BR9801778A - - Google Patents
Info
- Publication number
- BR9801778A BR9801778A BR9801778A BR9801778A BR9801778A BR 9801778 A BR9801778 A BR 9801778A BR 9801778 A BR9801778 A BR 9801778A BR 9801778 A BR9801778 A BR 9801778A BR 9801778 A BR9801778 A BR 9801778A
- Authority
- BR
- Brazil
- Prior art keywords
- chem
- formula
- optionally substituted
- ring
- membered heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Patente de Invenção: <B>"QUINOLINAS E QUINAZOLINASe R^ 1^ representa C~ 1~-C~ 4~alcóxi opcionalmente substituído com um ou mais átomos de flúor; R^ 2^~-C~ 6~alcóxi (o qual é opcionalmente substituído); R^ 4^ representa um anel heterocíclico de 4-, 5-, 6- ou 7-membros, estando o anel opcionalmente condensado com um anel benzênico ou um anel heterocíclico de 5- ou 6-membros, estando o sistema de anéis, como um todo, opcionalmente substituído. X representa CH ou N; e L está ausente, ou representa um grupo cíclico de fórmula Ia ou representa uma cate aceitáveis; são úteis em terapia, em particular no tratamento da hiperplasia benigna prostática.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711650.3A GB9711650D0 (en) | 1997-06-05 | 1997-06-05 | Compounds useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9801778A true BR9801778A (pt) | 2000-03-21 |
Family
ID=10813629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9801778A BR9801778A (pt) | 1997-06-05 | 1998-06-04 |
Country Status (11)
Country | Link |
---|---|
US (2) | US6048864A (pt) |
EP (1) | EP0887344B1 (pt) |
JP (1) | JP3163281B2 (pt) |
AT (1) | ATE255563T1 (pt) |
BR (1) | BR9801778A (pt) |
CA (1) | CA2239603C (pt) |
DE (1) | DE69820159T2 (pt) |
DK (1) | DK0887344T3 (pt) |
ES (1) | ES2210673T3 (pt) |
GB (1) | GB9711650D0 (pt) |
PT (1) | PT887344E (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9700504D0 (en) | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
GB9708917D0 (en) * | 1997-05-01 | 1997-06-25 | Pfizer Ltd | Compounds useful in therapy |
GB9711650D0 (en) * | 1997-06-05 | 1997-07-30 | Pfizer Ltd | Compounds useful in therapy |
US6191300B1 (en) | 1999-04-16 | 2001-02-20 | Eastman Chemical Company | Process for the preparation of cyclopropylacetonitrile |
KR100420663B1 (ko) * | 2001-01-09 | 2004-03-02 | 주식회사 켐온 | 퀴놀린 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물 |
IL164302A0 (en) * | 2002-03-29 | 2005-12-18 | Chiron Corp | Substituted benzazoles and use thereof as raf kinase inhibitors |
US8299108B2 (en) * | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
WO2004087153A2 (en) * | 2003-03-28 | 2004-10-14 | Chiron Corporation | Use of organic compounds for immunopotentiation |
EP1682126B1 (en) * | 2003-10-16 | 2009-07-01 | Novartis Vaccines and Diagnostics, Inc. | Substituted benzazoles and use thereof as inhibitors of raf kinase |
US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
US9603848B2 (en) | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
US8993580B2 (en) * | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
EP2252293B1 (en) | 2008-03-14 | 2018-06-27 | Intellikine, LLC | Kinase inhibitors and methods of use |
NZ590258A (en) | 2008-07-08 | 2013-10-25 | Intellikine Llc | Kinase inhibitors and methods of use |
WO2010014666A2 (en) | 2008-07-31 | 2010-02-04 | Senomyx, Inc. | Processes and intermediates for making sweet taste enhancers |
JP5513508B2 (ja) * | 2008-09-10 | 2014-06-04 | セルジーン コーポレイション | アミノスルホン化合物を調製するためのプロセス |
US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
WO2013070852A2 (en) * | 2011-11-08 | 2013-05-16 | Emory University | Compounds and compositions used to epigenetically transform cells and methods related thereto |
KR20150041040A (ko) | 2012-08-06 | 2015-04-15 | 세노믹스, 인코포레이티드 | 단맛 향미 개질제 |
JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3956495A (en) * | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
US4656174A (en) * | 1982-07-24 | 1987-04-07 | Pfizer Inc. | Quinoline therapeutic agents |
GB8506174D0 (en) * | 1985-03-09 | 1985-04-11 | Pfizer Ltd | 4-amino-6 7-dimethoxy-2-piperazin-1-ylquinazoline derivatives |
GB8719378D0 (en) * | 1987-08-15 | 1987-09-23 | Pfizer Ltd | Antiarrythmic agents |
IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
US6015819A (en) * | 1992-11-13 | 2000-01-18 | Synaptic Pharmaceutical Corporation | Use of alpha-1C specific compounds to treat benign prostatic hyperplasia |
IT1270993B (it) * | 1994-03-18 | 1997-05-26 | Recordati Chem Pharm | Derivati chinzolilamminici attivi come alfa-antagonisti |
GB9526546D0 (en) * | 1995-12-23 | 1996-02-28 | Pfizer Ltd | Compounds useful in therapy |
IL120302A0 (en) * | 1996-03-27 | 1997-06-10 | Pfizer | Use of alpha1-adrenoreceptor antagonists in the prevention and treatment of benign prostatic hyperplasia |
GB9711650D0 (en) * | 1997-06-05 | 1997-07-30 | Pfizer Ltd | Compounds useful in therapy |
-
1997
- 1997-06-05 GB GBGB9711650.3A patent/GB9711650D0/en active Pending
-
1998
- 1998-04-28 US US09/067,588 patent/US6048864A/en not_active Expired - Fee Related
- 1998-05-18 PT PT98303897T patent/PT887344E/pt unknown
- 1998-05-18 AT AT98303897T patent/ATE255563T1/de not_active IP Right Cessation
- 1998-05-18 DK DK98303897T patent/DK0887344T3/da active
- 1998-05-18 EP EP98303897A patent/EP0887344B1/en not_active Expired - Lifetime
- 1998-05-18 ES ES98303897T patent/ES2210673T3/es not_active Expired - Lifetime
- 1998-05-18 DE DE69820159T patent/DE69820159T2/de not_active Expired - Fee Related
- 1998-06-03 CA CA002239603A patent/CA2239603C/en not_active Expired - Fee Related
- 1998-06-04 JP JP15610798A patent/JP3163281B2/ja not_active Expired - Fee Related
- 1998-06-04 BR BR9801778A patent/BR9801778A/pt not_active Application Discontinuation
-
2000
- 2000-02-07 US US09/499,623 patent/US6417194B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0887344A1 (en) | 1998-12-30 |
JPH1112274A (ja) | 1999-01-19 |
ATE255563T1 (de) | 2003-12-15 |
US6048864A (en) | 2000-04-11 |
DE69820159T2 (de) | 2004-05-27 |
PT887344E (pt) | 2004-02-27 |
DK0887344T3 (da) | 2004-03-08 |
DE69820159D1 (de) | 2004-01-15 |
US6417194B1 (en) | 2002-07-09 |
ES2210673T3 (es) | 2004-07-01 |
GB9711650D0 (en) | 1997-07-30 |
JP3163281B2 (ja) | 2001-05-08 |
MX9804482A (es) | 1998-12-31 |
CA2239603A1 (en) | 1998-12-05 |
CA2239603C (en) | 2003-07-22 |
EP0887344B1 (en) | 2003-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |