BR112018004325A2 - - Google Patents
Info
- Publication number
- BR112018004325A2 BR112018004325A2 BR112018004325A BR112018004325A BR112018004325A2 BR 112018004325 A2 BR112018004325 A2 BR 112018004325A2 BR 112018004325 A BR112018004325 A BR 112018004325A BR 112018004325 A BR112018004325 A BR 112018004325A BR 112018004325 A2 BR112018004325 A2 BR 112018004325A2
- Authority
- BR
- Brazil
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1516504.6 | 2015-09-17 | ||
| GBGB1516504.6A GB201516504D0 (en) | 2015-09-17 | 2015-09-17 | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| PCT/EP2016/071782 WO2017046216A1 (en) | 2015-09-17 | 2016-09-15 | 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018004325A2 true BR112018004325A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2018-10-02 |
| BR112018004325B1 BR112018004325B1 (pt) | 2023-10-17 |
Family
ID=54544418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018004325-7A BR112018004325B1 (pt) | 2015-09-17 | 2016-09-15 | Composto de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, sal farmaceuticamente aceitável, forma cristalina, composição farmacêutica e uso do dito composto ou de um sal farmaceuticamente aceitável do mesmo |
Country Status (37)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201608227D0 (en) * | 2016-05-11 | 2016-06-22 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| WO2019057757A1 (en) | 2017-09-20 | 2019-03-28 | Astrazeneca Ab | 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER |
| CN112752758B (zh) | 2018-09-14 | 2023-05-23 | 苏州赞荣医药科技有限公司 | 作为ATM激酶选择性调节剂的咪唑并[4,5-c]噌啉-2-酮化合物及其用途 |
| WO2021139814A1 (zh) * | 2020-01-09 | 2021-07-15 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
| EP4115883A4 (en) * | 2020-03-04 | 2024-04-10 | Pharos Ibio Co., Ltd. | USE OF A 2,3,5-SUBSTITUTED THIOPHENE COMPOUND TO PREVENT, MITIGATE OR TREAT OVARIAN CANCER |
| EP4171651A1 (en) | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and atm inhibitor |
| EP4219499A4 (en) * | 2020-09-28 | 2025-04-02 | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | A class of fused ring compounds, and preparation and use thereof |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
| WO2022125614A1 (en) * | 2020-12-09 | 2022-06-16 | Stingray Therapeutics, Inc. | Phosphonates as inhibitors of enpp1 and cdnp |
| WO2022193166A1 (en) * | 2021-03-17 | 2022-09-22 | Suzhou Zanrong Pharma Limited | Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof |
| CN115304598B (zh) * | 2021-08-25 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一种杂环类化合物及其制备方法和用途 |
| GB202114704D0 (en) | 2021-10-14 | 2021-12-01 | Univ Birmingham | ATM inhibition |
| TW202340189A (zh) * | 2022-01-26 | 2023-10-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有肼基的化合物 |
| CN118984706A (zh) * | 2022-04-11 | 2024-11-19 | 钟卫 | 一种取代的1-(3,3-二氟哌啶-4-基)-咪唑并[4,5-c]喹啉-2-酮衍生物的晶型、其盐的晶型、制备方法及应用 |
| WO2025056741A1 (en) | 2023-09-13 | 2025-03-20 | Astrazeneca Ab | Azd1390, or a pharmaceutically acceptable salt thereof, in combination with radiation for use in a method of treatment of a cns tumour |
| WO2025190957A1 (en) | 2024-03-13 | 2025-09-18 | Astrazeneca Ab | Azd1390, or a pharmaceutically acceptable salt thereof, in combination with radiation for use in a method of treatment of a central nervous system (cns) tumour |
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| US10858316B2 (en) | 2015-07-10 | 2020-12-08 | University Of Maryland, Baltimore | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof |
| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| MX388839B (es) | 2016-03-16 | 2025-03-20 | Kura Oncology Inc | Inhibidores sustituidos de menina-mll y metodos de uso |
-
2015
- 2015-09-17 GB GBGB1516504.6A patent/GB201516504D0/en not_active Ceased
-
2016
- 2016-09-14 TW TW105129931A patent/TWI714631B/zh active
- 2016-09-14 TW TW109145998A patent/TWI762109B/zh active
- 2016-09-15 MX MX2018003186A patent/MX384930B/es unknown
- 2016-09-15 RS RS20210170A patent/RS61435B1/sr unknown
- 2016-09-15 HU HUE20156172A patent/HUE058884T2/hu unknown
- 2016-09-15 ES ES20156172T patent/ES2920876T3/es active Active
- 2016-09-15 HU HUE16770461A patent/HUE053066T2/hu unknown
- 2016-09-15 KR KR1020197028342A patent/KR102469153B1/ko active Active
- 2016-09-15 EP EP16770461.8A patent/EP3350180B1/en active Active
- 2016-09-15 MY MYPI2023000366A patent/MY198813A/en unknown
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