BR112021018555A2 - Saponin-based vaccine adjuvants - Google Patents
Saponin-based vaccine adjuvantsInfo
- Publication number
- BR112021018555A2 BR112021018555A2 BR112021018555A BR112021018555A BR112021018555A2 BR 112021018555 A2 BR112021018555 A2 BR 112021018555A2 BR 112021018555 A BR112021018555 A BR 112021018555A BR 112021018555 A BR112021018555 A BR 112021018555A BR 112021018555 A2 BR112021018555 A2 BR 112021018555A2
- Authority
- BR
- Brazil
- Prior art keywords
- saponin
- based vaccine
- prepared
- side chain
- natural
- Prior art date
Links
- 229930182490 saponin Natural products 0.000 title abstract 6
- 150000007949 saponins Chemical class 0.000 title abstract 6
- 239000001397 quillaja saponaria molina bark Substances 0.000 title abstract 4
- 239000012646 vaccine adjuvant Substances 0.000 title abstract 3
- 229940124931 vaccine adjuvant Drugs 0.000 title abstract 3
- 235000017709 saponins Nutrition 0.000 abstract 5
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 abstract 1
- 238000010640 amide synthesis reaction Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000003523 triterpene group Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
adjuvantes de vacina à base de saponina. uma série de candidatas adjuvantes de vacina à base de saponina naturais e msforam preparadas. os derivados de ms foram preparados incorporando uma cadeia lateral funcionalizada terminal na unidade de ácido glucurônico c3 das saponinas naturais ms i e ii por meio da reação de formação de amida; e os análogos qs foram preparados por meio de síntese orgânica em múltiplas etapas. estas saponinas não naturais mostraram perfis de atividade imunoestimulante significativamente diferentes, sugerindo que a estrutura da cadeia lateral, núcleo triterpenoide e domínio de oligossacarídeo juntos orquestram cada potenciação característica da saponina de respostas imunes.saponin-based vaccine adjuvants. A number of natural and MS saponin-based vaccine adjuvant candidates have been prepared. ms derivatives were prepared by incorporating a terminal functionalized side chain into the c3 glucuronic acid unit of natural saponins ms i and ii via the amide formation reaction; and qs analogs were prepared via multistep organic synthesis. These unnatural saponins showed significantly different immunostimulatory activity profiles, suggesting that the structure of the side chain, triterpenoid core, and oligosaccharide domain together orchestrate each saponin's characteristic potentiation of immune responses.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962820477P | 2019-03-19 | 2019-03-19 | |
| PCT/US2020/023185 WO2020190959A1 (en) | 2019-03-19 | 2020-03-17 | Saponin-based vaccine adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021018555A2 true BR112021018555A2 (en) | 2021-11-30 |
Family
ID=72519135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021018555A BR112021018555A2 (en) | 2019-03-19 | 2020-03-17 | Saponin-based vaccine adjuvants |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220152196A1 (en) |
| EP (1) | EP3941219A4 (en) |
| JP (1) | JP2022525768A (en) |
| KR (1) | KR20220004970A (en) |
| CN (1) | CN114126419A (en) |
| AU (1) | AU2020241955A1 (en) |
| BR (1) | BR112021018555A2 (en) |
| CA (1) | CA3133985A1 (en) |
| MX (1) | MX2021011275A (en) |
| WO (1) | WO2020190959A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3976627A4 (en) * | 2019-06-03 | 2023-07-19 | Pi-Hui Liang | Saponin conjugate and vaccine or pharmaceutical composition comprising the same |
| WO2023225457A1 (en) * | 2022-05-18 | 2023-11-23 | The Uab Research Foundation | Saponin-based immunostimulants, pharmaceutical composition comprising said immunostimulants, therapeutic use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0362278A4 (en) | 1987-06-05 | 1990-05-14 | Us Health | Autocrine motility factors in cancer diagnosis and management. |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| US20150050319A1 (en) * | 2012-03-23 | 2015-02-19 | The Uab Research Foundation | Natural saponin-based synthetic immunoadjuvants |
| US20210040143A1 (en) * | 2018-03-20 | 2021-02-11 | The Uab Research Foundation | Saponin-based vaccine adjuvants |
-
2020
- 2020-03-17 US US17/440,009 patent/US20220152196A1/en active Pending
- 2020-03-17 WO PCT/US2020/023185 patent/WO2020190959A1/en active Search and Examination
- 2020-03-17 EP EP20772529.2A patent/EP3941219A4/en active Pending
- 2020-03-17 CA CA3133985A patent/CA3133985A1/en active Pending
- 2020-03-17 CN CN202080034302.4A patent/CN114126419A/en active Pending
- 2020-03-17 AU AU2020241955A patent/AU2020241955A1/en active Pending
- 2020-03-17 MX MX2021011275A patent/MX2021011275A/en unknown
- 2020-03-17 BR BR112021018555A patent/BR112021018555A2/en unknown
- 2020-03-17 KR KR1020217033391A patent/KR20220004970A/en unknown
- 2020-03-17 JP JP2021555818A patent/JP2022525768A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020241955A1 (en) | 2021-10-21 |
| MX2021011275A (en) | 2021-12-10 |
| EP3941219A1 (en) | 2022-01-26 |
| EP3941219A4 (en) | 2022-12-21 |
| CA3133985A1 (en) | 2020-09-24 |
| US20220152196A1 (en) | 2022-05-19 |
| KR20220004970A (en) | 2022-01-12 |
| WO2020190959A1 (en) | 2020-09-24 |
| JP2022525768A (en) | 2022-05-19 |
| CN114126419A (en) | 2022-03-01 |
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