BR0213213A - composições farmacêuticas pró-micela - Google Patents

composições farmacêuticas pró-micela

Info

Publication number
BR0213213A
BR0213213A BRPI0213213-3A BR0213213A BR0213213A BR 0213213 A BR0213213 A BR 0213213A BR 0213213 A BR0213213 A BR 0213213A BR 0213213 A BR0213213 A BR 0213213A
Authority
BR
Brazil
Prior art keywords
pro
pharmaceutical compositions
compositions
micelle
active agent
Prior art date
Application number
BRPI0213213-3A
Other languages
English (en)
Inventor
Young W Cho
Keith Kwang-Ho Lee
Original Assignee
Imi Biomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imi Biomed Inc filed Critical Imi Biomed Inc
Publication of BR0213213A publication Critical patent/BR0213213A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçõES FARMACêUTICAS PRó-MICELA". A presente invenção provê composições pró-micela compreendendo agente farmaceuticamente ativo encapsulado com uma membrana de ácidos graxos C~ 12~-C~ 18~ esterificados. No intestino do mamífero, a exposição a ácidos graxos C~ 12~-C~ 18~ resulta em conversão da pró-micela a uma micela estável que distribui eficazmente o agente farmaceuticamente ativo à circulação sistêmica. A presente invenção também provê processos de fabricação e uso de tais composições.
BRPI0213213-3A 2001-10-11 2002-09-05 composições farmacêuticas pró-micela BR0213213A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/974,942 US6951655B2 (en) 2001-10-11 2001-10-11 Pro-micelle pharmaceutical compositions
PCT/US2002/028159 WO2003030865A1 (en) 2001-10-11 2002-09-05 Pro-micelle pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BR0213213A true BR0213213A (pt) 2007-04-10

Family

ID=25522533

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0213213-3A BR0213213A (pt) 2001-10-11 2002-09-05 composições farmacêuticas pró-micela

Country Status (9)

Country Link
US (1) US6951655B2 (pt)
EP (1) EP1439821A1 (pt)
JP (1) JP2005508938A (pt)
KR (1) KR20040058196A (pt)
CN (1) CN1303977C (pt)
BR (1) BR0213213A (pt)
HK (1) HK1072200A1 (pt)
MX (1) MXPA04003440A (pt)
WO (1) WO2003030865A1 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759058B1 (en) * 2001-04-25 2004-07-06 Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences Enteric-coated proliposomal formulations for poorly water soluble drugs
US8658202B2 (en) 2001-04-25 2014-02-25 Western University Of Health Sciences Coated drug delivery formulations
IE20040202A1 (en) * 2003-03-28 2004-10-06 Sigmoid Biotechnologies Ltd Solid oral dosage form containing seamless microcapsules
GB0308732D0 (en) * 2003-04-15 2003-05-21 Axcess Ltd Absorption enhancers
GB0308734D0 (en) 2003-04-15 2003-05-21 Axcess Ltd Uptake of macromolecules
CN100371018C (zh) * 2003-06-12 2008-02-27 刘青松 降钙素组合物
RU2006101616A (ru) * 2003-06-20 2006-07-27 Ньютриниа Лтд. (Il) Способ защиты биоактивных соединений и композиции, содержащие указанные соединения
CN1557479A (zh) * 2004-01-16 2004-12-29 深圳市海王英特龙生物技术股份有限公 干扰素脂质体乳膏
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
WO2006035417A2 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule - formulations
EP1652513A1 (en) 2004-11-02 2006-05-03 Denderah Pharm Sa Reverse micelles based on sterols and acylglycerols and therapeutic uses thereof
WO2008122967A2 (en) * 2007-04-04 2008-10-16 Sigmoid Pharma Limited An oral pharmaceutical composition
EP2061587A1 (en) 2007-04-26 2009-05-27 Sigmoid Pharma Limited Manufacture of multiple minicapsules
CA2685591A1 (en) * 2007-05-01 2008-11-06 Sigmoid Pharma Limited Pharmaceutical nimodipine compositions
US8110226B2 (en) * 2007-07-20 2012-02-07 Mylan Pharmaceuticals Inc. Drug formulations having inert sealed cores
US8486452B2 (en) 2007-07-20 2013-07-16 Mylan Pharmaceuticals Inc. Stabilized tolterodine tartrate formulations
JP5640079B2 (ja) 2009-05-18 2014-12-10 シグモイド・ファーマ・リミテッドＳｉｇｍｏｉｄ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ 油滴含有組成物
WO2011018504A2 (en) 2009-08-12 2011-02-17 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
WO2011086093A2 (en) 2010-01-12 2011-07-21 Novo Nordisk A/S Pharmaceutical compositions for oral administration of insulin peptides
US8877237B2 (en) 2010-03-24 2014-11-04 Medesis Pharma Reverse micelle system comprising nucleic acids and use thereof
ES2833075T3 (es) * 2010-09-20 2021-06-14 Spi Pharma Inc Procedimiento de microencapsulación y producto
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
CN102125520A (zh) * 2011-02-24 2011-07-20 美迪思生物科技(北京)有限公司 含亲水性生物大分子的乳剂、其制备方法及用途
WO2012140155A1 (en) 2011-04-14 2012-10-18 Novo Nordisk A/S Fatty acid acylated amino acids for oral peptide delivery
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
EP2908846A1 (en) 2012-10-17 2015-08-26 Novo Nordisk A/S Fatty acid acylated d-amino acids for oral peptide delivery
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP2946788A1 (en) 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
SI3215127T1 (sl) 2014-11-07 2021-03-31 Sublimity Therapeutics Limited DCU Alpha Innovation Campus Sestavki, obsegajoči ciklosporin
BR112018069444A2 (pt) 2016-03-24 2019-10-08 Nutrinia Ltd método para promover esvaziamento gástrico num sujeito em necessidade do mesmo, insulina para uso na promoção do esvaziamento gástrico num sujeito em necessidade do mesmo e kit para uso na promoção do esvaziamento gástrico
US11318095B2 (en) * 2017-06-02 2022-05-03 Teika Pharmaceutical Co., Ltd. Micelle for solubilizing a sparingly water-soluble ingredient and solution comprising the same
EP3820455B1 (en) * 2018-07-10 2024-06-19 Universidade de Santiago de Compostela Nanostructure lipid system
WO2020257260A1 (en) 2019-06-17 2020-12-24 Massachusetts Institute Of Technology Formulation of peptide loaded liposomes and related applications
EP4251134A4 (en) * 2020-11-30 2024-05-29 Royal Melbourne Institute of Technology ORAL THERAPEUTIC ADMINISTRATION
CN117224483B (zh) * 2023-09-01 2024-05-10 山东京卫制药有限公司 一种适用于热辅助治疗的硝酸2-(4-甲基噻唑-5-基)乙酯盐脑靶向脂质体

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615885A (en) * 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
US4656289A (en) * 1984-10-25 1987-04-07 The Research Foundation Of State Univ. Of New York 1,3-dibenzyl-4-halohexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one intermediates
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
GB9007052D0 (en) 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
US5552156A (en) 1992-10-23 1996-09-03 Ohio State University Liposomal and micellular stabilization of camptothecin drugs
US5427301A (en) * 1994-05-06 1995-06-27 Ford Motor Company Ultrasonic flip chip process and apparatus
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions

Also Published As

Publication number Publication date
KR20040058196A (ko) 2004-07-03
WO2003030865A1 (en) 2003-04-17
US6951655B2 (en) 2005-10-04
EP1439821A1 (en) 2004-07-28
US20030078194A1 (en) 2003-04-24
MXPA04003440A (es) 2005-02-17
CN1303977C (zh) 2007-03-14
HK1072200A1 (en) 2005-08-19
CN1582143A (zh) 2005-02-16
JP2005508938A (ja) 2005-04-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.