CA1071911A - Specimen test slide with hinged cover means - Google Patents

Specimen test slide with hinged cover means

Info

Publication number
CA1071911A
CA1071911A CA276,698A CA276698A CA1071911A CA 1071911 A CA1071911 A CA 1071911A CA 276698 A CA276698 A CA 276698A CA 1071911 A CA1071911 A CA 1071911A
Authority
CA
Canada
Prior art keywords
sheet
openings
slide
opening
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA276,698A
Other languages
French (fr)
Inventor
Joseph F. Pagano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SMITH KLINE AND FRENCH CANADA Ltd
Original Assignee
SMITH KLINE AND FRENCH CANADA LTD.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US05/681,080 priority Critical patent/US3996006A/en
Application filed by SMITH KLINE AND FRENCH CANADA LTD. filed Critical SMITH KLINE AND FRENCH CANADA LTD.
Application granted granted Critical
Publication of CA1071911A publication Critical patent/CA1071911A/en
Application status is Expired legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721Haemoglobin
    • G01N33/726Devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525Multi-layer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood

Abstract

(Pagano Case 4) SPECIMEN TEST SLIDE

Abstract of the Disclosure A specimen test slide has a front panel and a rear panel. The front panel has a plurality of openings. Sheet means underlie each of these openings for the reception of a specimen. The portion of the sheet under each opening carries a test reagent. A hinged cover overlies the openings. The rear panel has tab means opposite the said openings which are pivotable to expose the underside of the sheet to permit the application of a developing solution. The reagent at each location may be the sane or different. When the reagents are different, they can be separately printed on the sheet to underlie different openings. A single sheet is disclosed underlying all of the openings with the employment of a barrier to limit the migration between adjacent portions of the sheet. The use of separate sheets under each opening is also disclosed.

Description

o~

l A specimen test slide has a front panel and a rear panel. The front panel has a plurality of openings.
Sheet means underlie each of these openings for the recep-tion of a specimen. The portion of the sheet under each opening carries a test reagent. A hinged cover overlies the openings. The rear panel has tab means opposite the said openings which are pivotable to e~pose the underside of the sheet to permit the application of a developing solution. The reagent at each location may be the same or different. When the reagents are different, they can be separa~ely printed on the sheet to underlie diferent openings. A single sheet is disclosed underlying all of the openings with the employment of a barrier to llmit the migration between adjacent portions of the sheet. The use of separate sheets under each opening is also disclosed.
~ Background of the Invention ; It is known to employ specimen slides having a specimen receiving sheet between a front panel and a rear panel with an opening in the front panel and an opening in the rear panel and pivotaL covers to cover these openings.
TypicallyJ in the case of a test for occult blood in feces, the specimen receiving sheet is paper impregnated with guaiac and a developing solution such as a peroxide solution is applied through the opening in the rear panel.
Fre~uently it is highly desirable to have two or more specimens for a close side-by-side comparison in the test involved. For example, it is desirable to test more than one portion of a fecal sample when testing Eor occult blood. At times it is desirable ~o test a specimen by more ~han one test, for example, testing a fecal sample by both 1 the guaiac test and the o-tolidine test which have different sensitivities is valuable in the diagnosis for occult blood.
The invention provides for the achievement of these objec-tives.
Brief Summary of the Invention The invention provides for side-by-side comparison testing with the same and differen~ t~es~ reagents by pro-viding multiple openings in the ront and rear panlels with provisions for covering these openings. Advantageously barrier means are provided to prevent migration from one test portion of the slide to another test portion. An entire sheet lying under all openings may carry the test reagent or the sheet may carry the same or different test reagents onl~ in selected portions opposite the openings with the application of the reagent made, for example, by printing Separate sheets may be employed under the open ings with the same or different test reagents being used on the sheets and applied, for example, by printing.
Brief Description o the Drawin~s Figure lis a plan view o a partially processed blank for making a slide in accordance with the invention;
Figure 2 is a front elevational view of a slide formed from the blank of Figure 1 with the front cover open;
Figure 3 is a rear view of the slide of Figure 2 with the front cover closed;
Figure 4 is a view, partially broken away, of a modified blank for forming a slide; and Figure ~ is a view, partially broken away, of another modified blank for forming a slide employirlg ~o~

1 separate sheets.
Detailed Description A blank 2 formed, for example, from paper or ~ardboard has a front panel 4, a rear panel ~ and a cover 8.
The blank 2 is creased between panels 4 and 6 along the line indicated at 10 to facilitate folding. A crease along the line indicated at 12 between panel 6 and cover 8 facilitates the hinging of cover 8. Cover 8 has a tab 14 which is adapted to pass through circular slit 16 in panel 4 and circular slit 18 in panel 6 to lock the cover in the closed position.
Front panel 4 has a pair o~ ad~acent openings 22 and 24. A sheet of absorbent paper 26, for example J filter paper overlies (as viewed in Figure 1) openings 22 and 24.
Sheet 26 is impregnated with a reagent such as guaiacO A
barrier 28 in the central portion of sheet 2~ prevents migration of the specimen or a developing solution between :.
the two halves of sheet 26. Barrier 28 may be any material impregnating paper 26 which will prevent migration, ~or example, gLue, a wax or a syn~hetic resin such as an epoxy, phenolic~ polyester or silicone resin commonly used in paper~resin laminates. As illustrated, barrier 28 is formed of glue which is also deposi~ed on the front panel 24 as indicated at 32 and on rear panel 6 as indicated at 34 in order to adhere sheet 26 to both panels 4 and 6.
Panels 4 and 6 are adhered together by an adhesive such as glue indicated at 35.
: For the application of the developing solution, for example, a peroxide solution~ the rear panel 6 is provided with tabs 38 and 40 opposite openings 22 and 243 9'~

1 respectively. Perforations 42 are provid~d ~o permit moving the tabs 38 and 40 away rom sheet 26 pi~oting about crease lines 44 and 46, respectively.
To form the completed slide 50 shown in Figure 2, blank 2 is folded along crease line 10 to bring panels 4 and 6 together and hold them together principally by the glue at 35, Cover 8 is now hinged about crease 12 and secured to panel 4 by a spot of glue 52.
To use the slide device, the patient sep~rates cover 8 from panel 4 at the spot 52, opens the cover and applies with an applicator a thin smear of a specimen from one portion of his stool on paper 26 through opening 22.
He then applies from another portion of his stool a thin smear on paper 26 through opening 24. He then closes the cover locking tab 14 in openings 16 and 18 and returns the slide to his physician. On receiving the slide, the physician pulls tabs 38 and 40 free of rear panel 6 and open~
them outwardly. Through the opening thus made the physician applies a peroxide solution on the guaiac impregnated paper 26 opposite each o the openings 22 and 24 and observes the test results, i.e,, in the occult blood test the degree to which the color blue is developed. This provides a good side-by-side comparison of tes~ results from two different portions of the patient 19 stool.
As shown in Figure 4, a blank 2 for making a slide in accordance with the invention has secured there~o in lieu of sheet 26 a sheet 62 of paper which has a central glue barrier 64. ShPet 62 differs from sheet 26 in that rather than being impregnated throughout with one reagent, it has printed thereon opposite opening 22 one reagent 66 1 and it has printed thereon opposite opening 24 a second different reagent 68. Reagent 66 may be, for example, guaiac and reagent 68 may be, for example, o-tolidine. In use the reagents 66 and 68 may be developed with a peroxide or an organic peroxide solution.
As shown in Figures 5 a blank 2 for use in making a slide in accordance with the invent:ion has a separate sheet 72 opposite opening 22 and a separate sheet 74 opposite opening 24. Sheet 22 may be impregnated with, for example, guaiac and sheet 74 impregnated with, for example, o-tolidine.
Sheet 72 is impregnated with epoxy resin indicatecl at 76 which acts as a barrier and secures sheet 72 to both the front and rear panels. Similarly, sheet 74 is impregnated with epoxy resin 78 which secures sheet 74 to both the front and rear panels.
The above embodiments are illustrative and are not intended to be limiting.
:.

Claims (10)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. A specimen test slide comprising:
a front panel;
a rear panel;
said front panel having a plurality of openings;
sheet means between the front and rear panels underlying each of said openings for the reception of a specimen and with the portion of the sheet under each opening carrying a test reagent;
a hinged cover adapted to overlie a portion of the front panel and said openings; and tab means in the rear panel opposite said openings and pivotable to expose the underside of the sheet.
2. The slide of claim 1 in which the sheet means is a single sheet underlying all of the openings and the reagent under each opening is the same.
3. The slide of claim 1 in which the sheet means is a single sheet underlying all of the openings and the reagent under each opening is different.
4. The slide of claim 2 in which the sheet has a barrier to prevent the migration of material from the portion of the sheet under one opening to a portion of the sheet under another opening.
5. The slide of claim 4 in which said plurality of openings consists of a pair of adjacent openings.
6. The slide of claim 3 in which the sheet has a barrier to prevent the migration of material from the portion of the sheet under one opening to a portion of the sheet under another opening.
7. The slide of claim 1 in which the sheet means comprises a separate sheet under each opening.
8. The slide of claim 7 in which at least one of the separate sheets has a reagent different from the reagent on another of the separate sheets.
9. The slide of claim 7 in which each sheet has barrier means to prevent material from passing from the sheet in the direction of an adjacent sheet.
10. The slide of claim 9 in which the plurality of openings consists of a pair of adjacent openings.
CA276,698A 1974-08-16 1977-04-21 Specimen test slide with hinged cover means Expired CA1071911A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US05/681,080 US3996006A (en) 1974-08-16 1976-04-28 Specimen test slide

Publications (1)

Publication Number Publication Date
CA1071911A true CA1071911A (en) 1980-02-19

Family

ID=24733727

Family Applications (1)

Application Number Title Priority Date Filing Date
CA276,698A Expired CA1071911A (en) 1974-08-16 1977-04-21 Specimen test slide with hinged cover means

Country Status (13)

Country Link
JP (1) JPS52132579A (en)
AT (1) AT360174B (en)
AU (1) AU502691B2 (en)
BR (1) BR7702658A (en)
CA (1) CA1071911A (en)
CH (1) CH616236A5 (en)
ES (1) ES458182A1 (en)
FI (1) FI771274A (en)
GB (1) GB1585127A (en)
IT (1) IT1115516B (en)
MX (1) MX144487A (en)
NO (1) NO771428L (en)
SE (1) SE7704665A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2150834B (en) * 1983-10-08 1988-03-23 Fumakilla Ltd Pest control sheet and device for indicating the termination of its effectiveness
DE3729473C2 (en) * 1987-09-03 1989-06-15 Emil Schlutius Gmbh, 6908 Wiesloch, De
US5100619A (en) * 1989-05-09 1992-03-31 Beckman Instruments, Inc. Device and method for collecting fecal occult blood specimens
ES2163356B1 (en) * 1999-06-16 2003-04-16 Univ Granada Stand-alone equipment for collection, storage and shipment of samples bio logical human, animal and plant.
DE10150269B4 (en) * 2001-10-11 2004-02-19 Beck, Christoph, Prof.Dr. Micro-chamber for non-invasive measurement of biological material
ES2232314B1 (en) * 2003-11-06 2006-07-16 Julio Alvarez Caballero Device for biological tests.
GB2482726A (en) * 2010-08-13 2012-02-15 Invicta Plastics Ltd Specimen slide for microscope

Also Published As

Publication number Publication date
CA1071911A1 (en)
AU2451177A (en) 1978-10-26
AU502691B2 (en) 1979-08-02
CH616236A5 (en) 1980-03-14
JPS52132579A (en) 1977-11-07
IT1115516B (en) 1986-02-03
ATA238177A (en) 1980-05-15
AT360174B (en) 1980-12-29
BR7702658A (en) 1978-02-21
ES458182A1 (en) 1978-04-01
NO771428L (en) 1977-10-31
GB1585127A (en) 1981-02-25
MX144487A (en) 1981-10-20
SE7704665A (en) 1977-10-29
FI771274A (en) 1977-10-29

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