectional diameter to form a sarety wire segment of the metal core wire. A coil spring is secured to the distal core wire to extend distally fro~
the balloon about the distal safety wire segment. The distal end of the distal safety wire segment is ~hen secured to a distal end cap on the coil spring.
BRIEF DESCRIPTION OF THE INVENTION
FIG. 1 shows generally an angioplasty balloon catheter in accordance with the present invention.
FIG. 2 is a detailed sectional view of the distal portion of a first preferred embodiment the angioplasty catheter.
FIG. 3 is a detailed sectional view of the distal portion of a second preferred embodiment of the angioplasty catheter.
DET~I~Æ~ ~ESCRIPTION O~ HE PREFERRED_~MBODIMENTS
FIG. l shows generally an angioplasty balloon catheter 10 in accordance with the present invention, W~91/~9~0 PCT/US9~t~7~97 2 ~ 7 2 Ir3 ~ ~
includin~ a catheter tube 12, inflation manifold 14, and an inflatable balloon 16. A distal section 18 of the catheter 10 has a flexible spring tip 20. Catheter tube 12 is an elongated, flexible, one-piece tube, preferably of stainless steel, or of semi-rigid plastic, coated on its outer surface with a lubricious material, such as silicon or Teflon. The lubricious coating allows the catheter to move with ease through the vascuiature of the body. Inflation manifold 14 is attached at the proximal end of the tube 12 to provide fluid under pressure to inflate the balloon segment 16. Inflatable balloon 16 is preferably fabricated from a polymeric ma~erial such as polyolefin copolymer.
In one preferred embodiment, anyioplasty balloon catheter 10 has a length of approximately 135 centimeters (53.15 inches) with catheter tube 12 having an outer diameter between 0.020 and 0.040 inch (0.51 and 1.02 millimeters) in its proximal end and with the coil spring tip 20 at the distal end of catheter lO having an outer diameter between 0.012 and 0.016 inch (0.30 and 0.41 millimeters).
FIG. 2 shows in detailed sectional view the balloon or distal portion of a first preferred embodlment of the angioplasty balloon catheter 10 of the present invention. In this embodiment, catheter tube 12 is a stainless steel hypotube and has a hollow proximal section 22, of a first diameter, which tapers at elongated tapered section 24 to terminate an inflation lumen 26 and form distal section 18 which has a second diameter that is smaller than the first diameter. The tapered section 24 of the tube 12 tapers from a tube (hollow W~91/0~0 PCT/US90/07597 -6- 2~72~
proximal section 22) to elongated distal section 13, which has a generally solid cross-section, as see~
FIG. 2. In a preferred embodiment, the tapering is uni-form in tube diameter reduction, but a stepped or pro-gressive reduction will also work. An inflatlon l~.an 26 is defined within the hollow proximal section 22 o~
the tube 12. The lumen 26 extends into the elon~ate~
tapered section 24 of the tube 12, and is in ~
communication with an interior 28 of the balloon 16 via one or more apertures extending through the tube, as at apertures 30 through tube wall 31 of the tapered section 24, as seen in FIG. 2.
The balloon 16 has a proximal section 32, an inflatable section 33, and a distal section 34. The proximal section 32 of the balloon 16 is connected to the tapered section 24 at proximal adhesive joint 36, and t.~e distal section 34 of the balloon 16 is connected to the solid distal section 18 at a distal adheslve joint 38.
The balloon ends are preferably attached to their resp~c-tive tube sections by an adhesive such as epoxy. Atleast one radiopaque marker band 40 circumscribes the generally solid distal section 18 of the tube within balloon 16. The proximal section 32 of the balloon segment 16 may be formed from a separate flexible plastic tube, such as polyethylene for increased flexibility, having its proximal end bonded to the proximal tu~e section 22 (proximally of apertures 30) and its distal end bonded to the proximal end of balloon segment 33.
W09~ 0 PCT/US90/075~7 2~72~
Preferably, elongated solid dista-l section i~
of tube 12 further ~apers distally to form safety rhlr ~2. Safety wire 42 is attached by braze ~3 at a dist~:
end of a coil spring ~4 to form coil sprinq tip 20.
Flexible coil spring tip 20 serves to safely ~u1 catheter lO through the tortuous passages of the coron2ri arteries. Coil sp.ring 44 is mounted on solid section l~.
at braze or solder joint 46 adjacent distal adhesive joint 38. The coil spring tip 20 is bendable, and the safety wire 42 can be bent to a position and wlll retai,~
the bend, thus facilitating the steerability of ~h~
ca~heter lO through a patien~'s vascular system. In use, torque is applied to a proximal end of tube 12, and is transmitted by (through) tube 12, tapered section 24, distal section 18 to spring tip 20.
FIG. 3 shows a second preferred embodiment of the angioplasty balloon catheter of the present inven-tion. In this embodiment, a catheter tube 12a has a hollow proximal section 22a, of a first diameter, which tapers distally at elongated tapered section 24a to a second smaller diameter. An elongated distal section 18a defines in part, the reduced diameter portion of tube 12a. In thi~ embodiment, catheter tube 12a is semi-rigid plastic tubing, and distal section 18a of the semi-ri~id plastic tube is ~ormed about a central metal core wire 50. Together, the plastic tubing and metal core wire ~0 comprise distal section 18a, which is essentially solid in lateral cross-section. Balloon 16a is identical to balloon 16 described with re~erence to the embodiment of FIG. 2.
W0~ 9~0 PCT/US9~/07597 ~8- 2~7~
An inflation lumen 26a is defined within the hollow proximal section 22a of the tube 12a. rrhe lu~en 26a extends lnto the elongated tapered section 2~a of the tube 12a and is terminated at a point ~here the tuDe fits about the metal core wire 50 at distal sec'iorl ~a.
The lumen 26a is in fluid communication with an interio~
28a of the balloon 16a via one or more apertures extend-ing through the tube, as at apertures 3Oa through tube wall 31a of the tapered section 24a, as seen in FIG. 3.
Preferably, metal core wire 50 is reduced in diameter as it extends di~tally and out of the distal section 18a to form safety wire 42a. Safety wire 42a is attached by braze 43a at distal end of a coil spring 44a to form coil spring tip 20a. Again, flexible (and benda-ble) coil spring tip 20a serves to safely guide the catheter of the present invention through the tor.uous passages of the coronary arteries.
The angioplasty balloon catheter of the present invention is relatively simple to manufacture. The method of manufacturing catheter includes the following steps. A lumen is formed from an elongated tube having a proximal section and a distal section. The tube can be either metal or semi-rigid plastic tubing. A tapered portion is formed iA the distal section of the tube. In the tapered section, the cross-sectional diameter of the tube is decreased distally. Preferably, the tapered sec-tion tapers uniformly from a first diameter to a smaller second diameter. In the instance where the tube is metal, a distal portion of the reduced cross-sectional diameter of tube forms an elongated, generally solid, WO91~09~0 PCT/US90/075~7 _g _ 2~72~
distal core, as seen in FIG. 2. Thus, a slngle-piece metal inflation lumen and balloon core is create~ b~ a ~etal tube that is reduced distally to a solid core or wire. In the instance where the tube is plastic, ~e cross-sectional diameter of the tube is also decreased distally in the tapered section and the tube ta3ers -^
a solid distal core section, or in a preferred embodi-ment, the tube taper~ uniformly to a distal section where the plastic tube is formed about a metal core wire as seen in FIG. 3. Thus, an inflation lumen and balloon core are created ~y a semi-rigid plastic tube which is reduced distally to fit about a metal core wire.
In either arrangement, at least one apertu~e through the taperPd section is then provided, and an inflatable balloon segment is mounted on the distal section of the tube. The proximal end of balloon segment is secured to the tube proximally of the aperture, and a distal end or balloon segment is secured to the solid core. As mentioned above, a separate praximal or waist segment of the balloon (extending generally over the tapered section of the tube) may be provided. This allows this proximal waist (i.e., segment 32 in FIG. 2) to be formed from a material different from the balloon segment, and which has enhanced flexibility characteris-ti~s, thereby achieving improved trackability.
The tapered section of the tube can be formedby any suitable means such as rolling or compressive loading of the tube. In this formation process, heating and axial stretching of the tube may b~ performed as well. The distal reduction in diameter of the tube thus WO91J09~ PCT/~S90/0~597 - 10- ~ ~ 7 2 ~
increases flexibility of the tube in its distal environs, which necessarily ~ust be the most ~lexible portion Oc the catheter to permit its advancement throuqh the c~n-voluted coronary arteries. Grinding techniques may also be employed in combination with the manufacturing pr~-cesses mentioned above to achieve the reduced dia~ete~
tube and to also achiev~ reduced wall thicknesses f~
those distal worked portions of the tube (the tapered section 24 and distal section 18, as seen in FIG. ~).
Preferably, the generally solid distal core is further formed to reduce its cross-sectional diamete~ to a very small wire or ribbon core, thus defining a benda-ble distal safety wire segment 42 of the tube 12, in the case where tube 12 is metal (see FIG.2j. In the case where the tube 12 is semi-rigid plastic tu~ing, the me~al core wire 50 is further formed to reduce its crcss-sectional diameter to a very small wire or core, thus defining a distal safety wire segment 42a of the metal core wire 50 (see FIG. 3). A coil spring is then secured to the solid distal sectlon of the tube to extend distal-ly from the balloon about the distal safety wire segment.
A distal end of the distal sa~ety wire segment is secured to the coil spring, thus defining a distal tip on the cathPter which is flexible and has no sharp edges. This minimiz2s the possibility of inadvertently puncturing or scraping the walls of the artery as the catheter is moved therethrough.
In use, a physician first follows the typical angioplasty procedura of positioning a guide catheter in tha vascular system. The angioplasty balloon cathete~
W~9l/~0 PCT/US9~/07597 2 ~ 7 2 ,~ 7 of the present invention is then advanced distall~
through the guide catheter and into the stenosed coronar~, artery. The phycician then further pushes the cathete~
to the point at ~hich the inflatable balloon thereon is positioned across the stenosis. 3y using a d~fe injec;e~
.i.nto the coronary artery throu~h the guide catheter ,:hich is detectable by fluoroscopy, the stenosis position is detectable. The radiopaque marker on the catheter also is detectable by fluoroscopy, thereby permitting the physician to accurately position the balloon across the stenosis for inflation. The flexible and steerable dis-tal coil spring tip of the catheter aids in the safe and effective movement of the catheter ~hrough the tortuous passages of the coronary artery. Using an inflation devicP (not shown) coupled to the inflation manifold 14, the physiclan inflates the balloon with an inflation medium (typically a 50/50 solution of saline and Renogra-fin 76) through lumen 26 and apertures 30 of tube 12 (FIG. 2). The lnflatable section 33 of the balloon 16 expands and stretches the arterial wall, pressing the lesion into the arterial wall and re~establlshin~
acceptable blood flow through the artery. The balloon 16 is then deflated via negative pressure applied from the inflation manifold 14. The artery is again visual-~5 ized using dye and angiography, and if the stenosis hasbeen dilated, the catheter is removed. If the stenos.s has not been sufficiently dilated, the inflation proce-dure may be repeated.
In conclusion, the present invention is an 33 improved angioplasty dilatation catheter. The one-piece WO91/~9~o PCT/US90/07~7 -12- ~72~.?~
design for the proximal inflation ~ube.and distal balloon core and catheter tip allows for ~ood torque transmission from the proximal to distal ends and is relatively easy to manufacture. The design wherein a semi-rigid plas ic tube is formed about a distal metal core ~ire also allohs for good torque transmission from the proximal to dis~al ends and is relatively easy to manufacture. In the _~se where the catheter tube is metal, the inventive catheter does not require a separate guide wire or safety wire since the one-piece tube itself tapers distally to form the guide or safety wire. In the case where cathe~er tube is semi-rigid plastic, the guide/safety wire i, provided by the ~etal core wire onto which the plastic tub~ is formed. These constructions provide a small outer diameter for the catheter, thus lessening the friction problems inherent in advancing an elongated tube longitudinally, and aLso allowing less obstruction in the guide catheter and coronary artery to the flow of dye.
~ lthough the present invention has been described with reference to preferred embodiments, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention.
sectional diameter of the tube tapers distall~ t~
terminate the lumen and form a qenerally solid dis.a' core, either of metal or plastic, of plastic form~d about a metal core wire; and mounting an inflatable balloo~ cn the distal section of the tube, with a proximal end 5~
the balloon se~ment secured to the tube proximally of the aperture and a distal end of the balloon segment secured to the solid distal core.
Preferably, the cross-sectional diameter of th~
distal core wire is further reduced to define a distal safety wire segment of the tube. In the case where tne tube is semi-rigid plastic tubing, the metal core ~ire is reduced in cross-sectional diameter to form a sarety wire segment of the metal core wire. A coil spring is secured to the distal core wire to extend distally fro~
the balloon about the distal safety wire segment. The distal end of the distal safety wire segment is ~hen secured to a distal end cap on the coil spring.
BRIEF DESCRIPTION OF THE INVENTION
FIG. 1 shows generally an angioplasty balloon catheter in accordance with the present invention.
FIG. 2 is a detailed sectional view of the distal portion of a first preferred embodiment the angioplasty catheter.
FIG. 3 is a detailed sectional view of the distal portion of a second preferred embodiment of the angioplasty catheter.
DET~I~Æ~ ~ESCRIPTION O~ HE PREFERRED_~MBODIMENTS
FIG. l shows generally an angioplasty balloon catheter 10 in accordance with the present invention, W~91/~9~0 PCT/US9~t~7~97 2 ~ 7 2 Ir3 ~ ~
includin~ a catheter tube 12, inflation manifold 14, and an inflatable balloon 16. A distal section 18 of the catheter 10 has a flexible spring tip 20. Catheter tube 12 is an elongated, flexible, one-piece tube, preferably of stainless steel, or of semi-rigid plastic, coated on its outer surface with a lubricious material, such as silicon or Teflon. The lubricious coating allows the catheter to move with ease through the vascuiature of the body. Inflation manifold 14 is attached at the proximal end of the tube 12 to provide fluid under pressure to inflate the balloon segment 16. Inflatable balloon 16 is preferably fabricated from a polymeric ma~erial such as polyolefin copolymer.
In one preferred embodiment, anyioplasty balloon catheter 10 has a length of approximately 135 centimeters (53.15 inches) with catheter tube 12 having an outer diameter between 0.020 and 0.040 inch (0.51 and 1.02 millimeters) in its proximal end and with the coil spring tip 20 at the distal end of catheter lO having an outer diameter between 0.012 and 0.016 inch (0.30 and 0.41 millimeters).
FIG. 2 shows in detailed sectional view the balloon or distal portion of a first preferred embodlment of the angioplasty balloon catheter 10 of the present invention. In this embodiment, catheter tube 12 is a stainless steel hypotube and has a hollow proximal section 22, of a first diameter, which tapers at elongated tapered section 24 to terminate an inflation lumen 26 and form distal section 18 which has a second diameter that is smaller than the first diameter. The tapered section 24 of the tube 12 tapers from a tube (hollow W~91/0~0 PCT/US90/07597 -6- 2~72~
proximal section 22) to elongated distal section 13, which has a generally solid cross-section, as see~
FIG. 2. In a preferred embodiment, the tapering is uni-form in tube diameter reduction, but a stepped or pro-gressive reduction will also work. An inflatlon l~.an 26 is defined within the hollow proximal section 22 o~
the tube 12. The lumen 26 extends into the elon~ate~
tapered section 24 of the tube 12, and is in ~
communication with an interior 28 of the balloon 16 via one or more apertures extending through the tube, as at apertures 30 through tube wall 31 of the tapered section 24, as seen in FIG. 2.
The balloon 16 has a proximal section 32, an inflatable section 33, and a distal section 34. The proximal section 32 of the balloon 16 is connected to the tapered section 24 at proximal adhesive joint 36, and t.~e distal section 34 of the balloon 16 is connected to the solid distal section 18 at a distal adheslve joint 38.
The balloon ends are preferably attached to their resp~c-tive tube sections by an adhesive such as epoxy. Atleast one radiopaque marker band 40 circumscribes the generally solid distal section 18 of the tube within balloon 16. The proximal section 32 of the balloon segment 16 may be formed from a separate flexible plastic tube, such as polyethylene for increased flexibility, having its proximal end bonded to the proximal tu~e section 22 (proximally of apertures 30) and its distal end bonded to the proximal end of balloon segment 33.
W09~ 0 PCT/US90/075~7 2~72~
Preferably, elongated solid dista-l section i~
of tube 12 further ~apers distally to form safety rhlr ~2. Safety wire 42 is attached by braze ~3 at a dist~:
end of a coil spring ~4 to form coil sprinq tip 20.
Flexible coil spring tip 20 serves to safely ~u1 catheter lO through the tortuous passages of the coron2ri arteries. Coil sp.ring 44 is mounted on solid section l~.
at braze or solder joint 46 adjacent distal adhesive joint 38. The coil spring tip 20 is bendable, and the safety wire 42 can be bent to a position and wlll retai,~
the bend, thus facilitating the steerability of ~h~
ca~heter lO through a patien~'s vascular system. In use, torque is applied to a proximal end of tube 12, and is transmitted by (through) tube 12, tapered section 24, distal section 18 to spring tip 20.
FIG. 3 shows a second preferred embodiment of the angioplasty balloon catheter of the present inven-tion. In this embodiment, a catheter tube 12a has a hollow proximal section 22a, of a first diameter, which tapers distally at elongated tapered section 24a to a second smaller diameter. An elongated distal section 18a defines in part, the reduced diameter portion of tube 12a. In thi~ embodiment, catheter tube 12a is semi-rigid plastic tubing, and distal section 18a of the semi-ri~id plastic tube is ~ormed about a central metal core wire 50. Together, the plastic tubing and metal core wire ~0 comprise distal section 18a, which is essentially solid in lateral cross-section. Balloon 16a is identical to balloon 16 described with re~erence to the embodiment of FIG. 2.
W0~ 9~0 PCT/US9~/07597 ~8- 2~7~
An inflation lumen 26a is defined within the hollow proximal section 22a of the tube 12a. rrhe lu~en 26a extends lnto the elongated tapered section 2~a of the tube 12a and is terminated at a point ~here the tuDe fits about the metal core wire 50 at distal sec'iorl ~a.
The lumen 26a is in fluid communication with an interio~
28a of the balloon 16a via one or more apertures extend-ing through the tube, as at apertures 3Oa through tube wall 31a of the tapered section 24a, as seen in FIG. 3.
Preferably, metal core wire 50 is reduced in diameter as it extends di~tally and out of the distal section 18a to form safety wire 42a. Safety wire 42a is attached by braze 43a at distal end of a coil spring 44a to form coil spring tip 20a. Again, flexible (and benda-ble) coil spring tip 20a serves to safely guide the catheter of the present invention through the tor.uous passages of the coronary arteries.
The angioplasty balloon catheter of the present invention is relatively simple to manufacture. The method of manufacturing catheter includes the following steps. A lumen is formed from an elongated tube having a proximal section and a distal section. The tube can be either metal or semi-rigid plastic tubing. A tapered portion is formed iA the distal section of the tube. In the tapered section, the cross-sectional diameter of the tube is decreased distally. Preferably, the tapered sec-tion tapers uniformly from a first diameter to a smaller second diameter. In the instance where the tube is metal, a distal portion of the reduced cross-sectional diameter of tube forms an elongated, generally solid, WO91~09~0 PCT/US90/075~7 _g _ 2~72~
distal core, as seen in FIG. 2. Thus, a slngle-piece metal inflation lumen and balloon core is create~ b~ a ~etal tube that is reduced distally to a solid core or wire. In the instance where the tube is plastic, ~e cross-sectional diameter of the tube is also decreased distally in the tapered section and the tube ta3ers -^
a solid distal core section, or in a preferred embodi-ment, the tube taper~ uniformly to a distal section where the plastic tube is formed about a metal core wire as seen in FIG. 3. Thus, an inflation lumen and balloon core are created ~y a semi-rigid plastic tube which is reduced distally to fit about a metal core wire.
In either arrangement, at least one apertu~e through the taperPd section is then provided, and an inflatable balloon segment is mounted on the distal section of the tube. The proximal end of balloon segment is secured to the tube proximally of the aperture, and a distal end or balloon segment is secured to the solid core. As mentioned above, a separate praximal or waist segment of the balloon (extending generally over the tapered section of the tube) may be provided. This allows this proximal waist (i.e., segment 32 in FIG. 2) to be formed from a material different from the balloon segment, and which has enhanced flexibility characteris-ti~s, thereby achieving improved trackability.
The tapered section of the tube can be formedby any suitable means such as rolling or compressive loading of the tube. In this formation process, heating and axial stretching of the tube may b~ performed as well. The distal reduction in diameter of the tube thus WO91J09~ PCT/~S90/0~597 - 10- ~ ~ 7 2 ~
increases flexibility of the tube in its distal environs, which necessarily ~ust be the most ~lexible portion Oc the catheter to permit its advancement throuqh the c~n-voluted coronary arteries. Grinding techniques may also be employed in combination with the manufacturing pr~-cesses mentioned above to achieve the reduced dia~ete~
tube and to also achiev~ reduced wall thicknesses f~
those distal worked portions of the tube (the tapered section 24 and distal section 18, as seen in FIG. ~).
Preferably, the generally solid distal core is further formed to reduce its cross-sectional diamete~ to a very small wire or ribbon core, thus defining a benda-ble distal safety wire segment 42 of the tube 12, in the case where tube 12 is metal (see FIG.2j. In the case where the tube 12 is semi-rigid plastic tu~ing, the me~al core wire 50 is further formed to reduce its crcss-sectional diameter to a very small wire or core, thus defining a distal safety wire segment 42a of the metal core wire 50 (see FIG. 3). A coil spring is then secured to the solid distal sectlon of the tube to extend distal-ly from the balloon about the distal safety wire segment.
A distal end of the distal sa~ety wire segment is secured to the coil spring, thus defining a distal tip on the cathPter which is flexible and has no sharp edges. This minimiz2s the possibility of inadvertently puncturing or scraping the walls of the artery as the catheter is moved therethrough.
In use, a physician first follows the typical angioplasty procedura of positioning a guide catheter in tha vascular system. The angioplasty balloon cathete~
W~9l/~0 PCT/US9~/07597 2 ~ 7 2 ,~ 7 of the present invention is then advanced distall~
through the guide catheter and into the stenosed coronar~, artery. The phycician then further pushes the cathete~
to the point at ~hich the inflatable balloon thereon is positioned across the stenosis. 3y using a d~fe injec;e~
.i.nto the coronary artery throu~h the guide catheter ,:hich is detectable by fluoroscopy, the stenosis position is detectable. The radiopaque marker on the catheter also is detectable by fluoroscopy, thereby permitting the physician to accurately position the balloon across the stenosis for inflation. The flexible and steerable dis-tal coil spring tip of the catheter aids in the safe and effective movement of the catheter ~hrough the tortuous passages of the coronary artery. Using an inflation devicP (not shown) coupled to the inflation manifold 14, the physiclan inflates the balloon with an inflation medium (typically a 50/50 solution of saline and Renogra-fin 76) through lumen 26 and apertures 30 of tube 12 (FIG. 2). The lnflatable section 33 of the balloon 16 expands and stretches the arterial wall, pressing the lesion into the arterial wall and re~establlshin~
acceptable blood flow through the artery. The balloon 16 is then deflated via negative pressure applied from the inflation manifold 14. The artery is again visual-~5 ized using dye and angiography, and if the stenosis hasbeen dilated, the catheter is removed. If the stenos.s has not been sufficiently dilated, the inflation proce-dure may be repeated.
In conclusion, the present invention is an 33 improved angioplasty dilatation catheter. The one-piece WO91/~9~o PCT/US90/07~7 -12- ~72~.?~
design for the proximal inflation ~ube.and distal balloon core and catheter tip allows for ~ood torque transmission from the proximal to distal ends and is relatively easy to manufacture. The design wherein a semi-rigid plas ic tube is formed about a distal metal core ~ire also allohs for good torque transmission from the proximal to dis~al ends and is relatively easy to manufacture. In the _~se where the catheter tube is metal, the inventive catheter does not require a separate guide wire or safety wire since the one-piece tube itself tapers distally to form the guide or safety wire. In the case where cathe~er tube is semi-rigid plastic, the guide/safety wire i, provided by the ~etal core wire onto which the plastic tub~ is formed. These constructions provide a small outer diameter for the catheter, thus lessening the friction problems inherent in advancing an elongated tube longitudinally, and aLso allowing less obstruction in the guide catheter and coronary artery to the flow of dye.
~ lthough the present invention has been described with reference to preferred embodiments, workers skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention.
Claims (28)
1. An angioplasty catheter, comprising:
a one-piece, flexible elongate tube having a hollow proximal end formed by tubular wall defining a lumen, and a distal end;
a tapered section formed in the distal end of the tube and having a diameter which necks down from a first diameter to a second diameter less than the first diameter;
a distal section formed in the distal end of the tube and having a generally solid cross-section of the second diameter; and an inflatable balloon segment circumscribing the tube and having a proximal end bonded to the tube adjacent the tapered section and a distal end bonded to the tube adja-cent the generally solid distal section and wherein the interior of the balloon segment is in communication with the lumen through at least one aperture extending through the tubular wall.
a one-piece, flexible elongate tube having a hollow proximal end formed by tubular wall defining a lumen, and a distal end;
a tapered section formed in the distal end of the tube and having a diameter which necks down from a first diameter to a second diameter less than the first diameter;
a distal section formed in the distal end of the tube and having a generally solid cross-section of the second diameter; and an inflatable balloon segment circumscribing the tube and having a proximal end bonded to the tube adjacent the tapered section and a distal end bonded to the tube adja-cent the generally solid distal section and wherein the interior of the balloon segment is in communication with the lumen through at least one aperture extending through the tubular wall.
2. The angioplasty catheter of claim 1, and further comprising:
a flexible tip extending from the generally solid distal section of the tube.
a flexible tip extending from the generally solid distal section of the tube.
3. The angioplasty catheter of claim 2, wherein the flexible tip is mounted to the generally solid distal section adjacent the end of the balloon segment.
4. The angioplasty catheter of claim 2, wherein the flexible tip is soldered to the generally solid distal section of the tube.
5. The angioplasty catheter of claim 2, when the flexible tip is a coil spring tip.
6. The angioplasty catheter of claim 5, wherein the one-piece tube tapers at the distal end to form a safety wire attached to an end cap of the coil spring tip.
7. The angioplasty catheter of claim 1, wherein the tapered section tapers uniformly from the first diameter to the second diameter.
8. The angioplasty catheter of claim 1, wherein the tube is form d from a stainless steel hypotube.
9. The angioplasty catheter of claim 8, wherein the stainless steel hypotube is coated with a lubricious material.
10. The angioplasty catheter of claim 1, wherein the tube is formed from semi-rigid plastic tubing.
11. The angioplasty catheter of claim 10, wherein the semi-rigid plastic tubing is coated with a lubricious material.
12. The angioplasty catheter of claim 10, wherein the tapered section tapers uniformly to a distal section and wherein the distal section is formed about a metal core wire.
13. The angioplasty catheter of claim 12, wherein the metal core wire further tapers distally to form a safety wire.
14. The angioplasty catheter of claim 1, wherein the tube has a plurality of apertures through its tapered section to provide communication between the lumen and the interior of the balloon segment.
15. The angioplasty catheter of claim 1, wherein the inflatable balloon segment is formed from a polymeric material.
16. The angioplasty catheter of claim 1, wherein a radiopaque marker band circumscribes a portion of the tube within the balloon segment.
17. The angioplasty catheter of claim 1, wherein the proximal and distal ends of the balloon segment are bonded to the tube with epoxy.
18. An angioplasty catheter, comprising:
a one-piece, flexible elongate tube having a hollow proximal section formed by a wall defining a lumen, and a distal section;
a tapered portion formed in the distal section of the tube and having a diameter which changes from a first proximal diameter a second distal diameter smaller than the first diameter;
a solid portion formed in the distal section of the tube continuous with the proximal section thereof, with the solid section extending distally from the tapered por-tion and having a solid cross-section;
an inflatable balloon segment circumscribing the tube and having a proximal end bonded to the tube adjacent the tapered portion and a distal end bonded to the tube adja-cent the solid portion and wherein the interior of the balloon segment is in communication with the lumen through at least one aperture sited along the tapered portion extending through the tube wall between the lumen and the balloon segment interior;
a wire portion formed in the distal section of the tube continuous with the proximal section thereof, with the wire portion being of reduced diameter from the solid portion and extending distally thereof;
and a flexible coil spring mounted on the distal section of the tube to extend distally about the wire portion, with the coil spring secured to the wire portion adjacent their respective distal ends.
a one-piece, flexible elongate tube having a hollow proximal section formed by a wall defining a lumen, and a distal section;
a tapered portion formed in the distal section of the tube and having a diameter which changes from a first proximal diameter a second distal diameter smaller than the first diameter;
a solid portion formed in the distal section of the tube continuous with the proximal section thereof, with the solid section extending distally from the tapered por-tion and having a solid cross-section;
an inflatable balloon segment circumscribing the tube and having a proximal end bonded to the tube adjacent the tapered portion and a distal end bonded to the tube adja-cent the solid portion and wherein the interior of the balloon segment is in communication with the lumen through at least one aperture sited along the tapered portion extending through the tube wall between the lumen and the balloon segment interior;
a wire portion formed in the distal section of the tube continuous with the proximal section thereof, with the wire portion being of reduced diameter from the solid portion and extending distally thereof;
and a flexible coil spring mounted on the distal section of the tube to extend distally about the wire portion, with the coil spring secured to the wire portion adjacent their respective distal ends.
19. A method of manufacturing an angioplasty balloon catheter which comprises the steps of:
forming a lumen from an elongated tube having a proximal section and a distal section;
forming a tapered portion in the distal section of the tube wherein the cross-sectional diameter of the tube is reduced distally;
forming a distal portion of the reduced cross-sectional diameter of the tube into a generally solid distal core;
providing at least one aperture through the tapered portion of the tube; and mounting an inflatable balloon on the distal section of the tube, with a proximal end of the balloon secured to the tube proximally of the aperture and with a distal end of the balloon secured to the generally solid distal core.
forming a lumen from an elongated tube having a proximal section and a distal section;
forming a tapered portion in the distal section of the tube wherein the cross-sectional diameter of the tube is reduced distally;
forming a distal portion of the reduced cross-sectional diameter of the tube into a generally solid distal core;
providing at least one aperture through the tapered portion of the tube; and mounting an inflatable balloon on the distal section of the tube, with a proximal end of the balloon secured to the tube proximally of the aperture and with a distal end of the balloon secured to the generally solid distal core.
20. The method of claim 19, and further comprising the step of:
further reducing the cross-sectional diameter of the solid distal core wire to define a distal safety wire segment of the tube.
further reducing the cross-sectional diameter of the solid distal core wire to define a distal safety wire segment of the tube.
21. The method of claim 20, and further comprising the step of:
securing a coil spring to the solid distal core wire to extend distally from the balloon about the distal safety wire segment.
securing a coil spring to the solid distal core wire to extend distally from the balloon about the distal safety wire segment.
22. The method of claim 21, and further comprising the step of:
securing a distal end of the distal safety wire segment to a distal end cap on the coil spring.
securing a distal end of the distal safety wire segment to a distal end cap on the coil spring.
23. The method of claim 19, and further comprising the step of:
uniformly decreasing the cross sectional diameter of the tube distally.
uniformly decreasing the cross sectional diameter of the tube distally.
24. A method of manufacturing an angioplasty balloon catheter which comprises the steps of:
forming a lumen from an elongated tube having a proximal section and a distal section;
forming a tapered portion in the distal section of the tube wherein the cross-sectional diameter of the tube is reduced distally;
forming a distal portion of the reduced cross-sectional diameter of the tube about a metal core wire;
providing at least one aperture through the tapered portion of the tube; and mounting an inflatable balloon on the distal section of the tube, with a proximal end of the balloon secured to the tube proximally of the aperture and with a distal end of the balloon secured to the distal portion.
forming a lumen from an elongated tube having a proximal section and a distal section;
forming a tapered portion in the distal section of the tube wherein the cross-sectional diameter of the tube is reduced distally;
forming a distal portion of the reduced cross-sectional diameter of the tube about a metal core wire;
providing at least one aperture through the tapered portion of the tube; and mounting an inflatable balloon on the distal section of the tube, with a proximal end of the balloon secured to the tube proximally of the aperture and with a distal end of the balloon secured to the distal portion.
25. The method of claim 24, and further comprising the step of:
further reducing the cross-sectional diameter of the metal core wire to define a distal safety wire segment of the tube.
further reducing the cross-sectional diameter of the metal core wire to define a distal safety wire segment of the tube.
26. The method of claim 25, and further comprising the step of:
securing a coil spring to the distal portion to extend distally from the balloon about the distal safety wire segment.
securing a coil spring to the distal portion to extend distally from the balloon about the distal safety wire segment.
27. The method of claim 26, and further comprising the step of:
securing a distal end of the distal safety wire segment to a distal end cap on the coil spring.
securing a distal end of the distal safety wire segment to a distal end cap on the coil spring.
28. The method of claim 24, and further comprising the step of:
uniformly decreasing the cross-sectional diameter of the tube distally.
uniformly decreasing the cross-sectional diameter of the tube distally.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45832789A | 1989-12-28 | 1989-12-28 | |
| US458,327 | 1989-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2072584A1 true CA2072584A1 (en) | 1991-06-29 |
Family
ID=23820357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002072584A Abandoned CA2072584A1 (en) | 1989-12-28 | 1990-12-21 | Dilatation balloon catheter and method of manufacture |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0507857A4 (en) |
| JP (1) | JPH05502813A (en) |
| CA (1) | CA2072584A1 (en) |
| WO (1) | WO1991009640A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5501668A (en) * | 1991-08-09 | 1996-03-26 | Boston Scientific Corporation | Angioplasty balloon catheter and adaptor |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2184056C (en) * | 1994-03-01 | 2007-09-11 | Bruce S. Hamilton | Asymmetric dilatation balloon |
| US5836912A (en) * | 1996-10-21 | 1998-11-17 | Schneider (Usa) Inc. | Catheter having nonlinear flow portion |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3435826A (en) * | 1964-05-27 | 1969-04-01 | Edwards Lab Inc | Embolectomy catheter |
| US3485234A (en) * | 1966-04-13 | 1969-12-23 | Cordis Corp | Tubular products and method of making same |
| DE2438273A1 (en) * | 1974-08-08 | 1976-02-19 | Teldix Gmbh | METHOD FOR CONVERTING A DIGITAL MEASURED VALUE AND ARRANGEMENT FOR IT |
| US4917088A (en) * | 1985-05-02 | 1990-04-17 | C. R. Bard, Inc. | Balloon dilation probe |
| JPS6269120A (en) * | 1985-09-21 | 1987-03-30 | Yamatake Honeywell Co Ltd | Signal processing system |
| US4646742A (en) * | 1986-01-27 | 1987-03-03 | Angiomedics Incorporated | Angioplasty catheter assembly |
| US4906241A (en) * | 1987-11-30 | 1990-03-06 | Boston Scientific Corporation | Dilation balloon |
| US4943278A (en) * | 1988-02-29 | 1990-07-24 | Scimed Life Systems, Inc. | Dilatation balloon catheter |
| US4884579A (en) * | 1988-04-18 | 1989-12-05 | Target Therapeutics | Catheter guide wire |
-
1990
- 1990-12-21 WO PCT/US1990/007597 patent/WO1991009640A1/en not_active Application Discontinuation
- 1990-12-21 JP JP50291091A patent/JPH05502813A/en not_active Expired - Lifetime
- 1990-12-21 EP EP19910902439 patent/EP0507857A4/en not_active Withdrawn
- 1990-12-21 CA CA002072584A patent/CA2072584A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5800391A (en) * | 1989-09-06 | 1998-09-01 | Boston Scientific Corporation | Angioplasty balloon catheter and adaptor |
| US6033381A (en) * | 1989-09-06 | 2000-03-07 | Boston Scientific Corporation | Angioplasty balloon catheter and adaptor |
| US5501668A (en) * | 1991-08-09 | 1996-03-26 | Boston Scientific Corporation | Angioplasty balloon catheter and adaptor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05502813A (en) | 1993-05-20 |
| EP0507857A4 (en) | 1992-12-09 |
| WO1991009640A1 (en) | 1991-07-11 |
| EP0507857A1 (en) | 1992-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 19960623 |