New! View global litigation for patent families

CA2067188A1 - Multi-color laser scanning confocal imaging system - Google Patents

Multi-color laser scanning confocal imaging system

Info

Publication number
CA2067188A1
CA2067188A1 CA 2067188 CA2067188A CA2067188A1 CA 2067188 A1 CA2067188 A1 CA 2067188A1 CA 2067188 CA2067188 CA 2067188 CA 2067188 A CA2067188 A CA 2067188A CA 2067188 A1 CA2067188 A1 CA 2067188A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
laser
multi
single
images
scanning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2067188
Other languages
French (fr)
Other versions
CA2067188C (en )
Inventor
Todd Clark Brelje
Robert L. Sorenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Classifications

    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0076Optical details of the image generation arrangements using fluorescence or luminescence
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052Optical details of the image generation
    • G02B21/0064Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling

Abstract

A true multi-color laser scanning confocal imaging system for use with a microscope is described in which a single laser having a multi-line output is used to simultaneously or individually excite a plurality of dyes. The images may be simultaneously viewed by a plurality of photomultiplier tubes to reconstruct an image showing distinct features of a specimen stained with different dyes. The images may also be constructed using a single detector is a time-multiplex fashion and using a computer to construct the image.
CA 2067188 1990-08-10 1991-01-28 Multi-color laser scanning confocal imaging system Expired - Lifetime CA2067188C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US07/565,625 1990-08-10
US07565625 US5127730A (en) 1990-08-10 1990-08-10 Multi-color laser scanning confocal imaging system
PCT/US1991/000607 WO1992002839A1 (en) 1990-08-10 1991-01-28 Laser for confocal microscope

Publications (2)

Publication Number Publication Date
CA2067188A1 true true CA2067188A1 (en) 1992-02-11
CA2067188C CA2067188C (en) 2001-05-15

Family

ID=24259447

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2067188 Expired - Lifetime CA2067188C (en) 1990-08-10 1991-01-28 Multi-color laser scanning confocal imaging system

Country Status (8)

Country Link
US (1) US5127730A (en)
EP (1) EP0495930B1 (en)
JP (1) JP2824462B2 (en)
CA (1) CA2067188C (en)
DE (3) DE69131176T2 (en)
DK (1) DK0495930T3 (en)
ES (1) ES2133283T3 (en)
WO (1) WO1992002839A1 (en)

Families Citing this family (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5214658A (en) * 1990-07-27 1993-05-25 Ion Laser Technology Mixed gas ion laser
US5296703A (en) * 1992-04-01 1994-03-22 The Regents Of The University Of California Scanning confocal microscope using fluorescence detection
DE4323129C2 (en) * 1992-07-24 2002-10-02 Zeiss Carl The inverted microscope
GB9302799D0 (en) * 1993-02-12 1993-03-31 Medical Res Council Detecting means for a scanning optical microscope
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5280548A (en) * 1993-03-11 1994-01-18 Boc Health Care, Inc. Emission based fiber optic sensors for pH and carbon dioxide analysis
US5479252A (en) * 1993-06-17 1995-12-26 Ultrapointe Corporation Laser imaging system for inspection and analysis of sub-micron particles
USH1530H (en) * 1993-06-17 1996-05-07 Ultrapointe Corporation Surface extraction from a three-dimensional data set
US5923430A (en) 1993-06-17 1999-07-13 Ultrapointe Corporation Method for characterizing defects on semiconductor wafers
US5463897A (en) * 1993-08-17 1995-11-07 Digital Instruments, Inc. Scanning stylus atomic force microscope with cantilever tracking and optical access
US5381224A (en) * 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
US5528426A (en) * 1994-07-14 1996-06-18 Tti Medical Laser block beam splitter for microscopes
US5591981A (en) * 1995-03-16 1997-01-07 Bio-Rad Laboratories, Inc. Tunable excitation and/or tunable emission fluorescence imaging
US5784152A (en) * 1995-03-16 1998-07-21 Bio-Rad Laboratories Tunable excitation and/or tunable detection microplate reader
US5863504A (en) * 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
JP3526489B2 (en) * 1995-05-25 2004-05-17 オリンパス株式会社 Epi-fluorescence microscope
US20050100946A1 (en) * 1995-06-29 2005-05-12 Affymetrix, Inc. Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
CA2227895C (en) 1995-10-11 2012-07-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
FR2754341B1 (en) * 1996-10-04 1998-12-24 Dilor Apparatus for spectral analysis adapted to operate in several spectral ranges of different wavelengths
WO1998017992A3 (en) * 1996-10-25 1998-07-09 Applied Imaging Inc Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration
US6148114A (en) * 1996-11-27 2000-11-14 Ultrapointe Corporation Ring dilation and erosion techniques for digital image processing
US6282013B1 (en) 1997-04-30 2001-08-28 Lasermed, Inc. System for curing polymeric materials, such as those used in dentistry, and for tailoring the post-cure properties of polymeric materials through the use of light source power modulation
US6008264A (en) 1997-04-30 1999-12-28 Laser Med, Inc. Method for curing polymeric materials, such as those used in dentistry, and for tailoring the post-cure properties of polymeric materials through the use of light source power modulation
US5880473A (en) * 1997-07-28 1999-03-09 Applied Imaging, Inc. Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
EP1027010A1 (en) 1997-10-29 2000-08-16 Bisco, Inc. Dental composite light curing system
US6116900A (en) * 1997-11-17 2000-09-12 Lumachem, Inc. Binary energizer and peroxide delivery system for dental bleaching
US6051835A (en) * 1998-01-07 2000-04-18 Bio-Rad Laboratories, Inc. Spectral imaging apparatus and methodology
WO1999036564A9 (en) * 1998-01-16 1999-10-28 Luminex Corp Multiplexed analysis of clinical specimens apparatus and methods
US6200134B1 (en) 1998-01-20 2001-03-13 Kerr Corporation Apparatus and method for curing materials with radiation
JP4709969B2 (en) 1998-02-26 2011-06-29 ザ ジェネラル ホスピタル コーポレイション Confocal microscope using multispectral coding
US6831781B2 (en) 1998-02-26 2004-12-14 The General Hospital Corporation Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
DE69939259D1 (en) * 1998-05-16 2008-09-18 Applera Corp Device for monitoring the polymerase-chain reaction of dna
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
DE19829944C2 (en) * 1998-07-04 2002-03-28 Zeiss Carl Jena Gmbh Method and arrangement for device configuration of a fluorescence laser scanning microscope
DE19829981C2 (en) * 1998-07-04 2002-10-17 Zeiss Carl Jena Gmbh Method and arrangement for confocal microscopy
DE19835070B4 (en) * 1998-08-04 2006-03-16 Carl Zeiss Jena Gmbh An arrangement for adjustable wavelength-dependent detection in a fluorescence microscope
US6603537B1 (en) * 1998-08-21 2003-08-05 Surromed, Inc. Optical architectures for microvolume laser-scanning cytometers
DE19842153C2 (en) * 1998-09-15 2003-07-31 Leica Microsystems fluorescence microscope
JP4270610B2 (en) * 1998-09-24 2009-06-03 オリンパス株式会社 Scanning optical microscope
US6628385B1 (en) 1999-02-05 2003-09-30 Axon Instruments, Inc. High efficiency, large field scanning microscope
US6541778B1 (en) * 1999-04-23 2003-04-01 Iowa State University Research Foundation, Inc. Method and apparatus for ceramic analysis
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
US6157661A (en) * 1999-05-12 2000-12-05 Laserphysics, Inc. System for producing a pulsed, varied and modulated laser output
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
US20040224421A1 (en) * 2000-06-15 2004-11-11 Deweerd Herman Bi-directional scanning method
US6548796B1 (en) 1999-06-23 2003-04-15 Regents Of The University Of Minnesota Confocal macroscope
CA2379836A1 (en) * 1999-07-21 2001-02-01 Aaron B. Kantor System for microvolume laser scanning cytometry
US6687395B1 (en) 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
EP1102101A1 (en) * 1999-11-22 2001-05-23 Leica Microsystems Heidelberg GmbH Laser scanning microscope
DE10024135B4 (en) * 2000-01-28 2004-07-08 Leica Microsystems Heidelberg Gmbh microscope
DE10004233B4 (en) * 2000-02-01 2005-02-17 Leica Microsystems Heidelberg Gmbh The microscope assemblage
US6313433B1 (en) 2000-04-03 2001-11-06 Universal Laser Systems, Inc Laser material processing system with multiple laser sources apparatus and method
US6556293B2 (en) 2000-04-06 2003-04-29 Orbotech Ltd. Optical inspection of laser vias
EP1164402B1 (en) * 2000-06-17 2010-04-28 Leica Microsystems CMS GmbH Scanning microscope with multiband illumination and optical element for a scanning microsscope with multiband illumination
EP1164406A3 (en) 2000-06-17 2004-02-04 Leica Microsystems Heidelberg GmbH Method and device for illuminating an object
DE20122783U1 (en) 2000-06-17 2007-11-15 Leica Microsystems Cms Gmbh Arrangement for examining microscopic preparations with a scanning microscope and illuminating device for a scanning microscope
DE20122782U1 (en) 2000-06-17 2007-11-15 Leica Microsystems Cms Gmbh lighting device
DE20122791U1 (en) 2000-06-17 2007-11-29 Leica Microsystems Cms Gmbh scanning microscope
US6898367B2 (en) 2000-06-17 2005-05-24 Leica Microsystems Heidelberg Gmbh Method and instrument for microscopy
DE10115577A1 (en) 2000-06-17 2001-12-20 Leica Microsystems Scanning microscope with mehrbandiger lighting and optical device for a scanning microscope with illumination mehrbandiger
GB0015412D0 (en) * 2000-06-23 2000-08-16 Yokogawa Electric Corp Optical image separation system and confocal scanner unit
DE10044636A1 (en) 2000-09-08 2002-03-21 Leica Microsystems Optical arrangement for illuminating objects for confocal scanning microscopes
EP1434522B1 (en) * 2000-10-30 2010-01-13 The General Hospital Corporation Optical systems for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
CA2429824A1 (en) * 2000-11-28 2002-06-06 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
DE10065784C2 (en) * 2000-12-30 2003-12-04 Leica Microsystems A method for finding points of contact between cells in a stimulable microscopic sample at a calcium migration and scanning microscope for performing the method
DE10120425C2 (en) * 2001-04-26 2003-12-18 Leica Microsystems scanning microscope
WO2002088684A1 (en) * 2001-04-30 2002-11-07 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
DE10297689B4 (en) 2001-05-01 2007-10-18 The General Hospital Corp., Boston Method and apparatus for determination of atherosclerotic plaque by measurement of tissue optical properties
JP2003028797A (en) * 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd Fluorescence reader
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
DE10150542B4 (en) * 2001-10-12 2007-03-29 Leica Microsystems Cms Gmbh A method for fluorescence microscopy
US6980299B1 (en) * 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
WO2003038503A1 (en) * 2001-11-02 2003-05-08 Olympus Corporation Scanning con-focal microscope
DE10156506C1 (en) 2001-11-16 2003-05-22 Leica Microsystems A method for producing a multicolor image and microscope
EP1316794A1 (en) * 2001-11-28 2003-06-04 Cambridge University Technical Services Limited A dual wavelength optical fluorescence analyser
US7158294B2 (en) * 2001-12-18 2007-01-02 Olympus Optical Co., Ltd. Laser scanning confocal microscope apparatus, image recording method, and recording medium
CA2473465C (en) 2002-01-11 2011-04-05 The General Hospital Corporation Apparatus for low coherence ranging
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
DE10212554A1 (en) * 2002-03-16 2003-10-30 Zeiss Carl Jena Gmbh Apparatus and method for an imaging spectrometer
KR100483706B1 (en) * 2002-04-04 2005-04-18 바디텍메드 주식회사 A Apparatus for the Detection of Laser-induced Epifluoresecne
DE10217545A1 (en) * 2002-04-17 2003-11-06 Zeiss Carl Jena Gmbh Microscope with position detection of optical elements changers
EP1501917A4 (en) * 2002-05-03 2006-04-19 Immunivest Corp Device and method for analytical cell imaging
US6989100B2 (en) * 2002-05-09 2006-01-24 Ppd Biomarker Discovery Sciences, Llc Methods for time-alignment of liquid chromatography-mass spectrometry data
DE10225838A1 (en) 2002-06-11 2003-12-24 Leica Microsystems A method for scanning microscopy, scanning microscope and apparatus for encoding an illuminating light beam
DE10231475A1 (en) 2002-07-12 2004-01-22 Leica Microsystems Heidelberg Gmbh Scanning microscope with an optical component, and optical component
DE10231776A1 (en) * 2002-07-13 2004-01-22 Leica Microsystems Heidelberg Gmbh A method for scanning microscopy and scanning microscope
JP2004163413A (en) 2002-08-28 2004-06-10 Carl-Zeiss-Stiftung Trading As Carl Zeiss Microscope system and microscope inspection method
US7038848B2 (en) * 2002-12-27 2006-05-02 Olympus Corporation Confocal microscope
DE10302259B3 (en) * 2003-01-22 2004-06-03 Leica Microsystems Heidelberg Gmbh Confocal scanning microscope has acousto-optical component for directing partial beam obtained from illumination beam onto monitoring detector for illumination intensity regulation
EP1596716B1 (en) 2003-01-24 2014-04-30 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
CA2519937C (en) 2003-03-31 2012-11-20 Guillermo J. Tearney Speckle reduction in optical coherence tomography by path length encoded angular compounding
DE10324478B3 (en) * 2003-05-30 2004-12-09 Leica Microsystems Heidelberg Gmbh Apparatus for determining the light power of a light beam and scanning microscope
WO2005001401A3 (en) 2003-06-06 2005-04-28 Gen Hospital Corp Process and apparatus for a wavelength tuning source
DE10331906B4 (en) * 2003-07-15 2005-06-16 Leica Microsystems Heidelberg Gmbh Light source with a Mikrostruktuierten optical element and the microscope with light source
DE10334145A1 (en) * 2003-07-26 2005-02-24 Leica Microsystems Heidelberg Gmbh scanning microscope
DE10340964A1 (en) 2003-09-05 2005-03-31 Leica Microsystems Heidelberg Gmbh Light source with a microstructured optical element
JP4756819B2 (en) 2003-10-21 2011-08-24 オリンパス株式会社 Scanning microscope system
EP2293031A3 (en) 2003-10-27 2015-11-18 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
JP5214883B2 (en) * 2003-11-28 2013-06-19 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for three-dimensional spectrally encoded imaging
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP4323369B2 (en) * 2004-04-09 2009-09-02 オリンパス株式会社 Scanning fluorescence microscope apparatus
WO2005117534A3 (en) 2004-05-29 2006-11-30 Gen Hospital Corp Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
FR2871358B1 (en) * 2004-06-14 2007-02-09 Mauna Kea Technologies Soc Par Method and microscopic imaging system of fibered multimarking fluorescence
DE102004030669A1 (en) 2004-06-24 2006-01-19 Leica Microsystems Cms Gmbh microscope
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
JP5053845B2 (en) 2004-08-06 2012-10-24 ザ ジェネラル ホスピタル コーポレイション The method for determining at least one position in a sample using optical coherence tomography, system and software device
EP1989997A1 (en) 2004-08-24 2008-11-12 The General Hospital Corporation Process, System and Software Arrangement for Measuring a Mechanical Strain and Elastic Properties of a Sample
EP2272420B1 (en) 2004-08-24 2013-06-19 The General Hospital Corporation Apparatus for imaging of vessel segments
EP2302364A3 (en) * 2004-09-10 2011-04-06 The General Hospital Corporation System and method for optical coherence imaging
EP2329759B1 (en) * 2004-09-29 2014-03-12 The General Hospital Corporation System and method for optical coherence imaging
DE102004047820A1 (en) 2004-09-29 2006-03-30 Leica Microsystems Cms Gmbh Scanning microscope and scanning microscopic method
WO2006050320A3 (en) * 2004-10-29 2006-10-19 Johannes F Deboer Polarization-sensitive optical coherence tomography
JP5623692B2 (en) * 2004-11-02 2014-11-12 ザ ジェネラル ホスピタル コーポレイション Optical fiber rotating device for imaging the sample, an optical system and method
EP2278265A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US7264794B2 (en) * 2004-12-17 2007-09-04 The General Hospital Methods of in vivo cytometry
US7491502B2 (en) * 2004-12-17 2009-02-17 The General Hospital Corporation In vivo flow cytometry system and method
JP2006208681A (en) * 2005-01-27 2006-08-10 Olympus Corp Connection unit and optical scanning type fluorescent observation device
WO2006092317A1 (en) * 2005-03-03 2006-09-08 Ese Embedded System Engineering Gmbh Fluorescence meter
US7686820B2 (en) 2005-04-14 2010-03-30 Ethicon Endo-Surgery, Inc. Surgical clip applier ratchet mechanism
US7740641B2 (en) 2005-04-14 2010-06-22 Ethicon Endo-Surgery, Inc. Clip applier with migrational resistance features
US8038686B2 (en) * 2005-04-14 2011-10-18 Ethicon Endo-Surgery, Inc. Clip applier configured to prevent clip fallout
US7261724B2 (en) * 2005-04-14 2007-08-28 Ethicon Endo-Surgery, Inc. Surgical clip advancement mechanism
US7297149B2 (en) 2005-04-14 2007-11-20 Ethicon Endo-Surgery, Inc. Surgical clip applier methods
US7288098B2 (en) * 2005-04-14 2007-10-30 Ethicon Endo-Surgery, Inc. Force limiting mechanism for medical instrument
US8523882B2 (en) 2005-04-14 2013-09-03 Ethicon Endo-Surgery, Inc. Clip advancer mechanism with alignment features
ES2337497T3 (en) 2005-04-28 2010-04-26 The General Hospital Corporation Evaluation of characteristics of the image of an anatomical structure images of optical coherence tomography.
EP1887926B1 (en) * 2005-05-31 2014-07-30 The General Hospital Corporation System and method which use spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
CN101238347B (en) 2005-08-09 2011-05-25 通用医疗公司 Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography
CA2624109A1 (en) 2005-09-29 2007-04-12 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
JP5203951B2 (en) 2005-10-14 2013-06-05 ザ ジェネラル ホスピタル コーポレイション Spectrum and frequency encoding fluorescent imaging
US8290239B2 (en) * 2005-10-21 2012-10-16 Orbotech Ltd. Automatic repair of electric circuits
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
EP1971848A1 (en) 2006-01-10 2008-09-24 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
WO2007084995A3 (en) 2006-01-19 2008-07-03 Gen Hospital Corp Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
US20070223006A1 (en) * 2006-01-19 2007-09-27 The General Hospital Corporation Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements
US20070171430A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and methods for providing mirror tunnel micropscopy
US7418169B2 (en) 2006-02-01 2008-08-26 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
EP2659852A3 (en) 2006-02-01 2014-01-15 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
JP5519152B2 (en) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション Apparatus for acquiring information related to anatomical sample using optical microscopy
JP2009527770A (en) 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション Angle-resolved Fourier domain optical coherence tomography performing method and system
WO2007109540A3 (en) * 2006-03-17 2007-11-22 Gen Hospital Corp Arrangement, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue using spectral domain low coherence interferometry
EP2004041B1 (en) 2006-04-05 2013-11-06 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
EP2015669A2 (en) 2006-05-10 2009-01-21 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
WO2007133964A3 (en) * 2006-05-12 2008-08-21 Gen Hospital Corp Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
EP3006920A3 (en) 2006-08-25 2016-08-03 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
DE102006047816A1 (en) * 2006-10-07 2008-04-17 Leica Microsystems Cms Gmbh Method and apparatus for high-resolution optical scanning a sample
WO2008049118A3 (en) 2006-10-19 2008-11-27 Gen Hospital Corp Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US8155730B2 (en) * 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
WO2008089406A3 (en) 2007-01-19 2008-09-18 Gen Hospital Corp Apparatus and method for simultaneous inspection at different depths based on the principle of frequency domain optical coherence tomography
EP2662674A3 (en) 2007-01-19 2014-06-25 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadbend light
EP2132840A2 (en) 2007-03-23 2009-12-16 The General Hospital Corporation Methods, arrangements and apparatus for utlizing a wavelength-swept laser using angular scanning and dispersion procedures
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
US20110060232A1 (en) * 2007-05-04 2011-03-10 The General Hospital Corporation Retinal flow cytometry
US8115919B2 (en) 2007-05-04 2012-02-14 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy
CN101821608B (en) * 2007-07-27 2012-08-08 皇家飞利浦电子股份有限公司 Method and system for imaging samples
WO2009018456A3 (en) 2007-07-31 2009-03-19 Gen Hospital Corp Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
JP5536650B2 (en) 2007-08-31 2014-07-02 ザ ジェネラル ホスピタル コーポレイション System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith
EP2255241A1 (en) 2007-09-03 2010-12-01 Szegedi Tudomanyegyetem Optical microscope system and method carried out therewith for reconstructing an image of an object
WO2009049296A3 (en) * 2007-10-12 2009-06-11 Brett Eugene Bouma Systems and processes for optical imaging of luminal anatomic structures
WO2009059034A1 (en) 2007-10-30 2009-05-07 The General Hospital Corporation System and method for cladding mode detection
US9332942B2 (en) * 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US8574859B2 (en) * 2008-03-27 2013-11-05 The General Hospital Corporation In vivo flow cytometry based on cellular autofluorescence
WO2009137701A3 (en) 2008-05-07 2010-02-11 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP5795531B2 (en) 2008-06-20 2015-10-14 ザ ジェネラル ホスピタル コーポレイション Fused fiber optic coupler structure, and methods of use thereof
EP2309923A4 (en) 2008-07-14 2015-03-18 Gen Hospital Corp Apparatus and methods for color endoscopy
DE102008034008B4 (en) * 2008-07-21 2010-07-01 Carl Zeiss Surgical Gmbh Filter set for observing fluorescent radiation in biological tissue
US8937724B2 (en) 2008-12-10 2015-01-20 The General Hospital Corporation Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
EP2382456A4 (en) 2009-01-26 2012-07-25 Gen Hospital Corp System, method and computer-accessible medium for providing wide-field superresolution microscopy
WO2010091190A3 (en) 2009-02-04 2010-11-04 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
US9066777B2 (en) 2009-04-02 2015-06-30 Kerr Corporation Curing light device
US9072572B2 (en) 2009-04-02 2015-07-07 Kerr Corporation Dental light device
US8267945B2 (en) 2009-10-09 2012-09-18 Ethicon Endo-Surgery, Inc. Clip advancer with lockout mechanism
US8262679B2 (en) 2009-10-09 2012-09-11 Ethicon Endo-Surgery, Inc. Clip advancer
EP2542154A4 (en) 2010-03-05 2014-05-21 Gen Hospital Corp Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011149972A3 (en) 2010-05-25 2012-01-19 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
JP5778762B2 (en) 2010-05-25 2015-09-16 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for spectral analysis of optical coherence tomography images
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
WO2012112911A3 (en) * 2011-02-17 2012-10-18 University Of Massachusetts - Lowell Devices and methods for optical pathology
DE102011016138A1 (en) * 2011-03-30 2012-10-04 Karl Storz Gmbh & Co. Kg Device for fluorescence diagnosis
JP6240064B2 (en) 2011-04-29 2017-11-29 ザ ジェネラル ホスピタル コーポレイション Method for determining the depth-resolved physical and / or optical properties of the scattering medium
JP2014523536A (en) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション System for providing a polarization mode dispersion compensation in an optical coherence tomography method, apparatus and computer-accessible medium
EP2769491A4 (en) 2011-10-18 2015-07-22 Gen Hospital Corp Apparatus and methods for producing and/or providing recirculating optical delay(s)
WO2013059432A1 (en) 2011-10-19 2013-04-25 Ethicon Endo-Surgery, Inc. Clip applier adapted for use with a surgical robot
WO2013148306A1 (en) 2012-03-30 2013-10-03 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
US8964183B2 (en) * 2012-05-31 2015-02-24 General Electric Company Systems and methods for screening of biological samples
WO2014031748A1 (en) 2012-08-22 2014-02-27 The General Hospital Corporation System, method, and computer-accessible medium for fabrication minature endoscope using soft lithography
US9347852B1 (en) 2013-05-08 2016-05-24 Thomas DiMatteo Microscope illumination diagnostic cube
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
EP3025173A4 (en) 2013-07-26 2017-03-22 Massachusetts Gen Hospital System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography
JP6252598B2 (en) * 2013-12-09 2017-12-27 株式会社ニコン Optical device, measuring device, measuring method, a screening apparatus and screening method
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
DE102014008243A1 (en) * 2014-05-27 2015-12-03 Carl Zeiss Meditec Ag Fluoreszenbeobachtungssystem and optical filter system for this purpose
DE102014016850B9 (en) * 2014-11-13 2017-07-27 Carl Zeiss Meditec Ag An optical system for fluorescence observation
DE102015011429A1 (en) * 2015-09-01 2017-03-02 Carl Zeiss Meditec Ag An optical filter system and fluorescence observation system

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1265232A (en) * 1984-10-22 1990-01-30 Sune Svanberg Fluorescence imaging system
US4689491A (en) * 1985-04-19 1987-08-25 Datasonics Corp. Semiconductor wafer scanning system
JPS62138819A (en) * 1985-12-13 1987-06-22 Hitachi Ltd Scanning type laser microscope
GB8531011D0 (en) * 1985-12-17 1986-01-29 Medical Res Council Confocal scanning microscope
US4710635A (en) * 1986-04-14 1987-12-01 Becton, Dickinson And Company Dual laser excitation from single laser source
EP0267278A4 (en) * 1986-05-13 1989-12-19 Richard Kennedy Mixing device.
US4684602A (en) * 1986-06-30 1987-08-04 Eastman Kodak Company Multicolor laser recording method and element
US4745285B1 (en) * 1986-08-21 1992-08-11 Becton Dickinson Co
US4791310A (en) * 1986-10-02 1988-12-13 Syracuse University Fluorescence microscopy
GB8626576D0 (en) * 1986-11-06 1986-12-10 Amersham Int Plc Imaging method
WO1988007695A1 (en) * 1987-03-27 1988-10-06 The Board Of Trustees Of The Leland Stanford Junio Scanning confocal optical microscope
US4847823A (en) * 1987-06-19 1989-07-11 Siscan Systems, Inc. Method and apparatus for reading or measuring magneto-optical storage media using pinhole aperture
DE3821648A1 (en) * 1987-07-24 1989-02-02 Jednotne Zemedelske Druzstvo Light Distribution System
US4884880A (en) * 1987-11-16 1989-12-05 Washington University Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope
US4884881A (en) * 1987-11-16 1989-12-05 Washington University Single aperture confocal scanning epi-illumination microscope
US4802748A (en) * 1987-12-14 1989-02-07 Tracor Northern, Inc. Confocal tandem scanning reflected light microscope
FR2626383B1 (en) * 1988-01-27 1991-10-25 Commissariat Energie Atomique Method of scanning confocal optical microscopy and has extended depth of field and devices for implementation of METHOD
EP0393165B2 (en) * 1988-07-13 2007-07-25 Optiscan Pty Ltd Scanning confocal endoscope
DE68924460T2 (en) * 1988-10-11 1996-06-13 Du Pont Laser scanning and application procedures.
US4972258A (en) * 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use

Also Published As

Publication number Publication date Type
DE69131176D1 (en) 1999-06-02 grant
EP0495930A1 (en) 1992-07-29 application
JP2824462B2 (en) 1998-11-11 grant
DE495930T1 (en) 1993-02-25 grant
CA2067188C (en) 2001-05-15 grant
US5127730A (en) 1992-07-07 grant
ES2133283T3 (en) 1999-09-16 grant
EP0495930B1 (en) 1999-04-28 grant
DE69131176T2 (en) 1999-12-30 grant
WO1992002839A1 (en) 1992-02-20 application
JPH05501458A (en) 1993-03-18 application
DK0495930T3 (en) 1999-11-08 grant

Similar Documents

Publication Publication Date Title
Shotton et al. Confocal scanning microscopy: three-dimensional biological imaging
White et al. An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy.
Ratzlaff et al. A tandem-lens epifluorescence macroscope: hundred-fold brightness advantage for wide-field imaging
US6320174B1 (en) Composing microscope
Wright et al. Introduction to confocal microscopy and three-dimensional reconstruction
Bajer Role of phragmoplast filaments in cell-plate formation
Rakos Photoelectric area scanner
DE3345465A1 (en) Dental diagnostic instrument
Bertani et al. A scanning device for infrared reflectography
US5475212A (en) Apparatus for imaging multiple radiation beams
JPS63118115A (en) Projection lens
JPH03191389A (en) Display device
Grimes Morphological discontinuity of kinetosomes during the life cycle of Oxytricha fallax
JPS62173415A (en) Endoscope objective lens
JPS60181720A (en) Endoscope incorporating solid-state image pickup element
JPH04316478A (en) Device for observing test specimen of organism, system and method
JPH02284113A (en) Binocular with vibration proof means
DE2731914A1 (en) Multi-colour printer monitoring system - has optical searching heads to scan datum lines with misalignment transmitted to control system
Takamatsu et al. Imaging of calcium wave propagation in guinea-pig ventricular cell pairs by confocal laser scanning microscopy
JPH03102478A (en) Image processing device
Walker et al. The Observation of Monochromatic Intensity Distributions in Planetary Nebulae by Means of Electronography
Box et al. Flying‐Spot Microscope Adapted for Quantitative Measurements
US4989060A (en) Solid-state imaging device with pixels having weighted sensitivity distribution
US20060012870A1 (en) Light scanning microscope with line-by-line scanning and use
JPS61214666A (en) Image outputting system

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry