BE843691A - Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine) - Google Patents

Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine)

Info

Publication number
BE843691A
BE843691A BE168562A BE168562A BE843691A BE 843691 A BE843691 A BE 843691A BE 168562 A BE168562 A BE 168562A BE 168562 A BE168562 A BE 168562A BE 843691 A BE843691 A BE 843691A
Authority
BE
Belgium
Prior art keywords
lofepramino
chlorhydrate
dibenz
azepinyl
acetophenone
Prior art date
Application number
BE168562A
Other languages
English (en)
French (fr)
Inventor
E Eriksoo
S S Kelfve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE843691A publication Critical patent/BE843691A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE168562A 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine) BE843691A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28145/75A GB1497306A (en) 1975-07-03 1975-07-03 Preparation of lofepramine and its hydrochloride

Publications (1)

Publication Number Publication Date
BE843691A true BE843691A (fr) 1977-01-03

Family

ID=10270996

Family Applications (1)

Application Number Title Priority Date Filing Date
BE168562A BE843691A (fr) 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine)

Country Status (10)

Country Link
US (1) US4172074A (en, 2012)
JP (1) JPS6014030B2 (en, 2012)
BE (1) BE843691A (en, 2012)
CA (1) CA1079274A (en, 2012)
CH (1) CH618686A5 (en, 2012)
DE (1) DE2628558A1 (en, 2012)
FR (1) FR2316234A1 (en, 2012)
GB (1) GB1497306A (en, 2012)
IE (1) IE43255B1 (en, 2012)
SE (1) SE7607565L (en, 2012)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108119A1 (de) * 1991-03-13 1992-09-17 Jellalabad Ltd Verfahren zur herstellung von 4'-chlor-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl) methylaminno) acetophenon und seiner salze, die stabilisierungseiner salze, hierbei erhaeltliche produkte und pharmmazeutische zubereitungen, die diese enthalten
GB2308065B (en) * 1994-10-05 1999-01-13 Cari Loder Treatment of multiple sclerosis (MS) and other demyelinating conditions
CA2200761C (en) 1994-10-05 2008-02-26 Cari Loder Treatment of multiple sclerosis (ms) and other demyelinating conditions using lofepramine in combination with l-phenylalanine, tyrosine or tryptophan and possibly a vitamin b12 compound
JP5646126B2 (ja) 2003-12-11 2014-12-24 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法
EP1793829A1 (en) * 2004-10-01 2007-06-13 Neurocure Ltd. Use of pharmaceutical compositions of lofepramine for the treatment of adhd, cfs, fm and depression
JP2009500043A (ja) * 2005-07-08 2009-01-08 ブレインセルス，インコーポレイティド 神経新生を調節する薬剤及び条件を同定する方法
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
WO2008086483A2 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
WO2009128058A1 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest

Also Published As

Publication number Publication date
US4172074A (en) 1979-10-23
JPS6014030B2 (ja) 1985-04-11
FR2316234B1 (en, 2012) 1979-06-08
DE2628558C2 (en, 2012) 1989-11-16
FR2316234A1 (fr) 1977-01-28
IE43255L (en) 1977-01-03
CA1079274A (en) 1980-06-10
CH618686A5 (en, 2012) 1980-08-15
DE2628558A1 (de) 1977-01-20
IE43255B1 (en) 1981-01-14
JPS527982A (en) 1977-01-21
SE7607565L (sv) 1977-01-04
GB1497306A (en) 1978-01-05

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Legal Events

Date Code Title Description
CN Change of patent owner's name
RE20 Patent expired

Owner name: PHARMACIA BIOSYSTEMS A.B.

Effective date: 19960701