BR112018011021A2 - método para inativar xenoantígenos em tecidos biológicos - Google Patents

método para inativar xenoantígenos em tecidos biológicos

Info

Publication number
BR112018011021A2
BR112018011021A2 BR112018011021A BR112018011021A BR112018011021A2 BR 112018011021 A2 BR112018011021 A2 BR 112018011021A2 BR 112018011021 A BR112018011021 A BR 112018011021A BR 112018011021 A BR112018011021 A BR 112018011021A BR 112018011021 A2 BR112018011021 A2 BR 112018011021A2
Authority
BR
Brazil
Prior art keywords
tissues
biological tissues
treated
xenoantigens
inactivating
Prior art date
Application number
BR112018011021A
Other languages
English (en)
Other versions
BR112018011021B1 (pt
Inventor
GANDAGLIA Alessandro
NASO Filippo
Original Assignee
Biocompatibility Innovation Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibility Innovation Srl filed Critical Biocompatibility Innovation Srl
Publication of BR112018011021A2 publication Critical patent/BR112018011021A2/pt
Publication of BR112018011021B1 publication Critical patent/BR112018011021B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Abstract

a presente invenção refere-se a um método para inativar xenoantígenos em tecidos biológicos, particularmente em tecidos que podem ser utilizados para fabricar substitutos bioprotéticos e / ou em substitutos bioprotéticos que já são preparados e destinados ao uso clínico humano ou veterinário. tal método envolve as seguintes etapas: - prover uma solução baseada em compostos fenólicos, compostos polifenólicos ou seus derivados, para a inativação de pelo menos parte dos epítopos xenogênicos de tais tecidos; - incubar as amostras a serem tratadas nas várias soluções baseadas em fenóis / polifenóis em condições controladas; - submeter os tecidos tratados a uma série de lavagens.
BR112018011021-3A 2015-11-30 2016-11-25 Mètodo para a inativaçâo de xenoantígenos em tecidos biológicos, uso de tecido conjuntivo e kit para realizar o método BR112018011021B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102015000078236 2015-11-30
ITUB2015A006019A ITUB20156019A1 (it) 2015-11-30 2015-11-30 Metodo per l'inattivazione di xenoantigeni in tessuti biologici
PCT/EP2016/078898 WO2017093147A1 (en) 2015-11-30 2016-11-25 Method for inactivating xenoantigens in biological tissues

Publications (2)

Publication Number Publication Date
BR112018011021A2 true BR112018011021A2 (pt) 2018-11-21
BR112018011021B1 BR112018011021B1 (pt) 2021-12-07

Family

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Also Published As

Publication number Publication date
RU2018123621A3 (pt) 2020-04-10
IL259591B (en) 2022-04-01
JP2019503821A (ja) 2019-02-14
AU2016363536B2 (en) 2021-04-01
RS62100B1 (sr) 2021-08-31
CA3006234A1 (en) 2017-06-08
CU20180048A7 (es) 2018-11-06
US20180353647A1 (en) 2018-12-13
KR20180090816A (ko) 2018-08-13
RU2018123621A (ru) 2020-01-09
CN108367098A (zh) 2018-08-03
WO2017093147A1 (en) 2017-06-08
RU2754197C2 (ru) 2021-08-30
PL3383446T3 (pl) 2021-11-02
CN108367098B (zh) 2021-06-11
DK3383446T3 (da) 2021-07-26
JP7169645B2 (ja) 2022-11-11
ITUB20156019A1 (it) 2017-05-30
ES2881603T3 (es) 2021-11-30
AU2016363536A1 (en) 2018-06-28
IL259591A (en) 2018-07-31
CU24631B1 (es) 2022-12-12
EP3383446A1 (en) 2018-10-10
MX2018006577A (es) 2018-09-05
EP3383446B1 (en) 2021-04-28
ZA201803786B (en) 2019-02-27

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/11/2016, OBSERVADAS AS CONDICOES LEGAIS.