BR112012006502A2 - fragmentos de cofator ll de heparina com atividade anti-inflamatória e anticoagulante - Google Patents

fragmentos de cofator ll de heparina com atividade anti-inflamatória e anticoagulante

Info

Publication number
BR112012006502A2
BR112012006502A2 BR112012006502A BR112012006502A BR112012006502A2 BR 112012006502 A2 BR112012006502 A2 BR 112012006502A2 BR 112012006502 A BR112012006502 A BR 112012006502A BR 112012006502 A BR112012006502 A BR 112012006502A BR 112012006502 A2 BR112012006502 A2 BR 112012006502A2
Authority
BR
Brazil
Prior art keywords
inflammatory
fragments
anticoagulant activity
heparin cofactor
cofactor
Prior art date
Application number
BR112012006502A
Other languages
English (en)
Portuguese (pt)
Inventor
Artur Schmidtchen
Björn Ulrilk Walse
Gopinath Kasetty
Martina Kalle
Nils Martin Malmsten
Praveen Papareddy
Original Assignee
Ximmune Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ximmune Ab filed Critical Ximmune Ab
Publication of BR112012006502A2 publication Critical patent/BR112012006502A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
BR112012006502A 2009-09-22 2010-09-21 fragmentos de cofator ll de heparina com atividade anti-inflamatória e anticoagulante BR112012006502A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0916578.8A GB0916578D0 (en) 2009-09-22 2009-09-22 Polypeptides and uses thereof
PCT/GB2010/001780 WO2011036444A1 (en) 2009-09-22 2010-09-21 Heparin cofactor ii fragments with anti-inflammatory and anti-coagulant activity

Publications (1)

Publication Number Publication Date
BR112012006502A2 true BR112012006502A2 (pt) 2016-08-16

Family

ID=41278086

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112012006502A BR112012006502A2 (pt) 2009-09-22 2010-09-21 fragmentos de cofator ll de heparina com atividade anti-inflamatória e anticoagulante
BR112012006501A BR112012006501A8 (pt) 2009-09-22 2010-09-22 Polipeptídios e usos dos mesmos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112012006501A BR112012006501A8 (pt) 2009-09-22 2010-09-22 Polipeptídios e usos dos mesmos

Country Status (12)

Country Link
US (2) US9169315B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP2480244A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JP2013505030A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN102655874B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU2010299630A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (2) BR112012006502A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (2) CA2774288A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EA (1) EA201200515A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB0916578D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (2) IN2012DN02981A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX2012003425A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (2) WO2011036444A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2748616B1 (en) * 2011-08-23 2018-08-08 Synapse B.V. Thermostable inhibitors of activation of the blood clotting system through contact with foreign surfaces.
RU2476231C1 (ru) * 2011-10-11 2013-02-27 Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения и социального развития Российской Федерации Способ купирования некроза краев кожи послеоперационной раны после эндопротезирования голеностопного сустава
GB2500184A (en) * 2012-03-12 2013-09-18 Ximmune Ab Polypeptide derived from helix A of heparin cofactor II
CN104292309B (zh) * 2014-09-29 2017-04-12 广西中医药大学 一种小分子多肽
JPWO2016104436A1 (ja) * 2014-12-22 2017-10-26 国立大学法人 岡山大学 サイトカインストーム抑制剤
RU2606836C2 (ru) * 2015-03-12 2017-01-10 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Антикоагулянтный, антитромбоцитарный и фибриндеполимеризационный комплекс на основе гепарина, способ его получения и применение
RU2610433C1 (ru) * 2016-02-17 2017-02-10 Людмила Анисимовна Ляпина Антикоагулянт
CN107875372A (zh) * 2017-12-20 2018-04-06 辽宁师范大学 重组肽rLj‑112在制备协同肝素抗凝药物中的应用
CN108338163A (zh) * 2018-03-28 2018-07-31 陈太师 一种持效型杀菌灭藻剂的制备方法
WO2019230509A1 (ja) * 2018-05-31 2019-12-05 国立大学法人 岡山大学 活性酸素の産生抑制剤及び／又は消去促進剤
JP7340862B2 (ja) * 2018-06-28 2023-09-08 国立大学法人 岡山大学 好中球貪食能増強剤
JP7518061B2 (ja) * 2018-08-16 2024-07-17 エフ． ホフマン－ラ ロシュ アーゲー 心房細動および抗凝固療法の評価における循環ｔｆｐｉ－２（組織因子経路阻害剤２）
CN109432513B (zh) * 2018-12-12 2021-03-23 中国医科大学 一种具有抗血栓再形成功能的生物材料及其制备方法
US11904000B2 (en) 2019-05-06 2024-02-20 Brown University Compositions and methods to enhance cutaneous wound healing
CN114364394A (zh) * 2020-05-26 2022-04-15 约翰内斯·古滕伯格美因兹大学医学院 用于治疗冠状病毒感染及相关凝血病的方法和组合物
CN114113601A (zh) * 2020-08-25 2022-03-01 张曼 尿液肝素辅因子ii及其多肽片段在烧伤中的应用
CN114292765B (zh) * 2021-09-24 2023-04-07 江西康之康中药科技有限公司 枯草芽孢杆菌纳豆亚种r3及其在发酵水蛭低温干燥品中的应用
CN114886116B (zh) * 2022-03-18 2023-11-21 广东丸美生物技术股份有限公司 一种调理育龄女性健康的组合物及其制备方法和饮料及应用
CN116510074A (zh) * 2023-03-13 2023-08-01 西南交通大学 一种胆碱磷酸功能化可植入钛支架的制备方法
CN116836233B (zh) * 2023-08-31 2023-11-14 中国农业大学 抗炎活性多肽及其应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5118793A (en) * 1989-10-20 1992-06-02 Washington University Modified heparin cofactor II
US5102995A (en) * 1989-10-20 1992-04-07 Washington University Dna encoding modified heparin cofactor ii
US5643872A (en) 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
WO1992018139A1 (en) 1991-04-09 1992-10-29 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
US6008058A (en) 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5712247A (en) * 1995-02-21 1998-01-27 University Of North Carolina Use of lactoferrin to modulate and/or neutralize heparin activity
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
JPH09176040A (ja) * 1995-12-27 1997-07-08 Green Cross Corp:The ヘパリンコファクターｉｉの医薬用途
US6946439B2 (en) * 1997-02-06 2005-09-20 Entre Med, Inc. Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
US6207419B1 (en) * 1998-02-27 2001-03-27 The University Of North Carolina At Chapel Hill Thrombin inhibitory agents and methods of using same
WO2001036632A2 (en) * 1999-11-17 2001-05-25 Compugen Ltd. Variants of alternative splicing
JP2005504025A (ja) * 2001-07-20 2005-02-10 アイトゲネシシェ テクニシェ ホッヒシュル チューリッヒ（エーテーハーツェット） スルフォネート化またはスルフェート化アミノ酸から誘導された生物学的薬剤の使用法と組成物
GB0131112D0 (en) 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
EP1530629B1 (en) * 2002-05-31 2011-08-31 The University of Utah Research Foundation Variants of antithrombin iii
JP5348651B2 (ja) * 2002-11-22 2013-11-20 ネクスバイオ，インク． 広域抗ウイルス治療および予防薬
GB0316294D0 (en) 2003-07-11 2003-08-13 Polytherics Ltd Conjugated biological molecules and their preparation
WO2005015206A2 (en) 2003-08-08 2005-02-17 Genova Ltd. Secreted polypeptide species associated with cardiovascular disorders
RU2006136267A (ru) * 2004-03-17 2008-04-27 Чирон Корпорейшн (Us) Лечение тяжелой внебольничной пневмонии путем введения ингибитора пути тканевого фактора (tfpi)
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
RU2007145202A (ru) * 2005-05-06 2009-06-20 Новартис Аг (Us) Использование tfpi для лечения тяжелых бактериальных инфекций
BRPI0613676A2 (pt) * 2005-07-22 2011-01-25 Novartis Ag polipeptìdeo, seu uso e composição farmacêutica compreendendo o mesmo
LT1981519T (lt) * 2005-12-29 2018-04-25 Dyax Corp. Proteazės slopinimas
EP2653542B1 (en) * 2005-12-29 2016-06-29 The Regents of The University of California Methods and compositions related to mutant kunitz domain I of TFPI-2
US8076286B2 (en) * 2006-02-10 2011-12-13 Dermagen Ab Antimicrobial peptides and use thereof
KR20150067772A (ko) * 2007-04-13 2015-06-18 카탈리스트 바이오사이언시즈, 인코포레이티드 변형 제ｖｉｉ 인자 폴리펩타이드 및 이의 용도
KR20100044238A (ko) * 2007-07-24 2010-04-29 넥스바이오, 인코퍼레이티드 마이크로입자를 제조하는 기술

Also Published As

Publication number Publication date
IN2012DN03368A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-10-23
CN102655874B (zh) 2015-06-10
AU2010299630A2 (en) 2012-05-03
EP2480564A2 (en) 2012-08-01
MX2012003425A (es) 2012-10-09
CA2774288A1 (en) 2011-03-31
CA2774296A1 (en) 2011-03-31
WO2011036445A2 (en) 2011-03-31
GB0916578D0 (en) 2009-10-28
BR112012006501A2 (pt) 2016-08-16
WO2011036445A3 (en) 2011-09-01
EA201200515A1 (ru) 2012-10-30
IN2012DN02981A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-07-31
JP2013505286A (ja) 2013-02-14
WO2011036444A4 (en) 2011-06-23
US9169315B2 (en) 2015-10-27
CN102655874A (zh) 2012-09-05
US20120177715A1 (en) 2012-07-12
CN102639556A (zh) 2012-08-15
US20120189673A1 (en) 2012-07-26
EP2480244A1 (en) 2012-08-01
WO2011036444A1 (en) 2011-03-31
JP2013505030A (ja) 2013-02-14
AU2010299630A1 (en) 2012-04-26
BR112012006501A8 (pt) 2017-07-11
AU2010299631A1 (en) 2012-05-03

Similar Documents

Publication Publication Date Title
BR112012006502A2 (pt) fragmentos de cofator ll de heparina com atividade anti-inflamatória e anticoagulante
BRPI0906404A2 (pt) construções de fusão com dominio lítico e processos de produção e de utilização das mesmas
PT2391129T (pt) Novo modo de previsão planar
BR112012002955A2 (pt) estruturas fibrosas e métodos de fabricação das mesmas.
EP3865162C0 (en) SYRINGE ARRANGEMENT
BRPI0924902A2 (pt) Linhagens de bactérias com alta atividade anti-inflamatória
BRPI1014404A2 (pt) cânula dotada de recurso de cânula e recurso de encaixe em sobreposição
EP2289368A4 (en) CARRIER ARRANGEMENT
HRP20160737T1 (hr) Anti-her3-protutijela i njihove uporabe
DK2007981T3 (da) Vindmølle med slank vinge
BRPI1015379A2 (pt) sistemas de cálculo biométrico e métodos
BRPI1011404A2 (pt) mutantes e usos dos mesmos
BRPI0911242A2 (pt) conjunto de articulação e/ou mancal
BR112013015531A2 (pt) liga de alumínio-cobre-lítio com resistência em compressão e tenacidade melhoradas
EP2500449A4 (en) PHOTOELECTROCHEMICAL CELL AND ENERGY SYSTEM THEREWITH
BR112012011363A2 (pt) estrutura de colméia e painél sanduíche estrutural
PT3686183T (pt) Fenilacetato de l-ornitina e métodos de preparação do mesmo
EP2463758A4 (en) Touch panel
EP2529124A4 (en) BEARING ARRANGEMENT
EP2198781A4 (en) Puncture
BRPI0910116A2 (pt) desvio transparente e mecanismos associados
BRPI1007811A2 (pt) nacela de turborreator, e, turborreator
BRPI0918218A2 (pt) montagem e modelagem de painel laminado
EP2352640A4 (en) LEADING LAMINATE ARRANGEMENT
BR112012015240A2 (pt) sensor de fibra ótica com base na estrutura em espiral

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority
B25G Requested change of headquarter approved

Owner name: XIMMUNE AB (SE)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]