BRPI0506507A - processo para a purificação de ramipril, monohidrato de ramipril, processo para a preparação de monohidrato de ramipril e composição farmacêutica - Google Patents

processo para a purificação de ramipril, monohidrato de ramipril, processo para a preparação de monohidrato de ramipril e composição farmacêutica

Info

Publication number
BRPI0506507A
BRPI0506507A BRPI0506507-0A BRPI0506507A BRPI0506507A BR PI0506507 A BRPI0506507 A BR PI0506507A BR PI0506507 A BRPI0506507 A BR PI0506507A BR PI0506507 A BRPI0506507 A BR PI0506507A
Authority
BR
Brazil
Prior art keywords
ramipril
monohydrate
purifying
pharmaceutical composition
preparing
Prior art date
Application number
BRPI0506507-0A
Other languages
English (en)
Inventor
Girij Pal Singh
Umesh Babanrao Rananaware
Vilas Nathu Dhake
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of BRPI0506507A publication Critical patent/BRPI0506507A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"PROCESSO PARA A PURIFICAçãO DE RAMIPRIL, MONOHIDRATO DE RAMIPRIL, PROCESSO PARA A PREPARAçãO DE MONOHIDRATO DE RAMIPRIL E COMPOSIçãO FARMACêUTICA". A presente invenção refere-se a um novo método inovador para a obtenção de ácido (2S, 3aS, 6aS) -1- ¢(S)-2-¢¢(S)-1-(etoxicarbonila)-3-fenilpropila!-amino!propanoila!octahid rociclopenta¢b!pirrolo-2-carboxílico, também conhecido como Ramipril(I) com uma alta pureza ótica, livre de outros estéreo isómeros, e com uma alta densidade de massa. A presente invenção também refere-se a uma nova forma hidratada de Ramipril (I) e a um processo para a preparação da mesma.
BRPI0506507-0A 2004-01-19 2005-01-17 processo para a purificação de ramipril, monohidrato de ramipril, processo para a preparação de monohidrato de ramipril e composição farmacêutica BRPI0506507A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN56MU2004 2004-01-19
PCT/IN2005/000019 WO2005068422A2 (en) 2004-01-19 2005-01-17 Process for crystallization of ramipril and preparation of a hydrated form thereof

Publications (1)

Publication Number Publication Date
BRPI0506507A true BRPI0506507A (pt) 2007-02-27

Family

ID=34779381

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506507-0A BRPI0506507A (pt) 2004-01-19 2005-01-17 processo para a purificação de ramipril, monohidrato de ramipril, processo para a preparação de monohidrato de ramipril e composição farmacêutica

Country Status (10)

Country Link
US (1) US7732620B2 (pt)
EP (1) EP1706378A2 (pt)
JP (1) JP2007518794A (pt)
AU (1) AU2005205251B2 (pt)
BR (1) BRPI0506507A (pt)
CA (1) CA2554199C (pt)
IL (1) IL176959A0 (pt)
MX (1) MXPA06008148A (pt)
WO (1) WO2005068422A2 (pt)
ZA (1) ZA200605793B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009126186A1 (en) 2008-04-10 2009-10-15 Cardinal Ig Company Manufacturing of photovoltaic subassemblies
CN109721524A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种雷米普利的精制方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
US6407262B1 (en) * 2001-11-21 2002-06-18 Brantford Chemicals Inc. Process for the preparation of Ramipril
US6541635B1 (en) * 2002-03-29 2003-04-01 Everlight Usa, Inc. Method for producing angiotensin converting enzyme inhibitor
WO2004064809A1 (en) 2003-01-22 2004-08-05 Sandoz Ag Solid pharmaceutical composition comprising ramipril

Also Published As

Publication number Publication date
WO2005068422A2 (en) 2005-07-28
ZA200605793B (en) 2007-04-25
IL176959A0 (en) 2006-12-10
US20080171780A1 (en) 2008-07-17
WO2005068422A3 (en) 2006-01-19
EP1706378A2 (en) 2006-10-04
AU2005205251A1 (en) 2005-07-28
US7732620B2 (en) 2010-06-08
AU2005205251B2 (en) 2008-07-03
CA2554199C (en) 2013-07-02
CA2554199A1 (en) 2005-07-28
JP2007518794A (ja) 2007-07-12
MXPA06008148A (es) 2007-01-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2094 DE 22/02/2011.