CA1310017C - Process for the preparation of 2, 6-dichlorodiphenylamino-acetic acid derivatives - Google Patents
Process for the preparation of 2, 6-dichlorodiphenylamino-acetic acid derivativesInfo
- Publication number
- CA1310017C CA1310017C CA000603909A CA603909A CA1310017C CA 1310017 C CA1310017 C CA 1310017C CA 000603909 A CA000603909 A CA 000603909A CA 603909 A CA603909 A CA 603909A CA 1310017 C CA1310017 C CA 1310017C
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- compound corresponding
- compound
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- Prior art date
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- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 50
- HDUUZPLYVVQTKN-UHFFFAOYSA-N 2,6-dichloro-n-phenylaniline Chemical class ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 HDUUZPLYVVQTKN-UHFFFAOYSA-N 0.000 claims abstract description 5
- 230000000875 corresponding effect Effects 0.000 claims description 51
- 238000006243 chemical reaction Methods 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 10
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 claims description 6
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 claims description 5
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 150000001340 alkali metals Chemical group 0.000 claims description 5
- 230000003197 catalytic effect Effects 0.000 claims description 5
- AULKDLUOQCUNOK-UHFFFAOYSA-N 3,5-dichloro-4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC(Cl)=C(O)C(Cl)=C1 AULKDLUOQCUNOK-UHFFFAOYSA-N 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
- 238000005904 alkaline hydrolysis reaction Methods 0.000 claims description 3
- 238000007098 aminolysis reaction Methods 0.000 claims description 3
- HOPRXXXSABQWAV-UHFFFAOYSA-N anhydrous collidine Natural products CC1=CC=NC(C)=C1C HOPRXXXSABQWAV-UHFFFAOYSA-N 0.000 claims description 3
- UTBIMNXEDGNJFE-UHFFFAOYSA-N collidine Natural products CC1=CC=C(C)C(C)=N1 UTBIMNXEDGNJFE-UHFFFAOYSA-N 0.000 claims description 3
- 238000006114 decarboxylation reaction Methods 0.000 claims description 3
- 238000011065 in-situ storage Methods 0.000 claims description 3
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 claims description 3
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical class OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 239000003586 protic polar solvent Substances 0.000 claims 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 229960001193 diclofenac sodium Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000013067 intermediate product Substances 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000005191 phase separation Methods 0.000 description 3
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 3
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- JDMFXJULNGEPOI-UHFFFAOYSA-N 2,6-dichloroaniline Chemical compound NC1=C(Cl)C=CC=C1Cl JDMFXJULNGEPOI-UHFFFAOYSA-N 0.000 description 2
- VONWPEXRCLHKRJ-UHFFFAOYSA-N 2-chloro-n-phenylacetamide Chemical compound ClCC(=O)NC1=CC=CC=C1 VONWPEXRCLHKRJ-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- OKNYKYRPQGNADZ-UHFFFAOYSA-N ethyl 2-(2,6-dichlorophenoxy)acetate Chemical compound CCOC(=O)COC1=C(Cl)C=CC=C1Cl OKNYKYRPQGNADZ-UHFFFAOYSA-N 0.000 description 2
- 239000012442 inert solvent Substances 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- HOLHYSJJBXSLMV-UHFFFAOYSA-N 2,6-dichlorophenol Chemical compound OC1=C(Cl)C=CC=C1Cl HOLHYSJJBXSLMV-UHFFFAOYSA-N 0.000 description 1
- -1 2,6-dichlorophenyl sodamide Chemical compound 0.000 description 1
- DWXSYDKEWORWBT-UHFFFAOYSA-N 2-(2-bromophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC=C1Br DWXSYDKEWORWBT-UHFFFAOYSA-N 0.000 description 1
- IUJAAIZKRJJZGQ-UHFFFAOYSA-N 2-(2-chlorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC=C1Cl IUJAAIZKRJJZGQ-UHFFFAOYSA-N 0.000 description 1
- KFLKTDAONDZLAN-UHFFFAOYSA-N 2-(n-phenylanilino)acetic acid Chemical class C=1C=CC=CC=1N(CC(=O)O)C1=CC=CC=C1 KFLKTDAONDZLAN-UHFFFAOYSA-N 0.000 description 1
- CNJGWCQEGROXEE-UHFFFAOYSA-N 3,5-Dichlorosalicylicacid Chemical compound OC(=O)C1=CC(Cl)=CC(Cl)=C1O CNJGWCQEGROXEE-UHFFFAOYSA-N 0.000 description 1
- 238000006816 Chapman rearrangement reaction Methods 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- YCOXTKKNXUZSKD-UHFFFAOYSA-N as-o-xylenol Natural products CC1=CC=C(O)C=C1C YCOXTKKNXUZSKD-UHFFFAOYSA-N 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229940106681 chloroacetic acid Drugs 0.000 description 1
- 230000000332 continued effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical class C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
- VEUUMBGHMNQHGO-UHFFFAOYSA-N ethyl chloroacetate Chemical compound CCOC(=O)CCl VEUUMBGHMNQHGO-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 description 1
- 150000002497 iodine compounds Chemical class 0.000 description 1
- SNHMUERNLJLMHN-UHFFFAOYSA-N iodobenzene Chemical compound IC1=CC=CC=C1 SNHMUERNLJLMHN-UHFFFAOYSA-N 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- DWVWVSLAIJHBBG-UHFFFAOYSA-N n-(2,6-dichlorophenyl)acetamide Chemical compound CC(=O)NC1=C(Cl)C=CC=C1Cl DWVWVSLAIJHBBG-UHFFFAOYSA-N 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 125000004436 sodium atom Chemical group 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A b s t r a c t Process for the Preparation of 2,6-dichlorodiphenyl-aminoacetic acid derivatives A new process for the preparation of 2,6-dichlorodiphenyl-amine derivatives is described, which process provides the desired active compound in a high yield and with a very high degree of purity by a technically simple and realisable procedure.
Description
i ~ 7 Process for the preparation of 2,6-dichlorodiphenylamino-acetic acid derivatives 2,6-Dichloro-substituted diphenylaminoacetic acid derivatives play a major role in the therapy of rheumatic diseases,for which diclofenac sodium corresponding to formula I
(R = sodium atom) ~2 -CC~2R
NH (I) : Cl ~ Cl has proved to be particularly effective. This compound and its medical use has already been disclosed in DE-A-15 43 639. The preparation of this compound generally proceeds via an intermediate product corresponding to formula V
~1 IH ~
Various methods are already known for the preparation of this intermediate product which is the central structure of the above mentioned active compound. The disadvantages ~ 31~ 7 of these methods lie in the necessity of employing long reaction times and high temperatures and of providing only moderate to poor yields.
One known process for the preparation of the diphenylamine derivative corresponding to formula V
proceeds from 2,6-dichloroacetanilide and bromobenzene and requires long reaction times, e.g. 96 hours ~see D.C.
Atkins et al., J. Med. Chem. 26, 1361 (1983); CH-PS 473 770 published July 31, 1969; and us-Ps 3,536,758). Another process uses iodobenzene as starting material but no yields are published for this process (see JP-OS-57 167 947 published Oct. 19, 1982 and C.A. 98, 53 379 K (1983)).
In a more recent process (see J.S. Kaltenbronn, R.A. Scherer, Arzneim. Forsch. 33, 62 (1983)), the re~uired substance is again only obtained in poor yields. In the process acc~rding to DE-OS 15 43 639 published Feb. 5, 1970, the yield obtained, as indicated there, is only 43%
of the theoretical yield. According to the information given in the above mentioned documents, the intermediate product corresponding to formula V is obtained as a yellow oil. This substance, however, is a colourless solid (mp.
47.5 - 48C).
JP-OS-58 144 350 published Aug. 27, 1983 describes the Chapman rearrangement of N-phenyl-o-(2,6-dichlorophenyl)benzimidoester at 275C as an alternative for the preparation of compound V.
Direct processes for the preparation of diclofenac sodium have also been described, but they are not reproducible. In one known process of this type, 2-chlorophenyl acetic acid is reacted with 2,6-dichloroaniline (JP-OS-81 158 744 published Dec. 7, 1981, C.A. 97, 23 467 z (1980)). The desired product, however, is only obtained in a yield of 37% after 12 hours in DMF at 150C. Processes in which 2-bromophenyl acetic acid and 2,6-dichlorophenyl sodamide are used as starting materials also only provide low yields of the desired substance (22%
~, .
in HMPT; see JP-OS-77 oo 240 published Jan. 5, 1977, C.A.
87, 39 078 c (1977)). Other processes employ molar quantities of iodine compounds (see JP-OS 80-66 550 published ~ay 20, 1980, C.A. 93, 167 946 v (1980) and DE-OS
29 32 198 published Feb. 14, 1980).
A process by which the desired compound corresponding to formula I ls directly obtained from the compound corresponding to formula V is disclosed in CH-PS
473 770 published July 31, 1969 and DE-OS-15 43 639 published Feb. 5, 1970. This process is based on the known Stollé reaction (Ber. dtsch. Chem. Ges. 47, 2120 (1914) and is carried out in molten aluminum chloride.
It is an object of this invention to pro~ide a technically simple process for the preparation of the compound corresponding to formula I by which the desired substance may be obtained in high yields and with a very high degree of purity from readily available starting materials without the extreme reaction conditions of the known processes required for the preparation of the sterically difficult molecule of formula V.
This problem is solved by the present invention.
The invention relates to a process for the preparation of 2,6-dichlorodiphenylamine derivatives corresponding to the general formula I Cl~2-CO2~
(I) I~IU
Cl ~ Cl wherein R denotes a hydrogen atom, a Cl-C4-alkyl group or an alkali metal atom, characterized in that a 2,6-dichlorophenoxyacetic derivative corresponding to formula II Cl -0-CR_P~3-C02Rl (II) Cl .
wherein R1 denotes a hydrogen atom or a C1- to C6-alkyl group and R2 and R3 each denotes a hydrogen atom or a C1- to C4-alkyl group is reacted with aniline in a one-shot reaction, first to form the compound corresponding to formula III
~ 2 3 CO ~ ~III) wherein R2 and R3 have the meanings indicated above, which is then rearranged in situ to form the compound corresponding to formula IV
Cl N ~ ~IV) Cl C=O
wherein R2 and R3 have the meanings indicated above,.
and the resulting compound corresponding to formula IV
is then aminolysed to form the compound corresponding to formula V
~NH~) ~V) 1 5 Cl and after isolation of the compound corresponding to formula V, the latter ls converted into the compound corresponding to formula VI
(R = sodium atom) ~2 -CC~2R
NH (I) : Cl ~ Cl has proved to be particularly effective. This compound and its medical use has already been disclosed in DE-A-15 43 639. The preparation of this compound generally proceeds via an intermediate product corresponding to formula V
~1 IH ~
Various methods are already known for the preparation of this intermediate product which is the central structure of the above mentioned active compound. The disadvantages ~ 31~ 7 of these methods lie in the necessity of employing long reaction times and high temperatures and of providing only moderate to poor yields.
One known process for the preparation of the diphenylamine derivative corresponding to formula V
proceeds from 2,6-dichloroacetanilide and bromobenzene and requires long reaction times, e.g. 96 hours ~see D.C.
Atkins et al., J. Med. Chem. 26, 1361 (1983); CH-PS 473 770 published July 31, 1969; and us-Ps 3,536,758). Another process uses iodobenzene as starting material but no yields are published for this process (see JP-OS-57 167 947 published Oct. 19, 1982 and C.A. 98, 53 379 K (1983)).
In a more recent process (see J.S. Kaltenbronn, R.A. Scherer, Arzneim. Forsch. 33, 62 (1983)), the re~uired substance is again only obtained in poor yields. In the process acc~rding to DE-OS 15 43 639 published Feb. 5, 1970, the yield obtained, as indicated there, is only 43%
of the theoretical yield. According to the information given in the above mentioned documents, the intermediate product corresponding to formula V is obtained as a yellow oil. This substance, however, is a colourless solid (mp.
47.5 - 48C).
JP-OS-58 144 350 published Aug. 27, 1983 describes the Chapman rearrangement of N-phenyl-o-(2,6-dichlorophenyl)benzimidoester at 275C as an alternative for the preparation of compound V.
Direct processes for the preparation of diclofenac sodium have also been described, but they are not reproducible. In one known process of this type, 2-chlorophenyl acetic acid is reacted with 2,6-dichloroaniline (JP-OS-81 158 744 published Dec. 7, 1981, C.A. 97, 23 467 z (1980)). The desired product, however, is only obtained in a yield of 37% after 12 hours in DMF at 150C. Processes in which 2-bromophenyl acetic acid and 2,6-dichlorophenyl sodamide are used as starting materials also only provide low yields of the desired substance (22%
~, .
in HMPT; see JP-OS-77 oo 240 published Jan. 5, 1977, C.A.
87, 39 078 c (1977)). Other processes employ molar quantities of iodine compounds (see JP-OS 80-66 550 published ~ay 20, 1980, C.A. 93, 167 946 v (1980) and DE-OS
29 32 198 published Feb. 14, 1980).
A process by which the desired compound corresponding to formula I ls directly obtained from the compound corresponding to formula V is disclosed in CH-PS
473 770 published July 31, 1969 and DE-OS-15 43 639 published Feb. 5, 1970. This process is based on the known Stollé reaction (Ber. dtsch. Chem. Ges. 47, 2120 (1914) and is carried out in molten aluminum chloride.
It is an object of this invention to pro~ide a technically simple process for the preparation of the compound corresponding to formula I by which the desired substance may be obtained in high yields and with a very high degree of purity from readily available starting materials without the extreme reaction conditions of the known processes required for the preparation of the sterically difficult molecule of formula V.
This problem is solved by the present invention.
The invention relates to a process for the preparation of 2,6-dichlorodiphenylamine derivatives corresponding to the general formula I Cl~2-CO2~
(I) I~IU
Cl ~ Cl wherein R denotes a hydrogen atom, a Cl-C4-alkyl group or an alkali metal atom, characterized in that a 2,6-dichlorophenoxyacetic derivative corresponding to formula II Cl -0-CR_P~3-C02Rl (II) Cl .
wherein R1 denotes a hydrogen atom or a C1- to C6-alkyl group and R2 and R3 each denotes a hydrogen atom or a C1- to C4-alkyl group is reacted with aniline in a one-shot reaction, first to form the compound corresponding to formula III
~ 2 3 CO ~ ~III) wherein R2 and R3 have the meanings indicated above, which is then rearranged in situ to form the compound corresponding to formula IV
Cl N ~ ~IV) Cl C=O
wherein R2 and R3 have the meanings indicated above,.
and the resulting compound corresponding to formula IV
is then aminolysed to form the compound corresponding to formula V
~NH~) ~V) 1 5 Cl and after isolation of the compound corresponding to formula V, the latter ls converted into the compound corresponding to formula VI
4 ~.
~-C-C1~2-Cl (VI) Cl 1 Cl ~ .' by reaction with chloroacetyl chloride, and the compound of formula VI is cyclised to form the compound correspond-ing to formula VII
S ~ (VII) Cl~Cl and the resulting compound corresponding to formula VII
is converted into the compound corresponding to formula I by alkaline hydrolysis.
In the first stage of the process according to the invention, a 2,6-dich~orophenoxyester corresponding to formula II
~ -o-CR_P3-cO~Pl (II) wherein R1 denotes a hydrogen atom or a C1- to C6-alkyl group and R2 and R3 denote hydrogen or a C1- to C4-alkyl group is reacted with aniline in the presence of cata-lytic quantities of an alkali metal alcoholate such as ~ ~3~
sodium methanolate in an alcohol such as methanol, ethanol, n-propanol, i-propanol, n-butanol or i-butanol at tempera-tures below 120C, for example at 90C, preferably at 1 OOC.
Accordinq to a preferred embodiment of the invention, the starting compound corresponding to formula II is prepared from 3,5-dichlorohydroxybenzoic acid corresponding to formula VIII
llO~ COO ~1 ( VI I I ) by first subjectlng the compound corresponding to formula VIII in a one-shot reaction to a decarboxylation reaction in dimethylformamide or dimethylacetamide in the presence of catalytic quantities (e.g. 1/10 mol-~) of collidine at temperatures below 160C, for example at 156C, followed immediately by a reaction with a chloroacetic acid deriva-tive corresponding to formula IX
Cl-C-COORl (IX) Potassium carbonate may advantageously be used as base without the ester being saponified.
The intermediate compound corresponding to formula III
may also be prepared directly from 2,6-dichlorophenol and chloroacetanilide by a base catalysed reaction but this procedure is not suitable for the preparation of large quantities of compound III on account of the toxic side effect of chloroacetanilide.
~ J~
In the second stage of the process according to the invention, the intermediate compound of formula III obtained according to the invention is not isolated but directly rearranged in situ to the compound corresponding to formula IV
Cl ~1 ~ (IV) Cl c=o at reaction temperatures of from 90C to 100C, for example at 95C to 100C. The rearrangement is brought about -by the alkali metalalcoholate present in the reaction medium. As mentioned above, the reaction medium consists of an alcohol such as methanol, ethanol, n-propanol, i-propanol, n-butanol or i-butanol.
In the third stage of the process according to the invention, the compound of formula IV obtained by the molecular rearrangement is aminolysed to the compound corresponding to formula V
V~
again without isolation, the aminolysis being brought about by the alkali metal alcoholate present in the reaction mixture. The reaction temperatures are the same as in the third stage of the process according to the invention.
The 2,6-dichlorophenylamine of formula V obtained is isolated by the usual methods and optionally purified.
The aforesaid compound is obtained in the form of a solid.
In the fourth stage of the process according to the invention, the compound corresponding to formula V
'? . r! ~ ~` ` fi i! `J ~,J 'I ~J
is converted into the derivative corresponding to formula VI
1l N-C-CI~2 -cl ¦ (VIl cl by a reaction with chloroacetyl chloride. In the process according to the invention, chloroacetylation is preferably carried out as an aminolysis in an inert solvent, preferably xylene or chlorobenzene, at temperatures of from 90C
to 120C, preferably from 110C to 120C. According to a preferred embodiment of the invention, this stage is carried out in the presence of catalytic quantities, e.g. from 1/20th mol-% to 1/10th mol-~,of 4-dimethylamino-pyridine. The desired compound corresponding to formu~a VI
is obtained in almost quantitative yields.
In the fifth stage of the process according to the invention, an intramolecular cyclisation of the compound of formula VI to the indollnone corresponding to formula VII
N (VII) Cl I Cl \~/ ,. , takes place. This stage of the process according to the invention is carried out in an inert solvent, preferably o-dichlorobenzene, and at elevated temperatures, prefer-ably at 140C to 160C. Yields of over 90% are obtained.
In the last stage of the process according to the invention, the compound corresponding to formula VII is converted into the sodium salt of the desired compound of formula I by alkaline hydrolysis, preferably with g sodium hydroxide solution in an alcohol as described above, in particular n-butanol. The reaction temperature at this stage is from 90C to 110C, preferably from 100C to 110C.
The resulting compound corresponding to formula I
may be isolated from~ the reaction mixture by conventional methods, e.g. by extraction, and purified by conventional methods, e.g. by crystallisation.
It is to be regarded as an essential feature of the present invention that the first, second and third stage of the process are carried out as one-shot processes without isolation of the intermediate compounds III and IV.
This not only simplifies the process but also provides relatively high overall yields, e.g. from 80~ to 90%
of the theoretical yield.
~ . , ~ 3; !~1 The invention will now be illustrated with the aid of the following Examples:
Example 1 Preparation of 2,6-dichlorophenoxyacetic acid ethYl ester 675 g of 3,5-dichloro-4-hydroxybenzoic acid are introduced into 0.5 l of DMF at about 90C. 75 ml of collidine are added and the reaction mixture is heated to 120C to bring about decarboxylation.
The sump temperature is slowly raised to 155C and this temperature is maintained until no more CO2 evolves.
240 g of potash, 0.6 l of ethyl acetate and 0.35 l of ethylchloroacetate are added to the sump at 50C.
The reaction is left to proceed with liberation of CO2 at 70C and the reaction mixture is then boiled under reflux for 2 hours. After the addition of 1.7 l of water, phase separation is carried out at 20C and the organic phase is fractionated.
Bp. 0.1 = 100 to 130C
Yield: 617 g = 83% of th.
ExamPle 2 Preparation of 2,6-dichlorodiphenYlamine A mixture of 99~ g of 2,6-dichlorophenoxyacetic acid ethyl ester, 500 ml of aniline and 400 ml of n-butanol is preheated to 100C in a distillation apparatus.
400 ml of 5.5 N sodium methylate are run in over a period of 30 minutes during which a flow of distillate is maintained by the exothermic heat of the reaction.
After addition of the sodium methylate, stirring is con-tinued for 15 minutes at 100C with continued removal of distillate.
1 l of water is then added and solvent is distilled off down to the sump temperature of 90C. Phase separation takes place at 60C. The solvent is drawn off in a vacuum and the product is crystallised from 1 l of 90~ i-propanol.
The product is separated by suction filtration at 0C
and washed with dilute i-propanol.
Yield: 727 g = 76.5%oE the theoretical yield with exploita-tion of the mother liquor to an extent of 82%
of the theoretical.
DSCmaX = 54C at a heating rate of 2 degrees Centigrade per min.
Example 3 Preparation of N-(2,6-dichlorophenyl)indolinone(2) 476 g of 2,6-Dichlorodiphenylamine are introduced into 900 ml of o-dichlorobenzene and 271 g of chloroacetyl chloride are added at 150C in the course of 1.5 hours.
Stirring of the mixture is continued for a further 2 hours at 150C until no more gases evolve.
533 g of aluminium chloride are added at 60C and thè mixture is slowly heated to 160C. Hydrogen chloride begins to evolve at 100C. After one hour at 110C, the reaction mixture is cooled to 60C and hydrolysed with 1.5 1 of ice water at a maximum temperature of 80C.
After phase separation, the reaction product is again washed with water and the solvent is drawn off under vacuum. The product is crystallised from 1 l of i-propanol.
Yield: 512 g = 92% of theoretical yield.
DSCmaX = 121C at a heating rate of 2 degrees Centigrade per min.
Example 4 Preparation of diclofenac sodium 1 Part of the indolinone from Example 3 is boiled in 2 parts of n-butanol and the equivalent quantity of sodium hydroxide solution with azeotropic removal of water, 0.2 parts of toluene being added.
When no more water separates and the salt has precipi-tated, 2 parts of i-propanol are added and the product is suction filtered at 10C.
This product is recrystallised from water and dried at 100C.
Yield: 88.6% of theoretical yield DSCmax = 106C (of the hydrate) DSCmin = 268 to 270C at a heating rate of 2 degrees Centigrade per min.
~-C-C1~2-Cl (VI) Cl 1 Cl ~ .' by reaction with chloroacetyl chloride, and the compound of formula VI is cyclised to form the compound correspond-ing to formula VII
S ~ (VII) Cl~Cl and the resulting compound corresponding to formula VII
is converted into the compound corresponding to formula I by alkaline hydrolysis.
In the first stage of the process according to the invention, a 2,6-dich~orophenoxyester corresponding to formula II
~ -o-CR_P3-cO~Pl (II) wherein R1 denotes a hydrogen atom or a C1- to C6-alkyl group and R2 and R3 denote hydrogen or a C1- to C4-alkyl group is reacted with aniline in the presence of cata-lytic quantities of an alkali metal alcoholate such as ~ ~3~
sodium methanolate in an alcohol such as methanol, ethanol, n-propanol, i-propanol, n-butanol or i-butanol at tempera-tures below 120C, for example at 90C, preferably at 1 OOC.
Accordinq to a preferred embodiment of the invention, the starting compound corresponding to formula II is prepared from 3,5-dichlorohydroxybenzoic acid corresponding to formula VIII
llO~ COO ~1 ( VI I I ) by first subjectlng the compound corresponding to formula VIII in a one-shot reaction to a decarboxylation reaction in dimethylformamide or dimethylacetamide in the presence of catalytic quantities (e.g. 1/10 mol-~) of collidine at temperatures below 160C, for example at 156C, followed immediately by a reaction with a chloroacetic acid deriva-tive corresponding to formula IX
Cl-C-COORl (IX) Potassium carbonate may advantageously be used as base without the ester being saponified.
The intermediate compound corresponding to formula III
may also be prepared directly from 2,6-dichlorophenol and chloroacetanilide by a base catalysed reaction but this procedure is not suitable for the preparation of large quantities of compound III on account of the toxic side effect of chloroacetanilide.
~ J~
In the second stage of the process according to the invention, the intermediate compound of formula III obtained according to the invention is not isolated but directly rearranged in situ to the compound corresponding to formula IV
Cl ~1 ~ (IV) Cl c=o at reaction temperatures of from 90C to 100C, for example at 95C to 100C. The rearrangement is brought about -by the alkali metalalcoholate present in the reaction medium. As mentioned above, the reaction medium consists of an alcohol such as methanol, ethanol, n-propanol, i-propanol, n-butanol or i-butanol.
In the third stage of the process according to the invention, the compound of formula IV obtained by the molecular rearrangement is aminolysed to the compound corresponding to formula V
V~
again without isolation, the aminolysis being brought about by the alkali metal alcoholate present in the reaction mixture. The reaction temperatures are the same as in the third stage of the process according to the invention.
The 2,6-dichlorophenylamine of formula V obtained is isolated by the usual methods and optionally purified.
The aforesaid compound is obtained in the form of a solid.
In the fourth stage of the process according to the invention, the compound corresponding to formula V
'? . r! ~ ~` ` fi i! `J ~,J 'I ~J
is converted into the derivative corresponding to formula VI
1l N-C-CI~2 -cl ¦ (VIl cl by a reaction with chloroacetyl chloride. In the process according to the invention, chloroacetylation is preferably carried out as an aminolysis in an inert solvent, preferably xylene or chlorobenzene, at temperatures of from 90C
to 120C, preferably from 110C to 120C. According to a preferred embodiment of the invention, this stage is carried out in the presence of catalytic quantities, e.g. from 1/20th mol-% to 1/10th mol-~,of 4-dimethylamino-pyridine. The desired compound corresponding to formu~a VI
is obtained in almost quantitative yields.
In the fifth stage of the process according to the invention, an intramolecular cyclisation of the compound of formula VI to the indollnone corresponding to formula VII
N (VII) Cl I Cl \~/ ,. , takes place. This stage of the process according to the invention is carried out in an inert solvent, preferably o-dichlorobenzene, and at elevated temperatures, prefer-ably at 140C to 160C. Yields of over 90% are obtained.
In the last stage of the process according to the invention, the compound corresponding to formula VII is converted into the sodium salt of the desired compound of formula I by alkaline hydrolysis, preferably with g sodium hydroxide solution in an alcohol as described above, in particular n-butanol. The reaction temperature at this stage is from 90C to 110C, preferably from 100C to 110C.
The resulting compound corresponding to formula I
may be isolated from~ the reaction mixture by conventional methods, e.g. by extraction, and purified by conventional methods, e.g. by crystallisation.
It is to be regarded as an essential feature of the present invention that the first, second and third stage of the process are carried out as one-shot processes without isolation of the intermediate compounds III and IV.
This not only simplifies the process but also provides relatively high overall yields, e.g. from 80~ to 90%
of the theoretical yield.
~ . , ~ 3; !~1 The invention will now be illustrated with the aid of the following Examples:
Example 1 Preparation of 2,6-dichlorophenoxyacetic acid ethYl ester 675 g of 3,5-dichloro-4-hydroxybenzoic acid are introduced into 0.5 l of DMF at about 90C. 75 ml of collidine are added and the reaction mixture is heated to 120C to bring about decarboxylation.
The sump temperature is slowly raised to 155C and this temperature is maintained until no more CO2 evolves.
240 g of potash, 0.6 l of ethyl acetate and 0.35 l of ethylchloroacetate are added to the sump at 50C.
The reaction is left to proceed with liberation of CO2 at 70C and the reaction mixture is then boiled under reflux for 2 hours. After the addition of 1.7 l of water, phase separation is carried out at 20C and the organic phase is fractionated.
Bp. 0.1 = 100 to 130C
Yield: 617 g = 83% of th.
ExamPle 2 Preparation of 2,6-dichlorodiphenYlamine A mixture of 99~ g of 2,6-dichlorophenoxyacetic acid ethyl ester, 500 ml of aniline and 400 ml of n-butanol is preheated to 100C in a distillation apparatus.
400 ml of 5.5 N sodium methylate are run in over a period of 30 minutes during which a flow of distillate is maintained by the exothermic heat of the reaction.
After addition of the sodium methylate, stirring is con-tinued for 15 minutes at 100C with continued removal of distillate.
1 l of water is then added and solvent is distilled off down to the sump temperature of 90C. Phase separation takes place at 60C. The solvent is drawn off in a vacuum and the product is crystallised from 1 l of 90~ i-propanol.
The product is separated by suction filtration at 0C
and washed with dilute i-propanol.
Yield: 727 g = 76.5%oE the theoretical yield with exploita-tion of the mother liquor to an extent of 82%
of the theoretical.
DSCmaX = 54C at a heating rate of 2 degrees Centigrade per min.
Example 3 Preparation of N-(2,6-dichlorophenyl)indolinone(2) 476 g of 2,6-Dichlorodiphenylamine are introduced into 900 ml of o-dichlorobenzene and 271 g of chloroacetyl chloride are added at 150C in the course of 1.5 hours.
Stirring of the mixture is continued for a further 2 hours at 150C until no more gases evolve.
533 g of aluminium chloride are added at 60C and thè mixture is slowly heated to 160C. Hydrogen chloride begins to evolve at 100C. After one hour at 110C, the reaction mixture is cooled to 60C and hydrolysed with 1.5 1 of ice water at a maximum temperature of 80C.
After phase separation, the reaction product is again washed with water and the solvent is drawn off under vacuum. The product is crystallised from 1 l of i-propanol.
Yield: 512 g = 92% of theoretical yield.
DSCmaX = 121C at a heating rate of 2 degrees Centigrade per min.
Example 4 Preparation of diclofenac sodium 1 Part of the indolinone from Example 3 is boiled in 2 parts of n-butanol and the equivalent quantity of sodium hydroxide solution with azeotropic removal of water, 0.2 parts of toluene being added.
When no more water separates and the salt has precipi-tated, 2 parts of i-propanol are added and the product is suction filtered at 10C.
This product is recrystallised from water and dried at 100C.
Yield: 88.6% of theoretical yield DSCmax = 106C (of the hydrate) DSCmin = 268 to 270C at a heating rate of 2 degrees Centigrade per min.
Claims (4)
1. Process for the preparation of 2,6-dichlorodiphenylamine derivatives corresponding to the general formula I
(I) wherein R denotes a hydrogen atom, a C1- to C4-alkyl group or an alkali metal atom, characterised in that a 2,6-dichlorophenoxyacetlc acid derivative corresponding to formula:II
(II) wherein R1 denotes a hydrogen atom or a C1 to C6-alkyl group and R2 and R3 each denote a hydrogen atom or a C1- to C4-alkyl group is reacted with aniline in a one-shot process, first to form the compound corresponding to formula III
(III) wehrein R2 and R3 have the meanings indicated above, and then to rearrange the compound of formula III in situ to form the compound corresponding to formula IV
(IV) wherein R2 and R3 have the meanings indicated above, and the resulting compound corresponding to formula IV
is aminolysed to the compound corresponding to formula V
(V) and this compound corresponding to formula V is isolated and then converted into the compound corresponding to formula VI
(VI) by a reaction with chloroacetyl chloride, and the compound corresponding to formula VI is cyclised to the compound corresponding to formula VII
(VII) and the resulting compound of formula VII is converted into the compound corresponding to formula I by alkaline hydrolysis.
(I) wherein R denotes a hydrogen atom, a C1- to C4-alkyl group or an alkali metal atom, characterised in that a 2,6-dichlorophenoxyacetlc acid derivative corresponding to formula:II
(II) wherein R1 denotes a hydrogen atom or a C1 to C6-alkyl group and R2 and R3 each denote a hydrogen atom or a C1- to C4-alkyl group is reacted with aniline in a one-shot process, first to form the compound corresponding to formula III
(III) wehrein R2 and R3 have the meanings indicated above, and then to rearrange the compound of formula III in situ to form the compound corresponding to formula IV
(IV) wherein R2 and R3 have the meanings indicated above, and the resulting compound corresponding to formula IV
is aminolysed to the compound corresponding to formula V
(V) and this compound corresponding to formula V is isolated and then converted into the compound corresponding to formula VI
(VI) by a reaction with chloroacetyl chloride, and the compound corresponding to formula VI is cyclised to the compound corresponding to formula VII
(VII) and the resulting compound of formula VII is converted into the compound corresponding to formula I by alkaline hydrolysis.
2. Process according to claim 1, characterised in that the compound corresponding to formula II is prepared by a one-shot reaction from 3,5-dichloro-4-hydroxybenzoic acid corresponding to formula VIII
(VIII) by decarboxylation in dimethylformamide or dimethylacetamide in the presence of catalytic quantities of collidine and reaction with a chloroacetic acid derivative corres-ponding to formula IX
(IX) wherein R1, R2 and R3 have the meanings defined in claim 1.
(VIII) by decarboxylation in dimethylformamide or dimethylacetamide in the presence of catalytic quantities of collidine and reaction with a chloroacetic acid derivative corres-ponding to formula IX
(IX) wherein R1, R2 and R3 have the meanings defined in claim 1.
3. Process according to claim 1, characterised in that the preparation of the compound corresponding to formula V
is carried out in an alcohol at temperatures below 120°C
in the presence of catalytic to equimolar quantities of an alkali metal alcoholate.
is carried out in an alcohol at temperatures below 120°C
in the presence of catalytic to equimolar quantities of an alkali metal alcoholate.
4. Process according to claim 1, characterised in that the reaction of the compound corresponding to formula V with chloroacetyl chloride is carried out as an aminolysis and the resulting compound corresponding to formula VI is cyclised to the compound corresponding to formula VII in o-dichlorobenzene and this compound of formula VII is converted into the compound correspond-ing to formula I by means of an alkali liquor in a protic solvent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89101437A EP0380712B1 (en) | 1989-01-27 | 1989-01-27 | Process for the preparation of 2,6-dichlorodiphenylaminoacetic-acid derivatives |
| EP89101437.5 | 1989-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1310017C true CA1310017C (en) | 1992-11-10 |
Family
ID=8200913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000603909A Expired - Lifetime CA1310017C (en) | 1989-01-27 | 1989-06-26 | Process for the preparation of 2, 6-dichlorodiphenylamino-acetic acid derivatives |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4978773A (en) |
| EP (1) | EP0380712B1 (en) |
| JP (1) | JP2682705B2 (en) |
| KR (1) | KR960008664B1 (en) |
| AT (1) | ATE116636T1 (en) |
| AU (1) | AU611813B2 (en) |
| CA (1) | CA1310017C (en) |
| DE (1) | DE58908857D1 (en) |
| DK (1) | DK175838B1 (en) |
| ES (1) | ES2065928T3 (en) |
| HU (1) | HU202826B (en) |
| IE (1) | IE65880B1 (en) |
| IL (1) | IL90674A0 (en) |
| NZ (1) | NZ229636A (en) |
| PT (1) | PT91093B (en) |
| ZA (1) | ZA894667B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2072462T3 (en) * | 1991-02-07 | 1995-07-16 | Heumann Pharma Gmbh & Co | NEW SALTS OF PHENYLACETIC ACID 2- (2,6-DICHLOROANILINE), PROCEDURE FOR ITS PREPARATION AND USE OF THEM IN TOPICAL PHARMACEUTICAL PREPARATIONS. |
| ES2046141B1 (en) * | 1992-07-15 | 1994-06-16 | Prodesfarma Sa | "PROCEDURE FOR OBTAINING ACID 2 - ((2,6-DICHLOROPHENYL) AMINO) PHENYLACETOXIACETIC" |
| US5475139A (en) * | 1993-10-22 | 1995-12-12 | Yung Shin Pharm. Ind. Co., Ltd. | Method for the preparation of substituted derivatives of diphenyl amine |
| GB9922830D0 (en) | 1999-09-27 | 1999-11-24 | Novartis Ag | Processes |
| CN103113236A (en) * | 2013-03-15 | 2013-05-22 | 河南东泰制药有限公司 | Preparation method of 2,6-dichlorodiphenylamine |
| CN106957237B (en) * | 2017-03-24 | 2019-04-09 | 苏州汇和药业有限公司 | A method of synthesis bromfenac sodium |
| CN108947861A (en) * | 2018-08-17 | 2018-12-07 | 复旦大学 | The synthetic method of C14H10Cl2NNaO2 |
| CN111116391A (en) * | 2019-12-17 | 2020-05-08 | 浙江工业大学 | A kind of preparation method of sodium 2-[(2,6-dichlorophenyl)amino]phenylacetate |
| CN114539086B (en) | 2022-02-25 | 2023-10-03 | 复旦大学 | A kind of synthesis method of diclofenac sodium |
| CN114516813B (en) | 2022-02-25 | 2024-05-28 | 复旦大学 | A continuous flow preparation method of diclofenac sodium |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| NL137301C (en) * | 1966-03-30 | |||
| JPS51113842A (en) * | 1975-03-31 | 1976-10-07 | Ikeda Mohandou:Kk | Process for preparing o-(2,6-dichloroanilino)phenyl acetic acid |
| IT1097265B (en) * | 1978-06-23 | 1985-08-31 | Acraf | NOUVA SYNTHESIS OF A PHENYLACETIC ACID |
| JPS5545615A (en) * | 1978-09-27 | 1980-03-31 | Nissan Chem Ind Ltd | Derivative of (n-allyl-o-(2,6-dichloroanilino) phenyl) acetic acid |
| JPS5770848A (en) * | 1980-10-20 | 1982-05-01 | Zenyaku Kogyo Kk | Preparation of o-substituted phenylacetic acid |
| JPS5920256A (en) * | 1982-07-27 | 1984-02-01 | Hokuriku Seiyaku Co Ltd | 2-(2,6-difluoroanilino)phenylacetic acid derivative |
-
1989
- 1989-01-27 EP EP89101437A patent/EP0380712B1/en not_active Expired - Lifetime
- 1989-01-27 ES ES89101437T patent/ES2065928T3/en not_active Expired - Lifetime
- 1989-01-27 AT AT89101437T patent/ATE116636T1/en not_active IP Right Cessation
- 1989-01-27 DE DE58908857T patent/DE58908857D1/en not_active Expired - Lifetime
- 1989-06-16 DK DK198903004A patent/DK175838B1/en not_active IP Right Cessation
- 1989-06-20 NZ NZ229636A patent/NZ229636A/en unknown
- 1989-06-20 IE IE199689A patent/IE65880B1/en not_active IP Right Cessation
- 1989-06-20 IL IL90674A patent/IL90674A0/en unknown
- 1989-06-20 HU HU893149A patent/HU202826B/en unknown
- 1989-06-20 ZA ZA894667A patent/ZA894667B/en unknown
- 1989-06-21 US US07/369,618 patent/US4978773A/en not_active Expired - Lifetime
- 1989-06-23 AU AU36749/89A patent/AU611813B2/en not_active Expired
- 1989-06-26 CA CA000603909A patent/CA1310017C/en not_active Expired - Lifetime
- 1989-07-01 KR KR1019890009376A patent/KR960008664B1/en not_active Expired - Lifetime
- 1989-07-07 PT PT91093A patent/PT91093B/en not_active IP Right Cessation
- 1989-08-07 JP JP1205559A patent/JP2682705B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4978773A (en) | 1990-12-18 |
| DK300489D0 (en) | 1989-06-16 |
| IE891996L (en) | 1990-07-27 |
| DK175838B1 (en) | 2005-03-21 |
| DE58908857D1 (en) | 1995-02-16 |
| KR900011710A (en) | 1990-08-02 |
| HU202826B (en) | 1991-04-29 |
| PT91093A (en) | 1990-07-31 |
| PT91093B (en) | 1995-03-31 |
| AU611813B2 (en) | 1991-06-20 |
| AU3674989A (en) | 1990-08-02 |
| ES2065928T3 (en) | 1995-03-01 |
| KR960008664B1 (en) | 1996-06-28 |
| JP2682705B2 (en) | 1997-11-26 |
| ATE116636T1 (en) | 1995-01-15 |
| ZA894667B (en) | 1990-02-28 |
| IE65880B1 (en) | 1995-11-29 |
| EP0380712B1 (en) | 1995-01-04 |
| JPH02215750A (en) | 1990-08-28 |
| IL90674A0 (en) | 1990-01-18 |
| DK300489A (en) | 1990-07-28 |
| HUT53064A (en) | 1990-09-28 |
| NZ229636A (en) | 1991-03-26 |
| EP0380712A1 (en) | 1990-08-08 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20091110 |