BR112015031079A2 - derivados de aminotriazina e composição farmacêutica contendo os referidos derivados - Google Patents

derivados de aminotriazina e composição farmacêutica contendo os referidos derivados

Info

Publication number
BR112015031079A2
BR112015031079A2 BR112015031079A BR112015031079A BR112015031079A2 BR 112015031079 A2 BR112015031079 A2 BR 112015031079A2 BR 112015031079 A BR112015031079 A BR 112015031079A BR 112015031079 A BR112015031079 A BR 112015031079A BR 112015031079 A2 BR112015031079 A2 BR 112015031079A2
Authority
BR
Brazil
Prior art keywords
aminotriazine derivatives
pharmaceutical composition
composition containing
aminotriazine
derivatives
Prior art date
Application number
BR112015031079A
Other languages
English (en)
Other versions
BR112015031079B1 (pt
Inventor
Kai Hiroyuki
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BR112015031079A2 publication Critical patent/BR112015031079A2/pt
Publication of BR112015031079B1 publication Critical patent/BR112015031079B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção refere-se a novos compostos tendo um antagônismo receptores p2x3 e/ou p2x2/3. um composto indicado pela fórmula (i) : fórmula química 1 ou seu sal farmaceuticamente aceitável do mesmo. na fórmula (i) em que ra e rb, e rd e re juntos formam oxo ou similar; r4a e r4b são hidrogênio ou similar; n é 1 ou similar; r2 é arila ou similar; s e s' são 0 ou similar; r9 e r9 são halogênio ou similar; r20a e r20b são hidrogênio, alquila similar; u é 1 a 4; r13 é hidrogênio ou similar.
BR112015031079-6A 2013-06-14 2014-06-13 Derivados de aminotriazina e composição farmacêutica contendo os referidos derivados BR112015031079B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013125134 2013-06-14
JP2013-125134 2013-06-14
PCT/JP2014/065678 WO2014200078A1 (ja) 2013-06-14 2014-06-13 アミノトリアジン誘導体およびそれらを含有する医薬組成物

Publications (2)

Publication Number Publication Date
BR112015031079A2 true BR112015031079A2 (pt) 2017-07-25
BR112015031079B1 BR112015031079B1 (pt) 2022-08-02

Family

ID=52022364

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015031079-6A BR112015031079B1 (pt) 2013-06-14 2014-06-13 Derivados de aminotriazina e composição farmacêutica contendo os referidos derivados

Country Status (20)

Country Link
US (2) US9732060B2 (pt)
EP (1) EP3009432B1 (pt)
JP (1) JP6132371B2 (pt)
KR (2) KR20170116177A (pt)
CN (1) CN105452234B (pt)
AR (1) AR096620A1 (pt)
AU (1) AU2014279116B2 (pt)
BR (1) BR112015031079B1 (pt)
CA (1) CA2915325C (pt)
DK (1) DK3009432T3 (pt)
EA (1) EA030198B1 (pt)
ES (1) ES2675528T3 (pt)
IL (1) IL243042A0 (pt)
MX (1) MX362995B (pt)
PH (1) PH12015502775A1 (pt)
PL (1) PL3009432T3 (pt)
SG (1) SG11201510179PA (pt)
TR (1) TR201809085T4 (pt)
TW (1) TWI637949B (pt)
WO (1) WO2014200078A1 (pt)

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CN107709299B (zh) 2015-04-24 2021-07-16 盐野义制药株式会社 6元杂环衍生物及含有其的药物组合物
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AU2019353424B2 (en) * 2018-10-05 2022-12-08 Shionogi & Co., Ltd. Medicine for treating chronic cough
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TW202203930A (zh) * 2020-04-03 2022-02-01 日商塩野義製藥股份有限公司 睡眠時呼吸中止症候群治療用醫藥
TW202203929A (zh) * 2020-04-03 2022-02-01 日商塩野義製藥股份有限公司 疼痛治療用醫藥
JP7029875B1 (ja) * 2020-05-15 2022-03-04 塩野義製薬株式会社 不純物の生成を抑制した医薬組成物
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CN113773300B (zh) * 2021-09-27 2022-10-11 成都施贝康生物医药科技有限公司 磺酰胺类化合物、其制备方法及用途
CN113620888B (zh) * 2021-09-27 2023-06-06 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物及其制备方法和应用
CN113801097B (zh) * 2021-09-27 2022-11-22 成都施贝康生物医药科技有限公司 二氢嘧啶类化合物、其制备方法及用途
TW202320793A (zh) 2021-09-28 2023-06-01 日商塩野義製藥股份有限公司 含有三嗪衍生物之醫藥組合物
MX2024003600A (es) 2021-09-28 2024-04-09 Shionogi & Co Composicion farmaceutica que contiene un derivado de triazina.
AU2022333823A1 (en) 2021-11-24 2024-05-02 Shionogi & Co., Ltd. Preparation for oral administration containing triazine derivative
JPWO2023095860A1 (pt) * 2021-11-26 2023-06-01
TW202339757A (zh) 2022-01-19 2023-10-16 日商塩野義製藥股份有限公司 新型冠狀病毒感染症治療用醫藥
CN115650959B (zh) * 2022-05-20 2023-10-20 南京济群医药科技股份有限公司 化合物的制备方法或纯化方法
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Also Published As

Publication number Publication date
EP3009432A4 (en) 2016-11-02
US10065941B2 (en) 2018-09-04
BR112015031079B1 (pt) 2022-08-02
TWI637949B (zh) 2018-10-11
PH12015502775A1 (en) 2016-03-21
KR101813411B1 (ko) 2017-12-28
TR201809085T4 (tr) 2018-07-23
EP3009432B1 (en) 2018-04-25
AU2014279116B2 (en) 2016-11-10
PL3009432T3 (pl) 2018-09-28
EA030198B1 (ru) 2018-07-31
JP6132371B2 (ja) 2017-05-24
CA2915325C (en) 2021-09-14
ES2675528T3 (es) 2018-07-11
IL243042A0 (en) 2016-02-01
US9732060B2 (en) 2017-08-15
WO2014200078A1 (ja) 2014-12-18
KR20170116177A (ko) 2017-10-18
AR096620A1 (es) 2016-01-20
DK3009432T3 (en) 2018-07-16
TW201529567A (zh) 2015-08-01
MX362995B (es) 2019-03-01
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