BRPI0714562A2 - composiÇÕes e mÉtodos para o tratamento de mucosites - Google Patents

composiÇÕes e mÉtodos para o tratamento de mucosites Download PDF

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Publication number
BRPI0714562A2
BRPI0714562A2 BRPI0714562-4A BRPI0714562A BRPI0714562A2 BR PI0714562 A2 BRPI0714562 A2 BR PI0714562A2 BR PI0714562 A BRPI0714562 A BR PI0714562A BR PI0714562 A2 BRPI0714562 A2 BR PI0714562A2
Authority
BR
Brazil
Prior art keywords
compound
formula
alkyl
mucositis
substituted
Prior art date
Application number
BRPI0714562-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Eric Schwartz
Per Gjorstrup
Original Assignee
Resolvyx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolvyx Pharmaceuticals Inc filed Critical Resolvyx Pharmaceuticals Inc
Publication of BRPI0714562A2 publication Critical patent/BRPI0714562A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0714562-4A 2006-07-19 2007-07-19 composiÇÕes e mÉtodos para o tratamento de mucosites BRPI0714562A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83186606P 2006-07-19 2006-07-19
US60/831.866 2006-07-19
PCT/US2007/016338 WO2008011085A1 (en) 2006-07-19 2007-07-19 Compositions and methods for the treatment of mucositis

Publications (1)

Publication Number Publication Date
BRPI0714562A2 true BRPI0714562A2 (pt) 2013-04-02

Family

ID=38617335

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0714562-4A BRPI0714562A2 (pt) 2006-07-19 2007-07-19 composiÇÕes e mÉtodos para o tratamento de mucosites

Country Status (14)

Country Link
US (1) US20100035989A1 (US20070167479A1-20070719-C00034.png)
EP (1) EP2049099A1 (US20070167479A1-20070719-C00034.png)
JP (1) JP2009545527A (US20070167479A1-20070719-C00034.png)
KR (1) KR20090040323A (US20070167479A1-20070719-C00034.png)
CN (1) CN101528218A (US20070167479A1-20070719-C00034.png)
AU (1) AU2007275658B2 (US20070167479A1-20070719-C00034.png)
BR (1) BRPI0714562A2 (US20070167479A1-20070719-C00034.png)
CA (1) CA2658361C (US20070167479A1-20070719-C00034.png)
IL (1) IL196465A0 (US20070167479A1-20070719-C00034.png)
MX (1) MX2009000657A (US20070167479A1-20070719-C00034.png)
RU (1) RU2009101324A (US20070167479A1-20070719-C00034.png)
SG (1) SG173397A1 (US20070167479A1-20070719-C00034.png)
WO (1) WO2008011085A1 (US20070167479A1-20070719-C00034.png)
ZA (1) ZA200900388B (US20070167479A1-20070719-C00034.png)

Families Citing this family (23)

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DE60144401D1 (de) 2000-02-16 2011-05-19 Brigham & Womens Hospital Aspirin-ausgelöste Lipidmediatoren
US7902257B2 (en) * 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
US8481772B2 (en) * 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US20100190735A1 (en) * 2006-03-28 2010-07-29 Myrex Pharmaceuticals Inc. Mouthwash and Method of Using Same for the Treatment of Mucositis or Stomatitis
EP2180787B1 (en) 2007-08-01 2013-10-30 University of Pittsburgh - Of the Commonwealth System of Higher Education Nitro oleic acid modulation of type ii diabetes
US20090118243A1 (en) * 2007-10-12 2009-05-07 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of ophthalmic conditions
US20090326070A1 (en) 2008-05-01 2009-12-31 Complexa Inc. Vinyl substituted fatty acids
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
CN102099024B (zh) 2008-06-19 2015-11-25 犹他大学研究基金会 硝化脂质在毒性医疗疗法的副作用的治疗上的用途
EP2393353A4 (en) * 2009-02-05 2013-12-25 Resolvyx Pharmaceuticals Inc COMPOSITIONS AND METHODS OF ORGAN CONSERVATION
WO2010095706A1 (ja) 2009-02-20 2010-08-26 国立大学法人東京大学 新規抗炎症性化合物
JP2013500966A (ja) 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
US8686167B2 (en) 2009-10-02 2014-04-01 Complexa, Inc. Heteroatom containing substituted fatty acids
EP2744491B1 (en) 2011-08-19 2020-07-29 The University of Utah Research Foundation Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
JP2015508065A (ja) * 2012-02-03 2015-03-16 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 抗炎症薬としての脂肪酸
CN103417471A (zh) * 2012-05-22 2013-12-04 吴升华 一种治疗湿疹等皮肤炎症的脂氧素乳膏
EP3037090B1 (en) 2013-08-19 2019-07-31 Enzychem Lifesciences Corporation Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating rheumatoid arthritis
ES2810323T3 (es) * 2014-01-24 2021-03-08 Univ Kyoto Agente antiinflamatorio que contiene ácido graso raro
CN106535887A (zh) 2014-05-15 2017-03-22 株式会社Enzychem生命科学 治疗白细胞减少症和血小板减少症的方法
FI3865484T3 (fi) 2015-07-07 2024-01-24 H Lundbeck As Pde9:n estäjä, jossa on imidatsopyratsinonirunko, perifeeristen sairauksien hoitoon
KR20180098222A (ko) 2015-10-02 2018-09-03 컴플렉사, 인코포레이티드 활성화된 지방산의 치료학적 유효량을 이용한 질환의 예방, 치료 및 역행
US9808438B2 (en) * 2015-11-09 2017-11-07 Enzychem Lifesciences Corporation Method for treating mucositis
HRP20240363T1 (hr) 2018-05-25 2024-06-07 Cardurion Pharmaceuticals, Inc. Monohidratni i kristalni oblici 6-[(3s,4s)-4-metil-1-(pirimidin-2-ilmetil)pirolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a] pirazin-8-ona

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576758A (en) * 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
US6887901B1 (en) * 1993-06-15 2005-05-03 Brigham & Women's Hospital, Inc. Lipoxin compounds and their use in treating cell proliferative disorders
ATE466582T1 (de) * 1999-03-18 2010-05-15 Brigham & Womens Hospital 16-phenoxy-lipoxin analoge zur medizinischen verwendung
DE60144401D1 (de) * 2000-02-16 2011-05-19 Brigham & Womens Hospital Aspirin-ausgelöste Lipidmediatoren
US7700650B2 (en) * 2000-03-20 2010-04-20 Trustees Of Boston University Lipoxin analogs and method for the treatment of periodontal disease
DE60229640D1 (de) * 2001-03-02 2008-12-11 Brigham & Womens Hospital Lipoxin analoge als neue inhibitoren der angiogenese
US7304091B2 (en) * 2001-12-03 2007-12-04 Myco Teo A/S Statin-like compounds
EP2361622A1 (en) * 2001-12-18 2011-08-31 The Brigham and Women's Hospital Use of lipoxin analogs to promote cell defense against gram-negative infections
US7030159B2 (en) * 2001-12-18 2006-04-18 The Brigham And Women's Hospital, Inc. Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
DK2022775T3 (en) * 2002-04-01 2015-01-19 Univ Southern California polyunsaturated TRIHYDROXYEICOSANOIDER
EP1537069B1 (en) * 2002-06-17 2008-01-02 Resolvyx Pharmaceuticals ANALOGUES OF LIPID MEDIATORS DERIVED FROM OMEGA-3 PUFAs AND METHODS OF USE
US7759395B2 (en) * 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
EP3584235A3 (en) * 2002-08-12 2020-04-22 Brigham and Women's Hospital Resolvins: biotemplates for novel therapeutic interventions
WO2004110426A1 (en) * 2003-06-01 2004-12-23 Petasis Nicos A Modulation of airway inflammation in patients with cystic fibrosis and related diseases
US20050203184A1 (en) * 2003-09-10 2005-09-15 Petasis Nicos A. Benzo lipoxin analogues
KR20070090928A (ko) * 2004-11-19 2007-09-06 마텍 바이오싸이언스스 코포레이션 장쇄 다가불포화 지방산으로부터의 옥시리핀, 및 이의 제조방법 및 사용 방법
US20060293288A1 (en) * 2005-01-07 2006-12-28 Serhan Charles N Use of resolvins to treat gastrointestinal diseases

Also Published As

Publication number Publication date
US20100035989A1 (en) 2010-02-11
KR20090040323A (ko) 2009-04-23
IL196465A0 (en) 2009-11-18
RU2009101324A (ru) 2010-07-27
SG173397A1 (en) 2011-08-29
CA2658361C (en) 2013-04-23
AU2007275658B2 (en) 2011-09-01
EP2049099A1 (en) 2009-04-22
AU2007275658A1 (en) 2008-01-24
MX2009000657A (es) 2009-05-28
WO2008011085A1 (en) 2008-01-24
CN101528218A (zh) 2009-09-09
ZA200900388B (en) 2010-03-31
CA2658361A1 (en) 2008-01-24
JP2009545527A (ja) 2009-12-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2315 DE 19-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.