CA2015079C - Chemical disinfectant and sterilant - Google Patents

Chemical disinfectant and sterilant Download PDF

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Publication number
CA2015079C
CA2015079C CA 2015079 CA2015079A CA2015079C CA 2015079 C CA2015079 C CA 2015079C CA 2015079 CA2015079 CA 2015079 CA 2015079 A CA2015079 A CA 2015079A CA 2015079 C CA2015079 C CA 2015079C
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sterilant
chemical
disinfectant
glutaraldehyde
grams
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CA 2015079
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CA2015079A1 (en
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Howard Martin
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Abstract

The invention is an improved disinfectant and sterilant in a chemical form. The disinfectant and sterilant formulation is based upon glutaraldehyde which must be in acidic form. The normal pH range for the disinfectant and sterilant is 3.0-3.5. However, under controlled circumstances the range may be 2.5-7.0; as the disinfectant and sterilant must be acidic, it cannot be over pH 7Ø In use as a disinfectant by immersion, the items or materials remain inmersed for up to ten minutes. As a sterilant, the immersion is between six and ten hours. The disinfectant and sterilant consists of a plurality of chemicals mixed with the glutaraldehyde as a solution.

Description

TITLE OF THE INVENTION
Chemical Disinfectant and Sterilant PRIOR ART PATENTS
3,915,877 10/1975 - Ware - 252/106 -4,208,404 06/1980 - Cowan - 424/153 -4,469,614 09/1984 - Martin - 514/705 -4,654,374 05/1987 - Martin - 514/698 -BACKGROUND AND SUMMARY OF THE INVENTION
This invention is an improvement over the chemical disinfectant and sterilant composition disclosed in my U.S. Letters Patent No. 4,469,614 and U.S. Patent No.
4,654,374.
This invention relates to antiseptic and germicidal compositions and in particular to disinfectants and sterilants. Specifically, it relates to chemical compositions for use as disinfectants and sterilants.
There have been many compositions, developed for antiseptic and germicidal cleaning purposes, but each in the prior art has had some limitations as to the applications. For some, the limitation has been the extent to which they could successfully disinfect.

For others the limitation has been the extent to which they could consistently sterilize. Still others were limited because of the toxic effect on the skin or other organs of the user. Other compositions were limited because of their corroding effect on metal, such as spotting or tarnishing.
The present invention has been developed to avoid or overcome these prior art limitations especially in the general use solutions of the disinfectant and sterilant. This is particularly so when used as a disinfectant and sterilant for inanimate objects.
The present invention has many uses for disinfecting or sterilizing hard surfaces, such as counter tops, laboratory tables, laboratory equipment, hospital walls, and other such hard surface items or areas in medical, surgical or dental environments as well as for industrial, commercial, and agricultural purposes and uses.
The disinfectant and sterilant of the present invention is specifically intended as a means of fighting organisms that cause disease and have industrial products. The disinfectant and sterilant may be used in laboratories, operating rooms, patient-care rooms or areas, and other similar places in public or private facilities such as schools, hospitals, homes, factories, and similar locations.
The disinfectant and sterilant is intended for use to eliminate bacteria. that is found on hard surfaces as aforementioned. The use of the present invention may be for application by spraying, wiping, rinsing, dipping, brushing, .. , , . . . _ ' . ' ..: J.: i.'~'..~:.._ _ ,."...._...~... .... . _ or by other methods of application.
The basic ingredients of the formula for the disinfectant and sterilant composition, which is delineated in detail hereinafter, is composad of glutaraldehyde, ortho phenyl phenol, paratertiaryamylpher.ol, sodium arylalkylsulfonate, and citric acid. The plurality of chemicals is mixed as a solution.
The disinfectant and sterilant is provided as a stock solution, thereafter, in activated form, it is diluted with water ir. various proportions or ratios depe~:ding upon t'..~.e level necessary to achiave a specified a~.d result. This is discussed in detail hereinafter.
Of aarticular r_ota is the fact that in the prior art the use of glutaralde;yde has usually been in the alkaline for:,, whereas iz the present invention the use of glutaraldehyd~ is in the acid form. Previous acid forms pol~-merize and therefor lose effectiveness.
Th= prior art disinfectants in the zlkaline solutions tend to leave a residue in the more concentrated forms. This cauld be an irritant. Several rinses may be required to remove the slippery residua.
The present invention is primarily for use as a disinfectant and starilant on inanimate surfaces for ' disinfection and sterilization of contaminated areas. For example, on dental or surgical instruments that are , ,.. :..a .v . , , . .. . ~ , ~ . ' . .. :v.~vtcM.. ::. . , . . . . .. . . .
. . . .. . . ~ . . . . . . .. . .. . . . . . . . ...

contaminated.
As a secondary use, the present invention may be used in .
a milder form, by dilution, as a hand disinfectant in health case offices, laboratories, and treatment rooms, or in more concentrated form.
The normal pH range for the disinfecta_-:t and sterilant of this invention is 3.0-3.5, however, under controlled circumstance s the range may be 2.5-7.0; as the disinfectant and sterilant must be acidic, it cannot b~ over pH 7Ø
As noted, the present invention uses the glutarald'hydes in t?~° acidic form. In the prior art the glutaraldehydes in the al~cal?re form present certain disadvantages. Some of these disadvar.tagas are: it needs ar. activator of a sp=cial solution or powder to make it active: once activated, it tzen has a li::!it~d lifa oa one to four :~.eeks and mist be disposed of entirely; the composition, ~.ahic~: is normally activated in approximate amounts of a lire r, is uneconomical if not used because it is dated at time of activation and rust be discarded; th= solution yellows the skin due to a tanning action; it has a disagreeable odor; it is corrosive and acids polymerize and lose potency.
In the present invention, the acid foz-m of the glutaraldehyde needs no activation and has a morn or less indefinite shelf life of close to one year. The solution of the present invention permits mixing and diluting just the 20i50~9 amount needed, thereby preserving the stock solution which makes it more economical. In this manner it does not need dating, for the mixture being used is only what is needed.
In the prior art the corrosion of instruments (~nhen used for dental and surgical instrument disinfection or sterilization), the tanning effect on the skin, irritation of the skin and allergic dermatitis to the skin, its noxious odor, general toxicity, and the tarnishing of carbon steel instruments were all undesirable problems. The present invention overcomes these problems.
The pr=sent invention has a much wider and universal use than the disinfectants and sterilants of the prior art which were limited because of the prior a=t problems. The present invention may be used on and for all hard surfaces tha~ are non-porous. Hard surface items include catheters, scalpels, trays, bowls, dental mirrors, lights, and other similar equipment. Even cotton. swabs may be soaked in it and then used t~o disinfect.
The formation of the present invention can be used in industrial areas, such as oil industry recovery, for iron and steel cleaning, for damuliszfection, degreasing an,3 janitorial work.
In 3eneral use the present invention may be used for instrument immersion, wiping surfaces and instruments, dipping, and spraying (by pump or aerosol means).
The present invention may also be used by placing instruments in a tray containing the disinfectants and sterilar.t in diluted solution form. This includes all medical and other health care arrangements, including veterinary, podiatry, hospital, nursing, and other health care facilities or laboratories. Cages for laboratory animals and the laboratory areas may be disin~~cted with the present iw~entio~. In household use the present inve-:tion may be used where ordinary sprays are used, such as in toilet bowls, animal areas, and kitchen areas. The present invention is effecti-Ye or. ite:;~s t::at cannot be heated or autoclaved, and includes rubber and plastics items.
It is to be noted that the corrosion: of iron and steel in th2 iOr.:~ Of. StOra7e tonkS, p?p21 ineS, p'1~p5, dnd Ot:'ler systems by sulfate reduci.~.g bas;,teri a and pseudor~onas type bacteria particularly is a serious problem faced by the petroleum industry. These bacteria also cause impede the secondary recovery ofpetroleum. Several general measures hava bezn t3'.K?n by the industry to prevent these effects.
One method has been to employ biocides to kill the bacteria. However success has been variable. The biocide can be incorporated in the oil formulation or the end use may be diluted down to suit a particular need. It usually has taken several hours for the biocide to work in the wells or tanks.
This is a severe down time problem and it has been found that the biocides wire not completely effective being unable to get beneath a sludge level to attack the sessile organisms.
The problem of penetration of the sludge biofilm inhibits present biocides. The use of a biocide to disrupt the biofilm and kill the bacteria as well as prevent reattac ~~ent is the important factor to reduce this problem.
The new formulation of 25~ glutaraladehyde plus the dual synergistic phenols are sufficie~.t based upon testing to equal the benchark biocide, which is a 50o concentration oT
glutaraldeh,,~de. The solution of this invention coupled with the special surfactant/detergent/solubizer component enables the biofilm to be penetrated and removed thus allowing a less toxic formulation to penetrate, attack, and kill the particular organisms present.
Therefore the invention of this formulation acts as both a cleanser and disinfectant, thus combining two key attributes into or.e product and is morn effective than the higher concentrations of single components. This biocide is stable, at selected temperatures and starts to polymerize at high temperatures, shortening its life but increasing its killing effectiveness.
In one of the milder forms, the present invention may be used in soaps for degerming the hands or as a presurgical lotion as a hand degerming agent.
It is, therefore, an object of this invention to provide a disinfectant and sterilant that is a chemical composition.
Another object of this invention is to provide a formulation that can be effectively used in industrial, commercial, and agricultural areas to kill sulfate reducing bacteria that are specific to corrosion proble,s in the oil producing business.
Another object is to product a formulation which will clean as ~~:ell as disinT'ct the wall head and holding tanks and reservoirs and will main=ain itself in the field and will not polymerize leading to premature loss of activity, all due to the low pH of the formula_ion.
It 's another object of this invention to provide an invention that can be used in industrial situations requiring cleaning and disinfecting at a higher concentration.
It is another object of this invention to provide a disinfectant and sterilant that may be used on had sur~ace inanimate obj=cts.
It is also an object of this invention to provide a disinfectant and sterilant that may be used on living tissue.
.- .._-. , - . _. :.....: ~ ..
' 2015079 It is yet another object of this invention to provide a disinfectant and sterilant that fights organisms that cause disease, and industrial destruction.
It is still another object of this invention to provide a disinfectant and sterilant that uses glutaraldehyde in acid form.
Further objects and advantages of the invention will become more apparent in light of the following description of the preferred embodiments.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The formula of the present invention for a chemical disinfectant and sterilant is as follows:
s glutaraldehyde (acidic) 57.06%
orthophenyl phenol 1.32 paratertiaryamylphenol 0.27$
sodium arylalkylsulfonate 0.16$
citric acid 0.10$
water 41.09$
TOTAL (By Weight) 100.00%
The above formulation is the base stock solution and when used, as hereinafter described, it is diluted and/or concentrated. The base stock solution is the concentrated form and it is further diluted or a higher concentration with 20150'79 water for clinical or general use. The percentages are by weight of the ingredients to the total weight of the mixture.
It is to be noted that the aforementioned stock solution is shown as a liquid solution, however it is to be understood that the reduction or trans'ormation to a dry powder state as a dry base stoc'.~c che:~ical compound, for subsequent dissolving in wate r or other suitable solvent to form the base stock solutio:~, is within the scope and intent of this invention.
It is also to be understood that the mixing of the formula without the ;~;ater contEnt as a liquid base stock chemical compound, for subsecuent addition of tha water conte:~t to ferm the base stoci: solution; is also within ti~.e scope and intent of this irver_ti or..
The for:r.slation o~ the aforementioned chemical disinfectant and sterilant in a dry base stock che-t'cal compound a:~d in a liquid base stock chemical conpound are means by which economical storage and shipment can be obtai.ed in relation to the aforementioned base stock solution which is of groaLer volume.
T:~e glutaraldehyde in tha formula is in acid form with a preferred pH range of 3.0-3.5. however, a pH range of 2.5-7.0 is possible and useable un3~r controlled conditions. The glutaraldehyde for this invention must be acidic and, therefore, must not exceed a pH of 7.0 in that regard the range slightly below the pH of 7.0 is desirable, say S0~ to 10%.

The glutaraldehyde has 258 concentration chemical compound, mixed into the formulation in weights, or percentages of the total weight, as noted ereinbefore.
h The formulation given previously es of the total by percentag weight for each ingredient, by actual weight are shown below of each ingredient for the formulation:

Ingredient Weight Percent of (grams) Total Weight glutaraladehyde (acidic) 2156.25 57.06 orthophenyl phenol 50.00 1.32 paratertiaryamylphenol 10.00 0.27 sodium arylalkylsulfonate 6.00 0.16 citric acid 3.80 0.10 water 1553.00 41.09 TOTAL 3779.05 100.00 The citric acid removes a noxious odor and provides additional acidification.
The concentration of glutaraldehyde which can be used in the basic formula ranges between 10~ and 50~ glutaraladehyde.
Thus, the range of concentration of the active ingredients can be from two times the concentration listed to one half the concentration of the active ingredients: Acid glutaraladehyde, orthophenyl phenol and paratertiaryamylphenol. The rest of the ingredients follow the same usage as in my U. S. Patent No. 4,654,374 issued May 31, 1987. This formula omits benzotriazole.
To activate the chemical disinfectant and sterilant for use, the base stock solution is diluted in controlled ratios with water. The range of the solution can be 50o glut to 10~
glut. A strong solution would be 25$ glut ar.d a weak solution 10~ glut.
The determination of the ratio to use may be determined by test for the wide plurality of applications which exist.
The sodiun arylalkysulfonate acts as a surfactant and corrosion inhibitor.
The weights for each ir.gredier.t, and thei_ corresponding oerce~taces of tze total wei7ht of the r.ix=ure, are for the optimal formula and ore'erred e;:,bodimer.t of the invention of a cremical disinfectant and sterilant. iiocae~.~er, it is to be under rood tzar vari~tior.s from this optical formula of up to plus or minus ten percent of each weight are ~.~oricabla and sre :aithia the scope and intent of this invention, any difference in tote l weight being adjusted in the water content; the percentages by weight being adjusted accordingly. Thus, the formula ~'13s a range of weight for each ingredient with the optima l and preferred embodiment being as specifically listed.
The rarga for phenols hatches the ratio as glutaraldehyde increases or decreases.
~' 20150'9 This improvement is made possible by the fact that the disinfecting and sterilant agent glutaraldehyde is enhanced by the synergistic action of the two phenols (orthophenyl phenol and pa=atertiaryamyl phenol) which are interactive and additive, making the sum greater than any of the parts.
As can be readily understood from the foregoing description of the invention, the present structured formulation of a chemical disinfectant and sterilant can be further structured in different modes of formulation to provide an ability to disinfect and sterilize objects.
Accordingly, modifications and variations to which the inve:tio=, is susceptible may be practiced withost d?parting from the scope and intent of the appended claims.

Claims (8)

1. A chemical disinfectant and sterilant, comprising: a basic formulation of chemical ingredients, said basic formulation of said chemical ingredients consisting of the following optimal quantities of said chemical ingredients, said optimal quantities being by weight of the total weight of said basic formulation: glutaraldehyde (acidic) 2156.25 grams; orthophenyl phenol 50.00 grams; papatertiaryamyl phenol 10.00 grams; sodium arylalkylsulfonate 6.00 grams; citric acid 3.80 grams; and 1553.00 grams of water, the total mixture of said disinfectant and sterilant having a total optimal weight of 3779.05 grams; said respective weights of said chemical ingredients and said water being 57.06% glutaraldehyde (acidic); 1.32% orthophenyl phenol; 0.27% paratertiaryamyl phenol; 0.16% sodium arylalkylsulfonate; 0.10% citric acid;
and 41.09% water, said formulation of said chemical ingredients forming a base stock solution.
2. A chemical disinfectant and sterilant as recited in claim 1, wherein said chemical ingredients, including said principal chemical ingredient, are liquids.
3. A chemical disinfectant and sterilant as recited in claim 1, wherein said chemical ingredients, including said principal chemical ingredient, are dry ingredients in a powder-like consistency, said dry ingredients being suitably dissolved when being readied for use.
4. A chemical disinfectant and sterilant as recited in claim 1, wherein said glutaraldehyde, being acidic, has a pH
range held within 3.0 to 3.5.
5. A chemical disinfectant and sterilant as recited in claim 1, wherein said glutaraldehyde, being acidic, has a pH
range of 2.5 to 7Ø
6. A chemical disinfectant and sterilant as recited in claim 1, wherein said glutaraldehyde, being acidic, has a pH
range not exceeding 7Ø
7. A chemical disinfectant and sterilant as recited in claim 1 and additionally, ultrasonic activation of the mass, said ultrasonic activation speeding up the process of disinfection.
8. A chemical disinfectant and sterilant as recited in claim 1, wherein said formulation includes glutaraldyhyde which has an initial concentration between 10% glutaraldehyde and 50% glutaraldehyde.
CA 2015079 1989-10-23 1990-04-20 Chemical disinfectant and sterilant Expired - Lifetime CA2015079C (en)

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US425,005 1989-10-23

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DE4317844A1 (en) * 1993-05-28 1994-12-01 Bayer Ag Chemical disinfectant based on phenolic components and glutaraldehyde

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