BRPI0412582A - plantas produtoras de ácido hialurÈnico - Google Patents

plantas produtoras de ácido hialurÈnico

Info

Publication number
BRPI0412582A
BRPI0412582A BRPI0412582-7A BRPI0412582A BRPI0412582A BR PI0412582 A BRPI0412582 A BR PI0412582A BR PI0412582 A BRPI0412582 A BR PI0412582A BR PI0412582 A BRPI0412582 A BR PI0412582A
Authority
BR
Brazil
Prior art keywords
hyaluronic acid
amino acid
acid producing
producing plants
dna encoding
Prior art date
Application number
BRPI0412582-7A
Other languages
English (en)
Inventor
Shigeo Shibatani
Shuhei Misawa
Izumi Ihara
Hiroaki Kitazawa
Original Assignee
Toyo Boseki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Boseki filed Critical Toyo Boseki
Publication of BRPI0412582A publication Critical patent/BRPI0412582A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Abstract

"PLANTAS PRODUTORAS DE áCIDO HIALURÈNICO". A presente invenção refere-se a um método de produção de ácido hialurónico que compreende (1) uma etapa de transformação de uma célula de planta empregando-se um vetor recombinante de expressão que compreende (i) um DNA de codificação de ácido hialurónico sintase ou (ii) um DNA de codificação de um polipeptídeo que tem uma seqüência de aminoácido que tem uma ou mais deleções, substituições, adições ou inserções de aminoácido em uma seqüência de aminoácido da ácido hialurónico sintase e que tem uma atividade de sintetização do ácido hialurónico, (2) uma etapa de desenvolvimento de um transformante obtido através de transformação, e (3) uma etapa de separação do ácido hialurónico produzido pelo transformante.
BRPI0412582-7A 2003-07-31 2004-07-30 plantas produtoras de ácido hialurÈnico BRPI0412582A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003204896 2003-07-31
JP2004089135 2004-03-25
PCT/JP2004/011306 WO2005012529A1 (ja) 2003-07-31 2004-07-30 ヒアルロン酸生産植物

Publications (1)

Publication Number Publication Date
BRPI0412582A true BRPI0412582A (pt) 2006-09-19

Family

ID=34117895

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412582-7A BRPI0412582A (pt) 2003-07-31 2004-07-30 plantas produtoras de ácido hialurÈnico

Country Status (9)

Country Link
US (1) US7547819B2 (pt)
EP (1) EP1652928B1 (pt)
JP (1) JP4816082B2 (pt)
CN (1) CN1833026A (pt)
BR (1) BRPI0412582A (pt)
CA (1) CA2533925C (pt)
DE (1) DE602004030345D1 (pt)
ES (1) ES2354696T3 (pt)
WO (1) WO2005012529A1 (pt)

Families Citing this family (195)

* Cited by examiner, † Cited by third party
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