BRPI0924543A2 - Composição farmacêutica de liberação controlada com resistência contra a influência de etanol empregando um revestimento compreendendo polímeros vinílicos neutros e excipientes - Google Patents
Composição farmacêutica de liberação controlada com resistência contra a influência de etanol empregando um revestimento compreendendo polímeros vinílicos neutros e excipientesInfo
- Publication number
- BRPI0924543A2 BRPI0924543A2 BRPI0924543-0A BRPI0924543A BRPI0924543A2 BR PI0924543 A2 BRPI0924543 A2 BR PI0924543A2 BR PI0924543 A BRPI0924543 A BR PI0924543A BR PI0924543 A2 BRPI0924543 A2 BR PI0924543A2
- Authority
- BR
- Brazil
- Prior art keywords
- excipients
- coating
- pharmaceutical composition
- controlled release
- release pharmaceutical
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 2
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 238000013270 controlled release Methods 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2009/053176 WO2010105672A1 (en) | 2009-03-18 | 2009-03-18 | Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising neutral vinyl polymers and excipients |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0924543A2 true BRPI0924543A2 (pt) | 2015-06-30 |
BRPI0924543B1 BRPI0924543B1 (pt) | 2021-02-02 |
BRPI0924543B8 BRPI0924543B8 (pt) | 2022-07-05 |
Family
ID=40694515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0924543A BRPI0924543B8 (pt) | 2009-03-18 | 2009-03-18 | composição farmacêutica de liberação controlada, e seu processo de preparação |
Country Status (15)
Country | Link |
---|---|
US (1) | US9730899B2 (pt) |
EP (1) | EP2408436B1 (pt) |
JP (1) | JP5619130B2 (pt) |
KR (1) | KR101571198B1 (pt) |
CN (1) | CN102355893A (pt) |
BR (1) | BRPI0924543B8 (pt) |
CA (1) | CA2755808C (pt) |
ES (1) | ES2624719T3 (pt) |
HK (1) | HK1214182A1 (pt) |
HU (1) | HUE032817T2 (pt) |
IL (1) | IL214570A (pt) |
MX (1) | MX2011009667A (pt) |
PL (1) | PL2408436T3 (pt) |
SI (1) | SI2408436T1 (pt) |
WO (1) | WO2010105672A1 (pt) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
NZ586792A (en) | 2008-01-25 | 2012-09-28 | Gruenenthal Chemie | Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces |
PT2273983T (pt) | 2008-05-09 | 2016-10-28 | Gruenenthal Gmbh | Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização |
SI2456424T1 (sl) | 2009-07-22 | 2013-10-30 | Gruenenthal Gmbh | Oksidacijsko stabilizirana odmerna oblika, varna pred zlorabo |
AU2010275753B2 (en) | 2009-07-22 | 2014-08-21 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
JP5885668B2 (ja) | 2009-12-02 | 2016-03-15 | アダマス ファーマシューティカルズ, インコーポレイテッド | アマンタジン組成物および使用方法 |
BR112012028656A2 (pt) | 2010-05-10 | 2016-08-09 | Euro Celtique Sa | combinação de grânulos carregados ativos com ativos adicionais |
AR083150A1 (es) | 2010-05-10 | 2013-02-06 | Euro Celtique Sa | Composiciones farmaceuticas que comprenden hidromorfona y naloxona |
BR112012028788A2 (pt) | 2010-05-10 | 2016-07-19 | Euro Celtique Sa | fabricação de grânulos sem ativos |
KR20130137627A (ko) | 2010-09-02 | 2013-12-17 | 그뤼넨탈 게엠베하 | 음이온성 중합체를 포함하는 내변조성 투여형 |
WO2012028319A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
AU2011370763A1 (en) | 2011-06-17 | 2013-10-03 | Evonik Rohm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
SI2720682T1 (sl) | 2011-06-17 | 2017-05-31 | Evonik Roehm Gmbh | Sestavek za oplaščenje primeren za farmacevtske ali nutracevtske dozirne oblike |
RU2649806C2 (ru) | 2011-06-17 | 2018-04-04 | Эвоник Рем ГмбХ | Желудочно-резистентная фармацевтическая или нутрицевтическая композиция с устойчивостью к воздействию этанола |
EP2736497B1 (en) | 2011-07-29 | 2017-08-23 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
AU2013225106B2 (en) | 2012-02-28 | 2017-11-02 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
ES2692944T3 (es) | 2012-04-18 | 2018-12-05 | Grünenthal GmbH | Forma de dosificación farmacéutica resistente a la manipulación y resistente a la descarga rápida de la dosis |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
WO2014017970A2 (en) * | 2012-07-24 | 2014-01-30 | Scientificmed Sweden Ab | Improved clinical effect of pharmaceutical products using communication tool and life-style factors |
ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
RU2015138784A (ru) | 2013-02-13 | 2017-03-17 | Эвоник Рем ГмбХ | Фармацевтическая композиция в виде мультичастиц, содержащая множество гранул двух видов |
US10064826B2 (en) * | 2013-03-15 | 2018-09-04 | Navinta, Llc | Direct compression and dry granulation processes for preparing carglumic acid tablets having less impurities than those produced by wet granulation process |
US10420729B2 (en) | 2013-03-15 | 2019-09-24 | R.P. Scherer Technologies, Llc | Abuse resistant capsule |
MX2015013231A (es) * | 2013-03-15 | 2016-06-07 | Inspirion Delivery Technologies Llc | Composiciones que disuaden el abuso y metodos de utilizacion. |
BR112015029616A2 (pt) | 2013-05-29 | 2017-07-25 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração com perfil de liberação bimodal |
WO2014191397A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
TWI649100B (zh) * | 2013-06-17 | 2019-02-01 | 地平線罕見醫學製藥有限責任公司 | 延遲釋放型半胱胺珠粒調配物,以及其製備及使用方法 |
US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US9814710B2 (en) | 2013-11-13 | 2017-11-14 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
CA2931553C (en) | 2013-11-26 | 2022-01-18 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
CA2947786A1 (en) | 2014-05-12 | 2015-11-19 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising tapentadol |
EP3148512A1 (en) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
JP6371463B2 (ja) | 2014-07-17 | 2018-08-08 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 即時放出性乱用抑止性液体充填剤形 |
WO2016042565A1 (en) * | 2014-09-16 | 2016-03-24 | Suresh Pareek | Extended release 'formulation of metoprolol |
US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
WO2016091805A2 (de) * | 2014-12-08 | 2016-06-16 | Develco Pharma Schweiz Ag | Naloxon-monopräparat und mehrschichttablette |
EP3285745A1 (en) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
WO2016193034A1 (en) * | 2015-06-05 | 2016-12-08 | Evonik Röhm Gmbh | Pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
US10143665B2 (en) | 2015-11-17 | 2018-12-04 | Horizon Orphan Llc | Methods for storing cysteamine formulations and related methods of treatment |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
CN117860718A (zh) | 2017-08-24 | 2024-04-12 | 阿达玛斯药物有限责任公司 | 金刚烷胺组合物、其制备和使用方法 |
CA3075204A1 (en) | 2017-09-14 | 2019-03-21 | Thomas Endres | Polymer and dosage form with sustained release properties and resistance against the influence of ethanol |
CA3093077A1 (en) | 2018-03-09 | 2019-09-12 | Evonik Operations Gmbh | Polymer mixture with resistance against the influence of ethanol |
CN114948898B (zh) * | 2022-03-28 | 2024-04-30 | 深圳善康医药科技股份有限公司 | 一种用于治疗肿瘤的盐酸纳曲酮微丸及其制备方法 |
Family Cites Families (16)
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US20030118641A1 (en) | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
DE10208335A1 (de) | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
NZ539174A (en) * | 2002-09-09 | 2007-05-31 | Biovail Lab Int Srl | Chronotherapeutic diltiazem formulations and the administration thereof |
DE10250543A1 (de) | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
US20040202717A1 (en) * | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
RU2372893C2 (ru) * | 2003-10-31 | 2009-11-20 | Хексал Аг | Содержащий фармацевтический агент состав с покрытием |
EP2319499A1 (en) * | 2005-01-28 | 2011-05-11 | Euro-Celtique S.A. | Alcohol resistant dosage forms |
DE102005024614A1 (de) | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
KR20080089653A (ko) * | 2006-01-21 | 2008-10-07 | 애보트 게엠베하 운트 콤파니 카게 | 남용 약물의 전달을 위한 투여형 및 방법 |
AU2007275034A1 (en) | 2006-07-21 | 2008-01-24 | Lab International Srl | Hydrophilic abuse deterrent delivery system |
DE102006051020A1 (de) | 2006-10-26 | 2008-04-30 | Evonik Röhm Gmbh | Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung |
WO2009036812A1 (en) | 2007-09-21 | 2009-03-26 | Evonik Röhm Gmbh | Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
WO2009036811A1 (en) | 2007-09-21 | 2009-03-26 | Evonik Röhm Gmbh | Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol |
JP5453434B2 (ja) | 2008-09-24 | 2014-03-26 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | エタノールの影響に対する耐性を有するオピオイドではないpH依存の制御放出の医薬組成物 |
US9757343B2 (en) | 2008-09-24 | 2017-09-12 | Evonik Röhm Gmbh | PH-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
-
2009
- 2009-03-18 EP EP09779169.3A patent/EP2408436B1/en active Active
- 2009-03-18 WO PCT/EP2009/053176 patent/WO2010105672A1/en active Application Filing
- 2009-03-18 CN CN2009801581042A patent/CN102355893A/zh active Pending
- 2009-03-18 KR KR1020117021576A patent/KR101571198B1/ko active IP Right Grant
- 2009-03-18 US US13/256,694 patent/US9730899B2/en active Active
- 2009-03-18 SI SI200931651A patent/SI2408436T1/sl unknown
- 2009-03-18 CA CA2755808A patent/CA2755808C/en active Active
- 2009-03-18 JP JP2012500078A patent/JP5619130B2/ja not_active Expired - Fee Related
- 2009-03-18 PL PL09779169T patent/PL2408436T3/pl unknown
- 2009-03-18 ES ES09779169.3T patent/ES2624719T3/es active Active
- 2009-03-18 MX MX2011009667A patent/MX2011009667A/es active IP Right Grant
- 2009-03-18 BR BRPI0924543A patent/BRPI0924543B8/pt not_active IP Right Cessation
- 2009-03-18 HU HUE09779169A patent/HUE032817T2/en unknown
-
2011
- 2011-08-09 IL IL214570A patent/IL214570A/en active IP Right Grant
-
2016
- 2016-03-02 HK HK16102434.2A patent/HK1214182A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010105672A1 (en) | 2010-09-23 |
CA2755808A1 (en) | 2010-09-23 |
SI2408436T1 (sl) | 2017-06-30 |
HK1214182A1 (zh) | 2016-07-22 |
EP2408436A1 (en) | 2012-01-25 |
IL214570A0 (en) | 2011-09-27 |
JP5619130B2 (ja) | 2014-11-05 |
MX2011009667A (es) | 2011-12-14 |
US20120045506A1 (en) | 2012-02-23 |
HUE032817T2 (en) | 2017-11-28 |
KR101571198B1 (ko) | 2015-11-23 |
PL2408436T3 (pl) | 2017-08-31 |
BRPI0924543B1 (pt) | 2021-02-02 |
EP2408436B1 (en) | 2017-02-22 |
CA2755808C (en) | 2016-01-19 |
KR20110128869A (ko) | 2011-11-30 |
US9730899B2 (en) | 2017-08-15 |
ES2624719T3 (es) | 2017-07-17 |
BRPI0924543B8 (pt) | 2022-07-05 |
JP2012520831A (ja) | 2012-09-10 |
CN102355893A (zh) | 2012-02-15 |
IL214570A (en) | 2016-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
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