BR0007742A - Conjugados iÈnicos moleculares de poliésteres biodegradáveis e polipeptìdeos bioativos - Google Patents

Conjugados iÈnicos moleculares de poliésteres biodegradáveis e polipeptìdeos bioativos

Info

Publication number
BR0007742A
BR0007742A BR0007742-9A BR0007742A BR0007742A BR 0007742 A BR0007742 A BR 0007742A BR 0007742 A BR0007742 A BR 0007742A BR 0007742 A BR0007742 A BR 0007742A
Authority
BR
Brazil
Prior art keywords
biodegradable polyesters
molecular ion
bioactive polypeptides
bioactive
ion conjugates
Prior art date
Application number
BR0007742-9A
Other languages
English (en)
Inventor
Shalaby W Shalaby
Eteven A Jackson
Jacques-Pierre Moreau
Original Assignee
Sod Conseils Rech Applic
Poly Med Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic, Poly Med Inc filed Critical Sod Conseils Rech Applic
Publication of BR0007742A publication Critical patent/BR0007742A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)

Abstract

Patente de Invenção: "CONJUGADOS IÈNICOS MOLECULARES DE POLIéSTERES BIODEGRADáVEIS E POLIPEPTìDEOS BIOATIVOS". Revelada é uma composição farmacêutica de liberação sustentada. A composição inclui um poliéster contendo um grupo COOH livre ionicamente conjugado com um polipeptídeo bioativo compreendendo pelo menos uma amina ionogênica eficaz, onde pelo menos 50% em peso do polipeptídeo presente na composição são ionicamente conjugados ao poliéster.
BR0007742-9A 1999-01-26 2000-01-26 Conjugados iÈnicos moleculares de poliésteres biodegradáveis e polipeptìdeos bioativos BR0007742A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/237,405 US6221958B1 (en) 1993-01-06 1999-01-26 Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
PCT/US2000/001753 WO2000043435A1 (en) 1999-01-26 2000-01-26 Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides

Publications (1)

Publication Number Publication Date
BR0007742A true BR0007742A (pt) 2001-10-23

Family

ID=22893577

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007742-9A BR0007742A (pt) 1999-01-26 2000-01-26 Conjugados iÈnicos moleculares de poliésteres biodegradáveis e polipeptìdeos bioativos

Country Status (18)

Country Link
US (1) US6221958B1 (pt)
EP (2) EP1695718A3 (pt)
JP (3) JP3476775B2 (pt)
KR (1) KR20020001724A (pt)
CN (2) CN1500820A (pt)
AR (1) AR036865A1 (pt)
AU (1) AU769658B2 (pt)
BR (1) BR0007742A (pt)
CA (1) CA2358829C (pt)
CZ (1) CZ20012670A3 (pt)
HK (1) HK1040406A1 (pt)
HU (1) HUP0500108A2 (pt)
IL (2) IL144398A0 (pt)
NZ (1) NZ513072A (pt)
PL (1) PL350552A1 (pt)
RU (1) RU2237681C2 (pt)
TW (1) TWI259189B (pt)
WO (1) WO2000043435A1 (pt)

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Also Published As

Publication number Publication date
EP1695718A3 (en) 2007-01-17
NZ513072A (en) 2003-10-31
JP3476775B2 (ja) 2003-12-10
CN1500820A (zh) 2004-06-02
KR20020001724A (ko) 2002-01-09
JP2003183364A (ja) 2003-07-03
CA2358829C (en) 2006-04-11
WO2000043435A1 (en) 2000-07-27
US6221958B1 (en) 2001-04-24
CN1344287A (zh) 2002-04-10
PL350552A1 (en) 2002-12-16
JP2002535426A (ja) 2002-10-22
EP1159328A1 (en) 2001-12-05
EP1695718A2 (en) 2006-08-30
AR036865A1 (es) 2004-10-13
HK1040406A1 (zh) 2002-06-07
AU769658B2 (en) 2004-01-29
IL144398A0 (en) 2002-05-23
IL144398A (en) 2006-08-20
TWI259189B (en) 2006-08-01
CA2358829A1 (en) 2000-07-27
HUP0500108A2 (en) 2006-09-28
JP2006176787A (ja) 2006-07-06
AU2736200A (en) 2000-08-07
CZ20012670A3 (cs) 2002-02-13
RU2237681C2 (ru) 2004-10-10
JP3990614B2 (ja) 2007-10-17

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