CA1334395C - Apparatus for separating cell suspension - Google Patents
Apparatus for separating cell suspensionInfo
- Publication number
- CA1334395C CA1334395C CA000531922A CA531922A CA1334395C CA 1334395 C CA1334395 C CA 1334395C CA 000531922 A CA000531922 A CA 000531922A CA 531922 A CA531922 A CA 531922A CA 1334395 C CA1334395 C CA 1334395C
- Authority
- CA
- Canada
- Prior art keywords
- separating
- cell suspension
- set forth
- fractionating apparatus
- shearing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000006285 cell suspension Substances 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 90
- 239000012528 membrane Substances 0.000 claims abstract description 68
- 230000007246 mechanism Effects 0.000 claims abstract description 12
- 238000010008 shearing Methods 0.000 claims description 67
- 239000008280 blood Substances 0.000 claims description 58
- 210000004369 blood Anatomy 0.000 claims description 58
- 239000004417 polycarbonate Substances 0.000 claims description 10
- 229920000515 polycarbonate Polymers 0.000 claims description 10
- 239000011148 porous material Substances 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 229920002492 poly(sulfone) Polymers 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 239000000306 component Substances 0.000 description 71
- 108010066114 cabin-2 Proteins 0.000 description 14
- 238000010586 diagram Methods 0.000 description 13
- 238000007796 conventional method Methods 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 5
- 239000012510 hollow fiber Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 229940000425 combination drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 241000557626 Corvus corax Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 102100034742 Rotatin Human genes 0.000 description 1
- 101710200213 Rotatin Proteins 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/16—Rotary, reciprocated or vibrated modules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/018—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements ring shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/50—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition
- B01D29/52—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in parallel connection
- B01D29/54—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in parallel connection arranged concentrically or coaxially
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/76—Handling the filter cake in the filter for purposes other than for regenerating
- B01D29/86—Retarding cake deposition on the filter during the filtration period, e.g. using stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/15—Filters with filtering elements which move during the filtering operation with rotary plane filtering surfaces
- B01D33/21—Filters with filtering elements which move during the filtering operation with rotary plane filtering surfaces with hollow filtering discs transversely mounted on a hollow rotary shaft
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/35—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition
- B01D33/37—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in parallel connection
- B01D33/39—Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in parallel connection concentrically or coaxially
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/58—Handling the filter cake in the filter for purposes other than for regenerating the filter cake remaining on the filtering element
- B01D33/68—Retarding cake deposition on the filter during the filtration period, e.g. using stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/087—Single membrane modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/08—Prevention of membrane fouling or of concentration polarisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/16—Use of chemical agents
- B01D2321/168—Use of other chemical agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/20—By influencing the flow
- B01D2321/2008—By influencing the flow statically
- B01D2321/2016—Static mixers; Turbulence generators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S210/00—Liquid purification or separation
- Y10S210/929—Hemoultrafiltrate volume measurement or control processes
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Centrifugal Separators (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61060780A JPS62217973A (ja) | 1986-03-20 | 1986-03-20 | 液体を分別する装置 |
| JP61-60780 | 1986-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1334395C true CA1334395C (en) | 1995-02-14 |
Family
ID=13152144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000531922A Expired - Fee Related CA1334395C (en) | 1986-03-20 | 1987-03-12 | Apparatus for separating cell suspension |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4968600A (zh) |
| EP (1) | EP0238335B1 (zh) |
| JP (1) | JPS62217973A (zh) |
| KR (1) | KR910005292B1 (zh) |
| CN (1) | CN1009709B (zh) |
| AU (1) | AU587114B2 (zh) |
| CA (1) | CA1334395C (zh) |
| DE (1) | DE3771535D1 (zh) |
| ES (1) | ES2023894B3 (zh) |
| IN (1) | IN170744B (zh) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0624595B2 (ja) * | 1988-05-31 | 1994-04-06 | 工業技術院長 | 血液分離装置 |
| US4935002A (en) * | 1988-06-29 | 1990-06-19 | Biodynamics, Inc. | Apparatus and method for the autotransfusion of blood |
| US5679249A (en) * | 1991-12-24 | 1997-10-21 | Pall Corporation | Dynamic filter system |
| US5298016A (en) * | 1992-03-02 | 1994-03-29 | Advanced Haemotechnologies | Apparatus for separating plasma and other wastes from blood |
| DE4207614C1 (zh) * | 1992-03-10 | 1993-09-23 | Pall Corp., Glen Cove, N.Y., Us | |
| US5318376A (en) * | 1992-12-07 | 1994-06-07 | Prescott Sr Everett J | Manhole frame |
| US6117322A (en) * | 1993-06-23 | 2000-09-12 | Pall Corporation | Dynamic filter system |
| DE29611336U1 (de) * | 1996-06-28 | 1996-09-19 | Gesellschaft für Biotechnologische Forschung mbH (GBF), 38124 Braunschweig | Filtrationsvorrichtung |
| ES2211117T3 (es) | 1998-08-03 | 2004-07-01 | Miltenyi Biotec Gmbh | Dispositivo de filtrado. |
| US6692702B1 (en) | 2000-07-07 | 2004-02-17 | Coulter International Corp. | Apparatus for biological sample preparation and analysis |
| AU2002366538A1 (en) * | 2001-12-13 | 2003-06-23 | Foss Analytical A/S | Method and device for extraction and filtration of a sample |
| US9144583B2 (en) * | 2002-03-29 | 2015-09-29 | Tissue Genesis, Inc. | Cell separation apparatus and methods of use |
| JP2006501449A (ja) | 2002-09-27 | 2006-01-12 | ザ ジェネラル ホスピタル コーポレーション | 細胞分離のためのマイクロ流体デバイスおよびその使用 |
| DE102005023152A1 (de) * | 2004-12-21 | 2006-06-22 | Rwth Aachen | Oxygenator zum Gasaustausch |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| CN100398451C (zh) * | 2006-01-16 | 2008-07-02 | 王雄鹰 | 一种结合陶瓷生产从石煤提钒并根治污染的方法 |
| US11174458B2 (en) | 2007-04-23 | 2021-11-16 | Koligo Therapeutics, Inc. | Cell separation apparatus and methods of use |
| WO2010072237A1 (de) * | 2008-12-23 | 2010-07-01 | Kmpt Ag | Verfahren und vorrichtung zum behandeln von fluiden |
| US20130153484A1 (en) * | 2010-07-07 | 2013-06-20 | Fenwal, Inc. | Fluid separators employing a fluidic bearing |
| DE102010043900A1 (de) * | 2010-11-15 | 2012-05-16 | Voith Patent Gmbh | Scheibenfilter |
| WO2012150226A1 (en) * | 2011-05-02 | 2012-11-08 | Technische Universiteit Eindhoven | Device for multiphase and single phase contacting |
| CN103509717B (zh) * | 2012-06-21 | 2016-01-20 | 中国农业机械化科学研究院 | 一种动态流膜浓缩装置 |
| US8900169B2 (en) | 2013-03-15 | 2014-12-02 | Tbi Innovations, Llc | Methods and devices to reduce the likelihood of injury from concussive or blast forces |
| CN103551038B (zh) * | 2013-11-15 | 2015-03-11 | 周小山 | 膜分离装置 |
| CN108601598A (zh) | 2015-11-16 | 2018-09-28 | Q30运动科学公司 | 创伤性脑损伤保护装置 |
| EA201891834A1 (ru) | 2016-03-02 | 2019-02-28 | Кью30 Спортс Сайенс, Ллк | Способы и устройства для уменьшения повреждающих эффектов сильного удара или воздействий, вызывающих сотрясение, у субъекта |
| SG11201808111TA (en) * | 2016-03-28 | 2018-10-30 | Univ Nanyang Tech | Cross-flow membrane filtration with inclined filtration channel |
| CN107522192B (zh) * | 2017-07-11 | 2019-08-16 | 南通大学 | 连续流立式平面型液相剪切方法 |
| TWI644883B (zh) * | 2017-10-03 | 2018-12-21 | 淡江大學 | 多孔性薄膜的製備方法、乳化元件及乳化裝置 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2734015A (en) * | 1956-02-07 | Process for the manufacture of hydrolyzed adrenocorticotrophin | ||
| US2362231A (en) * | 1942-07-27 | 1944-11-07 | Oliver United Filters Inc | Filter |
| GB1451432A (en) * | 1972-10-25 | 1976-10-06 | Atomic Energy Authority Uk | Reverse osmosis apparatus |
| AU516046B2 (en) * | 1975-10-08 | 1981-05-14 | Baxter Travenol Laboratories Inc. | Dialyzer construction |
| US4069151A (en) * | 1976-03-31 | 1978-01-17 | C. R. Bard, Inc. | Thin polycarbonate membranes for use in hemodialysis |
| US4071444A (en) * | 1976-10-12 | 1978-01-31 | Purdue Research Foundation | Portable chemical reactor for use as an artificial kidney |
| US4191182A (en) * | 1977-09-23 | 1980-03-04 | Hemotherapy Inc. | Method and apparatus for continuous plasmaphersis |
| DE2812042A1 (de) * | 1978-03-20 | 1979-10-31 | Harold Hebding | Trennanlage zum abtrennen von stoffen aus emulsionen |
| AU517953B2 (en) * | 1980-01-29 | 1981-09-03 | Baxter Travenol Laboratories Inc. | Plate dialyzer |
| JPS57121956A (en) * | 1981-01-22 | 1982-07-29 | Nissan Motor Co Ltd | Anti-skid controller |
| DD206937A1 (de) * | 1981-12-24 | 1984-02-15 | Siegfried Dreyer | Flachmembran-trenngeraet |
| JPS58155758A (ja) * | 1982-03-10 | 1983-09-16 | Matsushita Electric Ind Co Ltd | 光電変換素子およびその製造方法 |
| CA1258053A (en) * | 1982-12-13 | 1989-08-01 | Halbert Fischel | Blood fractionation system and method |
| US4668394A (en) * | 1983-01-10 | 1987-05-26 | Mcneilab, Inc. | Filtration media and supporting frame |
| DE3480588D1 (de) * | 1983-12-20 | 1990-01-04 | Hembrex Inc | Filtrierverfahren und vorrichtung. |
| US4713176A (en) * | 1985-04-12 | 1987-12-15 | Hemascience Laboratories, Inc. | Plasmapheresis system and method |
-
1986
- 1986-03-20 JP JP61060780A patent/JPS62217973A/ja active Granted
-
1987
- 1987-03-12 CA CA000531922A patent/CA1334395C/en not_active Expired - Fee Related
- 1987-03-13 US US07/025,338 patent/US4968600A/en not_active Expired - Lifetime
- 1987-03-17 IN IN224/DEL/87A patent/IN170744B/en unknown
- 1987-03-19 EP EP87302368A patent/EP0238335B1/en not_active Expired - Lifetime
- 1987-03-19 ES ES87302368T patent/ES2023894B3/es not_active Expired - Lifetime
- 1987-03-19 AU AU70185/87A patent/AU587114B2/en not_active Ceased
- 1987-03-19 DE DE8787302368T patent/DE3771535D1/de not_active Expired - Fee Related
- 1987-03-20 CN CN87103201A patent/CN1009709B/zh not_active Expired
- 1987-03-20 KR KR1019870002567A patent/KR910005292B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN87103201A (zh) | 1987-12-16 |
| EP0238335A3 (en) | 1988-01-07 |
| US4968600A (en) | 1990-11-06 |
| IN170744B (zh) | 1992-05-09 |
| JPH044908B2 (zh) | 1992-01-29 |
| JPS62217973A (ja) | 1987-09-25 |
| ES2023894B3 (es) | 1992-02-16 |
| CN1009709B (zh) | 1990-09-26 |
| EP0238335A2 (en) | 1987-09-23 |
| DE3771535D1 (de) | 1991-08-29 |
| AU7018587A (en) | 1987-09-24 |
| EP0238335B1 (en) | 1991-07-24 |
| AU587114B2 (en) | 1989-08-03 |
| KR870008590A (ko) | 1987-10-19 |
| KR910005292B1 (ko) | 1991-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20050214 |