BR112015022223A2 - topical compositions and methods of treating topical disorders - Google Patents

topical compositions and methods of treating topical disorders

Info

Publication number
BR112015022223A2
BR112015022223A2 BR112015022223A BR112015022223A BR112015022223A2 BR 112015022223 A2 BR112015022223 A2 BR 112015022223A2 BR 112015022223 A BR112015022223 A BR 112015022223A BR 112015022223 A BR112015022223 A BR 112015022223A BR 112015022223 A2 BR112015022223 A2 BR 112015022223A2
Authority
BR
Brazil
Prior art keywords
topical
film
body surface
composition
methods
Prior art date
Application number
BR112015022223A
Other languages
Portuguese (pt)
Other versions
BR112015022223B1 (en
Inventor
Eilat Eran
Lozinsky Evgenia
Original Assignee
Peritech Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peritech Pharma Ltd filed Critical Peritech Pharma Ltd
Publication of BR112015022223A2 publication Critical patent/BR112015022223A2/en
Publication of BR112015022223B1 publication Critical patent/BR112015022223B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015Drug-containing film-forming compositions, e.g. spray-on
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents

Abstract

resumo patente de invenção: "composições tópicas e métodos de tratamento de distúrbios tópicos". a presente invenção refere-se a uma composição tópica que inclui pelo menos um ingrediente formador de filme; pelo menos um tensoativo; pelo menos um solvente de siloxano volátil não polar; pelo menos 15% (p/p) de água; e uma concentração terapeuticamente eficaz de pelo menos um agente farmacêutico, em que a composição é suficientemente projetada para secar em 60 segundos após a aplicação a uma superfície corporal para formar uma composição seca e em que a composição seca forma: um filme flexível, em que o filme flexível segue de perto as irregularidades da superfície corporal bem como o movimento da superfície corporal, e (ii) um filme durável, em que o filme durável não racha ou descama e permanece intacto por mais de 12 horas, proporcionando a liberação do agente farmacêutico por um período de tempo estendido. 1/1Patent Summary: "Topical compositions and methods of treating topical disorders". The present invention relates to a topical composition comprising at least one film-forming ingredient; at least one surfactant; at least one nonpolar volatile siloxane solvent; at least 15% (w / w) water; and a therapeutically effective concentration of at least one pharmaceutical agent, wherein the composition is sufficiently designed to dry within 60 seconds after application to a body surface to form a dry composition and wherein the dry composition forms: a flexible film wherein the flexible film closely follows body surface irregularities as well as body surface movement, and (ii) a durable film in which the durable film does not crack or peel and remains intact for more than 12 hours, providing agent release pharmacist for an extended period of time. 1/1

BR112015022223-4A 2013-03-10 2014-03-10 TOPICAL COMPOSITION, ITS USE, AND KIT BR112015022223B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361775598P 2013-03-10 2013-03-10
US61/775,598 2013-03-10
IB2014140925 2014-09-18

Publications (2)

Publication Number Publication Date
BR112015022223A2 true BR112015022223A2 (en) 2017-07-18
BR112015022223B1 BR112015022223B1 (en) 2022-06-28

Family

ID=51488109

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022223-4A BR112015022223B1 (en) 2013-03-10 2014-03-10 TOPICAL COMPOSITION, ITS USE, AND KIT

Country Status (12)

Country Link
US (5) US9072747B2 (en)
EP (1) EP2968133A4 (en)
JP (1) JP2016510807A (en)
KR (1) KR20150136077A (en)
CN (1) CN105142611B (en)
AU (1) AU2014229497A1 (en)
BR (1) BR112015022223B1 (en)
CA (1) CA2904507C (en)
IL (1) IL241191B (en)
MX (1) MX2015012302A (en)
RU (1) RU2670750C9 (en)
WO (1) WO2014140925A2 (en)

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Also Published As

Publication number Publication date
US20140255521A1 (en) 2014-09-11
EP2968133A2 (en) 2016-01-20
CN105142611B (en) 2019-06-04
US20150272957A1 (en) 2015-10-01
JP2016510807A (en) 2016-04-11
KR20150136077A (en) 2015-12-04
RU2670750C9 (en) 2018-12-13
AU2014229497A1 (en) 2015-09-24
CA2904507C (en) 2021-05-04
US10085995B2 (en) 2018-10-02
CN105142611A (en) 2015-12-09
RU2015143158A3 (en) 2018-03-20
BR112015022223B1 (en) 2022-06-28
US20180344743A1 (en) 2018-12-06
WO2014140925A3 (en) 2015-07-30
US9072747B2 (en) 2015-07-07
RU2015143158A (en) 2017-04-18
US20140256688A1 (en) 2014-09-11
WO2014140925A2 (en) 2014-09-18
EP2968133A4 (en) 2016-03-09
IL241191B (en) 2020-02-27
US20140255522A1 (en) 2014-09-11
US10085994B2 (en) 2018-10-02
IL241191A0 (en) 2015-11-30
CA2904507A1 (en) 2014-09-18
RU2670750C2 (en) 2018-10-25
MX2015012302A (en) 2016-06-21

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