BR112015006264A2 - composições de oligonucleotídeos cpg ocorrendo naturalmente e suas aplicações terapêuticas - Google Patents

composições de oligonucleotídeos cpg ocorrendo naturalmente e suas aplicações terapêuticas

Info

Publication number
BR112015006264A2
BR112015006264A2 BR112015006264A BR112015006264A BR112015006264A2 BR 112015006264 A2 BR112015006264 A2 BR 112015006264A2 BR 112015006264 A BR112015006264 A BR 112015006264A BR 112015006264 A BR112015006264 A BR 112015006264A BR 112015006264 A2 BR112015006264 A2 BR 112015006264A2
Authority
BR
Brazil
Prior art keywords
naturally occurring
disorders
therapeutic applications
combination
oligonucleotide compositions
Prior art date
Application number
BR112015006264A
Other languages
English (en)
Inventor
Mckenna Elizabeth
Original Assignee
Mckenna Elizabeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mckenna Elizabeth filed Critical Mckenna Elizabeth
Publication of BR112015006264A2 publication Critical patent/BR112015006264A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

abstract: the present invention relates to combination therapies for the treatment of a variety of disorders in mammals, including hepatic disorders and cancer. the combination of agents includes naturally-occurring (versus synthetic) oligonucleotides, particularly immunostimulatory oligodeoxynucleotides such as cpg odns, obtained from a natural source and one or more extracts from a gram positive bacteria, such as lactobacillus spp. ----------------------------------------------------------------------------------------------- tradução do resumo resumo patente de invenção: "composições de oligonucleotídeos cpg ocorrendo naturalmente e suas aplicações terapêuticas". a presente invenção refere-se a terapias de combinação para o tratamento de uma variedade de distúrbios em mamíferos, incluindo distúrbios hepáticos e câncer. a combinação de agentes inclui oligonucleotídeos ocorrendo naturalmente (versus sintéticos), particularmente oligo desoxinucleotídeos imuno estimuladores tais como odns cpg, obtidos de uma fonte natural e um ou mais extratos de uma bactéria gram positiva, tal como lactobacillus spp.
BR112015006264A 2012-09-21 2013-09-23 composições de oligonucleotídeos cpg ocorrendo naturalmente e suas aplicações terapêuticas BR112015006264A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261704090P 2012-09-21 2012-09-21
PCT/US2013/061236 WO2014047588A1 (en) 2012-09-21 2013-09-23 Naturally occurring cpg oligonucleotide compositions and therapeutic applications thereof

Publications (1)

Publication Number Publication Date
BR112015006264A2 true BR112015006264A2 (pt) 2017-07-04

Family

ID=50339054

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015006264A BR112015006264A2 (pt) 2012-09-21 2013-09-23 composições de oligonucleotídeos cpg ocorrendo naturalmente e suas aplicações terapêuticas

Country Status (7)

Country Link
US (3) US20140086849A1 (pt)
EP (1) EP2898073A4 (pt)
JP (4) JP2015535829A (pt)
BR (1) BR112015006264A2 (pt)
HK (1) HK1213017A1 (pt)
IL (1) IL237865B (pt)
WO (1) WO2014047588A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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NZ625592A (en) 2012-01-16 2016-09-30 Elizabeth Mckenna Compositions and methods for the treatment of hepatic diseases and disorders
US20170232047A1 (en) * 2012-01-16 2017-08-17 Elizabeth McKenna Control of Cellular Redox Levels
EP2898073A4 (en) 2012-09-21 2016-03-23 Elizabeth Mckenna Naturally-occurring CPG-oligonucleotide compositions and therapeutic applications thereof
EP3554344A1 (en) 2016-12-14 2019-10-23 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
US20210123057A1 (en) * 2019-10-29 2021-04-29 Northwestern University Sequence Multiplicity Within Spherical Nucleic Acids
CN114515295B (zh) * 2022-03-31 2023-08-29 东莞市人民医院 CpG ODN在制备防治药物性肝损伤的药物中的应用
CN115227684B (zh) * 2022-07-28 2023-11-17 杭州师范大学 靶向M2型巨噬细胞CpG和ELE脂质体及制法和应用
CN117180317B (zh) * 2023-11-02 2024-01-26 深圳市第二人民医院(深圳市转化医学研究院) 詹氏乳杆菌来源纳米囊泡在制备防治卵巢早衰治疗药物中的应用

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Also Published As

Publication number Publication date
US20170266277A9 (en) 2017-09-21
US9931398B2 (en) 2018-04-03
EP2898073A4 (en) 2016-03-23
EP2898073A1 (en) 2015-07-29
US20180369367A1 (en) 2018-12-27
IL237865B (en) 2021-04-29
WO2014047588A1 (en) 2014-03-27
US20170087247A1 (en) 2017-03-30
JP2018076339A (ja) 2018-05-17
US20140086849A1 (en) 2014-03-27
JP2020090503A (ja) 2020-06-11
HK1213017A1 (zh) 2016-06-24
JP2015535829A (ja) 2015-12-17
JP2022078078A (ja) 2022-05-24
IL237865A0 (en) 2015-05-31
US10688177B2 (en) 2020-06-23

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