BRPI0410953A - elastomeric deposit compositions which may be implanted, uses thereof and production process - Google Patents

elastomeric deposit compositions which may be implanted, uses thereof and production process

Info

Publication number
BRPI0410953A
BRPI0410953A BRPI0410953-8A BRPI0410953A BRPI0410953A BR PI0410953 A BRPI0410953 A BR PI0410953A BR PI0410953 A BRPI0410953 A BR PI0410953A BR PI0410953 A BRPI0410953 A BR PI0410953A
Authority
BR
Brazil
Prior art keywords
compositions
elastomeric
production process
beneficial agent
implanted
Prior art date
Application number
BRPI0410953-8A
Other languages
Portuguese (pt)
Inventor
Guohua Chen
Paul Houston
Lothar Kleiner
Aruna Nathan
Joe Rosenblatt
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0410953A publication Critical patent/BRPI0410953A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating

Abstract

"COMPOSIçõES DE DEPóSITO ELASTOMéRICAS QUE PODEM SER IMPLANTADAS, USOS DAS MESMAS E PROCESSO DE PRODUçãO". A presente invenção refere-se a processos e composições para a administração sistêmica ou local de um agente benéfico a um indivíduo que incluem, por exemplo, composições de depósito elastoméricas que podem ser implantadas que podem ser injetadas em um local desejado e que pode fornecer a liberação controlada de um agente benéfico ao longo de um período de tempo prolongado. As composições incluem um polímero elastomérico biocompatível, um solvente biocompatível que possui baixa capacidade de se misturar em água que forma um gel elastomérico viscoso com o polímero e limita a captação de água pelo implante e um agente benéfico."ELASTOMERIC DEPOSIT COMPOSITIONS THAT MAY BE IMPLEMENTED, USES OF THE SAME AND PRODUCTION PROCESS". The present invention relates to methods and compositions for the systemic or local administration of a beneficial agent to an individual which include, for example, implantable elastomeric depot compositions which may be injected at a desired location and which may provide the controlled release of a beneficial agent over an extended period of time. Compositions include a biocompatible elastomeric polymer, a biocompatible solvent that has a low ability to mix in water that forms a viscous elastomeric gel with the polymer and limits the uptake of water by the implant and a beneficial agent.

BRPI0410953-8A 2003-05-30 2004-05-28 elastomeric deposit compositions which may be implanted, uses thereof and production process BRPI0410953A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47487403P 2003-05-30 2003-05-30
PCT/US2004/017004 WO2004108111A1 (en) 2003-05-30 2004-05-28 Implantable elastomeric depot compositions, uses thereof and method of manufacturing

Publications (1)

Publication Number Publication Date
BRPI0410953A true BRPI0410953A (en) 2006-06-27

Family

ID=33511636

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410953-8A BRPI0410953A (en) 2003-05-30 2004-05-28 elastomeric deposit compositions which may be implanted, uses thereof and production process

Country Status (11)

Country Link
US (1) US20050079202A1 (en)
EP (1) EP1643968A1 (en)
KR (1) KR20060023140A (en)
CN (1) CN1822816A (en)
AU (1) AU2004245022A1 (en)
BR (1) BRPI0410953A (en)
CA (1) CA2527664A1 (en)
MX (1) MXPA05013003A (en)
NO (1) NO20056200L (en)
WO (1) WO2004108111A1 (en)
ZA (1) ZA200510472B (en)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
DK1539101T3 (en) 2002-07-31 2009-04-27 Alza Corp Injectable, multi-modal polymeric compositions and applications thereof
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) * 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7252834B2 (en) 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue
US20070043416A1 (en) * 2005-08-19 2007-02-22 Cardiac Pacemakers, Inc. Implantable electrode array
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
US20070253994A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Intraspinal Drug Delivery Methods and Devices To Alleviate Chronic Pelvic Pain
MX2008014870A (en) 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Two-piece, internal-channel osmotic delivery system flow modulator.
US9173773B2 (en) * 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
ES2422864T3 (en) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Osmotic release systems and piston units
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
JP2010531807A (en) 2007-05-25 2010-09-30 トルマー セラピューティクス， インコーポレイテッド Slow-broadcast formulation of risperidone compound
US20090004243A1 (en) * 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
US8661630B2 (en) 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
US20090306120A1 (en) * 2007-10-23 2009-12-10 Florencia Lim Terpolymers containing lactide and glycolide
US20090104241A1 (en) * 2007-10-23 2009-04-23 Pacetti Stephen D Random amorphous terpolymer containing lactide and glycolide
US20090110713A1 (en) 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
WO2009064806A1 (en) * 2007-11-12 2009-05-22 Endologix, Inc. Method and agent for in-situ stabilization of vascular tissue
US9090737B2 (en) * 2007-11-13 2015-07-28 Surmodics, Inc. Viscous terpolymers as drug delivery platform
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
WO2009105265A2 (en) * 2008-02-21 2009-08-27 Vatrix Medical, Inc. Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle
US8557273B2 (en) * 2008-04-18 2013-10-15 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
US8420114B2 (en) * 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
US20090263443A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedics, Inc. Methods for treating post-operative effects such as spasticity and shivering with clondine
US8629172B2 (en) * 2008-04-18 2014-01-14 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising clonidine
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8697113B2 (en) * 2008-05-21 2014-04-15 Abbott Cardiovascular Systems Inc. Coating comprising a terpolymer comprising caprolactone and glycolide
US20100016833A1 (en) * 2008-07-15 2010-01-21 Ogle Matthew F Devices for the Treatment of Vascular Aneurysm
GB0819296D0 (en) * 2008-10-21 2008-11-26 Smith & Nephew Coating II
US20100119605A1 (en) * 2008-11-12 2010-05-13 Isenburg Jason C Compositions for tissue stabilization
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US8974808B2 (en) * 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
US20100261662A1 (en) * 2009-04-09 2010-10-14 Endologix, Inc. Utilization of mural thrombus for local drug delivery into vascular tissue
US8697110B2 (en) * 2009-05-14 2014-04-15 Abbott Cardiovascular Systems Inc. Polymers comprising amorphous terpolymers and semicrystalline blocks
WO2011037623A1 (en) 2009-09-28 2011-03-31 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
WO2011044455A1 (en) * 2009-10-09 2011-04-14 Vatrix Medical, Inc. In vivo chemical stabilization of vulnerable plaque
US8444624B2 (en) 2009-10-19 2013-05-21 Vatrix Medical, Inc. Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections
US20110097375A1 (en) * 2009-10-26 2011-04-28 Warsaw Orthopedic, Inc. Formulation for preventing or reducing bleeding at a surgical site
US20110097380A1 (en) * 2009-10-28 2011-04-28 Warsaw Orthopedic, Inc. Clonidine formulations having antimicrobial properties
US9993441B2 (en) 2009-12-30 2018-06-12 Surmodics, Inc. Controlled release matrix barrier structure for subcutaneous medical devices
WO2012030821A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymer blends and their use as pressure-sensitive adhesives
WO2012075447A2 (en) 2010-12-03 2012-06-07 Warsaw Orthopedic, Inc. Compositions and methods for delivering clonidine and bupivacaine to a target tissue site
WO2012075451A2 (en) 2010-12-03 2012-06-07 Warsaw Orthopedic, Inc. Clonidine and gaba compounds in a biodegradable polymer carrier
US8911468B2 (en) 2011-01-31 2014-12-16 Vatrix Medical, Inc. Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN102198080B (en) * 2011-05-18 2012-12-05 山东省医疗器械研究所 Adriamycin sustained-release medicinal rod for treating Cerebral gliomas disease and preparation method thereof
WO2012158944A1 (en) 2011-05-18 2012-11-22 Vatrix Medical, Inc. Coated balloons for blood vessel stabilization
PL2717914T3 (en) * 2011-06-10 2020-05-18 Ramscor, Inc. Sustained release formulations for delivery of proteins to the eye and methods of preparing same
CN102274164B (en) * 2011-08-22 2014-07-02 长春健欣生物医药科技开发有限公司 Sustained release gel for injection for paliperidone and paliperidone derivative
CN103998026B (en) * 2011-10-24 2017-08-04 布雷本制药有限公司 Implantable drug delivery composition and its treatment method
AU2012321101A1 (en) * 2011-11-23 2013-06-06 Durect Corporation Radiation-sterilized biodegradable drug delivery compositions
US9511018B2 (en) 2012-04-05 2016-12-06 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable matrix
US9283241B2 (en) 2012-07-10 2016-03-15 Clemson University Treatment to render implants resistant to diabetes
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US9066853B2 (en) * 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
RU2513838C1 (en) * 2013-02-21 2014-04-20 Общество с ограниченной ответственностью "ДЖИ-Групп" Histo-equivalent bioplastic material
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN115804749A (en) 2013-03-11 2023-03-17 度瑞公司 Injectable controlled release compositions comprising high viscosity liquid carriers
CN105764491A (en) 2013-12-09 2016-07-13 度瑞公司 Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
SI3134070T1 (en) 2014-04-21 2021-03-31 Heron Therapeutics, Inc. Compositions of a polyorthoester and an organic acid excipient
CA3174824A1 (en) * 2014-04-21 2015-10-29 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
AU2015341490C1 (en) 2014-11-07 2021-03-11 Indivior Uk Limited Buprenorphine dosing regimens
CN113598842A (en) 2015-06-03 2021-11-05 因塔西亚制药公司 Implant placement and removal system
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
EP3458084B1 (en) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD802755S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
CN106074361B (en) * 2016-07-14 2018-10-19 何伟 A kind of anti-intraocular inflammation implant and its preparation method and application
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
CN115666621A (en) 2020-01-13 2023-01-31 度勒科特公司 Sustained release drug delivery systems with reduced impurities and related methods
EP4173626A1 (en) 2021-10-29 2023-05-03 Charité - Universitätsmedizin Berlin Pentagalloyl glucose (pgg) for use in treatment of pulmonary hypertension
EP4218772A1 (en) 2022-01-26 2023-08-02 Charité - Universitätsmedizin Berlin Lithium salt for use in treatment of pulmonary hypertension

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4443340A (en) * 1981-10-09 1984-04-17 Betz Laboratories, Inc. Control of iron induced fouling in water systems
US4985404A (en) * 1984-10-04 1991-01-15 Monsanto Company Prolonged release of biologically active polypeptides
US4865845A (en) * 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5085866A (en) * 1988-12-02 1992-02-04 Southern Research Institute Method of producing zero-order controlled-released devices
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
GB9027422D0 (en) * 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5288214A (en) * 1991-09-30 1994-02-22 Toshio Fukuda Micropump
DE69230032T2 (en) * 1991-12-19 2000-02-03 Mitsui Chemicals Inc POLYHYDROXYCARBOXYLIC ACID AND METHOD FOR THE PRODUCTION THEREOF
US5456679A (en) * 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5209746A (en) * 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5656297A (en) * 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
PT674506E (en) * 1992-12-02 2001-01-31 Alkermes Inc MICROSPHERES CONTAINING GROWTH HORMONE WITH CONTROLLED LIBERATION
US5468253A (en) * 1993-01-21 1995-11-21 Ethicon, Inc. Elastomeric medical device
US5556905A (en) * 1994-03-30 1996-09-17 Reilly Industries, Inc. Physically-modified degradable thermoplastic compositions
CA2582666C (en) * 1994-04-08 2010-05-25 Qlt Usa, Inc. Controlled release implant
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5639851A (en) * 1995-10-02 1997-06-17 Ethicon, Inc. High strength, melt processable, lactide-rich, poly(lactide-CO-P-dioxanone) copolymers
US6113624A (en) * 1995-10-02 2000-09-05 Ethicon, Inc. Absorbable elastomeric polymer
ATE203157T1 (en) * 1996-12-20 2001-08-15 Alza Corp INJECTABLE DEPOSIT GEL PREPARATION AND PRODUCTION METHOD
US6193991B1 (en) * 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
AU779277B2 (en) * 1999-06-04 2005-01-13 Alza Corporation Implantable gel compositions and method of manufacture
JP2001249134A (en) * 1999-12-28 2001-09-14 Matsushita Electric Ind Co Ltd Reagent for measuring protein concentration, method for measuring protein concentration using it, and urinalysis
AU2002226000A1 (en) * 2000-11-13 2002-05-21 Atrix Laboratories, Inc. Injectable sustained release delivery system with loperamide
BR0206984A (en) * 2001-11-14 2004-02-03 Alza Corp Injectable Depot Compositions and Use of These
CN100446809C (en) * 2001-11-14 2008-12-31 阿尔扎有限公司 Injectable depot composition
ATE418323T1 (en) * 2002-11-06 2009-01-15 Alza Corp DEPOSIT DELAYED RELEASE FORMULATIONS

Also Published As

Publication number Publication date
CN1822816A (en) 2006-08-23
CA2527664A1 (en) 2004-12-16
US20050079202A1 (en) 2005-04-14
KR20060023140A (en) 2006-03-13
MXPA05013003A (en) 2006-03-17
ZA200510472B (en) 2007-03-28
AU2004245022A1 (en) 2004-12-16
WO2004108111A1 (en) 2004-12-16
NO20056200L (en) 2006-02-09
EP1643968A1 (en) 2006-04-12

Similar Documents

Publication Publication Date Title
BRPI0410953A (en) elastomeric deposit compositions which may be implanted, uses thereof and production process
BR0315304A (en) Depot formulations for controlled release
BR0206469A (en) Injectable Depot Composition
BRPI0416042A (en) composition and apparatus for transdermal delivery
BR9714268A (en) Bar composition for skin cleansing.
ATE203157T1 (en) INJECTABLE DEPOSIT GEL PREPARATION AND PRODUCTION METHOD
BRPI0416590A (en) excipients in drug delivery vehicles
BR0313539A (en) Injectable multimodal polymer deposit compositions and their uses
WO2008054772A3 (en) Implantable elastomeric caprolactone depot compositions and uses thereof
BRPI0500456A8 (en) COLLAGEN DEVICE AND METHOD FOR PREPARING THE SAME
AR052545A1 (en) INJECTABLE NON-WATERPROOF SUSPENSION
BRPI0416032A (en) excipients in drug delivery vehicles
BR0111257A (en) Formulation and use of a formulation
ATE502621T1 (en) CATHETER INJECTABLE DEPOSIT COMPOSITIONS AND USE THEREOF
BRPI0515684A (en) long-acting injectable crystal formulations of estradiol metabolites, and methods of using them
NO20050366L (en) Short-term deposit formulations
BR9714270A (en) Liquid skin cleansing composition
ATE507816T1 (en) INJECTABLE DEPOSIT COMPOSITIONS AND USE THEREOF
BR0001919A (en) Composition of skin cleansing cream so that it forms foam, and a sparkling skin cleaning system.
ATE427760T1 (en) ERODABLE POLYMERS FOR INJECTION
BRPI0608249A2 (en) formulation, method for topical application and kit for transdermal botulinum toxin delivery
ATE554804T1 (en) METHOD FOR PRODUCING COATED MEDICAL DEVICES
DE60041283D1 (en) HYDROPHOBIC MULTICOMPONENT HEPARIN CONJUGATES, A METHOD OF THEIR PREPARATION AND USE
MY149505A (en) Hyaluronic acid binary mixtures and therapeutic use thereof
WO2003082158A8 (en) Bone graft substitute composition

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.