AU3632878A - Spiro-hydantions - Google Patents

Spiro-hydantions

Info

Publication number
AU3632878A
AU3632878A AU36328/78A AU3632878A AU3632878A AU 3632878 A AU3632878 A AU 3632878A AU 36328/78 A AU36328/78 A AU 36328/78A AU 3632878 A AU3632878 A AU 3632878A AU 3632878 A AU3632878 A AU 3632878A
Authority
AU
Australia
Prior art keywords
hydantions
spiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU36328/78A
Other versions
AU499518B1 (en
Inventor
R Barges
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to USUS799586 priority Critical
Priority to US05/799,586 priority patent/US4130714A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of AU3632878A publication Critical patent/AU3632878A/en
Publication of AU499518B1 publication Critical patent/AU499518B1/en
Expired legal-status Critical Current

Links

AU36328/78A 1977-05-23 1978-05-22 Spiro-hydantions Expired AU499518B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
USUS799586 1977-05-23
US05/799,586 US4130714A (en) 1977-05-23 1977-05-23 Hydantoin therapeutic agents

Publications (2)

Publication Number Publication Date
AU3632878A true AU3632878A (en) 1979-04-26
AU499518B1 AU499518B1 (en) 1979-04-26

Family

ID=25176274

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36328/78A Expired AU499518B1 (en) 1977-05-23 1978-05-22 Spiro-hydantions

Country Status (37)

Country Link
US (1) US4130714A (en)
JP (1) JPS6035350B2 (en)
AR (1) AR219531A1 (en)
AT (1) AT357170B (en)
AU (1) AU499518B1 (en)
BE (1) BE867248A (en)
CA (1) CA1088073A (en)
CH (1) CH631455A5 (en)
CS (1) CS200550B2 (en)
DD (1) DD137107A5 (en)
DE (2) DE2821966C2 (en)
DK (1) DK147941C (en)
EG (1) EG13691A (en)
ES (1) ES470070A1 (en)
FI (1) FI62838C (en)
FR (1) FR2392024B1 (en)
GB (1) GB1572688A (en)
GR (1) GR68694B (en)
HK (1) HK53981A (en)
HU (1) HU177718B (en)
IE (1) IE47273B1 (en)
IL (1) IL54754A (en)
IN (1) IN147854B (en)
IT (1) IT1096306B (en)
KE (1) KE3168A (en)
LU (1) LU79685A1 (en)
MY (1) MY8200156A (en)
NL (1) NL7804158A (en)
NO (1) NO150206C (en)
NZ (1) NZ187334A (en)
PH (1) PH13828A (en)
PL (1) PL110460B1 (en)
PT (1) PT68071B (en)
SE (1) SE437375B (en)
SU (1) SU873885A3 (en)
YU (1) YU40829B (en)
ZA (1) ZA7802919B (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4210667A (en) * 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
IE50332B1 (en) * 1979-11-13 1986-04-02 Ici Ltd 1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones,processes for their manufacture and pharmaceutical compositions thereof
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
US4419521A (en) * 1981-11-12 1983-12-06 Pfizer Inc. 6-Halo-4-chromanamines useful as intermediates to make chiral hydantoins
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS6332793B2 (en) * 1980-07-21 1988-07-01 Eisai Co Ltd
JPH0345076B2 (en) * 1982-01-20 1991-07-09 Eisai Co Ltd
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
US4528387A (en) * 1982-11-10 1985-07-09 Pfizer Inc. Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US4431828A (en) * 1982-11-10 1984-02-14 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
US4556670A (en) * 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
DE3561198D1 (en) * 1984-03-23 1988-01-28 Pfizer Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4717725A (en) * 1984-04-11 1988-01-05 Alcon Laboratories, Inc. Ophthalmic wound healing with aldose reductase inhibitors
US4600717A (en) * 1984-04-11 1986-07-15 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in ophthalmic wound healing
JPH06772B2 (en) * 1984-07-09 1994-01-05 鐘淵化学工業株式会社 Process for producing 6-fluoro-4-chromanone using 3- (4-fluorophenoxy) propionitrile
WO1986000807A1 (en) * 1984-07-20 1986-02-13 Pfizer Inc. Spiro-imidazolones for treatment of diabetes complications
WO1986001107A1 (en) * 1984-08-14 1986-02-27 Pfizer Inc. Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making
AT37371T (en) * 1984-08-20 1988-10-15 Pfizer Method for producing asymmetric hydantoine.
US4704461A (en) * 1984-08-23 1987-11-03 Pfizer Inc. Processes and intermediates for sorbinil
US4620019A (en) * 1984-08-23 1986-10-28 Pfizer Inc. S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4609663A (en) * 1984-09-11 1986-09-02 Alcon Laboratories, Inc. Aldose reductase inhibitors useful in glaucoma therapy
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
WO1992000071A1 (en) * 1989-02-10 1992-01-09 Washington Research Foundation Immunoregulatory agents
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
JPH0372226B2 (en) * 1985-03-04 1991-11-18 Sanwa Kagaku Kenkyusho Co
WO1986007353A1 (en) 1985-06-14 1986-12-18 Pfizer Inc. Intermediate in the production of an asymmetric hydantoin
JPS627654U (en) * 1985-06-26 1987-01-17
US4853410A (en) * 1986-01-17 1989-08-01 Pfizer Inc. Hydroxyacetic acid derivatives for the treatment of diabetic complications
JPH0372227B2 (en) * 1986-08-28 1991-11-18 Sanwa Kagaku Kenkyusho Co
JPH01503460A (en) * 1987-03-20 1989-11-22
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US5006657A (en) * 1988-07-27 1991-04-09 Pfizer Inc. Intermediates in a resolution process for racemic spiro hydantoins
US4952694A (en) * 1988-07-27 1990-08-28 Pfizer Inc. Novel resolution process for racemic spiro-hydantoins
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4980357A (en) * 1990-03-01 1990-12-25 Pfizer Inc. Azolidinedione derivatives
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
US5236945A (en) * 1990-06-11 1993-08-17 Pfizer Inc. 1H-indazole-3-acetic acids as aldose reductase inhibitors
US5206367A (en) * 1992-02-18 1993-04-27 Pfizer Inc. Preparation of optically active spiro-hydantoins
NZ254550A (en) * 1992-09-28 1997-08-22 Pfizer Use of nitrogen-substituted pyrimidines to prepare medicaments useful for treatment or prevention of diabetic complications
US5521208A (en) * 1993-07-29 1996-05-28 Alcon Laboratories, Inc. Compositions and methods for the treatment of the metabolically impaired and for improved compliance
CN101239090A (en) * 1997-04-15 2008-08-13 Csir公司 Pharmaceutical compositions having appetite suppressant activity
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
CN1477976A (en) 2000-11-30 2004-02-25 辉瑞产品公司 Combination of GABA agonists and aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
US8158667B2 (en) 2006-08-21 2012-04-17 Kador Peter F Topical treatment of cataracts in dogs
US8877717B2 (en) 2007-03-12 2014-11-04 Zadec Aps Anti-diabetic extract of rooibos
US8273746B2 (en) * 2007-03-23 2012-09-25 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibitors
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
JP5976010B2 (en) 2010-12-23 2016-08-23 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Methods for treating COPD

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683718A (en) * 1952-01-11 1954-07-13 Searle & Co Spiro-[xanthene-9, 4'-imidazolidine]-2, 5-dione
DE1135915B (en) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Process for the production of new, more effective anticonvulsant Spirohydantoine
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents

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