BR0315605A - 11-beta-hydroxy steroid dehydrogenase inhibitors type 1 and type 2 - Google Patents

11-beta-hydroxy steroid dehydrogenase inhibitors type 1 and type 2

Info

Publication number
BR0315605A
BR0315605A BR0315605A BR0315605A BR0315605A BR 0315605 A BR0315605 A BR 0315605A BR 0315605 A BR0315605 A BR 0315605A BR 0315605 A BR0315605 A BR 0315605A BR 0315605 A BR0315605 A BR 0315605A
Authority
BR
Brazil
Prior art keywords
type
beta
steroid dehydrogenase
hydroxy steroid
group
Prior art date
Application number
BR0315605A
Other languages
Portuguese (pt)
Inventor
Nigel Vicker
Xiangdong Su
Dharshini Ganeshapillai
Atul Purohit
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0224830A priority Critical patent/GB0224830D0/en
Priority to US43663502P priority
Application filed by Sterix Ltd filed Critical Sterix Ltd
Priority to PCT/GB2003/004590 priority patent/WO2004037251A1/en
Publication of BR0315605A publication Critical patent/BR0315605A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring-systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring-systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring-systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70Sulfur atoms
    • C07D277/74Sulfur atoms substituted by carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring-systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms

Abstract

"11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2 INHIBITORS". A compound having the formula (I) is provided: wherein one of R 1 -, and R 2 - is a group of Formula (a) wherein R 4 - is selected from H and hydrocarbyl, R R 5 is a hydrocarbyl group and L is an optional linking group, or R 1 and R 2 together form a ring substituted with the group (Formula (a)) in which R 3 is H or R 2. a substituent, and wherein X is selected from S, O, NR ~ 6 ~ and C (R ~ 7 ~) (R ~ 8 ~), wherein R ~ 6 ~ is selected from H and hydrocarbyl groups wherein each of R 7 and R 8 is independently selected from H and hydrocarbyl groups.
BR0315605A 2002-10-24 2003-10-23 11-beta-hydroxy steroid dehydrogenase inhibitors type 1 and type 2 BR0315605A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB0224830A GB0224830D0 (en) 2002-10-24 2002-10-24 Compound
US43663502P true 2002-12-30 2002-12-30
PCT/GB2003/004590 WO2004037251A1 (en) 2002-10-24 2003-10-23 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2

Publications (1)

Publication Number Publication Date
BR0315605A true BR0315605A (en) 2005-08-30

Family

ID=32178879

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315605A BR0315605A (en) 2002-10-24 2003-10-23 11-beta-hydroxy steroid dehydrogenase inhibitors type 1 and type 2

Country Status (10)

Country Link
EP (1) EP1556040A1 (en)
JP (1) JP2006514614A (en)
KR (1) KR20050059294A (en)
AU (1) AU2003274373A1 (en)
BR (1) BR0315605A (en)
CA (1) CA2501228A1 (en)
MX (1) MXPA05004434A (en)
NO (1) NO20052469L (en)
PL (1) PL376301A1 (en)
WO (1) WO2004037251A1 (en)

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US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
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US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
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Also Published As

Publication number Publication date
KR20050059294A (en) 2005-06-17
NO20052469L (en) 2005-07-22
AU2003274373A1 (en) 2004-05-13
MXPA05004434A (en) 2005-07-26
CA2501228A1 (en) 2004-05-06
EP1556040A1 (en) 2005-07-27
JP2006514614A (en) 2006-05-11
PL376301A1 (en) 2005-12-27
WO2004037251A1 (en) 2004-05-06
NO20052469D0 (en) 2005-05-23

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B25G Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of headquarter granted

Owner name: STERIX LIMITED (UK)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070074749/RJ DE 05/06/2007.

B08F Application fees: dismissal - article 86 of industrial property law

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B08K Maintenance of archiving: application remains archived as no request for restauration (art. 87) has been received.

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