BR112023018593A2 - Processo - Google Patents

Processo

Info

Publication number
BR112023018593A2
BR112023018593A2 BR112023018593A BR112023018593A BR112023018593A2 BR 112023018593 A2 BR112023018593 A2 BR 112023018593A2 BR 112023018593 A BR112023018593 A BR 112023018593A BR 112023018593 A BR112023018593 A BR 112023018593A BR 112023018593 A2 BR112023018593 A2 BR 112023018593A2
Authority
BR
Brazil
Prior art keywords
dimethylimidazo
diazaspiro
octan
pyridazin
pyrido
Prior art date
Application number
BR112023018593A
Other languages
English (en)
Inventor
Christophe Pfleger
Georg Wuitschik
Jean-Michel Adam
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112023018593A2 publication Critical patent/BR112023018593A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"processo. a presente invenção refere-se a um processo para a preparação de derivados de 7-(4,7-diazaespiro[2.5]octan-7-il)-2-(2,8-dimetilimidazo[1,2-b]piridazin-6-il)pirido[1,2-a]pirimidin-4-ona úteis como compostos farmaceuticamente ativos.
BR112023018593A 2021-03-18 2022-03-16 Processo BR112023018593A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21163301 2021-03-18
PCT/EP2022/056778 WO2022194909A2 (en) 2021-03-18 2022-03-16 Novel process

Publications (1)

Publication Number Publication Date
BR112023018593A2 true BR112023018593A2 (pt) 2023-10-24

Family

ID=75108126

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023018593A BR112023018593A2 (pt) 2021-03-18 2022-03-16 Processo

Country Status (13)

Country Link
US (1) US20240182493A1 (pt)
EP (1) EP4308578A2 (pt)
JP (1) JP2024509995A (pt)
KR (1) KR20230145461A (pt)
CN (1) CN117015546A (pt)
AR (1) AR125144A1 (pt)
AU (1) AU2022237836B2 (pt)
BR (1) BR112023018593A2 (pt)
CA (1) CA3210678A1 (pt)
IL (1) IL304848A (pt)
MX (1) MX2023010761A (pt)
TW (1) TW202302605A (pt)
WO (1) WO2022194909A2 (pt)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3143025T3 (da) * 2014-05-15 2019-12-09 Hoffmann La Roche Forbindelser til behandling af spinal muskelatrofi
WO2019057740A1 (en) * 2017-09-22 2019-03-28 F. Hoffmann-La Roche Ag PROCESS FOR THE PREPARATION OF 7- (4,7-DIAZASPIRO [2.5] OCTAN-7-YL) -2- (2,8-DIMETHYLIMIDAZO [1,2-B] PYRIDAZIN-6-YL) PYRIDO [1,2-DERIVATIVES] ] pyrimidin-4-ONE

Also Published As

Publication number Publication date
KR20230145461A (ko) 2023-10-17
IL304848A (en) 2023-09-01
AU2022237836B2 (en) 2024-07-04
AR125144A1 (es) 2023-06-14
MX2023010761A (es) 2023-09-22
WO2022194909A2 (en) 2022-09-22
EP4308578A2 (en) 2024-01-24
CN117015546A (zh) 2023-11-07
AU2022237836A1 (en) 2023-07-27
TW202302605A (zh) 2023-01-16
JP2024509995A (ja) 2024-03-05
CA3210678A1 (en) 2022-09-22
US20240182493A1 (en) 2024-06-06
WO2022194909A3 (en) 2023-04-06

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