BR112013026868A2 - intermediário para a síntese de caspofungina e método para o seu preparo - Google Patents

intermediário para a síntese de caspofungina e método para o seu preparo

Info

Publication number
BR112013026868A2
BR112013026868A2 BR112013026868A BR112013026868A BR112013026868A2 BR 112013026868 A2 BR112013026868 A2 BR 112013026868A2 BR 112013026868 A BR112013026868 A BR 112013026868A BR 112013026868 A BR112013026868 A BR 112013026868A BR 112013026868 A2 BR112013026868 A2 BR 112013026868A2
Authority
BR
Brazil
Prior art keywords
caspofungin
preparation
synthesis
efficiently
represented
Prior art date
Application number
BR112013026868A
Other languages
English (en)
Inventor
Fuyao Zhang
Gaoqiang Hu
Piaoyang Sun
Xiaoming Shen
Original Assignee
Unitris Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unitris Biopharma Co Ltd filed Critical Unitris Biopharma Co Ltd
Publication of BR112013026868A2 publication Critical patent/BR112013026868A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Abstract

resumo patente de invenção: "intermediário para a síntese de caspofungina e método para o seu preparo". a presente invenção diz respeito a um intermediário, conforme representado na fórmula (i), para sintetizar caspofungina, e a um método para seu preparo. o intermediário possibilita preparar caspofungina de modo eficiente.
BR112013026868A 2011-04-28 2012-03-21 intermediário para a síntese de caspofungina e método para o seu preparo BR112013026868A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110107633 2011-04-28
PCT/CN2012/072714 WO2012146099A1 (zh) 2011-04-28 2012-03-21 用于合成卡帕芬净的中间体及其制备方法

Publications (1)

Publication Number Publication Date
BR112013026868A2 true BR112013026868A2 (pt) 2016-09-06

Family

ID=47071596

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013026868A BR112013026868A2 (pt) 2011-04-28 2012-03-21 intermediário para a síntese de caspofungina e método para o seu preparo

Country Status (13)

Country Link
US (1) US9321779B2 (pt)
EP (1) EP2703409B1 (pt)
JP (1) JP6032822B2 (pt)
KR (1) KR20140042805A (pt)
CN (1) CN103003295B (pt)
AU (1) AU2012248013B2 (pt)
BR (1) BR112013026868A2 (pt)
CA (1) CA2833206A1 (pt)
HK (1) HK1179274A1 (pt)
MX (1) MX2013012161A (pt)
RU (1) RU2592280C2 (pt)
TW (1) TWI597293B (pt)
WO (1) WO2012146099A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2922530T (lt) 2012-11-20 2017-01-25 Fresenius Kabi Usa, Llc Kaspofungino acetato kompozicijos
CN109721641B (zh) * 2017-10-31 2021-08-03 鲁南制药集团股份有限公司 一种卡泊芬净的合成方法
CN111233981A (zh) * 2020-03-17 2020-06-05 湖南欧亚药业有限公司 一种卡泊芬净的制备方法
CN113801202A (zh) * 2020-06-15 2021-12-17 杭州中美华东制药有限公司 一种醋酸卡泊芬净杂质g的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378804A (en) 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
US5936062A (en) 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
TW201024322A (en) 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
US9006391B2 (en) * 2009-05-07 2015-04-14 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for the preparation of cyclopeptides
CN101648994B (zh) * 2009-08-06 2012-09-05 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
US20120190815A1 (en) * 2009-08-06 2012-07-26 Tianhui Xu Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates

Also Published As

Publication number Publication date
AU2012248013B2 (en) 2016-07-14
TW201309732A (zh) 2013-03-01
MX2013012161A (es) 2014-07-30
US9321779B2 (en) 2016-04-26
HK1179274A1 (en) 2013-09-27
US20140058082A1 (en) 2014-02-27
WO2012146099A1 (zh) 2012-11-01
AU2012248013A1 (en) 2013-11-14
EP2703409B1 (en) 2017-01-18
TWI597293B (zh) 2017-09-01
EP2703409A1 (en) 2014-03-05
CN103003295B (zh) 2014-09-17
CA2833206A1 (en) 2012-11-01
RU2592280C2 (ru) 2016-07-20
CN103003295A (zh) 2013-03-27
RU2013150969A (ru) 2015-11-10
EP2703409A4 (en) 2014-10-29
JP6032822B2 (ja) 2016-11-30
JP2014513087A (ja) 2014-05-29
KR20140042805A (ko) 2014-04-07

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2506 DE 15-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.