BRPI0414450A - derivados de diazabicicloalcano substituìdos como ligandos nos receptores de alfa 7 acetilcolina nicotìnica - Google Patents
derivados de diazabicicloalcano substituìdos como ligandos nos receptores de alfa 7 acetilcolina nicotìnicaInfo
- Publication number
- BRPI0414450A BRPI0414450A BRPI0414450-3A BRPI0414450A BRPI0414450A BR PI0414450 A BRPI0414450 A BR PI0414450A BR PI0414450 A BRPI0414450 A BR PI0414450A BR PI0414450 A BRPI0414450 A BR PI0414450A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- substituted
- ligands
- phenyl
- nicotinically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DE DIAZABICICLOALCANO SUBSTITUìDOS COMO LIGANDOS NOS RECEPTORES DE ALFA 7 ACETILCOLINA NICOTìNICA". Compostos da fórmula (1) Z Ar~ 1~ Ar~ 2~ onde Z é uma amina diazabicíclica, Ar~ 1~ é um anel aromático com 5 ou 6 membros, e Ar~ 2~ é escolhido do grupo consistindo de um anel heteroarila de 5 ou 6 membros, substituído ou insubstituido; um anel heteroarila bicíclico substituído ou insubstituido; 3,4 (metilenodioxi)fenila; carbazolila; tetrahidrocarbazolila; naftila; e fenila; onde a fenila é substituída por 0, 1, 2, ou 3 substituintes nas posições meta ou para . Os compostos são úteis no tratamento de condições ou distúrbios evitados ou melhorados por ligandos <244>7 nAChR. Também são apresentadas composições farmacêuticas compreendendo compostos da fórmula (I), e métodos para o uso de tais compostos e composições.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/666,884 US20050065178A1 (en) | 2003-09-19 | 2003-09-19 | Substituted diazabicycloakane derivatives |
PCT/US2004/030735 WO2005028477A1 (en) | 2003-09-19 | 2004-09-17 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acety lcholine receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414450A true BRPI0414450A (pt) | 2006-11-14 |
Family
ID=34313215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414450-3A BRPI0414450A (pt) | 2003-09-19 | 2004-09-17 | derivados de diazabicicloalcano substituìdos como ligandos nos receptores de alfa 7 acetilcolina nicotìnica |
Country Status (13)
Country | Link |
---|---|
US (1) | US20050065178A1 (pt) |
EP (2) | EP2316836A1 (pt) |
JP (1) | JP2007521323A (pt) |
KR (1) | KR20060109428A (pt) |
CN (1) | CN101189233A (pt) |
AU (2) | AU2004274492B2 (pt) |
BR (1) | BRPI0414450A (pt) |
CA (1) | CA2538789A1 (pt) |
IL (1) | IL174400A0 (pt) |
NZ (1) | NZ545789A (pt) |
TW (1) | TW200526667A (pt) |
WO (1) | WO2005028477A1 (pt) |
ZA (1) | ZA200602274B (pt) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
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BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
CN101083994A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途 |
AR051090A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
AR051202A1 (es) | 2004-09-20 | 2006-12-27 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
EP1799668A1 (en) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
CN101083992A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物 |
NZ553622A (en) * | 2004-10-20 | 2010-08-27 | Neurosearch As | Novel diazabicyclic aryl derivatives and their medical use |
CA2601509A1 (en) * | 2005-03-18 | 2006-09-28 | Abbott Laboratories | Alpha7 neuronal nicotinic receptor ligand and antipsychotic compositions |
EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
US7524921B2 (en) * | 2005-12-21 | 2009-04-28 | E. I. Du Pont De Nemours And Company | Continuous manufacture of poly(trimethylene terephthalate) |
US7504474B2 (en) * | 2005-12-21 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Poly(trimethylene therephthalate) continuous manufacturing process |
US7531617B2 (en) * | 2005-12-21 | 2009-05-12 | E. I. Du Pont De Nemours And Company | Continuous process for producing poly(trimethylene terephthalate) |
JP2009544580A (ja) * | 2006-06-27 | 2009-12-17 | アボット・ラボラトリーズ | チアゾリンおよびオキサゾリン誘導体ならびにそれらの使用方法 |
JP2009544581A (ja) * | 2006-06-27 | 2009-12-17 | アボット・ラボラトリーズ | ピロール誘導体およびそれの使用方法 |
EP2049110B1 (en) * | 2006-07-14 | 2014-08-20 | Merck Sharp & Dohme Corp. | Bridged diazepan orexin receptor antagonists |
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
US8076350B2 (en) | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
JP5628043B2 (ja) * | 2007-11-21 | 2014-11-19 | アッヴィ・インコーポレイテッド | ビアリール置換ジアザビシクロアルカン誘導体 |
KR20100090706A (ko) * | 2007-11-21 | 2010-08-16 | 아보트 러보러터리즈 | 니코틴성 아세틸콜린 수용체 활성 조절제로서의 비아릴 치환된 아자바이사이클릭 알칸 유도체 |
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CA2713519A1 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
US7786171B2 (en) | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
US8148408B2 (en) | 2008-05-09 | 2012-04-03 | Abbott Laboratories | Selective substituted pyridine ligands for neuronal nicotinic receptors |
FR2937641A1 (fr) | 2008-10-28 | 2010-04-30 | Sanofi Aventis | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
US8563579B2 (en) * | 2009-01-15 | 2013-10-22 | Anvyl Llc | α-7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
AU2010262643B2 (en) * | 2009-06-19 | 2015-02-19 | Abbvie Inc. | Diazahomoadamantane derivatives and methods of use thereof |
US8796297B2 (en) * | 2009-06-30 | 2014-08-05 | Abbvie Inc. | 4-substituted-2-amino-pyrimidine derivatives |
TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
WO2011050202A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
USRE48841E1 (en) | 2009-10-23 | 2021-12-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
EP2491034B1 (en) | 2009-10-23 | 2013-12-18 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as orexin receptor modulators |
PE20131394A1 (es) | 2010-09-23 | 2014-01-11 | Abbvie Inc | Monohidrato de derivados de aza-adamantano |
MX2013008704A (es) | 2011-01-27 | 2013-08-21 | Novartis Ag | Uso de activadores del receptor de acetil-colina nicotinico alfa-7. |
EA201391348A8 (ru) | 2011-03-18 | 2014-11-28 | Новартис Аг | КОМБИНАЦИИ АКТИВАТОРОВ АЛЬФА-7 НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА И АНТАГОНИСТОВ mGluR5, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ ПРИ ВЫЗВАННОЙ ДОПАМИНОМ ДИСКИНЕЗИИ, СВЯЗАННОЙ С БОЛЕЗНЬЮ ПАРКИНСОНА |
US9586962B2 (en) | 2011-04-20 | 2017-03-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators |
MX2013013326A (es) | 2011-06-30 | 2014-02-27 | Toray Industries | Agente antipruritico. |
TW201311698A (zh) * | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之1,4-二氮雜雙環[3.2.2]壬烷 |
CA3083244C (en) | 2011-10-20 | 2023-01-03 | Novartis Ag | Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
WO2014009872A1 (en) | 2012-07-09 | 2014-01-16 | Lupin Limited | Tetrahydroquinazolinone derivatives as parp inhibitors |
CN102977105A (zh) * | 2012-11-30 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 3(甲基),7-二氮杂双环辛烷的合成 |
BR112015013771B1 (pt) | 2012-12-11 | 2022-10-04 | Novartis Ag | Composição que compreende um ativador do receptor alfa 7, nicotínico de acetilcolina (nachr) como biomarcador preditivo de resposta ao tratamento de ativador do dito receptor |
US9040712B2 (en) * | 2013-01-23 | 2015-05-26 | Novartis Ag | Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions |
US10301294B2 (en) | 2013-03-13 | 2019-05-28 | The Broad Institute Inc. | Compounds for the treatment of tuberculosis |
JP7066622B2 (ja) | 2016-03-10 | 2022-05-13 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン-2受容体アンタゴニストを用いてうつ病を治療する方法 |
CN107188900B (zh) * | 2017-05-27 | 2019-09-06 | 北京师范大学 | α7烟碱型乙酰胆碱受体的配体化合物及其应用 |
EP3802497B1 (de) * | 2018-05-24 | 2022-07-06 | Bayer Animal Health GmbH | Verfahren zur herstellung von halogenierten n-arylpyrazolen |
BR112021009211A2 (pt) | 2018-11-14 | 2021-08-03 | Janssen Pharmaceutica N.V. | métodos sintéticos aprimorados de produção de compostos heterocíclicos fundidos como moduladores de receptor de orexina |
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EP0393424B1 (de) | 1989-04-17 | 1995-09-27 | Bayer Ag | Verfahren zur Herstellung von 2,7-Diazabicyclo(3.3.0)octanen |
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EP1289996B1 (en) * | 2000-05-25 | 2005-04-06 | Targacept, Inc. | Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands |
AU2001267483A1 (en) | 2000-05-31 | 2001-12-11 | Aventis Pharma Deutschland Gmbh | Aryloxy ester and acid compounds |
WO2002002564A1 (en) * | 2000-07-04 | 2002-01-10 | Neurosearch A/S | Aryl and heteroaryl diazabicycloalkanes, their preparation and use |
JP4365094B2 (ja) * | 2001-03-02 | 2009-11-18 | メルク フロスト カナダ リミテツド | カテプシンシステインプロテアーゼ阻害薬 |
DE60203007T2 (de) * | 2001-06-01 | 2005-07-07 | Neurosearch A/S | Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren |
MXPA04010966A (es) * | 2002-05-07 | 2005-01-25 | Neurosearch As | Derivados novedosos de biarilo diazabiciclico. |
DE10232572A1 (de) * | 2002-07-18 | 2004-02-05 | Bayer Ag | Neue 2,5-disubstituierte Pyrimidinderivate |
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2003
- 2003-09-19 US US10/666,884 patent/US20050065178A1/en not_active Abandoned
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2004
- 2004-09-17 CA CA002538789A patent/CA2538789A1/en not_active Abandoned
- 2004-09-17 JP JP2006527109A patent/JP2007521323A/ja active Pending
- 2004-09-17 TW TW093128238A patent/TW200526667A/zh unknown
- 2004-09-17 NZ NZ545789A patent/NZ545789A/en unknown
- 2004-09-17 BR BRPI0414450-3A patent/BRPI0414450A/pt not_active IP Right Cessation
- 2004-09-17 EP EP10175824A patent/EP2316836A1/en not_active Withdrawn
- 2004-09-17 EP EP04784568A patent/EP1664045A1/en not_active Withdrawn
- 2004-09-17 KR KR1020067005426A patent/KR20060109428A/ko not_active Application Discontinuation
- 2004-09-17 WO PCT/US2004/030735 patent/WO2005028477A1/en active Application Filing
- 2004-09-17 CN CNA2004800335279A patent/CN101189233A/zh active Pending
- 2004-09-17 AU AU2004274492A patent/AU2004274492B2/en not_active Ceased
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2006
- 2006-03-17 ZA ZA200602274A patent/ZA200602274B/en unknown
- 2006-03-19 IL IL174400A patent/IL174400A0/en unknown
-
2010
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Also Published As
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JP2007521323A (ja) | 2007-08-02 |
AU2004274492A1 (en) | 2005-03-31 |
AU2010202299A1 (en) | 2010-06-24 |
EP1664045A1 (en) | 2006-06-07 |
WO2005028477A1 (en) | 2005-03-31 |
AU2004274492B2 (en) | 2010-04-29 |
EP2316836A1 (en) | 2011-05-04 |
TW200526667A (en) | 2005-08-16 |
NZ545789A (en) | 2010-03-26 |
CA2538789A1 (en) | 2005-03-31 |
IL174400A0 (en) | 2006-08-01 |
US20050065178A1 (en) | 2005-03-24 |
KR20060109428A (ko) | 2006-10-20 |
CN101189233A (zh) | 2008-05-28 |
ZA200602274B (en) | 2007-11-28 |
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