CA1082626A - Antibiotics sf-1771 from streptomyces - Google Patents
Antibiotics sf-1771 from streptomycesInfo
- Publication number
- CA1082626A CA1082626A CA264,223A CA264223A CA1082626A CA 1082626 A CA1082626 A CA 1082626A CA 264223 A CA264223 A CA 264223A CA 1082626 A CA1082626 A CA 1082626A
- Authority
- CA
- Canada
- Prior art keywords
- substance
- reagent
- soluble
- water
- copper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title claims description 26
- 229940088710 antibiotic agent Drugs 0.000 title description 23
- 241000187747 Streptomyces Species 0.000 title description 4
- 239000000126 substance Substances 0.000 claims abstract description 106
- 108010002201 SF-1771 substance Proteins 0.000 claims abstract description 77
- 239000010949 copper Substances 0.000 claims abstract description 31
- 229910052802 copper Inorganic materials 0.000 claims abstract description 30
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
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- 239000000706 filtrate Substances 0.000 claims abstract description 13
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- 238000000855 fermentation Methods 0.000 claims abstract description 9
- 230000004151 fermentation Effects 0.000 claims abstract description 9
- 229910052977 alkali metal sulfide Inorganic materials 0.000 claims abstract description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 58
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 42
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- DPLVEEXVKBWGHE-UHFFFAOYSA-N potassium sulfide Chemical compound [S-2].[K+].[K+] DPLVEEXVKBWGHE-UHFFFAOYSA-N 0.000 description 1
- AFHFWLNCUQBZAU-UHFFFAOYSA-N propan-1-ol 2-pyridin-2-ylacetic acid hydrate Chemical compound O.CCCO.OC(=O)CC1=CC=CC=N1 AFHFWLNCUQBZAU-UHFFFAOYSA-N 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 235000020183 skimmed milk Nutrition 0.000 description 1
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- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- XOKJUSAYZUAMGJ-WOUKDFQISA-N toyocamycin Chemical compound C1=C(C#N)C=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O XOKJUSAYZUAMGJ-WOUKDFQISA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 108010059327 zorbamycin Proteins 0.000 description 1
- UJKRUPHWCPAJIL-CPLCKGKLSA-N zorbamycin Chemical compound N([C@H](C(=O)N[C@H](CCO)[C@@H](O)[C@H](C)C(=O)N[C@H](C(=O)NCCC=1SC[C@@H](N=1)C=1SC=C(N=1)C(=O)NCCC(N)=N)C(C)(C)O)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](C)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C UJKRUPHWCPAJIL-CPLCKGKLSA-N 0.000 description 1
- UJKRUPHWCPAJIL-UHFFFAOYSA-N zorbamycin Natural products N=1C(C=2SC=C(N=2)C(=O)NCCC(N)=N)CSC=1CCNC(=O)C(C(C)(C)O)NC(=O)C(C)C(O)C(CCO)NC(=O)C(C(OC1C(C(O)C(O)C(C)O1)OC1C(C(OC(N)=O)C(O)C(CO)O1)O)C=1NC=NC=1)NC(=O)C1=NC(C(CC(N)=O)NCC(N)C(N)=O)=NC(N)=C1C UJKRUPHWCPAJIL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50129306A JPS5831196B2 (ja) | 1975-10-29 | 1975-10-29 | Ｓｆ−１７７１ ブツシツノ セイゾウホウ |
| JP129306/75 | 1975-10-29 | ||
| JP49892/76 | 1976-05-04 | ||
| JP4989276A JPS52133902A (en) | 1976-05-04 | 1976-05-04 | Novel antibiotic substance sf-1771-b and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1082626A true CA1082626A (en) | 1980-07-29 |
Family
ID=26390336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA264,223A Expired CA1082626A (en) | 1975-10-29 | 1976-10-26 | Antibiotics sf-1771 from streptomyces |
Country Status (4)
| Country | Link |
|---|---|
| CA (1) | CA1082626A (enrdf_load_stackoverflow) |
| DE (1) | DE2649604C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2361906A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1540466A (enrdf_load_stackoverflow) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1292081A (en) * | 1969-02-15 | 1972-10-11 | Zaidan Hojin Biseibutsu | Process for producing bleomycin antibiotics |
| JPS5243917B1 (enrdf_load_stackoverflow) * | 1971-02-13 | 1977-11-02 | ||
| JPS5547039B2 (enrdf_load_stackoverflow) * | 1972-02-17 | 1980-11-27 | ||
| JPS5128718B2 (enrdf_load_stackoverflow) * | 1972-09-07 | 1976-08-20 | ||
| US4051237A (en) * | 1975-08-28 | 1977-09-27 | Bristol-Myers Company | Glycopeptide antibiotics bu-2231 a and b and process for producing same |
-
1976
- 1976-10-22 GB GB44017/76A patent/GB1540466A/en not_active Expired
- 1976-10-26 CA CA264,223A patent/CA1082626A/en not_active Expired
- 1976-10-29 DE DE2649604A patent/DE2649604C2/de not_active Expired
- 1976-10-29 FR FR7633352A patent/FR2361906A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB1540466A (en) | 1979-02-14 |
| FR2361906A1 (fr) | 1978-03-17 |
| DE2649604A1 (de) | 1977-05-05 |
| FR2361906B1 (enrdf_load_stackoverflow) | 1980-09-26 |
| DE2649604C2 (de) | 1984-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |