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CA1225943A - Cuvette array - Google Patents

Cuvette array

Info

Publication number
CA1225943A
CA1225943A CA 474397 CA474397A CA1225943A CA 1225943 A CA1225943 A CA 1225943A CA 474397 CA474397 CA 474397 CA 474397 A CA474397 A CA 474397A CA 1225943 A CA1225943 A CA 1225943A
Authority
CA
Grant status
Grant
Patent type
Prior art keywords
cuvette
wall
side
chamber
arrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA 474397
Other languages
French (fr)
Inventor
Claude Borer
Andreas Greter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann-La Roche AG
Original Assignee
F Hoffmann-La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date
Family has litigation

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0325Cells for testing reactions, e.g. containing reagents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0357Sets of cuvettes

Abstract

Abstract A cuvette arrangement for use in a chemical analysis system, which cuvette arrangement comprises an integrally constructed unit which defines separate chambers, for the receipt of sample-reagent mixtures.

In order to overcome difficulties which arise in the use of the cuvette arrangement, and to reduce the manu-facturing costs thereof, it is formed as a cuvette ring segment which possesses means for positioning the latter in the analysis system, each chamber possessing the following elements: an open and a closed end, an outer side wall forming an outer edge which fits into a first arc, an inner side wall forming an inner edge which fits into a second arc concentric with the first arc, a bottom wall extending between the outer and inner side walls at the closed end of the chamber, and windows which enable radiation energy to be transmitted through the chamber with low loss and free from distortion, which windows comprise a pair of flat, mutually parallel parts which are separated from one another by a defined distance, one of the flat parts in each pair being integrated with the outer side wall and the other of the flat parts in each pair being integrated with the outer side wall and the other of the flat parts in each pair being integrated with the inner side wall.

Description

~2ZS943 R~N 4090/155 The invention relates a cuvette arrangement for use in a chemical analysis system, which cuvette arrangement com-prises an integrally constructed unit which de~ines the separate chambers, for the receipt of sample-reagent mixtures.
Cuvette arrangements of this type are known in the form of disposable cuvette rings which comprise 100 cuvettes for example. Cuvette rings of this type have the following dis-advantages:
The user is frequently unable to use all the cuvettes of the cuvette ring within one working cycle. Nevertheless, the whole cuvette ring must often be thrown away, because it contains liquids or liquid residues, which must be removed from the analysis system as rapidly as possible or, `- at the latest~, at~the end of the working~day. This Ieduces the rate of utilizat~ion of the cuvette rings.

Cuvett.e~rings, in particular those which aontain a relative}y large number of cuvettes and have therefore a relatively large diameter, tend to suffer distortion. The resulting deformations of the cuvette ring in~air the per-formance of optical measurements of the cuvette contents in an analysis system, because very exact positioning of all the cuvettes of the cuvette ring is necessary for such measurements. In order to minimise the extent of such deformations, a relatively complex shaping of the cuvette rings and special packaging of the latter are necessary.
This increases the manufacturing costs for the cuvette rings and theiI selling price. Moreover, when the cuvette rings are used in an analysis system, means must be pro-V~/17.12.84 ~22~;943

- 2 vided in the latter which enable all the cuvettes to be positioned accurately, even if the cuvette rings are slightly distocted. This increases the manufacturing c06ts of the analy6is system.

It i6 the~efore the object of the invention to provide a cuvette arrangemen~ which does not suffer from the above--mentioned disadvantages.

According to the invention, this object i8 achieved with a cuvette arrangement of the type described herein-afte~, said arrangement forming a cuvette ring segment and possessing means for positioning the latter in the analysis system, and each chamber possessing the following elements:
an open end and a closed end: an outer side wall fo~ming an outer edge which fits into a first arc; an inne~ side wall forming an inner edge which fits into a second arc concen-tric with the first arc; a bottom wall extending between the outer and inner 6ide walI at the closed end of the chamber: and windows which enable radiation energy to be transmitted through the chambe~ with low loss and free from disto~tion, which windows comp~ise a pair of flat, mutally parallel pa~ts which are separated from one another by a defined distance, one of the flat parts in each pair being integ~ated with the oute~ side wall and the other of the flat pa~ts in each pair being integrated with the inner side wall.

The cuvette arrangement according to the invention has 30 made it possible to overcome al} the above-mentioned dis-advantages of the previously known cuvette rings and, furthermore, to obtain a reduction in the manufacturing c06t6 of the cuvette arrangement.
The present invention relates to a cuvette arrange-ment for use in a chemical analysis system, which cuvette arrangement includes an integrally formed, partially annular unit which defines a plurality of chambers for the receipt ~3 ~ .

~22S943 2(a) of sample-reagent mixtures, said arrangement comprising means for positioning it in the analysis system. Each chamber of this novel cuvette arrangement is comprised of an open end and a closed end, and outer side wall forming an outer edge which fits into a first arc, an inner side wall forming an inner edge which fits into a second arc concentric with the first arc, a bottom wall extending between the outer and inner side walls at the closed end of the chamber, and windows which enable radiation energy to be transmitted through the chamber with low loss and free from distortion. The windows are comprised of a pair of flat, mutually parallel parts which are separated from one another by a defined distance, one of the flat parts in each pair being integrated with the outer side wall and the other of the flat parts in each pair being integrated with the inner side wall.
The positioning means is comprised of a lip which is integrated with the inner side walls and extends radially from the latter on the outer side of the chambers, and at least one projection which extends from the outer side of the bottom wall and along the longitudinal axis of a chamber.
The invention further relates to a cuvette arrange-ment for use in a chemical analysis system which contains a plurality of partitions integrated with the outer side wall the inner side walls and the bottom walls of the chambers, each partition having an upper section which is substantially parallel to the longitudinal axis of each chamber and one end of which is adjacent to the open end of the cuvette arrangement, a first lower SectiQn integrated with the bottom wall of a first chamber, and a second lower section integrated with the bottom wall of a second chamber, the first and second lower sections being separated by an air space.
A preferred embodiment of the cuvette arrangement according to the invention has a lip which is integrated "` 12259~3 _ 3 -with the inner side walls, extends radially from the latter on the outside of the chambers and can be used as means for positioning the cuvette arrangement in the analysis system.
This embodiment has the advantage that it enables the cuvette arrangement to be positioned fairly accurately at very low cost.

In a earticula~ly advantageous embodiment of the cuvette arrangement according to the invention. the bottom L0 wall of at least one of the chambers has a projection which extends from the outside of the bottom wall along the longitudinal axis of the chamber and can be used as means for positioning the cuvette arrangement in the analysis system. In this case, the advantage is that an even more ~S accurate positioning of the cuvette aLrangement is possible at virtually negligible extra cost.
' The cuvette arrangement according to the invention preferably~contains a plurality of partitions integrated with~the outer side walls, the inner side walls and the bottom walls of the chambers, each partition having an upper seation, of which at least a part is located at the open end of a chamber, a first lower section integrated with;the bottom wall of a first chamber, and a second lower section integrated with the bottom wall of a second chamber, the first and second Iower sections being sepa-rated by an air space. With this structure, on the one hand, a relatively large number of chambers can be accom-modated in one~cuvette ring segment and, on the other hand, the temperature of the chamber contents~can be controlled more easily and quickly.

~ n illustrative embodiment of the invention is explained in more detail below by reference to the a~tached 35 drawings in which:

-` ~X2~i9~3 " ~
-- 4 ~

Figure L shows a pers~ective view of a cuvette arrangement according to the invention, Figure 2 shows a plan view of the cuvette arrangement in Figure 1, Figure 3 shows a cross-section along the line ~-A in Figure 2, and L0 Figure 4 shows a cross-section along the line B-B in Figure 3.

The cuvette arrangement according to the invention, shown in Figures 1 and 2, forms a cuvette ring segment 11.
~5 The latter is produced integrally, for example from glass--clear unstablized po:lymethyl methacrylate (PMMA). The cuvette:ring segment 11 comprises 12 chambers, 12-1 to 12-lZ, in which 12 mutually separate samples can be mixed with sultable reagents and the sample-reagent mixture can be retained~for~optical analysis. As can be seen from Figures l and~2, these chambers are aeranged along an aLc.
~s shown by Figures~1-4, each of these chambers possesses the following elements:: an open end and a closed end, an :
outer sidei~-wall 41 forming an outer edge which fits into a first arc,~an inner side wall 42 forming an inner edge 44 which fits~into a second arc concentric with the first arc a bottom wall 36 extending between the outer and inner sidé
walls at the closed end of the chamber, and windows which enable radiation energy to be transmitted through the chamber with low loss and free from distortion, which windows comprise a pair of flat, mutually parallel parts 45, 46 which are separated from one another by a defined distance, one of the flat parts in each pair being inter-grated with the outer side wall 41 and the other of the flat parts in each pair being integrated with the inner side wall 42.

All the chambers 12-1 to 12-12 have the same shape and the sama dimensions. In order to indicate an order of magnitude of the dimensions of one of these chambers, such a chamber is, for example, 38 mm high and the distance between the outer edge 43 and the inner edge 44 amounts to, for example, 6 to 8 mm.

A complete cuvette ring can be formed with 6 cuvette ring segments like that shown in Figure 1. Within the scope of the invention, however, the cuvette ring segment accord-ing to Figure 1 can comprise more or less that 12 chambers.
Depending on the selected number of chambers per segment, more or fewer such segments are then required to form a complete cuvette ring.
~5 As shown in detail in Figure 3, the cuvette arrangement according to Figure 1 contains a plurality of partitions which are integrated with the outer side walls, the inner side walls and the bottom walls of the chambers, each partition having an upper section 31 or 32, of which at least a part is located at the open ends of a chamber, a first lower section 33 integrated with the bo~tom wall 36 of a first chamber~, and a second lower section 34 inte-grat~ed with the bottom wall 37 of a second chamber, the 25 f irst and second lower sections being separated by an air space 35.

The cuvette ring segment 11 contains the following means which aLe apt to be used for positioning the cuvette ring segment in the analytical system:

- a lip 16 which is integrated with the inner side walls 42 and extends radially from the lattec on the outside of the chambers, - the bottom wall 36 of at least one of the chambers, for example the chamber 12-4, has a projection 14 which ..

~ZZ~i943 ~ 6 --extends from the outside of the bottom wall along the longitudinal axis of the chamber.

The shaping of ~he lip 16, shown in the attached figures, and a matching guide or locking means in the cuvette carrier (not shown in the attached figures) of the analysis system ensure that, when the cuvette arrangement ac~ording to the invention is inserted into the analysis system, the windows of all the chambers are located in the correct position, and in particular at the correct height, which is necessary for carlying out optical mea~urements with the optical measuring instruments provided in the analysis~system. During such a measurement, a light beam traverses, for example, the window parts 45, 46 of the ~5 chamber 12-4 along the axis Y-Y, as shown in Figure 4.

The projection 14 in the form of a truncated cone and a corresponding guide in the cuvette carrier of the analysis - system ensure that, when the cuvette ring segment 11 is used in the analysis system, the longitudinal axis Z-Z of each chamber is perpendicular to the light beam along the axis Y-Y. In this way, the projection 14 also provides for an even more accurate positloning of the cuvet~e ring segment in-the analysis system.
Since the cuvette ring segment in Figure 1 is rela-tively long, two projections 14, 15 are provided therein at the chambers 12-4 and 12-9 respectively. With shorter cuvette ring segments, however, a single projection, for 30 example the projection 14, suffices for accurate position-ing of the cuvette ring segment. The projections 14 and 15 are preferably hollow.

In addition, the cuvette ring segment 11 contains a lip 35 17 which is integrated with the outer side walls 41 and extends radially outwards. This lip facilitatqs handling of ~;~Z~i9~3 the cuvette ~ing segment by the user, in particular when the segment has ~o be taken out of the analysis system.

.

~5 : :

~ 20 . .

`~ :
` =

Claims (2)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. A cuvette arrangement for use in a chemical analysis system, which cuvette arrangement includes:
an integrally formed, partially annular unit which defines a plurality of chambers, for the receipt of sample-reagent mixtures, said arrangement comprising means for positioning it in the analysis system and each chamber thereof comprising the following elements:
an open end and a closed end;
an outer side wall forming an outer edge which fits into a first arc;
an inner side wall forming an inner edge which fits into a second arc concentric with the first arc;
a bottom wall extending between the outer and inner side walls at the closed end of the chamber; and windows which enable radiation energy to be transmitted through the chamber with low loss and free from distortion, which windows comprise a pair of flat, mutually parallel parts which are separated from one another by a defined distance, one of the flat parts in each pair being integrated with the outer side wall and the other of the flat parts in each pair being integrated with the inner side wall, characterized in that the positioning means comprise:
a lip which is integrated with the inner side walls, and extends radially from the latter on the outside of the chambers; and at least one projection which extends from the outside of the bottom wall and along the longitudinal axis of a chamber.
2. A cuvette arrangement according to claim 1, which contains a plurality of partitions integrated with the outer side walls, the inner side walls and the bottom walls of the chambers, each partition having an upper section which is substantially parallel to the longitudinal axis of each chamber and one end of which is adjacent to the open end of the cuvette arrangement, a first lower section integrated with the bottom wall of a first chamber, and a second lower sec-tion integrated with the bottom wall of a second chamber, the first and second lower sections being separated by an air space.
CA 474397 1984-02-23 1985-02-15 Cuvette array Expired CA1225943A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH89684 1984-02-23
CH896/84 1984-02-23

Publications (1)

Publication Number Publication Date
CA1225943A true CA1225943A (en) 1987-08-25

Family

ID=4197702

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 474397 Expired CA1225943A (en) 1984-02-23 1985-02-15 Cuvette array

Country Status (8)

Country Link
US (1) US4639135A (en)
EP (1) EP0152964B1 (en)
JP (1) JPH0443807Y2 (en)
CA (1) CA1225943A (en)
DE (2) DE3575021D1 (en)
DK (1) DK161218C (en)
ES (1) ES8605096A1 (en)
FI (1) FI81913C (en)

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DE3823572C1 (en) * 1988-07-12 1989-06-01 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De Multiple cuvette arrangement for an analysis system
WO1990001168A3 (en) * 1988-07-25 1990-05-03 Precision Systems Inc Automatic multiple-sample multiple-reagent chemical analyzer
US5597733A (en) * 1988-07-25 1997-01-28 Precision Systems, Inc. Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer
US5229074A (en) * 1988-07-25 1993-07-20 Precision Systems, Inc. Automatic multiple-sample multiple-reagent chemical analyzer
EP0449434A3 (en) * 1990-03-30 1992-03-04 Beckman Instruments, Inc. Multi-cell module for spectrophotometry
DE9016832U1 (en) * 1990-12-17 1991-03-07 Labor Laborgeraete + Analysensysteme Vertriebsgesellschaft Mbh, 2070 Ahrensburg, De
CA2067425C (en) * 1991-05-07 1996-09-24 Alfons Balmer Cuvette for optical measurements
FI925117A0 (en) * 1992-11-11 1992-11-11 Labsystems Oy Kyvettmatris
DE4429155A1 (en) * 1994-08-17 1996-02-22 Hans Schiesl Measuring arrangement and method for performing luminometric series analyzes and Multiple cuvette for receiving liquid samples for this
US5683659A (en) * 1995-02-22 1997-11-04 Hovatter; Kenneth R. Integral assembly of microcentrifuge strip tubes and strip caps
DE29607461U1 (en) * 1996-04-24 1996-07-11 Kloth Bernd A cell
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
EP0832712A1 (en) * 1996-09-27 1998-04-01 Unilever Plc Improvements in or relating to assembly of components
EP0832713A1 (en) * 1996-09-27 1998-04-01 Unilever N.V. Improvements in or relating to assembly of components
FR2804510B1 (en) * 2000-01-28 2003-02-07 Biomerieux Sa Cuvettes, biological analysis apparatus automates using such cuvettes, cuvette transfer means in such an apparatus and transfer METHOD
EP1409138B1 (en) 2001-07-20 2010-09-01 Gen-Probe Incorporated Patent Dept Sample carrier and drip shield for use therewith
DE60316938T2 (en) 2002-05-17 2008-07-17 Gen-Probe Inc., San Diego Sample holder with detachable locking device
JP4235171B2 (en) * 2002-05-17 2009-03-11 ジェン−プロウブ インコーポレイテッド Drip shield for use sample carrier and therewith comprises a sample tube blocking means
GB0303453D0 (en) * 2003-02-14 2003-03-19 Thermo Clinical Labsystems Oy Automated sample analyzer and cuvette
US20050079103A1 (en) * 2003-10-14 2005-04-14 Merrit Jacobs Moving evaporation control cover
US20050078307A1 (en) * 2003-10-14 2005-04-14 Davis Freeman Packaging of multiple fluid receptacles
US7307718B2 (en) * 2004-02-23 2007-12-11 Ortho-Clinical Diagnostics, Inc. Determining an analyte by multiple measurements through a cuvette
US20050185176A1 (en) * 2004-02-23 2005-08-25 Moran Donald J.Jr. Determining an analyte by multiple measurements through a cuvette
US8313713B2 (en) * 2004-06-17 2012-11-20 Ortho-Clinical Diagnostics, Inc. Stabilizing a cuvette during measurement
US7799283B2 (en) * 2004-11-12 2010-09-21 Ortho-Clinical Diagnostics, Inc. Heating and cooling multiple containers or multi-chamber containers
US20060154372A1 (en) 2004-12-21 2006-07-13 Arter Thomas C Providing additional motion in assays
US7910067B2 (en) 2005-04-19 2011-03-22 Gen-Probe Incorporated Sample tube holder
CN2862037Y (en) * 2005-12-12 2007-01-24 深圳迈瑞生物医疗电子股份有限公司 Disposable reaction cup chain for full-automatic biochemistry analyzer
US20070291250A1 (en) * 2006-06-20 2007-12-20 Lacourt Michael W Solid control and/or calibration element for use in a diagnostic analyzer
US7867768B2 (en) * 2007-02-08 2011-01-11 Ortho-Clinical Diagnostics, Inc. Two dimensional sample handler
FI120818B (en) * 2008-05-28 2010-03-31 Thermo Fisher Scientific Oy The reaction vessel and a method of treating
US9144801B2 (en) 2010-08-31 2015-09-29 Abbott Laboratories Sample tube racks having retention bars
US9108772B2 (en) 2013-03-15 2015-08-18 Scientific Specialties, Inc. Container latching systems for one-handed operation
USD810959S1 (en) * 2015-09-29 2018-02-20 Bd Kiestra B.V. Cuvette tray
USD808036S1 (en) * 2015-09-29 2018-01-16 Bd Kiestra B.V. Cuvette

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Also Published As

Publication number Publication date Type
US4639135A (en) 1987-01-27 grant
JPS60143352U (en) 1985-09-24 application
DE8560014U1 (en) 1985-05-30 grant
FI850467A0 (en) 1985-02-05 application
CA1225943A1 (en) grant
FI850467D0 (en) grant
DE3575021D1 (en) 1990-02-01 grant
ES540616D0 (en) grant
DK161218C (en) 1991-11-25 grant
DK161218B (en) 1991-06-10 grant
FI81913C (en) 1990-12-10 grant
EP0152964A2 (en) 1985-08-28 application
FI850467A (en) application
ES8605096A1 (en) 1986-03-16 application
FI81913B (en) 1990-08-31 application
EP0152964B1 (en) 1989-12-27 grant
EP0152964A3 (en) 1986-06-25 application
ES540616A0 (en) 1986-03-16 application
JPH0443807Y2 (en) 1992-10-15 grant
DK84285A (en) 1985-08-24 application
FI850467L (en) 1985-08-24 grant
DK84285D0 (en) 1985-02-22 grant

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