New! View global litigation for patent families

CA1086704A - Fluid flow valve - Google Patents

Fluid flow valve

Info

Publication number
CA1086704A
CA1086704A CA 326697 CA326697A CA1086704A CA 1086704 A CA1086704 A CA 1086704A CA 326697 CA326697 CA 326697 CA 326697 A CA326697 A CA 326697A CA 1086704 A CA1086704 A CA 1086704A
Authority
CA
Grant status
Grant
Patent type
Prior art keywords
tubing
member
spike
membrane
end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA 326697
Other languages
French (fr)
Inventor
Wendell R. Parker
Willis L. Warner
Mark H. Silverman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cutter Laboratories Inc
Original Assignee
Cutter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/221Frangible or pierceable closures within tubing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M39/14Tube connectors; Tube couplings for connecting tubes having sealed ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10Bag-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/1475Inlet or outlet ports
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00Surgery
    • Y10S604/905Aseptic connectors or couplings, e.g. frangible, piercable
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/1624Destructible or deformable element controlled
    • Y10T137/1632Destructible element
    • Y10T137/1692Rupture disc
    • Y10T137/1759Knife or cutter causes disc to break
    • Y10T137/1767Movable knife or cutter

Abstract

ABSTRACT OF THE DISCLOSURE
An improvement in a fluid flow valve is disclosed. The valve com-prises a combination of flexible tubing joined to a tubular member having a membrane closing off the passageway in the tubular member. A pointed spike having at least three radially projecting ribs extending longitudinally is located within the tubing adjacent the membrane and is moveable by external manipulation of the tubing whereby the spike ruptures the membrane and creates a passageway permitting fluid to flow freely through the tubular member and adjoining tubing.

Description

6~
This invention relates to a ~luid ~low valve, and in particular to one which is intended for use with flexible blood bags and the like, but which also can used as a means for initiating flow of fluid in any con-duit system closed by a membrane.
Blood bag ~ystems employing two or more flexible bags interconnec-ted by lengths of flexible tubing are currently in use for separating whole blood into plasma, red cells, platelets and the like in a sterile manner.
Frequently, it is necessary to prevent the contents of one bag from Elowing through inter-connecting tubing into another bag during manipulative steps such as when blood is drawn from a donor into a bag and then centrifuged to separate red cells from the plasma. Externally located valves or clamps may become dislodged or may damage the tubing.
Several internally located valve devices have been developed which are all characterized by having a transverse membrane in the tubing which can be ruptured by a hollow cannula situated within the tubing. The membrane assures there will be no fluid flow from one bag to another until such time the cannula is manipulated to rupture the membrane. For example, United States Patent 3,685,795, G. Caster, August 22, 1972, shows a pointed cannula fixed at one end to the tubing and encased in a sleeve which is secured to a section of tubing containing a membrane. Such a valve device is quite complex in structure and expensive to mamlfacture. A much simpler valve is disclosed in United States Patent 3,110,308, D. Bellamy, November 12, 1963.
It consists of a pointed hollow unattached cannula in the tubing membrane located adjacent the pointed end of the ~annula.
By compressing the tubing adjacent the cannula, the cannula can be moved so as to penetrate the membrane and initiate flow of fluid through the tubing. Some cannulas are diEEicult to move because oE excessive drag gener-ated between walls of the tubing and the cannula. Smaller cannulas can be .~ ' ~

, . . ~ . . . ., . . . ~

~0867~4 moved mQre readll~ but the~ limit the ~lo~ o~ flui~d and they also run the ri`sk o~ ruptur~ng the bag ~all i~ they ~r~ moved too ar.
~ e have de~ised a fluid ~lo~ ~alve which is not only inexpensive to manufacture and easily manipulated but also in some preferred embodiments a~oids the passibility of rupturing of a container wall. The fluid flow valve of the present invention comprises flexible tubing in a fluid transfer system having at least one container in communication with the tubing, a piercèable membrane in the flow path of the tubing, and a unique spike member lying ~ithin the tubing adjacent the membr~ne. The spike member comprises a longitudinal body having at least three radially projecting ribs which ex-tend longitudinally along the body and converge towards a pointed end. The spike has a particular advantage over tubular cannulas in that, when the spike is moved, only the outside edges of the ribs come into contact with the interior wall surfaces of the tubing and any frictional drag effect is much less than that for a tubular cannula o the same diameter thus allo~ing for easier manipulation of the spike, Consequently, spikes having diameters significantly greater than tubular cannulas but having no greater drag can be used whereby greater fluid flo~ can be effected following rupture of the membrane by the spike. Another advantage the spike member has over a tubular

2~ cannula is that the pointed end i5 substantially centrally located and this facilitates rupturing of the membrane.
A preferred form of the fluid flow valve of this inventi.on, particu-larly ~hen used in a fluid transfer system employing plastic bags, further includes a tubular member interposed between the bag and the flexible tubing.
The pierceable membrane lies adjacent the juncture between the tubular member and the tubing~ The tubular member has; a rigidity such that ~hen the spike member is manipulated threugh the tubing to punckure the membrane and becomes positioned ~ithin the tubular member, the tubular mcmber cannot be manipulated , ., .: , . . , . ... . - :: . : . : , .. - ,, ~il67 014 so as to move the spike member beyond the tubular member. Rupturing of the bag by the spike is thus preven-ted.
In accordance with one aspect of this invention, there is provided in a system for handling fluids which includes at least one con-tainer in communication with flexible tubing, a fluid flow valve system which comprises a pierceable membrane lying transversely in the flow path of the tubing and adapted to prevent ~luid flow therethrough; a spike member having a pointed end and positioned within a portion of the tubing adjacent the membrane, -the spike member being unattached and capable of movement within the tubing and comprising a longitudinal body having at least three radially projecting ribs extending longitudinally subs-tantially the full length of the body and con-verging towards the pointed end; the spike member being adapted for rupturing the membrane by external manipulation of the tubing so as to create a passage-way for flow of fluid in the space between any two adjacent ribs and the ruptured membrane.
In accordance wi-th another aspect of this inven-tion, there is provided in a fluid transfer system which comprises flexible tubing communi-~ cating with the interior of at least one container, a fluid flow valve system ; which comprises a tubular member having one end in communication with the interior Or said one container and its other end joined to -the tubing; a pierceable membrane~lying transversely in the tubular member and adap-ted to prevent fluid flo~ therethrough, a spike member having a pointed end and loca-ted ~ithin a portion of-the tubing adjacent the membrane, the spike mem-ber being unattached and capable of movement wi-thin the -tubing and comprising a lon~itudinal body having at least three radially projecting ribs ex-tending longitudinally substantially the full length of the bod~ and converging towards the pointed end; the tubular member having a rigidi-ty sufficient to .
'' ' .
~ - 3 -, ,., , . ` ` ~ , . ,- ` ` `: . .
` . ' : ~ ~ :. , . ' : `

~8670~
prevent the spike member from being further manipulated after i~ has been externally manipulated through -the tubing to rupture the membrane and moved to a position within the tubular memberj the spike member creating a passage-way for flow of fluid in the space between any two adjacent ribs and the ruptured membrane.
~he invention can be better understoo~ and the advantages will be-come apparent from the following description of some preferred embodiments and as illustrated in the attached drawings, wherein:
Figure 1 illustrates a multi-bag blood processing system containing a fluid flow valve of the present invention;
Figure 2 is a side view in cross-section of a preferred embodiment of the fluid flow valve of this invention;
Figure 3 is a side view in cross-section of another embodimen-t of -the rluid flow valve of this invention; :
Figure 4 is a sectional view taken along line 4-4 o~ Figure 2;
Figure 5 is an end view of another form of the spike member of the fluid flow valve;
Figure 6 is representa-tive of an alternate form of a spike member;
and Figura 7 is a sectional view of a portion of still another form of -~he ~luid flow valve.
Referring to the drawing, Figure 1 illus-trates a multiple bag sys-tem 10 which comprises a blood collection bag 12 and a blood componen-t receiving bag 1ll connected by flexible tubing 16. Bag 12 is -typically ~joined to a donor~aadla as~o~bly lo by tubing 20. Each bag 12 or 1~ may hare one or more ports 22 ~or access to the contents a~ter collec-tion and processing.
~he fluid ~low valve 30 of this invention, which controls the flow ' - 3a -. . : , . .. : ., . , . .. .. . ., .. : .. .. . . .. ., .. , .. , . - . , . . , : .

'. " ' ' :: . ...................... .. -. ' : . , . . : . .: . . . . . . . .

~0~67[)~
of fluid between bags 12 and 14, is bes-t illustrated in Figures 2 and 4.
Valve 30 comprises a-tubular member 32 with a pierceable transverse membrane 34 intermediate the ends 36 and 38. Flexible tubing 16 is sealingly connected to end 36 and end 38 is sealed to and in communication with bag 12.

C - 3b -. . .

~86 7D~

A spike me~ber 40 is ~ositioned ~i~hin tubing 16 and has a pointed end 42 ~acing ~e~brane 34 Q~ tu~ular me~er 32.
T~e spike mem~er 40 as sh~wn in F~GUR~S 2-4 comprises four ribs 44 radiating from a common axis and tapering to the pointed end 42. ~he spike member can ha~e three ribs generally equally spaced as shown in FIGURE

3 or it can have ~ive or more ribs. A s~lke with four ribs is preferred.
The spike member can be made of any material which allows it to be manipula-ted externally through the tubing 16 to rupture membrane 34. Preferably the length of the spike member is substantially no greater than the length of tubular member 32 so that its pointed end ~2 does not extend into the bag 12 when the end 46 is in line with end 36 of the tub~lar member, thus avoiding possible rupture of the ~ag wall. ~he spike member can have other features such as that shown in FIGURE 6. Here two opposing ribs 44 converge at the pointed end 42 and the other two opposing ribs 44a taper to the axis at a spot rearwardly of the pointed end.
The spike member is made preferably as wide as possible without creating so tigh~ a fit within tubing 16 that it cannot be readily manipula-ted for movement through membrane 34. In some instances, the spike can be coated with an inert lubricant such as silicone oil to facilitate its move-ment ~ithin the tubing. Following external manipulation of tubing 16 to force the Spike through membrane 34, edges of the ruptured membrane exert pressure against the ribs of the spike and help to prevent its progression into the bag.
~ubular member 32 preferably is nlade of the same material as that of the tubing 16 and bag 12 so that heat or solvent bonding to the bag and tubing can be more readil~ effected. The walls of the tubular member 32 are generall~ somewhat thicker than the ~all ~ tubing 16 which imparts sufficient rigidit~ to the mem~er such that spike 40, once it has been forced within the ~ ' ` ' . ,.

- 4 -:' .. ,.. , . .... ,, ~, ... ... , j. . . . .

.,. . ~. , , ~ . .. .. . ...

.. - ~ . . .. ~ ~ . .

~6~8~d04 confines of tubular member 32, cannot be externally manipulated further and thus prevents the spike of any significant part of the pointed end from enter-ing bag 12. The tubular member 32 as shown in FIGURE 2 has an annular ledge 48 near end 36 which aids the user in get~ing a firmer grasp of the member while the spike is being manipulated through tubing 16. The presence of ledge 48 is not critical, however, to the function provided by the tubular member.
Another embodiment of the fluid flow valve of this inven~ion is illustrated in FIGURE 3. Here the tubular member 32a communicates with bag 12a by being sealed to a relatively short piece of tubing 50 whose inner end 52 is sealed between t~o sealed sheets comprising bag 12a.
Although tubing 16 is shown in FIGURES 2 and 3 as being sealed within tubular members 32 or 32a, alternatively tubing 16 can be made to fit over and enclose the ends 36 or 36a of the tubular members.
A further embodiment 60 of the fluid flow valve is sho~n in FIGURE
7. Here the pierceable membrane 62 is integrally a part of tubing 16a.
As an example of how the fluid flow valve of this invention may be used, following venipuncture with the needle of needle assembly 18, blood is drawn from a donor into bag 12~ tubin~ 20 is sealed off near the bag and the entire system 10 is centrifuged allowing separation o the plasma from the red hlood cells. Spike 40 is externally manipulated as for example, by com-pressing tubing 16 adjacent the blunt end 46 which forces spike 40 through membrane 34, causing the ruptured membrane to spread, thus creating a passage-way between each of two adjacent ribs 44. The plasma is then expressed from ~ag 12 through tubing 16 into bag I4 where it may be stored for further processing~
Although several examples o~ the ~luid flow valve of the present invention have been disclosed, these should be construed as illustrative only . - - . - . . - -,- ~ . . - . . ,. :

1E;7~9~
and the scope of the invention is intended to ~e llmited only by the follow-ing claims.

~` :

Claims (10)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. In a system for handling fluids which includes at least one contain-er in communication with flexible tubing, a fluid flow valve system which com-prises a pierceable membrane lying transversely in the flow path of the tubing and adapted to prevent fluid flow therethrough; a spike member having a point-ed end and positioned within a portion of the tubing adjacent the membrane, the spike member being unattached and capable of movement within the tubing and comprising a longitudinal body having at least three radially projecting ribs extending longitudinally substantially the full length of the body and converging towards the pointed end; the spike member being adapted for ruptur-ing the membrane by external manipulation of the tubing so as to create a passageway for flow of fluid in the space between any two adjacent ribs and the ruptured membrane.
2. The valve system of claim 1, wherein the spike member has four ribs spaced generally equidistant from each other.
3. In a fluid transfer system which comprises flexible tubing communi-cating with the interior of at least one container, a fluid flow valve system which comprises a tubular member having one end in communication with the interior of said one container and its other end joined to the tubing; a pierceable membrane lying transversely in the tubular member and adapted to prevent fluid flow therethrough; a spike member having a pointed end and located within a portion of the tubing adjacent the membrane, the spike member being unattached and capable of movement within the tubing and comprising a longitudinal body having at least three radially projecting ribs extending longitudinally substantially the full length of the body and converging towards the pointed end; the tubular member having a rigidity sufficient to prevent the spike member from being further manipulated after it has been externally manipulated through the tubing to rupture the membrane and moved to a position within the tubular member; the spike member creating a passageway for flow of fluid in the space between any two adjacent ribs and the ruptured membrane.
4. The valve of claim 3, wherein the spike has four ribs spaced sub-stantially equally from each other.
5. The valve of claim 3, wherein the membrane is located intermediate the two ends of the tubular member.
6. The valve of claim 3, wherein the membrane is integral with the tubular member.
7. The valve of claim 3, wherein the membrane is integral with the tubing.
8. The valve of claim 3, wherein said one end of the tubular member is secured directly to a wall portion of said one container.
9. The valve of claim 3, wherein said one end of the tubular member is spaced from said one container by a length of interconnecting tubing.
10. The valve of claim 4, wherein one pair of opposing ribs converge to meet at the pointed end and the other pair of opposing ribs converge at a spot on the axis of the spike rearward of the pointed end.
CA 326697 1978-05-03 1979-05-01 Fluid flow valve Expired CA1086704A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US902,328 1978-05-03
US05902328 US4195632A (en) 1978-05-03 1978-05-03 Fluid flow valve

Publications (1)

Publication Number Publication Date
CA1086704A true CA1086704A (en) 1980-09-30

Family

ID=25415699

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 326697 Expired CA1086704A (en) 1978-05-03 1979-05-01 Fluid flow valve

Country Status (6)

Country Link
US (1) US4195632A (en)
JP (1) JPS54146024A (en)
CA (1) CA1086704A (en)
DE (1) DE2916918A1 (en)
FR (1) FR2425024B1 (en)
GB (1) GB2020253B (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346703A (en) * 1979-01-23 1982-08-31 Baxter Travenol Laboratories, Inc. Solution container for continuous ambulatory peritoneal dialysis
US4439188A (en) * 1980-09-15 1984-03-27 Baxter Travenol Laboratories, Inc. Tube connector
US4334551A (en) * 1979-04-30 1982-06-15 Becton Dickinson & Company Connector
US4386622A (en) * 1979-10-18 1983-06-07 Baxter Travenol Laboratories, Inc. Breakaway valve
US4340049A (en) * 1979-10-18 1982-07-20 Baxter Travenol Laboratories, Inc. Breakaway valve
US4340147A (en) * 1980-11-03 1982-07-20 Mack-Wayne Plastics Company Cap with built in piercing device
US4465488A (en) * 1981-03-23 1984-08-14 Baxter Travenol Laboratories, Inc. Collapsible multi-chamber medical fluid container
US4396383A (en) * 1981-11-09 1983-08-02 Baxter Travenol Laboratories, Inc. Multiple chamber solution container including positive test for homogenous mixture
EP0096054A1 (en) * 1981-12-10 1983-12-21 Baxter Travenol Laboratories, Inc. Ultraviolet sterilizable connector having spike with projecting vanes
US4363418A (en) * 1982-02-11 1982-12-14 Bs&B Safety Systems, Inc. Knife blade apparatus for severing rupture disks
JPS58165865A (en) * 1982-03-26 1983-09-30 Kawasumi Lab Inc Body liquid treating apparatus
US4411662A (en) * 1982-04-06 1983-10-25 Baxter Travenol Laboratories, Inc. Sterile coupling
US4457749A (en) * 1982-04-19 1984-07-03 Baxter Travenol Laboratories, Inc. Shield for connectors
JPH0119955Y2 (en) * 1983-06-27 1989-06-09
US4609372A (en) * 1983-10-13 1986-09-02 Miles Laboratories, Inc. Heat sterilizable storage solution for red blood cells
US4869398A (en) * 1986-11-25 1989-09-26 Life Technologies, Inc. Liquid container delivery and storage system
US4816221A (en) * 1986-12-08 1989-03-28 Baxter Travenol Laboratories, Inc. Method of simultaneously assembling and sterilizing a unitary container and a fluid transfer set
US4846236A (en) * 1987-07-06 1989-07-11 Deruntz William R Bottled water dispenser insert
US5810398A (en) 1992-10-02 1998-09-22 Pall Corporation Fluid delivery systems and methods and assemblies for making connections
US5334180A (en) * 1993-04-01 1994-08-02 Abbott Laboratories Sterile formed, filled and sealed flexible container
US5514123A (en) * 1993-04-01 1996-05-07 Abbott Laboratories Sterile formed, filled and sealed flexible container
US5584825A (en) * 1994-12-01 1996-12-17 Isolyser Co., Inc. Closure delivery system
EP1716885A3 (en) 1997-05-09 2006-11-15 Pall Corporation Connector assemblies, fluid systems, and methods for making a connection
US6029946A (en) 1997-09-15 2000-02-29 Tiva Medical Inc. Needleless valve
US6132413A (en) * 1998-03-06 2000-10-17 Baxter International Inc. Breakable cannula assemblies and methods for manipulating them
DE19828650C2 (en) 1998-06-26 2000-10-19 Fresenius Medical Care De Gmbh A connector element with integrated shut-off
DE19828651C2 (en) * 1998-06-26 2000-07-13 Fresenius Medical Care De Gmbh Connector element with closing part for medical
FR2783808B1 (en) 1998-09-24 2000-12-08 Biodome Connecting arrangement between a container and a container together and ready to use such a device comprising
US7824343B2 (en) * 1999-07-29 2010-11-02 Fenwal, Inc. Method and apparatus for blood sampling
WO2001008546A3 (en) * 1999-07-29 2003-11-06 Baxter Int Sampling tube holder for blood sampling system
FR2802183B1 (en) * 1999-12-10 2002-02-22 Biodome Process for manufacturing a connection device between a container and a container connection device and corresponding set ready to use such a device comprising
FR2813784B1 (en) * 2000-09-13 2003-03-07 Pascal Lecointe substance packaging bag, has integrated cannula and constituted band such pouches
FR2815328B1 (en) * 2000-10-17 2002-12-20 Biodome Connecting arrangement between a container and a container together and ready to use such a device comprising
FR2821827B1 (en) * 2001-03-07 2003-06-13 Biodome Connecting arrangement between a container and a container together and ready to use such a device comprising
FR2836129B1 (en) * 2002-02-20 2004-04-02 Biodome Connecting arrangement between a container and a container together and ready to use such a device comprising
GB0224785D0 (en) 2002-10-24 2002-12-04 Guest John Int Ltd Temporary closure devices and tube couplings incorporating such devices
DK174883B1 (en) * 2003-02-27 2004-01-19 Unomedical As A disposable urine bag for collecting urine
US7306586B2 (en) * 2003-12-30 2007-12-11 Opmi Funding Corporation Continuous drainage adaptor
EP1701764A2 (en) 2003-12-30 2006-09-20 Vasogen Ireland Limited Valve assembly
DE102004015031A1 (en) * 2004-03-27 2005-10-20 Drk Blutspendedienst West Ggbm Transition closure for blood bag systems
US7306566B2 (en) * 2004-09-15 2007-12-11 Cardinal Health 303, Inc. Needle free blood collection device with male connector valve
US7651481B2 (en) * 2004-12-30 2010-01-26 CareFusion 303 Inc. Self-sealing male connector device with collapsible body
US20070088294A1 (en) 2005-07-06 2007-04-19 Fangrow Thomas F Jr Medical connector with closeable male luer
US7998134B2 (en) 2007-05-16 2011-08-16 Icu Medical, Inc. Medical connector
US20090270832A1 (en) * 2008-04-23 2009-10-29 Baxter International Inc. Needleless port assembly for a container
US8679090B2 (en) * 2008-12-19 2014-03-25 Icu Medical, Inc. Medical connector with closeable luer connector
US9168366B2 (en) 2008-12-19 2015-10-27 Icu Medical, Inc. Medical connector with closeable luer connector
US20100217179A1 (en) * 2009-02-20 2010-08-26 Baxter International Inc. Bulk delivery peritoneal dialysis system and method
CA2798470A1 (en) 2010-05-06 2011-11-10 Icu Medical, Inc. Medical connector with closeable luer connector
US8454059B2 (en) 2010-09-13 2013-06-04 Pall Corporation Connector assemblies, fluid systems including connector assemblies, and procedures for making fluid connections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3110308A (en) * 1960-10-20 1963-11-12 Baxter Laboratories Inc Parenteral fluid administration equiment
US3685795A (en) * 1970-07-06 1972-08-22 Baxter Laboratories Inc Fluid flow valve
US3796218A (en) * 1972-03-28 1974-03-12 Burron Medical Prod Inc Syringe adaptor for use with a wet/dry mixing vial
GB1428391A (en) * 1972-06-23 1976-03-17 Avon Medicals Couplings
DK147171C (en) * 1973-07-05 1984-10-29 Ims Ltd Fluidoverfoeringsapparat with two parallel fluid channels
CA1043744A (en) * 1974-04-29 1978-12-05 Abbott Laboratories Additive transfer unit having a slidable piercing member
US4004586A (en) * 1975-03-12 1977-01-25 Baxter Travenol Laboratories, Inc. Method and apparatus for sealed, sterile connection
US4056116A (en) * 1976-09-08 1977-11-01 Baxter Travenol Laboratories, Inc. Valve for interconnecting sterile containers and the like
US4080965A (en) * 1976-09-30 1978-03-28 Baxter Travenol Laboratories, Inc. In-line cannula valve assembly

Also Published As

Publication number Publication date Type
US4195632A (en) 1980-04-01 grant
GB2020253B (en) 1982-08-25 grant
FR2425024A1 (en) 1979-11-30 application
DE2916918A1 (en) 1979-11-15 application
GB2020253A (en) 1979-11-14 application
FR2425024B1 (en) 1986-05-09 grant
CA1086704A1 (en) grant
JPS54146024A (en) 1979-11-14 application

Similar Documents

Publication Publication Date Title
US3205889A (en) Parenteral fluid container and port structure
US6206861B1 (en) Needleless injection site
US4540411A (en) Catheter placement device
US6585229B2 (en) Medical nozzle securing apparatus
US3951801A (en) Serum/plasma separator-strut stop type
US4216776A (en) Disposable aortic perforator
US4242460A (en) Cell culture device
US5403304A (en) Blood collection device
US4236520A (en) Fluid drain or injection tube for an animal's udder
US6808510B1 (en) Multi-lumen catheter and tip configurations for use therewith
US4250872A (en) Blood pulsating and/or pumping device
US7306566B2 (en) Needle free blood collection device with male connector valve
US7470262B2 (en) Medical valve
US7140592B2 (en) Self-sealing male Luer connector with biased valve plug
US5738663A (en) Medical valve with fluid escape space
US4201208A (en) Sterile connecting device
US3897343A (en) Plasma separator-hydrostatic pressure type
US5824216A (en) Blood collection container
US4795426A (en) Catheter introducing device and method of placing catheter
US5474536A (en) Medical valve
US7615035B2 (en) Needleless access port valves
US4439179A (en) Dual tubing clamp
US7497848B2 (en) Needleless medical connector with expandable valve mechanism
US4388922A (en) Suction canister system for serial collection of fluids
US3211144A (en) Transfusion and storage set

Legal Events

Date Code Title Description
MKEX Expiry