BG108124A - "'алазинон-пип...ридинови производни ка'о pde4 инхиби'ори - Google Patents

"'алазинон-пип...ридинови производни ка'о pde4 инхиби'ори Download PDF

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Publication number
BG108124A
BG108124A BG108124A BG10812403A BG108124A BG 108124 A BG108124 A BG 108124A BG 108124 A BG108124 A BG 108124A BG 10812403 A BG10812403 A BG 10812403A BG 108124 A BG108124 A BG 108124A
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BG
Bulgaria
Prior art keywords
radical
phenyl
tetrahydro
alkyl
alkoxy
Prior art date
Application number
BG108124A
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Bulgarian (bg)
English (en)
Inventor
Gerhard Grundler
Beate Schmidt
Geert J. Sterk
Armin Hatzelmann
Daniela Bundschuh
Hans-Peter Kley
Hendrik Timmerman
Johannes A. Christiaans
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Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BG108124A publication Critical patent/BG108124A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • AIDS & HIV (AREA)
BG108124A 2001-02-15 2003-08-21 "'алазинон-пип...ридинови производни ка'о pde4 инхиби'ори BG108124A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01103496 2001-02-15
PCT/EP2002/001547 WO2002064584A1 (fr) 2001-02-15 2002-02-14 Derives de phtalazinone-piperidine en tant qu'inhibiteurs de pde4

Publications (1)

Publication Number Publication Date
BG108124A true BG108124A (bg) 2004-08-31

Family

ID=8176497

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108124A BG108124A (bg) 2001-02-15 2003-08-21 "'алазинон-пип...ридинови производни ка'о pde4 инхиби'ори

Country Status (22)

Country Link
US (3) US6953853B2 (fr)
EP (1) EP1362044A1 (fr)
JP (1) JP4301812B2 (fr)
KR (1) KR20030074817A (fr)
CN (1) CN1524080A (fr)
AU (1) AU2002234634B2 (fr)
BG (1) BG108124A (fr)
BR (1) BR0207278A (fr)
CA (1) CA2438520C (fr)
CZ (1) CZ20032491A3 (fr)
EA (1) EA200300836A1 (fr)
EE (1) EE05386B1 (fr)
HR (1) HRP20030636B1 (fr)
HU (1) HUP0303193A3 (fr)
IL (1) IL156812A0 (fr)
MX (1) MXPA03007310A (fr)
NO (1) NO325245B1 (fr)
NZ (1) NZ527424A (fr)
PL (1) PL363391A1 (fr)
SK (1) SK11382003A3 (fr)
WO (1) WO2002064584A1 (fr)
ZA (1) ZA200306815B (fr)

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Publication number Priority date Publication date Assignee Title
IL156812A0 (en) * 2001-02-15 2004-02-08 Altana Pharma Ag Phthalazinone-piperidino derivatives and pharmaceutical compositions containing the same
KR100949528B1 (ko) * 2001-09-19 2010-03-25 니코메드 게엠베하 Ｎｓａｉｄ 및 ｐｄｅ-4 억제제의 조합물
JP2005538137A (ja) * 2002-08-10 2005-12-15 アルタナ　ファルマ　アクチエンゲゼルシャフト ピペリジン−ｎ−オキシド誘導体
AU2003260376A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-pyridazones and phthalazones as pde4 inhibitors
EP1556369A1 (fr) * 2002-08-10 2005-07-27 ALTANA Pharma AG Derives de pyridazinone utilises comme inhibiteurs de pde4
WO2004018449A1 (fr) * 2002-08-10 2004-03-04 Altana Pharma Ag Derives de piperidine utilises comme inhibiteurs de la phospodiesterase-4 (pde4)
RS20050523A (en) * 2003-01-14 2007-09-21 Altana Pharma Ag., Pde4 inhibotors for the treatment of neoplasms of lymphoid cells
WO2004098633A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde-4 et un antagoniste du tnf-alpha
WO2004098605A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition pharmaceutique comprenant un inhibiteur de pde4 et il-1 trap
WO2004098606A1 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde4 et shuil-1r ii
WO2004098578A2 (fr) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprenant un inhibiteur de la pde4 et un antagoniste du tnf?
EA012279B1 (ru) * 2003-05-22 2009-08-28 Никомед Гмбх Композиция, включающая ингибитор pde4 и ингибитор pde5
AU2004269923B2 (en) * 2003-09-05 2010-05-13 Takeda Gmbh Use of PDE4 inhibitors for the treatment of diabetes mellitus
WO2005075457A1 (fr) * 2004-02-04 2005-08-18 Altana Pharma Ag Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4
EP1716123A1 (fr) * 2004-02-04 2006-11-02 Altana Pharma AG Derives de pyridazinone utiles comme inhibiteurs de pde4
ATE390419T1 (de) * 2004-02-04 2008-04-15 Nycomed Gmbh 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-o - derivate als pde4-inhibitoren
NZ560269A (en) 2005-03-08 2010-12-24 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
US20080004271A1 (en) * 2006-01-17 2008-01-03 Mckenna Jeffrey M Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith
ES2489265T3 (es) * 2006-07-05 2014-09-01 Takeda Gmbh Asociación de inhibidores de la HMG-CoA reductasa atorvastatina o simvastatina con un inhibidor de la fosfodiesterasa 4, tal como roflumilast para el tratamiento de enfermedades pulmonares inflamatorias
ES2341813T3 (es) * 2006-12-20 2010-06-28 Glaxo Group Limited 4-bencil-1 (2h)-ftalazinonas como antagonistas del receptor h1.
BRPI0811214A2 (pt) * 2007-05-16 2014-10-29 Nycomed Gmbh Derivados de pirazolona
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
US8885991B2 (en) * 2009-12-21 2014-11-11 Hewlett-Packard Development Company, L.P. Circuit switched optical interconnection fabric
JP5980318B2 (ja) 2011-06-17 2016-08-31 タケダ ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ 新規のフタラジノン−ピロロピリミジンカルボキサミド誘導体
EP2804603A1 (fr) 2012-01-10 2014-11-26 President and Fellows of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
EP3165224A1 (fr) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Utilisation d'inhibiteurs de pde4 pour la prophylaxie et/ou la thérapie de la dyslipoproteinémie et des troubles apparentés
JP6820717B2 (ja) 2016-10-28 2021-01-27 株式会社日立ハイテク プラズマ処理装置
CN113121417A (zh) * 2019-12-30 2021-07-16 苏州盛迪亚生物医药有限公司 一种新型哌啶衍生物及其药物用途
WO2021192210A1 (fr) 2020-03-27 2021-09-30 株式会社日立ハイテク Procédé de production d'un semi-conducteur

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EP0612321B1 (fr) 1991-10-09 1999-08-25 Syntex (U.S.A.) Inc. Composes pyrido pyridazinones et pyridazinthiones a activite inhibant la phosphodiesterase iv
EP0672031B1 (fr) 1992-12-02 2003-03-12 Pfizer Inc. Diethers de pyrocatechine utilises comme inhibiteurs selectifs de la pde iv
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EE04312B1 (et) * 1997-12-15 2004-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Dihüdrobensofuraanid, nende kasutamine ravimite valmistamiseks ning neid sisaldavad ravimid
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EP0934933A1 (fr) 1998-02-06 1999-08-11 Byk Gulden Lomberg Chemische Fabrik GmbH Phtalazinones
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AU7654200A (en) 1999-09-14 2001-04-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
WO2001030766A1 (fr) * 1999-10-25 2001-05-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Derives de phthalazinone, utilises comme inhibiteurs de pde4
KR20020043238A (ko) * 1999-10-25 2002-06-08 빅 굴덴 롬베르크 케미쉐 파브릭 게엠베하 Ｐｄｅ４ 억제제로서의 테트라히드로티오피란프탈라지논유도체
CA2411351A1 (fr) 2000-06-05 2001-12-13 Altana Pharma Ag Composes efficaces comme agonistes du recepteur beta 2-adrenergique et comme inhibiteurs de pde4
IL156812A0 (en) * 2001-02-15 2004-02-08 Altana Pharma Ag Phthalazinone-piperidino derivatives and pharmaceutical compositions containing the same
IL157908A0 (en) 2001-04-25 2004-03-28 Altana Pharma Ag Phthalazinone derivatives and pharmaceutical compositions containing the same
IL157870A0 (en) 2001-04-25 2004-03-28 Altana Pharma Ag Piperazino derivatives and pharmaceutical compositions containing the same
JP2005538137A (ja) 2002-08-10 2005-12-15 アルタナ　ファルマ　アクチエンゲゼルシャフト ピペリジン−ｎ−オキシド誘導体
AU2003260376A1 (en) 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-pyridazones and phthalazones as pde4 inhibitors
EP1556369A1 (fr) 2002-08-10 2005-07-27 ALTANA Pharma AG Derives de pyridazinone utilises comme inhibiteurs de pde4

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NO20033618L (no) 2003-10-15
EA200300836A1 (ru) 2004-02-26
HUP0303193A2 (hu) 2003-12-29
CZ20032491A3 (cs) 2004-01-14
NO20033618D0 (no) 2003-08-14
US6953853B2 (en) 2005-10-11
PL363391A1 (en) 2004-11-15
EE200300311A (et) 2003-10-15
IL156812A0 (en) 2004-02-08
JP4301812B2 (ja) 2009-07-22
US20050234062A1 (en) 2005-10-20
SK11382003A3 (sk) 2004-01-08
HRP20030636B1 (en) 2012-05-31
US7179810B2 (en) 2007-02-20
NZ527424A (en) 2005-02-25
MXPA03007310A (es) 2003-12-04
NO325245B1 (no) 2008-03-10
CA2438520A1 (fr) 2002-08-22
AU2002234634B2 (en) 2007-07-26
HUP0303193A3 (en) 2007-08-28
HRP20030636A2 (en) 2005-06-30
WO2002064584A1 (fr) 2002-08-22
KR20030074817A (ko) 2003-09-19
JP2004518727A (ja) 2004-06-24
EP1362044A1 (fr) 2003-11-19
US7531540B2 (en) 2009-05-12
CN1524080A (zh) 2004-08-25
US20040067946A1 (en) 2004-04-08
US20070129373A1 (en) 2007-06-07
ZA200306815B (en) 2004-06-17
EE05386B1 (et) 2011-02-15
CA2438520C (fr) 2011-10-04
BR0207278A (pt) 2004-02-10

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