BRPI0707239A8 - peptídeo de ligação de fgf2, peptídeo quimérico fundido ou conjugado, molécula de ácido nucléico, vetor de expressão, célula hospedeira e composição farmacêutica - Google Patents

peptídeo de ligação de fgf2, peptídeo quimérico fundido ou conjugado, molécula de ácido nucléico, vetor de expressão, célula hospedeira e composição farmacêutica

Info

Publication number
BRPI0707239A8
BRPI0707239A8 BRPI0707239A BRPI0707239A BRPI0707239A8 BR PI0707239 A8 BRPI0707239 A8 BR PI0707239A8 BR PI0707239 A BRPI0707239 A BR PI0707239A BR PI0707239 A BRPI0707239 A BR PI0707239A BR PI0707239 A8 BRPI0707239 A8 BR PI0707239A8
Authority
BR
Brazil
Prior art keywords
fused
nucleic acid
peptide
pharmaceutical composition
host cell
Prior art date
Application number
BRPI0707239A
Other languages
English (en)
Inventor
Mastroianni Domenico
Presta Marco
Rusnati Marco
Camozzi Maura
Colombo Maurizio
Original Assignee
Sigma Tau Ind Farmaceuti
Tecnogen Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Tecnogen Spa filed Critical Sigma Tau Ind Farmaceuti
Publication of BRPI0707239A2 publication Critical patent/BRPI0707239A2/pt
Publication of BRPI0707239A8 publication Critical patent/BRPI0707239A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)

Abstract

peptideos de ligação de fgf-2 e usos dos mesmos a presente invenção refere-se a peptideos de ligação de fgf2 são aqui descritos, os quais foram projetados partindo da região de n-terminal de ptx3, em particular abrangendo a região de ptx3(82-1 10).peptídeos sintéticos relacionados a esta seqúência são capazes de ligar fgf2 e inibir sua atividade pró-angiogênica in vitro e in vivo sem impacto antecipado em imunidade inata.
BRPI0707239A 2006-01-24 2007-01-23 peptídeo de ligação de fgf2, peptídeo quimérico fundido ou conjugado, molécula de ácido nucléico, vetor de expressão, célula hospedeira e composição farmacêutica BRPI0707239A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06001457.8 2006-01-24
EP06001457 2006-01-24
PCT/EP2007/000538 WO2007085412A1 (en) 2006-01-24 2007-01-23 Fgf2-binding peptides and uses thereof

Publications (2)

Publication Number Publication Date
BRPI0707239A2 BRPI0707239A2 (pt) 2011-04-26
BRPI0707239A8 true BRPI0707239A8 (pt) 2018-01-30

Family

ID=37421191

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707239A BRPI0707239A8 (pt) 2006-01-24 2007-01-23 peptídeo de ligação de fgf2, peptídeo quimérico fundido ou conjugado, molécula de ácido nucléico, vetor de expressão, célula hospedeira e composição farmacêutica

Country Status (19)

Country Link
US (1) US8076300B2 (pt)
EP (1) EP1973944B1 (pt)
JP (1) JP5427415B2 (pt)
KR (1) KR101467453B1 (pt)
CN (1) CN101384622B (pt)
AU (1) AU2007209581B2 (pt)
BR (1) BRPI0707239A8 (pt)
CA (1) CA2637295C (pt)
DK (1) DK1973944T3 (pt)
EA (1) EA015339B1 (pt)
ES (1) ES2575517T3 (pt)
HR (1) HRP20160600T1 (pt)
HU (1) HUE029212T2 (pt)
IL (1) IL192800A (pt)
MX (1) MX2008009289A (pt)
PL (1) PL1973944T3 (pt)
PT (1) PT1973944T (pt)
SI (1) SI1973944T1 (pt)
WO (1) WO2007085412A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11512141B2 (en) 2017-05-05 2022-11-29 Board Of Regents, The University Of Texas System Fibrinogen-like protein 2 (FGL2) monoclonal antibodies and their use in cancer detection and treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1298487B1 (it) * 1997-12-19 2000-01-10 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
IT1317930B1 (it) * 2000-11-08 2003-07-15 Sigma Tau Ind Farmaceuti Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patalogie associate ad una alterata attivazione
ITRM20020109A1 (it) * 2002-02-28 2003-08-28 Sigma Tau Ind Farmaceuti Derivati funzionali della pentraxina lunga ptx3 per preparare un vaccino autologo per la cura dei tumori.

Also Published As

Publication number Publication date
WO2007085412B1 (en) 2007-10-11
KR101467453B1 (ko) 2014-12-01
US20090215689A1 (en) 2009-08-27
EP1973944A1 (en) 2008-10-01
PT1973944T (pt) 2016-07-07
US8076300B2 (en) 2011-12-13
AU2007209581B2 (en) 2013-03-28
JP5427415B2 (ja) 2014-02-26
CA2637295C (en) 2017-06-13
CN101384622B (zh) 2013-03-27
HUE029212T2 (en) 2017-02-28
KR20080096794A (ko) 2008-11-03
SI1973944T1 (sl) 2016-07-29
CN101384622A (zh) 2009-03-11
MX2008009289A (es) 2008-10-17
ES2575517T3 (es) 2016-06-29
IL192800A0 (en) 2009-02-11
WO2007085412A1 (en) 2007-08-02
PL1973944T3 (pl) 2016-09-30
IL192800A (en) 2015-04-30
AU2007209581A1 (en) 2007-08-02
EA015339B1 (ru) 2011-06-30
EP1973944B1 (en) 2016-05-11
JP2009523457A (ja) 2009-06-25
EA200870188A1 (ru) 2009-02-27
CA2637295A1 (en) 2007-08-02
HRP20160600T1 (hr) 2016-07-01
DK1973944T3 (en) 2016-06-27
BRPI0707239A2 (pt) 2011-04-26

Similar Documents

Publication Publication Date Title
HRP20200325T1 (hr) T-stanični receptori koji prepoznaju mhc razred ii-ograničenog mage-a3
AR064555A1 (es) Peptido wt1 restringido a hla-a*1101 y composicion farmaceutica que comprende el mismo
PE20081140A1 (es) Agentes terapeuticos a base de peptidos derivados de toxinas
BR112019010699A2 (pt) receptores de células t e imunoterapia empregando os mesmos
BRPI0816405B8 (pt) complexos de rna e pepitídeos catiônicos para transfecção e para imunoestimulação
BRPI0807929A2 (pt) Anticorpo monoclonal humano isolado ou porção de ligação de antígeno do mesmo, polipeptídeo isolado, composição, ácido nucleico isolado, vetor de expressão, célula hospedeira, vacina do vírus da hepatite c (hcv), kit, métodos para tratar e detectar uma infecção por vírus da hepatite c (hcv) e para identificar um anticorpo ou fragmento do mesmo, anticorpo ou fragmento do mesmo, e, proteína e2 recombinante do vírus da hepatite c (hcv)
NZ602943A (en) Modified binding proteins inhibiting the vegf-a receptor interaction
WO2013151672A3 (en) Modified polynucleotides for the production of oncology-related proteins and peptides
RU2015143057A (ru) Гипергликозилированные связывающие полипептиды
CO6470863A2 (es) Mutantes fgf21 y usos de los mismos
WO2013036778A3 (en) Compstatin analogs with improved pharmacokinetic properties
NZ627111A (en) Variants of activin iib receptor polypeptides and uses thereof
PH12013502425A1 (en) Smoothened polypeptides and methods of use
BRPI0508935A (pt) agonistas de receptor seletivo y4 para intervenções terapêuticas
WO2011036445A3 (en) Polypeptides and uses thereof
ATE517118T1 (de) Bis-met-histone
WO2011036442A3 (en) Thrombin c- terminal polypeptides and uses thereof for treating inflammation coagulation disorders
WO2009004315A8 (en) Isolated peptides and uses thereof
HRP20150664T1 (hr) Antikancerogeni fuzijski protein
BR112014024282A2 (pt) anticorpos ligantes ao receptor b1 da bradicinina
WO2010085700A3 (en) Treatment for obesity
WO2012091564A3 (en) A cross linking polypeptide comprising an hexameric single chain antibody binding mhc-mage complex that induces apoptosis
WO2009081374A3 (en) Cosmetic use of plakoglobin-type proteins
WO2008093058A3 (en) Peptides and their use
CL2020003292A1 (es) Péptido que consiste en la secuencia de aminoácidos de seq id no: 2; anticuerpo que reconoce dicho péptido; receptor de linfocito t; célula hospedadora; linfocito t activado; composición farmacéutica; uso; y kit (divisional de la solicitud no. 201802969)

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2550 DE 19-11-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.