BG61974B1 - Комплекси, включващи n-морфолино-n-нитрозоаминоацетонитрил ициклодекстрин - Google Patents
Комплекси, включващи n-морфолино-n-нитрозоаминоацетонитрил ициклодекстрин Download PDFInfo
- Publication number
- BG61974B1 BG61974B1 BG100313A BG10031396A BG61974B1 BG 61974 B1 BG61974 B1 BG 61974B1 BG 100313 A BG100313 A BG 100313A BG 10031396 A BG10031396 A BG 10031396A BG 61974 B1 BG61974 B1 BG 61974B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- sin
- cyclodextrin
- morpholino
- complex
- complexes
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9401183A HU218280B (en) | 1994-04-26 | 1994-04-26 | Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes |
| PCT/HU1995/000011 WO1995029172A1 (en) | 1994-04-26 | 1995-04-25 | N-morpholino-n-nitrosaminoacetonitril cyclodextrin inclusion complexes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG100313A BG100313A (bg) | 1996-07-31 |
| BG61974B1 true BG61974B1 (bg) | 1998-11-30 |
Family
ID=10985114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100313A BG61974B1 (bg) | 1994-04-26 | 1996-01-26 | Комплекси, включващи n-морфолино-n-нитрозоаминоацетонитрил ициклодекстрин |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5698535A (lv) |
| EP (1) | EP0705255B1 (lv) |
| JP (1) | JP3434828B2 (lv) |
| KR (1) | KR960703404A (lv) |
| CN (1) | CN1060164C (lv) |
| AT (1) | ATE197708T1 (lv) |
| AU (1) | AU694219B2 (lv) |
| BG (1) | BG61974B1 (lv) |
| BR (1) | BR9506155A (lv) |
| CA (1) | CA2163539C (lv) |
| CZ (1) | CZ316395A3 (lv) |
| DE (1) | DE69519463T2 (lv) |
| DK (1) | DK0705255T3 (lv) |
| ES (1) | ES2153897T3 (lv) |
| FI (1) | FI956156A (lv) |
| GR (1) | GR3035356T3 (lv) |
| HR (1) | HRP950249A2 (lv) |
| HU (1) | HU218280B (lv) |
| IL (1) | IL113491A (lv) |
| LT (1) | LT4167B (lv) |
| LV (1) | LV11543B (lv) |
| MD (1) | MD1419G2 (lv) |
| NO (1) | NO311030B1 (lv) |
| NZ (1) | NZ285149A (lv) |
| PL (1) | PL312183A1 (lv) |
| PT (1) | PT705255E (lv) |
| RO (1) | RO114449B1 (lv) |
| RU (1) | RU2136698C1 (lv) |
| SI (1) | SI0705255T1 (lv) |
| SK (1) | SK155195A3 (lv) |
| WO (1) | WO1995029172A1 (lv) |
| YU (1) | YU25995A (lv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
| EP1272531B8 (en) * | 1999-11-12 | 2007-02-14 | Roquette Frˬres | Crystalline mixtures of partial methyl ethers of beta-cyclodextrin and related compounds |
| FR2805462B1 (fr) * | 2000-02-24 | 2003-08-15 | Therabel Res | Nouvelle forme galenique orale a liberation prolongee de la molsidomine |
| TWI321054B (en) * | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| EP1219306A1 (en) * | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| PT2277551E (pt) | 2002-09-06 | 2013-08-22 | Cerulean Pharma Inc | Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente |
| KR20050051686A (ko) * | 2002-10-09 | 2005-06-01 | 인설트 테라페틱스, 인코퍼레이티드 | 사이클로덱스트린-기초한 재료, 조성물 및 이의 용도 |
| JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス， インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
| EA201200617A1 (ru) * | 2009-11-23 | 2012-11-30 | Серулин Фарма Инк. | Полимеры на основе циклодекстрина для доставки лекарственных средств |
| US20140094432A1 (en) | 2012-10-02 | 2014-04-03 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| CA3078625C (en) | 2017-10-09 | 2023-01-17 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
| CN113614477B (zh) | 2019-03-14 | 2023-04-28 | 泰尔茂比司特生物技术有限公司 | 冷冻干燥装载托盘组件及系统 |
| WO2022016343A1 (zh) * | 2020-07-20 | 2022-01-27 | 深圳迈瑞生物医疗电子股份有限公司 | 一种组合物的血小板解聚用途、解聚试剂及解聚方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208233A (en) * | 1989-09-15 | 1993-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5366997A (en) * | 1991-09-24 | 1994-11-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
| US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5212204A (en) * | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
| HU212730B (en) * | 1990-03-28 | 1996-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them |
| US5389675A (en) * | 1992-03-27 | 1995-02-14 | The United States Of America As Represented By The Department Of Health And Human Services | Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents |
-
1994
- 1994-04-26 HU HU9401183A patent/HU218280B/hu not_active IP Right Cessation
-
1995
- 1995-04-25 KR KR1019950705912A patent/KR960703404A/ko not_active Application Discontinuation
- 1995-04-25 RO RO95-02248A patent/RO114449B1/ro unknown
- 1995-04-25 PL PL95312183A patent/PL312183A1/xx unknown
- 1995-04-25 BR BR9506155A patent/BR9506155A/pt not_active Application Discontinuation
- 1995-04-25 EP EP95918104A patent/EP0705255B1/en not_active Expired - Lifetime
- 1995-04-25 CN CN95190353A patent/CN1060164C/zh not_active Expired - Fee Related
- 1995-04-25 WO PCT/HU1995/000011 patent/WO1995029172A1/en not_active Application Discontinuation
- 1995-04-25 AT AT95918104T patent/ATE197708T1/de active
- 1995-04-25 SI SI9530435T patent/SI0705255T1/xx unknown
- 1995-04-25 DK DK95918104T patent/DK0705255T3/da active
- 1995-04-25 NZ NZ285149A patent/NZ285149A/en unknown
- 1995-04-25 RU RU96100760A patent/RU2136698C1/ru active
- 1995-04-25 YU YU25995A patent/YU25995A/sh unknown
- 1995-04-25 ES ES95918104T patent/ES2153897T3/es not_active Expired - Lifetime
- 1995-04-25 SK SK1551-95A patent/SK155195A3/sk unknown
- 1995-04-25 IL IL11349195A patent/IL113491A/en not_active IP Right Cessation
- 1995-04-25 US US08/571,853 patent/US5698535A/en not_active Expired - Fee Related
- 1995-04-25 CZ CZ953163A patent/CZ316395A3/cs unknown
- 1995-04-25 HR HRP9401183A patent/HRP950249A2/hr not_active Application Discontinuation
- 1995-04-25 CA CA002163539A patent/CA2163539C/en not_active Expired - Lifetime
- 1995-04-25 MD MD95-0440A patent/MD1419G2/ro unknown
- 1995-04-25 AU AU24159/95A patent/AU694219B2/en not_active Expired
- 1995-04-25 PT PT95918104T patent/PT705255E/pt unknown
- 1995-04-25 JP JP52720795A patent/JP3434828B2/ja not_active Expired - Lifetime
- 1995-04-25 DE DE69519463T patent/DE69519463T2/de not_active Expired - Lifetime
- 1995-12-20 FI FI956156A patent/FI956156A/fi not_active Application Discontinuation
- 1995-12-22 LV LVP-95-383A patent/LV11543B/en unknown
- 1995-12-22 NO NO19955283A patent/NO311030B1/no not_active IP Right Cessation
- 1995-12-22 LT LT95-133A patent/LT4167B/lt not_active IP Right Cessation
-
1996
- 1996-01-26 BG BG100313A patent/BG61974B1/bg unknown
-
2001
- 2001-02-02 GR GR20010400181T patent/GR3035356T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG61974B1 (bg) | Комплекси, включващи n-морфолино-n-нитрозоаминоацетонитрил ициклодекстрин | |
| ZA200602134B (en) | Methods and compositions for the oral adminstration of prodrugs of proton pump inhibitors | |
| JPH08506119A (ja) | 認識活性化剤ＣＩ−９７９ＨＣ▲ｌ▼の中性安定化複合体 | |
| EP0477315B1 (en) | Inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine or salts formed with cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same | |
| CA2054213C (en) | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same | |
| SI20974A (sl) | Alkoksi substituirane benzimidazolne spojine, farmacevtski pripravki, ki jih vsebujejo ter metode za njihovo uporabo | |
| JPH10265383A (ja) | 医薬組成物 | |
| JPH01287094A (ja) | ダナゾール−シクロデキストリン包接化合物 | |
| TW200522956A (en) | Method and compositions for the oral administration of prodrugs of proton pump inhibitors | |
| LU83081A1 (fr) | Compositions antitumeurs | |
| SK278809B6 (sk) | Inklúzny komplex 3-morfolinosydnonimínu alebo jeho | |
| MXPA06008032A (en) | Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms | |
| WO2006034849A1 (en) | Antitumoral pharmaceutical compositions comprising a spisulosine and a cyclodextrin |