BRPI0507436A - conjugados antagonistas de receptor do hormÈnio do crescimento humano quimicamente modificados - Google Patents
conjugados antagonistas de receptor do hormÈnio do crescimento humano quimicamente modificadosInfo
- Publication number
- BRPI0507436A BRPI0507436A BRPI0507436-3A BRPI0507436A BRPI0507436A BR PI0507436 A BRPI0507436 A BR PI0507436A BR PI0507436 A BRPI0507436 A BR PI0507436A BR PI0507436 A BRPI0507436 A BR PI0507436A
- Authority
- BR
- Brazil
- Prior art keywords
- chemically modified
- human growth
- modified human
- growth hormone
- receptor antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
CONJUGADOS ANTAGONISTAS DO RECEPTOR DO HORMÈNIO DO CRESCIMENTO HUMANO QUIMICAMENTE MODIFICADOS A presente invenção fornece antagonistas do receptor do hormónio do crescimento humano (hGH) quimicamente modificados preparados anexando um fração de polietileno glicol única ao N-terminal. A proteína quimicamente modificada de acordo com a presente invenção tem menor heterogeneidade de Peguilação e pode ter maior afinidade de ligação.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54307804P | 2004-02-09 | 2004-02-09 | |
PCT/IB2005/000228 WO2005075021A2 (en) | 2004-02-09 | 2005-01-31 | Chemically-modified human growth hormone receptor antagonist conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507436A true BRPI0507436A (pt) | 2007-07-03 |
Family
ID=34837575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507436-3A BRPI0507436A (pt) | 2004-02-09 | 2005-01-31 | conjugados antagonistas de receptor do hormÈnio do crescimento humano quimicamente modificados |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090203589A1 (pt) |
EP (1) | EP1715895A2 (pt) |
JP (1) | JP2007522198A (pt) |
BR (1) | BRPI0507436A (pt) |
CA (1) | CA2553899A1 (pt) |
MX (1) | MXPA06007848A (pt) |
WO (1) | WO2005075021A2 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101448512B (zh) * | 2005-12-14 | 2015-11-25 | Ambrx公司 | 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及非天然氨基酸和多肽的用途 |
EP2076245A2 (en) * | 2006-09-15 | 2009-07-08 | Enzon Pharmaceuticals, Inc. | Lysine-based polymeric linkers |
WO2013113074A1 (en) * | 2012-02-03 | 2013-08-08 | Antisense Therapeutics Ltd | Combination therapy comprising a growth hormone variant and an oligonucleotide targeted to the growth hormone receptor |
KR102167827B1 (ko) | 2017-12-20 | 2020-10-20 | 주식회사 알테오젠 | 신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질 |
EP3983002A4 (en) | 2019-06-17 | 2023-08-02 | Molecular Technologies Laboratories LLC | THERAPEUTIC PEGYLATED GROWTH HORMONE ANTAGONISTS |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE122006000003I1 (de) * | 1995-09-21 | 2006-05-04 | Genentech Inc | Varianten des Menschlichen Wachstumshormons |
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
WO2004026251A2 (en) * | 2002-09-20 | 2004-04-01 | Pharmacia Corporation | Process for decreasing aggregate levels of pegylated protein |
TWI281864B (en) * | 2002-11-20 | 2007-06-01 | Pharmacia Corp | N-terminally monopegylated human growth hormone conjugates and process for their preparation |
WO2004060406A2 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Polymeric reagents comprising a ketone or a related functional group |
-
2005
- 2005-01-31 EP EP05702379A patent/EP1715895A2/en not_active Withdrawn
- 2005-01-31 JP JP2006552707A patent/JP2007522198A/ja not_active Withdrawn
- 2005-01-31 WO PCT/IB2005/000228 patent/WO2005075021A2/en active Application Filing
- 2005-01-31 MX MXPA06007848A patent/MXPA06007848A/es unknown
- 2005-01-31 US US11/815,842 patent/US20090203589A1/en not_active Abandoned
- 2005-01-31 BR BRPI0507436-3A patent/BRPI0507436A/pt not_active IP Right Cessation
- 2005-01-31 CA CA002553899A patent/CA2553899A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2007522198A (ja) | 2007-08-09 |
MXPA06007848A (es) | 2006-09-04 |
CA2553899A1 (en) | 2005-08-18 |
WO2005075021A3 (en) | 2006-07-20 |
WO2005075021A2 (en) | 2005-08-18 |
EP1715895A2 (en) | 2006-11-02 |
US20090203589A1 (en) | 2009-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/48 (2006.01), A61P 5/04 (2006.01) |
|
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/60 (2017.01), A61P 5/04 (2006.01) |