BR9813595A - Cristal misto, processo para produzir o mesmo, e, adoçante - Google Patents

Cristal misto, processo para produzir o mesmo, e, adoçante

Info

Publication number
BR9813595A
BR9813595A BR9813595-3A BR9813595A BR9813595A BR 9813595 A BR9813595 A BR 9813595A BR 9813595 A BR9813595 A BR 9813595A BR 9813595 A BR9813595 A BR 9813595A
Authority
BR
Brazil
Prior art keywords
mixed crystal
sweetener
produce
same
apm
Prior art date
Application number
BR9813595-3A
Other languages
English (en)
Inventor
Akihiro Kishishita
Zazutaka Nagashima
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR9813595A publication Critical patent/BR9813595A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"CRISTAL MISTO, PROCESSO PARA PRODUZIR O MESMO, E, ADOçANTE" Provê-se um novo cristal misto compreendendo aspartame (APM) e éster metílico de N-[N-(3,3-dimetilbutil)-L<244>-aspartil]-L-fenilalanina, que pode ser usado como um adoçante tendo qualidade consideravelmente melhorada de doçura, etc. O cristal misto acima pode ser facilmente produzido industrialmente ao se submeter uma solução contendo o APM acima descrito e derivado de APM a uma operação de cristalização, seguido pela separação do cristal misto assim precipitado.
BR9813595-3A 1997-12-15 1998-12-07 Cristal misto, processo para produzir o mesmo, e, adoçante BR9813595A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9344777A JPH11169132A (ja) 1997-12-15 1997-12-15 アスパルテームとアスパルテーム誘導体の混晶及びその製造方法
PCT/JP1998/005532 WO1999030574A1 (fr) 1997-12-15 1998-12-07 Cristaux melanges comprenant de l'aspartame et un derive de l'aspartame, et procede de production associe

Publications (1)

Publication Number Publication Date
BR9813595A true BR9813595A (pt) 2000-10-17

Family

ID=18371907

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813595-3A BR9813595A (pt) 1997-12-15 1998-12-07 Cristal misto, processo para produzir o mesmo, e, adoçante

Country Status (10)

Country Link
US (1) US6346642B1 (pt)
EP (1) EP1062878B1 (pt)
JP (1) JPH11169132A (pt)
KR (1) KR100549633B1 (pt)
CN (1) CN1134224C (pt)
BR (1) BR9813595A (pt)
CA (1) CA2310760C (pt)
DE (1) DE69839132T2 (pt)
RU (1) RU2189988C2 (pt)
WO (1) WO1999030574A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010075419A (ko) 1998-10-30 2001-08-09 에가시라 구니오 안정성이 우수한 아스파르탐 유도체 결정의 결정 석출법
WO2000069283A1 (en) * 1999-05-13 2000-11-23 The Nutrasweet Company USE OF ADDITIVES TO MODIFY THE TASTE CHARACTERISTICS OF N-NEOHEXYL-α-ASPARTYL-L-PHENYLALANINE METHYL ESTER
WO2012026499A1 (ja) * 2010-08-25 2012-03-01 味の素株式会社 アスパルチルジペプチドエステル誘導体の保存方法及び安定化剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58177952A (ja) * 1982-04-12 1983-10-18 Ajinomoto Co Inc Ｌ−α−アスパルチル−Ｌ−フエニルアラニンメチルエステルの晶析法
JPH0631312B2 (ja) * 1983-03-18 1994-04-27 味の素株式会社 ジペプチド結晶及びその製造方法
DE68925450T2 (de) * 1988-10-03 1996-09-19 Ajinomoto Kk Verfahren zur Herstellung von trockenen IB Kristallen des alpha-L-Aspartyl-L-phenylalaninmethylesters, die eine verbesserte Löslichkeit besitzen
JP2671532B2 (ja) * 1989-10-20 1997-10-29 味の素株式会社 アスパルテーム顆粒
US5043169A (en) * 1990-05-25 1991-08-27 Warner-Lambert Company Stabilized Sweetner Composition
US5473097A (en) * 1991-05-24 1995-12-05 Ajinomoto Company, Inc. Granules of α-L-aspartyl-L-phenylalanine methyl ester
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719591B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Nouveau composé utile comme agent édulcorant, son procédé de préparation.
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
JP3651161B2 (ja) * 1997-03-10 2005-05-25 味の素株式会社 改善された呈味を有する甘味料組成物
EP1852020B8 (en) * 1997-03-10 2010-10-20 Ajinomoto Co., Inc. Sweetener composition improved in taste, its use and process for preparing it

Also Published As

Publication number Publication date
CN1281340A (zh) 2001-01-24
CA2310760A1 (en) 1999-06-24
EP1062878A1 (en) 2000-12-27
DE69839132T2 (de) 2008-06-19
DE69839132D1 (de) 2008-03-27
CA2310760C (en) 2008-02-05
EP1062878B1 (en) 2008-02-13
KR20010033121A (ko) 2001-04-25
US6346642B1 (en) 2002-02-12
JPH11169132A (ja) 1999-06-29
CN1134224C (zh) 2004-01-14
RU2189988C2 (ru) 2002-09-27
KR100549633B1 (ko) 2006-02-08
EP1062878A4 (en) 2005-01-26
WO1999030574A1 (fr) 1999-06-24

Similar Documents

Publication Publication Date Title
KR910020031A (ko) 펩티드 아미드, 이의 제조방법 및 피브린/트롬빈 응괴 억제제로서 이를 함유하는 약제
TR199901811T2 (xx) N-Alkilli bir aspartam t�revinin haz�rlanmas�na ve safla�t�r�lmas�na y�nelik geli�tirilmi� metod.
BR9714426A (pt) Processo para reforçar a intensidade adoçante e para aperfeiçoar o sabor de uma mistura de adoçantes altamente intensos
DK0759031T3 (da) Forbedret fremgangsmåde til fremstilling af en forbindelse afledt af aspartam som er anvendelig som sødemiddel
ATE81854T1 (de) Aminoluciferine, verfahren zu deren herstellung und ihre verwendung.
Merrifield et al. The synthesis of L-seryl-L-histidyl-L-leucyl-L-valyl-L-glutamic acid, a peptide with strepogenin activity
AU2001264679A1 (en) Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using oxazolidinone derivatives
BR0016316A (pt) Cristal
EP0092933B1 (en) Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester or its hydrochloride
BG104321A (en) Sweetener salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1 methyl ester
BR9813595A (pt) Cristal misto, processo para produzir o mesmo, e, adoçante
JPH10259194A (ja) 新規ジペプチド誘導体及び甘味剤
ATE248806T1 (de) N-3, 3-dimethylbutyl-l-asparaginsäure und ihre ester, verfahren zur herstellung dieser und das verfahren um daraus n-(n-(3,3-dimethylbutyl)-l- alpha-aspartyl)-l-phenylalanin-1-methylester herzustellen
ES515545A0 (es) &#34;un procedimiento para la purificacion o aislamiento de una amida de un dipeptido l-aspartil-d-aminoacido&#34;.
BR9306693A (pt) Processo para purificação de uma solução aquosa de enzima
DK0759030T3 (da) N-[N-(3,3-dimethylbutyl)-L-alfa-aspartyl]-L-hexahydrophenylalanin-1-methylester, som er anvendelig som sødemiddel, samt en
BR9813588A (pt) Processo para produção de uma composição adoçante contendo apm e referido derivado de apm, composição adoçante, e, adoçante
US3607859A (en) Furylacryloylgly-clycyl-l-leucinamide and relateo peptides and use thereof in spectrophotometric assay for neutral protease
DE60137686D1 (de) Verfahren zur kristallisation von n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanin n-carbonsäureanhydrid
DE60115106D1 (de) Herstellung von N-[N-(3,3-Dimethylbutyl)-l-Alpha-Aspartyl]-l-Phenylalanin-1-Methylester durch Verwendung vom l-Alpha-Aspartyl-l-Phenylalanin-1-Methylester als Vorläufer
BR9813522A (pt) Processos para separar e purificar apm e metil éster de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina e para a produção do derivado de apm, apm ou derivado de apm, e, adoçante
KR840004090A (ko) 씬-(2-아미노티아졸-4-일) (메톡시이미노) 아세트산의 디메틸 아세트아미드 용매화물의 제조방법
KR880005114A (ko) 광학적활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 그 제조방법
JPS5943159B2 (ja) アミノ酸エステルの光学分割方法
ES2000879A6 (es) Un procedimiento para preparar una sal de acido inorganico de cloruro de n-(1(s)-etoxicarbonil-3-fenilpropil)-l-alanilo

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 24 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C07K 5/072 (2006.01), A23L 27/30 (2016.0