CA1091223A - Process for the manufacture of steroid carboxylic acids and the esters thereof - Google Patents

Process for the manufacture of steroid carboxylic acids and the esters thereof

Info

Publication number
CA1091223A
CA1091223A CA276,066A CA276066A CA1091223A CA 1091223 A CA1091223 A CA 1091223A CA 276066 A CA276066 A CA 276066A CA 1091223 A CA1091223 A CA 1091223A
Authority
CA
Canada
Prior art keywords
alpha
acid
process according
anyone
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA276,066A
Other languages
English (en)
French (fr)
Inventor
Julius Schmidlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of CA1091223A publication Critical patent/CA1091223A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA276,066A 1976-04-15 1977-04-13 Process for the manufacture of steroid carboxylic acids and the esters thereof Expired CA1091223A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH484876A CH614960A5 (US07655688-20100202-C00010.png) 1976-04-15 1976-04-15
CH4848/76 1976-04-15

Publications (1)

Publication Number Publication Date
CA1091223A true CA1091223A (en) 1980-12-09

Family

ID=4283605

Family Applications (1)

Application Number Title Priority Date Filing Date
CA276,066A Expired CA1091223A (en) 1976-04-15 1977-04-13 Process for the manufacture of steroid carboxylic acids and the esters thereof

Country Status (9)

Country Link
US (1) US4119625A (US07655688-20100202-C00010.png)
JP (1) JPS52128363A (US07655688-20100202-C00010.png)
CA (1) CA1091223A (US07655688-20100202-C00010.png)
CH (1) CH614960A5 (US07655688-20100202-C00010.png)
DE (1) DE2715863A1 (US07655688-20100202-C00010.png)
FR (1) FR2348226A1 (US07655688-20100202-C00010.png)
GB (1) GB1580402A (US07655688-20100202-C00010.png)
IL (1) IL51879A (US07655688-20100202-C00010.png)
NL (1) NL7704105A (US07655688-20100202-C00010.png)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
DE3024008C2 (de) * 1980-06-24 1982-04-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 17α-Hydroxy-etiocarbonsäuren
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
FR2841304B1 (fr) 2002-06-20 2007-01-05 Skf Ab Dispositif de tension pour mise en precontrainte d'une tige et procede de tension associe
FR2841990B1 (fr) 2002-07-02 2005-07-29 Skf Ab Dispositif de palier a roulement instrumente et moteur electrique ainsi equipe
US20090180721A1 (en) * 2005-02-15 2009-07-16 Stellario Barbera Encoding Bearing Device and Rotating Machine
FR2902699B1 (fr) * 2006-06-26 2010-10-22 Skf Ab Dispositif de butee de suspension et jambe de force.
FR2906587B1 (fr) * 2006-10-03 2009-07-10 Skf Ab Dispositif de galet tendeur.
FR2906858B1 (fr) * 2006-10-04 2008-12-05 Skf Ab Dispositif de poulie debrayable.
FR2910129B1 (fr) * 2006-12-15 2009-07-10 Skf Ab Dispositif de palier a roulement instrumente
FR2913081B1 (fr) * 2007-02-27 2009-05-15 Skf Ab Dispositif de poulie debrayable

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
DE2260303C2 (de) * 1972-12-06 1983-12-15 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von Pregnansäurederivaten
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates

Also Published As

Publication number Publication date
US4119625A (en) 1978-10-10
GB1580402A (en) 1980-12-03
FR2348226A1 (fr) 1977-11-10
JPS52128363A (en) 1977-10-27
CH614960A5 (US07655688-20100202-C00010.png) 1979-12-28
NL7704105A (nl) 1977-10-18
IL51879A (en) 1981-06-29
FR2348226B1 (US07655688-20100202-C00010.png) 1980-07-04
IL51879A0 (en) 1977-06-30
DE2715863A1 (de) 1977-11-03

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Legal Events

Date Code Title Description
MKEX Expiry