BR112022009532A2 - Composição para cultura de células exterminadoras naturais e método para preparação de células exterminadoras naturais usando a mesma - Google Patents
Composição para cultura de células exterminadoras naturais e método para preparação de células exterminadoras naturais usando a mesmaInfo
- Publication number
- BR112022009532A2 BR112022009532A2 BR112022009532A BR112022009532A BR112022009532A2 BR 112022009532 A2 BR112022009532 A2 BR 112022009532A2 BR 112022009532 A BR112022009532 A BR 112022009532A BR 112022009532 A BR112022009532 A BR 112022009532A BR 112022009532 A2 BR112022009532 A2 BR 112022009532A2
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- composition
- natural
- exterminator
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000000822 natural killer cell Anatomy 0.000 abstract 5
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 102000001398 Granzyme Human genes 0.000 abstract 1
- 108060005986 Granzyme Proteins 0.000 abstract 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 abstract 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 abstract 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 abstract 1
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 abstract 1
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 abstract 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 229930192851 perforin Natural products 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/53—CD2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
COMPOSIÇÃO PARA CULTURA DE CÉLULAS EXTERMINADORAS NATURAIS E MÉTODO PARA PREPARAÇÃO DE CÉLULAS EXTERMINADORAS NATURAIS USANDO A MESMA. A invenção se refere a: uma composição para cultura de células exterminadoras naturais, compreendendo, como ingrediente ativo, uma proteína de fusão compreendendo uma proteína IL-2 e uma proteína CD80; e um método para preparar células exterminadoras naturais usando a mesma. Particularmente, uma composição para cultura de células exterminadoras naturais, compreendendo, como ingrediente ativo, uma proteína de fusão compreendendo IL-2 ou uma variante da mesma e CD80 ou um fragmento da mesma, da presente invenção, promove a proliferação de células exterminadoras naturais, induz a expressão de CD16 e NKp46 e aumenta a expressão e secreção de granzima B e perforina, sendo assim efetivamente utilizável na preparação de células exterminadoras naturais com uma excelente função imune anticâncer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20190149779 | 2019-11-20 | ||
| KR20200015802 | 2020-02-10 | ||
| PCT/KR2020/016376 WO2021101270A1 (ko) | 2019-11-20 | 2020-11-19 | 자연살해세포 배양용 조성물 및 이를 이용한 자연살해세포 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022009532A2 true BR112022009532A2 (pt) | 2022-08-02 |
Family
ID=75980974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022009532A BR112022009532A2 (pt) | 2019-11-20 | 2020-11-19 | Composição para cultura de células exterminadoras naturais e método para preparação de células exterminadoras naturais usando a mesma |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220372442A1 (pt) |
| EP (1) | EP4063491A4 (pt) |
| JP (2) | JP7381750B2 (pt) |
| KR (1) | KR102351020B1 (pt) |
| CN (2) | CN117660331A (pt) |
| AU (1) | AU2020387322B2 (pt) |
| BR (1) | BR112022009532A2 (pt) |
| CA (1) | CA3157592A1 (pt) |
| IL (1) | IL292932A (pt) |
| MX (1) | MX2022005998A (pt) |
| TW (1) | TWI776285B (pt) |
| WO (1) | WO2021101270A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114891740B (zh) * | 2022-03-25 | 2023-12-01 | 和携科技有限公司 | 一种高增殖能力和高细胞毒性nk细胞的培养方法及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
| US20030068306A1 (en) * | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| CA2824253C (en) | 2011-02-10 | 2019-09-17 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| JP6010136B2 (ja) * | 2011-12-22 | 2016-10-19 | モガム バイオテクノロジー インスティチュート | ナチュラルキラー細胞の製造方法、その方法により製造されたナチュラルキラー細胞、並びにそれを含む腫瘍及び感染性疾患治療用組成物 |
| US9597356B2 (en) * | 2012-07-05 | 2017-03-21 | Fullhope Biomedical Co., Ltd | Method for treating cancers with dendritic killer cells and pharmaceutical composition comprising the same |
| MA45488A (fr) * | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| PE20181300A1 (es) * | 2015-11-02 | 2018-08-09 | Five Prime Therapeutics Inc | Polipeptidos del dominio extracelular de cd80 y su uso en el tratamiento del cancer |
| WO2019052562A1 (zh) * | 2017-09-15 | 2019-03-21 | 科济生物医药（上海）有限公司 | Il-4r的融合蛋白及其应用 |
| WO2019152663A1 (en) * | 2018-02-01 | 2019-08-08 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| KR102201086B1 (ko) * | 2018-09-17 | 2021-01-11 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도 |
| CN117004564A (zh) * | 2019-11-20 | 2023-11-07 | 吉爱希公司 | 调节性t细胞培养组合物及其用途 |
| BR112022009521A2 (pt) * | 2019-11-20 | 2022-08-16 | Gi Cell Inc | Composição de meio para cultura de células t e método para cultura de células t usando a mesma |
| US20230014358A1 (en) * | 2019-11-27 | 2023-01-19 | Gi Cell, Inc. | Composition for anticancer treatment, comprising nk cells and fusion protein which comprises il-2 protein and cd80 protein |
| KR102400253B1 (ko) * | 2019-11-27 | 2022-05-23 | ㈜지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 면역관문 억제제를 포함하는 암 치료용 약학 조성물 |
| CA3175457A1 (en) * | 2020-03-18 | 2021-09-23 | Gi Innovation, Inc. | Pharmaceutical composition for treating cancer, comprising fusion protein comprising il-2 protein and cd80 protein and anticancer drug |
| US20240058420A1 (en) * | 2020-03-18 | 2024-02-22 | Gi Innovation, Inc. | Pharmaceutical composition for cancer treatment comprising fusion protein including il-2 protein and cd80 protein and anticancer drug |
-
2020
- 2020-11-19 AU AU2020387322A patent/AU2020387322B2/en active Active
- 2020-11-19 KR KR1020200155367A patent/KR102351020B1/ko active IP Right Grant
- 2020-11-19 JP JP2022529598A patent/JP7381750B2/ja active Active
- 2020-11-19 CN CN202311413975.2A patent/CN117660331A/zh not_active Withdrawn
- 2020-11-19 IL IL292932A patent/IL292932A/en unknown
- 2020-11-19 WO PCT/KR2020/016376 patent/WO2021101270A1/ko active Application Filing
- 2020-11-19 BR BR112022009532A patent/BR112022009532A2/pt unknown
- 2020-11-19 EP EP20890969.7A patent/EP4063491A4/en active Pending
- 2020-11-19 MX MX2022005998A patent/MX2022005998A/es unknown
- 2020-11-19 CA CA3157592A patent/CA3157592A1/en active Pending
- 2020-11-19 CN CN202080087831.0A patent/CN114867847A/zh active Pending
- 2020-11-20 TW TW109140810A patent/TWI776285B/zh active
-
2022
- 2022-05-17 US US17/746,835 patent/US20220372442A1/en active Pending
-
2023
- 2023-07-26 JP JP2023121590A patent/JP2023156351A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021101270A1 (ko) | 2021-05-27 |
| JP2023156351A (ja) | 2023-10-24 |
| MX2022005998A (es) | 2022-06-17 |
| AU2020387322B2 (en) | 2024-06-06 |
| IL292932A (en) | 2022-07-01 |
| CA3157592A1 (en) | 2021-05-27 |
| TW202132561A (zh) | 2021-09-01 |
| KR102351020B1 (ko) | 2022-01-14 |
| US20220372442A1 (en) | 2022-11-24 |
| EP4063491A4 (en) | 2023-02-01 |
| CN114867847A (zh) | 2022-08-05 |
| CN117660331A (zh) | 2024-03-08 |
| EP4063491A1 (en) | 2022-09-28 |
| JP2022547353A (ja) | 2022-11-11 |
| KR20210061949A (ko) | 2021-05-28 |
| JP7381750B2 (ja) | 2023-11-15 |
| AU2020387322A1 (en) | 2022-05-26 |
| TWI776285B (zh) | 2022-09-01 |
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