BG103491A - Използване на комт инхибитори за получаване на препарат за профилактика на диабетични съдови смущения - Google Patents
Използване на комт инхибитори за получаване на препарат за профилактика на диабетични съдови смущения Download PDFInfo
- Publication number
- BG103491A BG103491A BG103491A BG10349199A BG103491A BG 103491 A BG103491 A BG 103491A BG 103491 A BG103491 A BG 103491A BG 10349199 A BG10349199 A BG 10349199A BG 103491 A BG103491 A BG 103491A
- Authority
- BG
- Bulgaria
- Prior art keywords
- preparation
- inhibitors
- diabetic
- rats
- komt
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 26
- 239000003112 inhibitor Substances 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title claims description 9
- 230000002792 vascular Effects 0.000 title description 2
- 230000006492 vascular dysfunction Effects 0.000 claims abstract description 3
- 230000002265 prevention Effects 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 3
- 108010088751 Albumins Proteins 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 208000017442 Retinal disease Diseases 0.000 claims description 2
- 206010038923 Retinopathy Diseases 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 241000700159 Rattus Species 0.000 description 21
- 230000000694 effects Effects 0.000 description 10
- UPMRZALMHVUCIN-UHFFFAOYSA-N Nitecapone Chemical compound CC(=O)C(C(C)=O)=CC1=CC(O)=C(O)C([N+]([O-])=O)=C1 UPMRZALMHVUCIN-UHFFFAOYSA-N 0.000 description 7
- 229950008980 nitecapone Drugs 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 241001233037 catfish Species 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 230000001434 glomerular Effects 0.000 description 2
- 230000024924 glomerular filtration Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 208000007241 Experimental Diabetes Mellitus Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000011887 Necropsy Methods 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 230000001452 natriuretic effect Effects 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 125000006501 nitrophenyl group Chemical group 0.000 description 1
- -1 ocal Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9626472.6A GB9626472D0 (en) | 1996-12-20 | 1996-12-20 | New use of comt inhibitors |
| PCT/FI1997/000812 WO1998027973A1 (en) | 1996-12-20 | 1997-12-19 | Use of comt inhibitors for the manufacture of a medicament for the prevention of diabetic vascular dysfunctions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103491A true BG103491A (bg) | 2000-04-28 |
Family
ID=10804746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103491A BG103491A (bg) | 1996-12-20 | 1999-06-14 | Използване на комт инхибитори за получаване на препарат за профилактика на диабетични съдови смущения |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6207706B1 (cs) |
| EP (1) | EP0964678B1 (cs) |
| JP (1) | JP2001507006A (cs) |
| KR (1) | KR20000057628A (cs) |
| AT (1) | ATE234613T1 (cs) |
| AU (1) | AU714086B2 (cs) |
| BG (1) | BG103491A (cs) |
| CA (1) | CA2275681A1 (cs) |
| CZ (1) | CZ291117B6 (cs) |
| DE (1) | DE69720064D1 (cs) |
| EA (1) | EA001673B1 (cs) |
| EE (1) | EE9700350A (cs) |
| GB (1) | GB9626472D0 (cs) |
| HU (1) | HUP0001097A3 (cs) |
| IL (1) | IL130500A (cs) |
| NO (1) | NO992985D0 (cs) |
| NZ (1) | NZ336043A (cs) |
| PL (1) | PL334093A1 (cs) |
| SK (1) | SK79999A3 (cs) |
| TR (1) | TR199901206T2 (cs) |
| WO (1) | WO1998027973A1 (cs) |
| YU (1) | YU28599A (cs) |
| ZA (1) | ZA9711468B (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20000635A0 (fi) | 2000-03-17 | 2000-03-17 | Orion Yhtymae Oyj | COMT-inhibiittoreiden käyttö analgeettina |
| FI20001593A7 (fi) * | 2000-07-03 | 2002-01-04 | Orion Yhtymo Oyj | Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia |
| FI20002044A0 (fi) | 2000-09-15 | 2000-09-15 | Orion Yhtymae Oyj | Comt-entsyymiä estäviä naftaleenijohdannaisia |
| MY148644A (en) * | 2005-07-18 | 2013-05-15 | Orion Corp | New pharmaceutical compounds |
| TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚ｏ－甲基轉移酶活性抑制化合物 |
| JP2021532133A (ja) | 2018-07-25 | 2021-11-25 | オリオン コーポレーション | ４，５−ジヒドロキシ−２−（４−メチルベンジル）イソフタロニトリル溶媒和物およびその結晶形 |
| JP2022506697A (ja) | 2018-11-09 | 2022-01-17 | オリオン コーポレーション | ４，５－ジヒドロキシ－２－（４－メチルベンジル）イソフタロニトリルの製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4672042A (en) | 1981-12-21 | 1987-06-09 | Orion Research Puerto Rico, Inc. | Method of and apparatus for chromatographic analysis |
| US5236952A (en) * | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
| DK175069B1 (da) | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
| US5283352A (en) | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
| YU213587A (en) | 1986-11-28 | 1989-06-30 | Orion Yhtymae Oy | Process for obtaining new pharmacologic active cateholic derivatives |
| FI864875A0 (fi) | 1986-11-28 | 1986-11-28 | Orion Yhtymae Oy | Nya farmakologiskt aktiva foereningar, dessa innehaollande kompositioner samt foerfarande och mellanprodukter foer anvaendning vid framstaellning av dessa. |
| US5489614A (en) | 1987-11-27 | 1996-02-06 | Orion-Yhtyma Oy | Catechol derivatives, their physiologically acceptable salts, esters and use |
| MTP1031B (en) * | 1987-12-24 | 1990-10-04 | Orion Yhtymae Oy | New use of cathecol-o-methyl transferase (comt) inhibitors and their physiologically acceptable salts and esters |
| IL91382A (en) | 1988-09-01 | 1995-06-29 | Orion Yhtymae Oy | Alkenyl or arylmethylene-substituted beta-diketones their preparation and pharmaceutical compositions containing them |
| US5185370A (en) | 1988-09-01 | 1993-02-09 | Orion-Yhtyma Oy | Substituted β-diketones and their use |
| US5185332A (en) | 1989-02-11 | 1993-02-09 | Orion-Yhtyma Oy | Thiadiazines and pharmaceutical compositions thereof as well as method of use |
| GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| GB9510481D0 (en) | 1995-05-24 | 1995-07-19 | Orion Yhtymae Oy | New catechol derivatives |
-
1996
- 1996-12-20 GB GBGB9626472.6A patent/GB9626472D0/en active Pending
-
1997
- 1997-12-19 SK SK799-99A patent/SK79999A3/sk unknown
- 1997-12-19 CA CA002275681A patent/CA2275681A1/en not_active Abandoned
- 1997-12-19 EA EA199900579A patent/EA001673B1/ru not_active IP Right Cessation
- 1997-12-19 US US09/331,113 patent/US6207706B1/en not_active Expired - Fee Related
- 1997-12-19 PL PL97334093A patent/PL334093A1/xx unknown
- 1997-12-19 YU YU28599A patent/YU28599A/sh unknown
- 1997-12-19 IL IL13050097A patent/IL130500A/xx not_active IP Right Cessation
- 1997-12-19 EP EP97948919A patent/EP0964678B1/en not_active Expired - Lifetime
- 1997-12-19 WO PCT/FI1997/000812 patent/WO1998027973A1/en not_active Ceased
- 1997-12-19 CZ CZ19992231A patent/CZ291117B6/cs not_active IP Right Cessation
- 1997-12-19 AU AU78711/98A patent/AU714086B2/en not_active Ceased
- 1997-12-19 EE EE9700350A patent/EE9700350A/xx unknown
- 1997-12-19 NZ NZ336043A patent/NZ336043A/xx unknown
- 1997-12-19 AT AT97948919T patent/ATE234613T1/de not_active IP Right Cessation
- 1997-12-19 KR KR1019990705423A patent/KR20000057628A/ko not_active Ceased
- 1997-12-19 HU HU0001097A patent/HUP0001097A3/hu unknown
- 1997-12-19 DE DE69720064T patent/DE69720064D1/de not_active Expired - Lifetime
- 1997-12-19 ZA ZA9711468A patent/ZA9711468B/xx unknown
- 1997-12-19 JP JP52844098A patent/JP2001507006A/ja active Pending
- 1997-12-19 TR TR1999/01206T patent/TR199901206T2/xx unknown
-
1999
- 1999-06-14 BG BG103491A patent/BG103491A/bg unknown
- 1999-06-17 NO NO992985A patent/NO992985D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6207706B1 (en) | 2001-03-27 |
| ZA9711468B (en) | 1998-08-29 |
| EE9700350A (et) | 1998-10-15 |
| CA2275681A1 (en) | 1998-07-02 |
| PL334093A1 (en) | 2000-01-31 |
| EA001673B1 (ru) | 2001-06-25 |
| TR199901206T2 (xx) | 1999-08-23 |
| EA199900579A1 (ru) | 1999-12-29 |
| WO1998027973A1 (en) | 1998-07-02 |
| NO992985L (no) | 1999-06-17 |
| DE69720064D1 (de) | 2003-04-24 |
| ATE234613T1 (de) | 2003-04-15 |
| KR20000057628A (ko) | 2000-09-25 |
| SK79999A3 (en) | 2000-05-16 |
| YU28599A (sh) | 2002-03-18 |
| EP0964678B1 (en) | 2003-03-19 |
| AU7871198A (en) | 1998-07-17 |
| IL130500A (en) | 2003-02-12 |
| JP2001507006A (ja) | 2001-05-29 |
| HUP0001097A3 (en) | 2003-05-28 |
| GB9626472D0 (en) | 1997-02-05 |
| EP0964678A1 (en) | 1999-12-22 |
| IL130500A0 (en) | 2000-06-01 |
| HUP0001097A2 (hu) | 2000-09-28 |
| NZ336043A (en) | 2000-12-22 |
| CZ223199A3 (cs) | 1999-11-17 |
| NO992985D0 (no) | 1999-06-17 |
| AU714086B2 (en) | 1999-12-16 |
| CZ291117B6 (cs) | 2002-12-11 |
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