BR0014311A - quinazolinones - Google Patents

quinazolinones

Info

Publication number
BR0014311A
BR0014311A BR0014311A BR0014311A BR0014311A BR 0014311 A BR0014311 A BR 0014311A BR 0014311 A BR0014311 A BR 0014311A BR 0014311 A BR0014311 A BR 0014311A BR 0014311 A BR0014311 A BR 0014311A
Authority
BR
Brazil
Prior art keywords
quinazolinones
solvates
r4
r3
r1
Prior art date
Application number
BR0014311A
Other languages
Portuguese (pt)
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Daljit Dhanoa
Bao-Ping Zhao
James Rinker
Mark Player
Richard Soll
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US40793999A priority Critical
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Priority to PCT/EP2000/008939 priority patent/WO2001023364A1/en
Publication of BR0014311A publication Critical patent/BR0014311A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in positions 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

"QUINAZOLINONAS". "Quinazolinones". A presente invenção refere-se a quinazolinonas de fórmula ( I ) em que R, R^ 1^, R^ 2^, R^ 3^, R^ 4^, Y, nem têm os significados indicados na reivindicação 1 da patente, e seus sais ou solvatos como antagonistas de glicoproteína IbIx. The present invention relates to quinazolinones of formula (I) wherein R, R1, R ^ 2 ^, R3, R4, Y, or have the meanings given in claim 1 of the patent, and salts or solvates as glycoprotein IBIX antagonists.
BR0014311A 1999-09-28 2000-09-13 quinazolinones BR0014311A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US40793999A true 1999-09-28 1999-09-28
PCT/EP2000/008939 WO2001023364A1 (en) 1999-09-28 2000-09-13 Quinazolinones

Publications (1)

Publication Number Publication Date
BR0014311A true BR0014311A (en) 2002-05-21

Family

ID=23614192

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014311A BR0014311A (en) 1999-09-28 2000-09-13 quinazolinones

Country Status (7)

Country Link
EP (1) EP1216233A1 (en)
AR (1) AR025796A1 (en)
AU (1) AU7419300A (en)
BR (1) BR0014311A (en)
CA (1) CA2385918A1 (en)
NO (1) NO20021503D0 (en)
WO (1) WO2001023364A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7687625B2 (en) 2003-03-25 2010-03-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7470700B2 (en) 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2007505121A (en) 2003-09-08 2007-03-08 武田薬品工業株式会社 Dipeptidyl peptidase inhibitors
MXPA06010571A (en) 2004-03-15 2007-02-16 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors.
WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
ES2376351T5 (en) 2005-09-14 2014-07-15 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase for treating diabetes
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
CN102675221A (en) 2005-09-16 2012-09-19 武田药品工业株式会社 Intermediate in method for preparing pyrimidinedione derivative
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783577A (en) * 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof

Also Published As

Publication number Publication date
NO20021503D0 (en) 2002-03-26
AU7419300A (en) 2001-04-30
EP1216233A1 (en) 2002-06-26
NO20021503L (en) 2002-03-26
WO2001023364A1 (en) 2001-04-05
AR025796A1 (en) 2002-12-11
CA2385918A1 (en) 2001-04-05

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired